Health-Related Quality of Life and Associated Factors in Chinese Menstrual Migraine Patients

Health-Related Quality of Life and Associated Factors in Chinese Menstrual Migraine Patients | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Health-Related Quality of Life and Associated Factors in Chinese Menstrual Migraine Patients Wenxiu Luo, Xing Cao, Jiayu Zhao, Jiaming Yang, Yu Cen, Jinlong He, and 8 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-1055240/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Menstrual migraine is a special form of migraine with significant impact on quality of life for those women afflicted. Presently, there is no study reported on quality of life in menstrual migraine patients. The study reported here aimed to assess the health-related quality of life and identify its associated factors among Chinese menstrual migraine patients. Methods The cross-sectional study group consisted of 109 patients with menstrual migraine and the control group consisted of 397 female patients with non-menstrual migraine. In total, 506 patients completed questionnaires for demographic and clinical information, Self-rating Idea of Suicide Scale, Hamilton Depression Scale, Hamilton Anxiety Scale, Headache Impact Test-6, Perceived Social Support Scale, Pittsburgh Sleep Quality Index. Health-related quality of life was measured using the 36-Item Short Form Survey. Results Compared with non-menstrual migraine patients, five dimensions of health-related quality of life were all found to be significantly impaired in menstrual migraine patients. Headache frequency (ß=-0.218, P=0.014), the impact of headache on daily life (ß=-0.270, P=0.002), depression symptoms (ß=-0.345, P<0.001) were significantly associated with physical component summary, depression symptoms (ß= -0.379, P<0.001), social support (ß=0.270, P<0.001), suicidal ideation (ß=-0.344, P<0.001) were closely related to mental component summary. Conclusion Menstrual migraine patients had significantly poorer health-related quality of life in many domains than non-menstrual migraine patients. Headache frequency, the impact of headache on daily life, depression symptoms, social support and suicidal ideation were significantly associated with health-related quality of life in menstrual migraine patients. Trial registration: ChiCTR1800014343. Registered 01 July 2018 at Chinese Clinical Trial registry. http://www.chictr.org.cns Health Economics & Outcomes Research Menstrual migraine Health related quality of life Associated factors SF-36 Figures Figure 1 Background Migraine is a common debilitating headache disorder that was ranked as the second highest cause of disability in the 2016 Global Burden of Disease study[ 1 ]. Menstrual migraine (MM) is a subclass of migraine that can be classified into two types: pure menstrual migraine and menstrually-related migraine[ 2 ], and the prevalence of MM in female migraine patients is nearly 60%[ 3 ]. Compared with non-menstrual Migraine (NMM), MM is characterised by longer duration, greater frequency, less responsive to treatment, and may cause more severe disability and heavier life burden to patients[ 4 , 5 ]. Health-related quality of life is defined as an individual's subjective perception of the impact of disease and treatment on physical, psychological, social and somatic domains of functioning and well-being[ 6 ]. HRQoL assessments could provide patients, researchers and policy makers with information about the status of a patient’s health in an efficient manner[ 7 ]. Limited number of studies indicate a negative effect of migraine on quality of life[ 8 , 9 ]. In clinical practice, it has also been observed that a considerable proportion of MM patients suffer from anxiety and depression symptoms, sleep disorders and other unpleasant mental and physical experience, leading to decreased quality of life. Therefore, it is of great significance to actively search for and devote to improving controllable risk factors for MM patients. Clinicians have found the contribution of that demographic factors such as age, clinical factors such as frequency and severity of pain, and psychological factors such as anxiety and depression symptom play an important role in decreasing the migraine patients’ quality of life. However, studies on the quality of life and its associated factors in patients with MM are scarce. Based on the particularities of MM, further study of factors related to quality of life with MM is warranted. The purpose of this cross-sectional study was to explore the HRQoL of MM versus NMM and to identify its associated factors among Chinese MM patients. It was hypothesized that (1) MM patients have lower HRQoL when compared with NMM; (2) Some clinical and psychological factors could affect the HRQoL of MM patients. Our research would provide a more comprehensive understanding of the HRQoL and associated factors among Chinese MM patients. Understanding these factors may help the development of individualized strategies for patients, thereby raising the HRQoL and reducing the financial, social and psychological burden. Method Participants and study design A cross-sectional study was conducted from February 2019 to February 2020 at the neurology department of a hospital in western China. A total of 545 female migraine patients who met the diagnostic criteria were screened, and 39 persons who did not complete the HRQoL scale were excluded (3 with MM, 36 with NMM). A total of 506 female patients diagnosed with MM (n = 109) and NMM (n = 397) were included in this study, the inclusion criteria are in line with the International Classification of Headache Disorders, Third Edition (ICHD-3) developed by the Headache Classification Committee of the International Headache Society (Two experienced neurologists confirmed all diagnoses using ICHD-3 diagnostic criteria). Exclusion criteria: 1. Patients who had been diagnosed with psychiatric illness before the headache occurred, including anxiety disorder, depressive disorder, sleep disturbance, etc; 2. Patients with secondary headaches; 3. patients suffered from other disease that affect the quality of life; 4. patients who could not understand the content of questionnaire or did not complete the questionnaire; 5. Patients who refuse to sign informed consent. All participants signed an informed consent, and this study was approved by the Survey Ethics Committee of the first author’s affiliated institution. All authors had full access to all data. Data Collection Demographic and headache information Demographic variables include age, ethnicity (Han/minority), height (cm), weight (kg), body mass index (BMI), BMI is calculated as BMI = body mass (kg)/ (height (m))2. Headache related information include headache frequency (the average number of days with headache per month over the last 3 months), duration (72h), severity (mild/moderate/severe), with or without family History and with or without aura. Health-related quality of life HRQoL was measured using the Mandarin version of 36-Item Short Form Survey (SF-36) which has been tested with satisfactory reliability and validity[ 10 , 11 ]. The SF-36 is a widely used survey of self-reported physical and mental health with 36 questions that measures 8 dimensions of health: physical functioning (PF), role-physical (RP), bodily pain (BP), general health (GH), vitality (VT), social functioning (SF), role-emotional (RE), and mental health (MH). The eight dimensions can also be summarizes as physical component summary (PCS) and mental component summary (MCS), which are respectively average value of physical health dimensions (PF, RP, BP, GH) and mental health dimensions (VT, SF, RE, MH)[ 7 ]. Impact of Headache on daily life We performed the Headache Impact Test-6 (HIT-6) to assess the impact of headache on daily life. The HIT-6 is a concise and reliable tool for measuring headache burden based on six domains with total score ranging from 36 to 78. The higher the score, the greater impact of headaches on daily activities[ 12 ]. Anxiety and depression symptoms The severity of anxiety symptoms and depression symptoms of patients were assessed using the Hamilton Anxiety Scale (HAMA) and the Hamilton Depression Scale (HAMD) respectively. The higher the score, the more severe the anxiety or depression symptoms are[ 13 , 14 ]. Social support Perceived Social Support Scale (PSSS) consists of 12 items, assessing perceived support from family, friends, and significant others. The total score ranges from 12-84, with higher scores representing higher perceived social support[ 15 ]. Sleep quality We measured sleep quality of patients using the Pittsburgh Sleep Quality Index (PSQI), a questionnaire that assesses subjectively perceived sleep quality over the last month. The PSQI is a self-report instrument that consists of 7 components: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleeping medications, and daytime dysfunction. The total score ranges from 0-21, with higher scores indicating poorer sleep quality[ 16 ]. Suicidal ideation Self-rating Idea of Suicide Scale (SIOSS) is a self-report tool in Chinese with 26 questions that evaluate the suicide ideation of patients. We use the sum of three factors (despair, sleep and optimism) to assess the level of suicidal ideation. The SIOSS has been shown to have good reliability and validity[ 17 ]. A higher score reflects a higher level of suicidal ideation. Data quality control All the data collectors including psychiatrists and neurologists have received special training about data collection and management to ensure uniformity in criteria evaluation. Statistical methods Statistical analyses were performed with IBM SPSS version 26.0 software. Measurement data was expressed as Mean (standard deviation (SD)) and t test was used to compare between two groups. Count data was presented as percentages (N, %), and chi-square test was used to compare between two groups. Possible associated factors of PCS and MCS were analyzed using univariable logistic regression, stepwise multiple linear regression was performed on the factors with statistical significance in the univariate regression analyses to identify the independent factors that influenced PCS and MCS. P < 0.05 was considered statistically significant. Results Demographic and clinical characteristics A total of 506 patients consented to participate in the study, including 109 MM patients and 397 NMM patients, with mean ages of 23.62 years (SD=7.59) and 21.48 years (SD=7.08), respectively. Table 1 presents the demographic and clinical characteristics about the participants and illustrates the differences between MM and NMM. Health-related quality of life Figure 1 (Figure 1 : Mean scores in SF-36 for menstrual migraine (MM) patients vs. non-menstrual migraine (NMM). PF, physical functioning; RP, role-physical; BP, bodily pain; GH, general health; VT: vitality; SF: social functioning; RE: role-emotional; MH, mental health; PCS, physical component summary; MCS: mental component summary. * P<0.05) presents the mean scores of different dimensions of the HRQoL among the MM and NMM groups. MM patients had significantly lower mean scores for the five dimensions of HRQoL (PF, RF, GH, SF, MH) compared with NMM patients. The average PCS and MCS scores of MM patients were 67.82(14.08) and 67.82(14.08), respectively, which were significantly lower than those of NMM patients. Detailed data are presented in Table 1. Table 1 Demographic and clinical data of our study sample Variable MM (N=109) NMM (N=397) P value Mean (SD)/ N (%) Age, years * 23.62 (7.59) 21.48 (7.09) 0.009 BMI 20.19 (2.50) 20.14 (2.38) 0.848 Headache frequency, days/month 3.97 (4.57) 3.83 (4.58) 0.750 PF* 89.13 (12.07) 91.52 (10.18) 0.037 RF* 59.17 (38.29) 69.40 (36.99) 0.012 BP 70.28 (14.28) 72.90 (14.95) 0.102 GH* 53.11 (17.21) 57.84 (17.74) 0.013 VT 61.24 (15.43) 62.01 (15.29) 0.641 SF* 79.68 (15.90) 93.78 (13.18) <0.001 RE 42.20 (39.19) 46.26 (40.77) 0.353 MH* 58.80 (15.08) 62.21 (14.80) 0.034 PCS* 67.82 (14.08) 72.91 (14.25) 0.001 MCS* 60.31 (16.45) 66.07 (15.54) 0.001 Ethnicity 0.131 Han 105 (96.3) 366 (92.2) Minority 4 (3.7) 31 (7.8) Family history 0.058 Yes 78 (71.6) 245 (61.7) No 31 (28.4) 152 (38.3) Aura 0.547 Yes 17 (15.6) 53 (13.4) No 92 (84.4) 344 (86.6) Degree of headache 0.141 Mild 32 (29.4) 148 (37.3) Moderate 60 (55.0) 209 (52.6) Severe 17 (15.6) 40 (10.1) Headache duration 0.539 72h 3 (2.8) 9 (2.3) BMI, body mass index; PF, physical functioning; RP, role-physical; BP, bodily pain; GH, general health; VT: vitality; SF: social functioning; RE: role-emotional; MH, mental health; PCS, physical component summary; MCS: mental component summary. Univariate analysis of factors associated with PCS and MCS Univariate analysis showed that the PCS and MCS scores were both correlated with headache frequency, anxiety and depression symptoms, suicidal ideation, sleep quality and social support, while the impact of headache on daily life was only related to PCS scores. Detailed data are presented in Table 2 . Table 2 Univariate linear of factors associated with SF-36 Variable ß t Value 95%CI P Value PCS Headache frequency -0.364 -0.405 (-1.671,-0.572) <0.001 HIT-6 -0.359 -3.977 (-0.719,-0.241) <0.001 HAMD -0.399 -4.507 (-1.058,-0.412) <0.001 HAMA -0.400 -4.513 (-1.073,-0.418) <0.001 PSSS 0.260 2.786 (0.091,0.543) 0.006 PSQI -0.335 -3.658 (-2.279,-0.677) <0.001 SIOSS -0.360 -3.989 (-1.869,-0.628) <0.001 MCS Headache frequency -0.244 -2.607 (-1.547,-0.211) 0.010 HIT-6 -0.151 -1.585 (-0.533,-0.059) 0.116 HAMD -0.600 -7.760 (-1.619,-0.960) <0.001 HAMA -0.459 -5.351 (-1.371,-0.630) <0.001 PSSS 0.473 5.553 (0.433,0.914) <0.001 PSQI -0.306 -3.312 (2.517,-0.632) 0.001 SIOSS -0.630 -8.382 (-3.155,-1.948) <0.001 PCS, physical component summary; HIT-6, Headache Impact Text-6; HAMD, Hamilton Rating Scale for Depression; HAMA, Hamilton Rating Scale for Anxiety; PSSS, Perceived social support scale; PSQI, Pittsburgh Sleep Quality Index; SIOSS, Self-rating Idea of Suicide Scale.MCS: mental component summary. Step-wise multiple linear regression of factors associated with PCS and MCS Headache frequency (ß=-0.218, P=0.014), depression symptoms (ß=- 0.345, P<0.001), the impact of headache on daily life (ß=-0.270, P=0.002) were negatively associated with PCS, depression symptoms (ß=-0.379, P<0.001), suicidal ideation (ß=-0.344, P<0.001) were negatively associated with MCS, while social support (ß= 0.270, P<0.001) was positively associated with MCS. Detailed data are presented in Table3. Table 3: Step-wise multiple linear regression of factors associated with SF-36 Variable ß t Value 95%CI P Value PCS Headache frequency -0.218 -2.503 (-1.198,-0.139) 0.014 HIT-6 -0.270 -3.151 (-0.599,-0.136) 0.002 HAMD -0.345 -4.164 (-0.936,-0.332) <0.001 MCS HAMD -0.379 -5.134 (-1.124,-0.498) <0.001 PSSS 0.270 3.912 (0.190, 0.581) <0.001 SIOSS -0.344 -4.434 (-2.018,-0.771) <0.001 PCS, physical component summary; HIT-6, Headache Impact Text-6; HAMD, Hamilton Rating Scale for Depression; MCS: mental component summary; PSSS, Perceived social support scale;SIOSS, Self-rating Idea of Suicide Scale. Disussion This study provides, for the first time, a comprehensive assessment of the HRQoL and its associated factors in Chinese patients with MM. We found that the HRQoL in MM patients is lower in five dimensions of HRQoL (PF, RF, GH, SF, MH) compared with NMM patients. In addition, in the stepwise linear regression model, we found that PCS is related to headache frequency, depression symptoms, the impact of headache on daily life. MCS is related to depression symptoms, suicidal ideation, social support in MM patients. Such findings point the way to scientific strategies to improve HRQoL for MM patients. Migraine increases the burden of patients[ 18 ], and seriously affects the life quality of patients[ 8 ]. Nicodemo et al. used SF-36 to evaluate the life quality of MM, and found the scores of MM in the six dimensions of HRQoL (PF, RP, BP, GH, VT, SF)were lower than those of healthy women, and there is no significant difference in the scores of the two dimensions (RE, MH)[ 19 ]. Based on the severity and refractory of MM, we performed subgroup analysis of migraine to compare the HRQoL in patients with MM and NMM. We found MM patients had lower mean scores for the five dimensions (PF, RF, GH, SF, MH) compared with NMM patients, and there were no statistically significant differences in scores for the three dimensions (BP, VT, RE). In addition, patients with MM scored lower than NMM for both PCS and MCS. Our study demonstrated that depression symptoms are independently associated with PCS and MCS, after adjusting the confounding factors. Depression is a common comorbidity in migraine patients, and HRQoL was reduced in patients who had both migraine and depression relative to migraine patients who were not depressed[ 20 ]. A recent study in the United States found that depression symptoms are a predictor of headache frequency and migraine-related disability[ 21 ]. Hence, it is not difficult to understand that depression symptoms are closely associated with physical and mental health. In agreement with the study finding in Brazil, we demonstrated that the severity of depression symptoms is a predictor of HRQoL among MM[ 22 ]. Pradeep et al. reported the presence of depression was noted to add to the magnitude of migraine-related disability and diminished the quality of life in migraine patients, which is similar to the results of our study[ 23 ]. This study[ 23 ] also found that anxiety had a negative impact on the quality of life of patients who suffer from migraine. In our study, although univariate analysis showed that anxiety symptoms may be a significant risk factor for HRQoL in MM patients, no significant difference was detected by multivariate analysis. At present it cannot be certain that anxiety symptoms are independently associated with HRQoL among MM patients. MM patients who reported more frequent migraine attacks and greater impact of headaches on daily life could impair HRQoL by affecting their physical health. A downward trend in the quality of life of migraine was noted with the increased headache frequency[ 20 ]. Previous study has proved that the more frequent migraine attacks and greater impact of headaches on daily life were predictors of detrimental effects on quality of life in migraine patients[ 23 ], which is similar to our results. In a recent study, Irimia found that a positive linear association between headache frequency and the risk of anxiety, depression in migraine patients[ 24 ]. Patients with monthly headache days ≥ 3 days are at higher risk of anxiety, while those with ≥ 19 days are at risk of depression. Moreover, patients with monthly headache days ≥ 10 days are often accompanied by severe disability[ 24 ]. It is interesting to note that patients experiencing only one to six headaches per year still show a reduction in quality of life, it might be due to the unpredictability of attacks that magnifies the effect of the few headache days on quality of life in a remarkable way[ 20 ]. Richard et al[ 25 ] examined the association between headache-free days and the disease burden of migraine, and found headache-related disability shows a decrease tendency with the headache-free days increasing[ 25 ]. Our research showed that the perception of social support is positively associated with MCS. An Italian study of chronic migraine patients with medication overuse found that social support is a predictor of the quality of life to some extent[ 26 ]. Moreover, a French study also found that the higher perceived social support was, the higher the probability of being an active consulter for migraine[ 27 , 28 ]. Such headache counseling allowed patients to actively take prevention and treatment strategies to minimize the burden of migraine and relieve adverse emotions, and thus engaged more in social activities and improved HRQoL, especially in mental health related HRQoL. As the limitations of daily social and work-related activities caused by migraine, the mental health of patients was impacted, and severe cases may lead to suicidal ideation. Our research found that suicidal ideation can affect MCS and could consequently predict HRQoL of MM patients. Many scholars agreed that migraine patients are associated with a poor quality of life and a higher likelihood of suicidal ideation[ 8 , 9 , 29 , 30 ]. This study demonstrated, for the first time to our knowledge, the correlation between HRQoL and suicidal ideation among MM patients. Providing psychological treatment to MM patients with suicidal ideation may help to reduce suicide risk, as can the application of active treatment, improving their mental health and HRQoL. Sleep disturbance, as a clinical triggers for migraine, is associated with migraine, creating a vicious cycle[ 31 ]. Although sleep quality is associated with the PCS and MCS of patients with MM in the univariate analysis, it is no longer a significant associated factor after adjusting for the potential confounders in the multivariate model. Thus, we cannot consider sleep quality as a predictor for HRQoL in MM patients. In the current study, the evidence describing the relationship between sleep quality and HRQoL was still insufficient among migraine patients[ 32 ],and this result was in line with the previous study. Conclusion Considering HRQoL by migraine subtype, we found that MM patients had a worse HRQoL with statistically significantly lower mean scores in many domains than NMM patients. Depression symptoms are closely linked to physical and mental health in MM patients. For MM patients, PCS is related to the headache frequency and the impact of headaches on daily life, and MCS is related to the social support and suicidal ideation. Moreover, sleep quality did not have a significant impact on the HRQoL among MM patients. The early application of individualized treatment may help improve the HRQoL in patients with MM. There were some limitations to this study. The sample representativeness was limited because the sample was derived from the outpatient population of a hospital in southwest China. A multicenter study would be needed with a larger sample size and more associated factors to determine the factors that had an association with HRQoL of MM patients. List Of Abbreviations HRQoL: Health-related quality of life; MM: Menstrual migraine; NMM: non-menstrual migraine; SIOSS: Self-rating Idea of Suicide Scale; HAMD: Hamilton Depression Scale; HAMA: Hamilton Anxiety Scale; HIT-6: Headache Impact Test-6; PSSS: Perceived Social Support Scale; PSQI: Pittsburgh Sleep Quality Index; SF-36: 36-Item Short Form Survey; ICHD-3: International Classification of Headache Disorders, Third Edition; BMI: Body mass index; PF: Physical functioning; RP: Role-physical; BP: Bodily pain; GH:General health; VT:Vitality; SF:Social functioning; RE: Role-emotional; MH: Mental health; PCS: Physical component summary; MCS: Mental component summary; SD: Standard deviation. Declarations Ethics approval and consent to participate Approval was obtained from the ethics committee of Affiliated Hospital of North Sichuan Medical College.The procedures used in this study adhere to the tenets of the Declaration of Helsinki. An informed consent was obtained from each participant. Consent for publication Not applicable. Availability of data and materials The datasets used or analysed during the current study are available from the corresponding author on reasonable request. Conflicts of interest The authors declare that they have no competing interests Funding The research received funding from the Bureau of Science and Technology and Intellectual Property of Nanchong City (No. NSMC20170420). Authors’ contributions Material preparation, data collection and analysis were performed by Wenxiu Luo, Xing Cao and Jiaming Luo. The first draft of the manuscript was written by Wenxiu Luo and Xing Cao, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript. All authors certify responsibility of the paper. Acknowledgements We thank all the patients for their support in this research. 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J Affect Disord. 2020; 277 :253–259. doi: 10.1016/j.jad.2020.08.019 . Ferini-Strambi L, Galbiati A, Combi R: Sleep disorder-related headaches . Neurol Sci. 2019; 40 :107–113. doi: 10.1007/s10072-019-03837-z . Wang, XM, Zhang YH, Shao GF. Analysis of the factors affecting migraine patients' quality of life. (article in Chinese ) Journal of Neuroscience and Mental Health. 2018; 18 :28–31. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-1055240","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":65360576,"identity":"c1f7cd7f-34fa-4c89-a0e6-64816bccea5f","order_by":0,"name":"Wenxiu Luo","email":"","orcid":"","institution":"Affiliated Hospital of North Sichuan Medical College","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Wenxiu","middleName":"","lastName":"Luo","suffix":""},{"id":65360577,"identity":"4a0d6a09-c601-408e-b4a5-04671d0973de","order_by":1,"name":"Xing Cao","email":"","orcid":"","institution":"Affiliated Hospital of North Sichuan Medical College","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Xing","middleName":"","lastName":"Cao","suffix":""},{"id":65360578,"identity":"dd5ce0c0-6fea-454f-960d-e4afefa429d5","order_by":2,"name":"Jiayu Zhao","email":"","orcid":"","institution":"Affiliated Hospital of North Sichuan Medical College","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Jiayu","middleName":"","lastName":"Zhao","suffix":""},{"id":65360579,"identity":"907ed891-1b80-4e6e-8b11-aeda86524e58","order_by":3,"name":"Jiaming Yang","email":"","orcid":"","institution":"Affiliated Hospital of North Sichuan Medical College","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Jiaming","middleName":"","lastName":"Yang","suffix":""},{"id":65360580,"identity":"075d633e-d415-4428-9215-97733ffcc43d","order_by":4,"name":"Yu Cen","email":"","orcid":"","institution":"North Sichuan Medical College [Search North Sichuan Medical 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Luo","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA50lEQVRIie3PuwrCMBSA4VMK7XK0a4uirxAROuqrKK4VnJxUhEK7WHwVXapjRWiXuNdNB52chWwm3jZTR8H8QwKHfCQBUKl+MM3nSwegCqAnz1nnO4IAxutoAXnFCZLviB7qp8VxPUaSza5H5rXAMj0CbC17mOHmXZohobtVsxT3wJldiBZR6V84CVIkeT+uaHECJPeIrgUyYl6fxDs7jJN2MUFxy0gQwy6JW+xiMuQkQYemboX/BW16HmwiCWnMs3jPgkmtnPniYa2aFfaWByYj0/u2fQ9QLMlnAFB/bBPZGZVKpfr3bixdUe+0se8zAAAAAElFTkSuQmCC","orcid":"https://orcid.org/0000-0003-0025-0379","institution":"North Sichuan Medical College [Search North Sichuan Medical College]: North Sichuan Medical University","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Jiaming","middleName":"","lastName":"Luo","suffix":""}],"badges":[],"createdAt":"2021-11-06 07:26:43","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-1055240/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-1055240/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":16017174,"identity":"8706109a-b1e0-4de5-8d17-b19a63da6e63","added_by":"auto","created_at":"2021-11-30 15:18:11","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":72856,"visible":true,"origin":"","legend":"Mean scores in SF-36 for menstrual migraine (MM) patients vs. non-menstrual migraine (NMM). PF, physical functioning; RP, role-physical; BP, bodily pain; GH, general health; VT: vitality; SF: social functioning; RE: role-emotional; MH, mental health; PCS, physical component summary; MCS: mental component summary. * P\u003c0.05","description":"","filename":"fig1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-1055240/v1/933a6ab9d09a748b3df3f101.jpg"},{"id":16457477,"identity":"96cfe35a-72d8-4532-85f6-0a59e90d74ba","added_by":"auto","created_at":"2021-12-14 22:35:50","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1044655,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-1055240/v1/1c9e7e94-4f86-4e99-8625-0eb6b922d84c.pdf"}],"financialInterests":"","formattedTitle":"\u003cp\u003eHealth-Related Quality of Life and Associated Factors in Chinese Menstrual Migraine Patients\u003c/p\u003e","fulltext":[{"header":"Background","content":"\u003cp\u003eMigraine is a common debilitating headache disorder that was ranked as the second highest cause of disability in the 2016 Global Burden of Disease study[\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e]. Menstrual migraine (MM) is a subclass of migraine that can be classified into two types: pure menstrual migraine and menstrually-related migraine[\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e], and the prevalence of MM in female migraine patients is nearly 60%[\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e]. Compared with non-menstrual Migraine (NMM), MM is characterised by longer duration, greater frequency, less responsive to treatment, and may cause more severe disability and heavier life burden to patients[\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e, \u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eHealth-related quality of life is defined as an individual's subjective perception of the impact of disease and treatment on physical, psychological, social and somatic domains of functioning and well-being[\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e]. HRQoL assessments could provide patients, researchers and policy makers with information about the status of a patient\u0026rsquo;s health in an efficient manner[\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e]. Limited number of studies indicate a negative effect of migraine on quality of life[\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e, \u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e]. In clinical practice, it has also been observed that a considerable proportion of MM patients suffer from anxiety and depression symptoms, sleep disorders and other unpleasant mental and physical experience, leading to decreased quality of life. Therefore, it is of great significance to actively search for and devote to improving controllable risk factors for MM patients. Clinicians have found the contribution of that demographic factors such as age, clinical factors such as frequency and severity of pain, and psychological factors such as anxiety and depression symptom play an important role in decreasing the migraine patients\u0026rsquo; quality of life. However, studies on the quality of life and its associated factors in patients with MM are scarce. Based on the particularities of MM, further study of factors related to quality of life with MM is warranted.\u003c/p\u003e \u003cp\u003eThe purpose of this cross-sectional study was to explore the HRQoL of MM versus NMM and to identify its associated factors among Chinese MM patients. It was hypothesized that (1) MM patients have lower HRQoL when compared with NMM; (2) Some clinical and psychological factors could affect the HRQoL of MM patients. Our research would provide a more comprehensive understanding of the HRQoL and associated factors among Chinese MM patients. Understanding these factors may help the development of individualized strategies for patients, thereby raising the HRQoL and reducing the financial, social and psychological burden.\u003c/p\u003e"},{"header":"Method","content":"\u003cdiv id=\"Sec3\" class=\"Section2\"\u003e \u003ch2\u003eParticipants and study design\u003c/h2\u003e \u003cp\u003eA cross-sectional study was conducted from February 2019 to February 2020 at the neurology department of a hospital in western China. A total of 545 female migraine patients who met the diagnostic criteria were screened, and 39 persons who did not complete the HRQoL scale were excluded (3 with MM, 36 with NMM). A total of 506 female patients diagnosed with MM (n = 109) and NMM (n = 397) were included in this study, the inclusion criteria are in line with the International Classification of Headache Disorders, Third Edition (ICHD-3) developed by the Headache Classification Committee of the International Headache Society (Two experienced neurologists confirmed all diagnoses using ICHD-3 diagnostic criteria). Exclusion criteria: 1. Patients who had been diagnosed with psychiatric illness before the headache occurred, including anxiety disorder, depressive disorder, sleep disturbance, etc; 2. Patients with secondary headaches; 3. patients suffered from other disease that affect the quality of life; 4. patients who could not understand the content of questionnaire or did not complete the questionnaire; 5. Patients who refuse to sign informed consent. All participants signed an informed consent, and this study was approved by the Survey Ethics Committee of the first author\u0026rsquo;s affiliated institution. All authors had full access to all data.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec4\" class=\"Section2\"\u003e \u003ch2\u003eData Collection\u003c/h2\u003e \u003cdiv id=\"Sec5\" class=\"Section3\"\u003e \u003ch2\u003eDemographic and headache information\u003c/h2\u003e \u003cp\u003eDemographic variables include age, ethnicity (Han/minority), height (cm), weight (kg), body mass index (BMI), BMI is calculated as BMI = body mass (kg)/ (height (m))2. Headache related information include headache frequency (the average number of days with headache per month over the last 3 months), duration (\u0026lt;24h/24-72h/\u0026gt;72h), severity (mild/moderate/severe), with or without family History and with or without aura.\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv id=\"Sec6\" class=\"Section2\"\u003e \u003ch2\u003eHealth-related quality of life\u003c/h2\u003e \u003cp\u003eHRQoL was measured using the Mandarin version of 36-Item Short Form Survey (SF-36) which has been tested with satisfactory reliability and validity[\u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e, \u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e]. The SF-36 is a widely used survey of self-reported physical and mental health with 36 questions that measures 8 dimensions of health: physical functioning (PF), role-physical (RP), bodily pain (BP), general health (GH), vitality (VT), social functioning (SF), role-emotional (RE), and mental health (MH). The eight dimensions can also be summarizes as physical component summary (PCS) and mental component summary (MCS), which are respectively average value of physical health dimensions (PF, RP, BP, GH) and mental health dimensions (VT, SF, RE, MH)[\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e].\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec7\" class=\"Section2\"\u003e \u003ch2\u003eImpact of Headache on daily life\u003c/h2\u003e \u003cp\u003eWe performed the Headache Impact Test-6 (HIT-6) to assess the impact of headache on daily life. The HIT-6 is a concise and reliable tool for measuring headache burden based on six domains with total score ranging from 36 to 78. The higher the score, the greater impact of headaches on daily activities[\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e].\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec8\" class=\"Section2\"\u003e \u003ch2\u003eAnxiety and depression symptoms\u003c/h2\u003e \u003cp\u003eThe severity of anxiety symptoms and depression symptoms of patients were assessed using the Hamilton Anxiety Scale (HAMA) and the Hamilton Depression Scale (HAMD) respectively. The higher the score, the more severe the anxiety or depression symptoms are[\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e, \u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e].\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec9\" class=\"Section2\"\u003e \u003ch2\u003eSocial support\u003c/h2\u003e \u003cp\u003ePerceived Social Support Scale (PSSS) consists of 12 items, assessing perceived support from family, friends, and significant others. The total score ranges from 12-84, with higher scores representing higher perceived social support[\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e].\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec10\" class=\"Section2\"\u003e \u003ch2\u003eSleep quality\u003c/h2\u003e \u003cp\u003eWe measured sleep quality of patients using the Pittsburgh Sleep Quality Index (PSQI), a questionnaire that assesses subjectively perceived sleep quality over the last month. The PSQI is a self-report instrument that consists of 7 components: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleeping medications, and daytime dysfunction. The total score ranges from 0-21, with higher scores indicating poorer sleep quality[\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e].\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec11\" class=\"Section2\"\u003e \u003ch2\u003eSuicidal ideation\u003c/h2\u003e \u003cp\u003eSelf-rating Idea of Suicide Scale (SIOSS) is a self-report tool in Chinese with 26 questions that evaluate the suicide ideation of patients. We use the sum of three factors (despair, sleep and optimism) to assess the level of suicidal ideation. The SIOSS has been shown to have good reliability and validity[\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e]. A higher score reflects a higher level of suicidal ideation.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec12\" class=\"Section2\"\u003e \u003ch2\u003eData quality control\u003c/h2\u003e \u003cp\u003eAll the data collectors including psychiatrists and neurologists have received special training about data collection and management to ensure uniformity in criteria evaluation.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec13\" class=\"Section2\"\u003e \u003ch2\u003eStatistical methods\u003c/h2\u003e \u003cp\u003eStatistical analyses were performed with IBM SPSS version 26.0 software. Measurement data was expressed as Mean (standard deviation (SD)) and t test was used to compare between two groups. Count data was presented as percentages (N, %), and chi-square test was used to compare between two groups. Possible associated factors of PCS and MCS were analyzed using univariable logistic regression, stepwise multiple linear regression was performed on the factors with statistical significance in the univariate regression analyses to identify the independent factors that influenced PCS and MCS. P \u0026lt; 0.05 was considered statistically significant.\u003c/p\u003e \u003c/div\u003e"},{"header":"Results","content":"\u003cdiv id=\"Sec15\" class=\"Section2\"\u003e \u003ch2\u003eDemographic and clinical characteristics\u003c/h2\u003e \u003cp\u003eA total of 506 patients consented to participate in the study, including 109 MM patients and 397 NMM patients, with mean ages of 23.62 years (SD=7.59) and 21.48 years (SD=7.08), respectively. Table 1 presents the demographic and clinical characteristics about the participants and illustrates the differences between MM and NMM.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec16\" class=\"Section2\"\u003e \u003ch2\u003eHealth-related quality of life\u003c/h2\u003e \u003cp\u003eFigure \u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003e (Figure \u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003e: Mean scores in SF-36 for menstrual migraine (MM) patients vs. non-menstrual migraine (NMM). PF, physical functioning; RP, role-physical; BP, bodily pain; GH, general health; VT: vitality; SF: social functioning; RE: role-emotional; MH, mental health; PCS, physical component summary; MCS: mental component summary. * P\u0026lt;0.05) presents the mean scores of different dimensions of the HRQoL among the MM and NMM groups. MM patients had significantly lower mean scores for the five dimensions of HRQoL (PF, RF, GH, SF, MH) compared with NMM patients. The average PCS and MCS scores of MM patients were 67.82(14.08) and 67.82(14.08), respectively, which were significantly lower than those of NMM patients. Detailed data are presented in Table 1.\u003c/p\u003e \u003c/div\u003e\n\u003cp\u003e\u003cstrong\u003eTable 1 \u003c/strong\u003eDemographic and clinical data of our study sample\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eVariable\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003eMM (N=109)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003eNMM (N=397)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" width=\"25%\"\u003e\n \u003cp\u003eP value\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" width=\"100%\"\u003e\n \u003cp\u003eMean (SD)/ N (%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eAge, years *\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e23.62\u0026nbsp;(7.59)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e21.48 (7.09)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e0.009\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eBMI\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e20.19\u0026nbsp;(2.50)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e20.14 (2.38)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e0.848\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eHeadache frequency, days/month\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e3.97 (4.57)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e3.83 (4.58)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e0.750\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003ePF*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e89.13 (12.07)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e91.52 (10.18)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e0.037\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eRF*\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e59.17 (38.29)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e69.40 (36.99)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e0.012\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eBP\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e70.28 (14.28)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e72.90 (14.95)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e0.102\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eGH*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e53.11 (17.21)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e57.84 (17.74)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e0.013\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eVT\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e61.24 (15.43)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e62.01 (15.29)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e0.641\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eSF*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e79.68 (15.90)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e93.78 (13.18)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e\u0026lt;0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eRE\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e42.20 (39.19)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e46.26 (40.77)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e0.353\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eMH*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e58.80 (15.08)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e62.21 (14.80)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e0.034\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003ePCS*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e67.82 (14.08)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e72.91 (14.25)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eMCS*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e60.31 (16.45)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e66.07 (15.54)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eEthnicity\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e0.131\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eHan\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e105 (96.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e366 (92.2)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eMinority\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e4 (3.7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e31 (7.8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eFamily history\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e0.058\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e78 (71.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e245 (61.7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e31 (28.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e152 (38.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eAura\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e0.547\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e17 (15.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e53 (13.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e92 (84.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e344 (86.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eDegree of headache\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e0.141\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eMild\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e32 (29.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e148 (37.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eModerate\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e60 (55.0)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e209 (52.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eSevere\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e17 (15.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e40 (10.1)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003eHeadache duration\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e0.539\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003e\u0026lt;24h\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e99 (90.8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e372 (93.7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003e24-72h\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e7 (6.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e16 (4.0)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" width=\"35.2112676056338%\"\u003e\n \u003cp\u003e\u0026gt;72h\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e3 (2.8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.8943661971831%\"\u003e\n \u003cp\u003e9 (2.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eBMI, body mass index; PF, physical functioning; RP, role-physical; BP, bodily pain; GH, general health; VT: vitality; SF: social functioning; RE: role-emotional; MH, mental health; PCS, physical component summary; MCS: mental component summary.\u003c/p\u003e\n \u003cdiv id=\"Sec17\" class=\"Section2\"\u003e \u003ch2\u003eUnivariate analysis of factors associated with PCS and MCS\u003c/h2\u003e \u003cp\u003eUnivariate analysis showed that the PCS and MCS scores were both correlated with headache frequency, anxiety and depression symptoms, suicidal ideation, sleep quality and social support, while the impact of headache on daily life was only related to PCS scores. Detailed data are presented in Table \u003cspan refid=\"Tab1\" class=\"InternalRef\"\u003e2\u003c/span\u003e.\u003c/p\u003e \u003cp\u003e \u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab1\" border=\"1\"\u003e \u003ccaption language=\"En\"\u003e \u003cdiv class=\"CaptionNumber\"\u003eTable 2\u003c/div\u003e \u003cdiv class=\"CaptionContent\"\u003e \u003cp\u003eUnivariate linear of factors associated with SF-36\u003c/p\u003e \u003c/div\u003e \u003c/caption\u003e \u003ccolgroup cols=\"5\"\u003e \u003cthead\u003e \u003ctr\u003e \u003cth align=\"left\" colname=\"c1\"\u003e \u003cp\u003eVariable\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u0026szlig;\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c3\"\u003e \u003cp\u003et Value\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c4\"\u003e \u003cp\u003e95%CI\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c5\"\u003e \u003cp\u003eP Value\u003c/p\u003e \u003c/th\u003e \u003c/tr\u003e \u003c/thead\u003e \u003ctbody\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003ePCS\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eHeadache frequency\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e-0.364\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e-0.405\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e(-1.671,-0.572)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e\u0026lt;0.001\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eHIT-6\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e-0.359\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e-3.977\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e(-0.719,-0.241)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e\u0026lt;0.001\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eHAMD\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e-0.399\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e-4.507\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e(-1.058,-0.412)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e\u0026lt;0.001\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eHAMA\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e-0.400\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e-4.513\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e(-1.073,-0.418)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e\u0026lt;0.001\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003ePSSS\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e0.260\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e2.786\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e(0.091,0.543)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e0.006\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003ePSQI\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e-0.335\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e-3.658\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e(-2.279,-0.677)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e\u0026lt;0.001\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eSIOSS\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e-0.360\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e-3.989\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e(-1.869,-0.628)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e\u0026lt;0.001\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eMCS\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eHeadache frequency\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e-0.244\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e-2.607\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e(-1.547,-0.211)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e0.010\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eHIT-6\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e-0.151\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e-1.585\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e(-0.533,-0.059)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e0.116\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eHAMD\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e-0.600\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e-7.760\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e(-1.619,-0.960)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e\u0026lt;0.001\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eHAMA\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e-0.459\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e-5.351\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e(-1.371,-0.630)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e\u0026lt;0.001\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003ePSSS\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e0.473\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e5.553\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e(0.433,0.914)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e\u0026lt;0.001\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003ePSQI\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e-0.306\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e-3.312\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e(2.517,-0.632)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e0.001\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eSIOSS\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e-0.630\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e-8.382\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e(-3.155,-1.948)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e\u0026lt;0.001\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003c/tbody\u003e \u003c/colgroup\u003e \u003ctfoot\u003e \u003ctr\u003e\u003ctd colspan=\"5\"\u003ePCS, physical component summary; HIT-6, Headache Impact Text-6; HAMD, Hamilton Rating Scale for Depression; HAMA, Hamilton Rating Scale for Anxiety; PSSS, Perceived social support scale; PSQI, Pittsburgh Sleep Quality Index; SIOSS, Self-rating Idea of Suicide Scale.MCS: mental component summary.\u003c/td\u003e\u003c/tr\u003e \u003c/tfoot\u003e \u003c/table\u003e\u003c/div\u003e \u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec18\" class=\"Section2\"\u003e \u003ch2\u003eStep-wise multiple linear regression of factors associated with PCS and MCS\u003c/h2\u003e \u003cp\u003eHeadache frequency (\u0026szlig;=-0.218, P=0.014), depression symptoms (\u0026szlig;=- 0.345, P\u0026lt;0.001), the impact of headache on daily life (\u0026szlig;=-0.270, P=0.002) were negatively associated with PCS, depression symptoms (\u0026szlig;=-0.379, P\u0026lt;0.001), suicidal ideation (\u0026szlig;=-0.344, P\u0026lt;0.001) were negatively associated with MCS, while social support (\u0026szlig;= 0.270, P\u0026lt;0.001) was positively associated with MCS. Detailed data are presented in Table3.\u003c/p\u003e \u003cp\u003eTable 3: Step-wise multiple linear regression of factors associated with SF-36\u003c/p\u003e \u003cp\u003e \u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"No\" id=\"Taba\" border=\"1\"\u003e \u003ccolgroup cols=\"5\"\u003e \u003cthead\u003e \u003ctr\u003e \u003cth align=\"left\" colname=\"c1\"\u003e \u003cp\u003eVariable\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u0026szlig;\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c3\"\u003e \u003cp\u003et Value\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c4\"\u003e \u003cp\u003e95%CI\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c5\"\u003e \u003cp\u003eP Value\u003c/p\u003e \u003c/th\u003e \u003c/tr\u003e \u003c/thead\u003e \u003ctbody\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003ePCS\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eHeadache frequency\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e-0.218\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e-2.503\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e(-1.198,-0.139)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e0.014\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eHIT-6\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e-0.270\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e-3.151\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e(-0.599,-0.136)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e0.002\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eHAMD\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e-0.345\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e-4.164\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e(-0.936,-0.332)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e\u0026lt;0.001\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eMCS\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eHAMD\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e-0.379\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e-5.134\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e(-1.124,-0.498)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e\u0026lt;0.001\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003ePSSS\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e0.270\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e3.912\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e(0.190, 0.581)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e\u0026lt;0.001\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eSIOSS\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c2\"\u003e \u003cp\u003e-0.344\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e \u003cp\u003e-4.434\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e(-2.018,-0.771)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\".\" colname=\"c5\"\u003e \u003cp\u003e\u0026lt;0.001\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003c/tbody\u003e \u003c/colgroup\u003e \u003ctfoot\u003e \u003ctr\u003e\u003ctd colspan=\"5\"\u003ePCS, physical component summary; HIT-6, Headache Impact Text-6; HAMD, Hamilton Rating Scale for Depression; MCS: mental component summary; PSSS, Perceived social support scale;SIOSS, Self-rating Idea of Suicide Scale.\u003c/td\u003e\u003c/tr\u003e \u003c/tfoot\u003e \u003c/table\u003e\u003c/div\u003e \u003c/p\u003e \u003c/div\u003e"},{"header":"Disussion","content":"\u003cp\u003eThis study provides, for the first time, a comprehensive assessment of the HRQoL and its associated factors in Chinese patients with MM. We found that the HRQoL in MM patients is lower in five dimensions of HRQoL (PF, RF, GH, SF, MH) compared with NMM patients. In addition, in the stepwise linear regression model, we found that PCS is related to headache frequency, depression symptoms, the impact of headache on daily life. MCS is related to depression symptoms, suicidal ideation, social support in MM patients. Such findings point the way to scientific strategies to improve HRQoL for MM patients.\u003c/p\u003e \u003cp\u003eMigraine increases the burden of patients[\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e], and seriously affects the life quality of patients[\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e]. Nicodemo et al. used SF-36 to evaluate the life quality of MM, and found the scores of MM in the six dimensions of HRQoL (PF, RP, BP, GH, VT, SF)were lower than those of healthy women, and there is no significant difference in the scores of the two dimensions (RE, MH)[\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e]. Based on the severity and refractory of MM, we performed subgroup analysis of migraine to compare the HRQoL in patients with MM and NMM. We found MM patients had lower mean scores for the five dimensions (PF, RF, GH, SF, MH) compared with NMM patients, and there were no statistically significant differences in scores for the three dimensions (BP, VT, RE). In addition, patients with MM scored lower than NMM for both PCS and MCS.\u003c/p\u003e \u003cp\u003eOur study demonstrated that depression symptoms are independently associated with PCS and MCS, after adjusting the confounding factors. Depression is a common comorbidity in migraine patients, and HRQoL was reduced in patients who had both migraine and depression relative to migraine patients who were not depressed[\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e]. A recent study in the United States found that depression symptoms are a predictor of headache frequency and migraine-related disability[\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e]. Hence, it is not difficult to understand that depression symptoms are closely associated with physical and mental health. In agreement with the study finding in Brazil, we demonstrated that the severity of depression symptoms is a predictor of HRQoL among MM[\u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e]. Pradeep et al. reported the presence of depression was noted to add to the magnitude of migraine-related disability and diminished the quality of life in migraine patients, which is similar to the results of our study[\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e]. This study[\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e] also found that anxiety had a negative impact on the quality of life of patients who suffer from migraine. In our study, although univariate analysis showed that anxiety symptoms may be a significant risk factor for HRQoL in MM patients, no significant difference was detected by multivariate analysis. At present it cannot be certain that anxiety symptoms are independently associated with HRQoL among MM patients.\u003c/p\u003e \u003cp\u003eMM patients who reported more frequent migraine attacks and greater impact of headaches on daily life could impair HRQoL by affecting their physical health. A downward trend in the quality of life of migraine was noted with the increased headache frequency[\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e]. Previous study has proved that the more frequent migraine attacks and greater impact of headaches on daily life were predictors of detrimental effects on quality of life in migraine patients[\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e], which is similar to our results. In a recent study, Irimia found that a positive linear association between headache frequency and the risk of anxiety, depression in migraine patients[\u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e]. Patients with monthly headache days \u0026ge; 3 days are at higher risk of anxiety, while those with \u0026ge; 19 days are at risk of depression. Moreover, patients with monthly headache days \u0026ge; 10 days are often accompanied by severe disability[\u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e]. It is interesting to note that patients experiencing only one to six headaches per year still show a reduction in quality of life, it might be due to the unpredictability of attacks that magnifies the effect of the few headache days on quality of life in a remarkable way[\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e]. Richard et al[\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e] examined the association between headache-free days and the disease burden of migraine, and found headache-related disability shows a decrease tendency with the headache-free days increasing[\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eOur research showed that the perception of social support is positively associated with MCS. An Italian study of chronic migraine patients with medication overuse found that social support is a predictor of the quality of life to some extent[\u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e26\u003c/span\u003e]. Moreover, a French study also found that the higher perceived social support was, the higher the probability of being an active consulter for migraine[\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e, \u003cspan citationid=\"CR28\" class=\"CitationRef\"\u003e28\u003c/span\u003e]. Such headache counseling allowed patients to actively take prevention and treatment strategies to minimize the burden of migraine and relieve adverse emotions, and thus engaged more in social activities and improved HRQoL, especially in mental health related HRQoL.\u003c/p\u003e \u003cp\u003eAs the limitations of daily social and work-related activities caused by migraine, the mental health of patients was impacted, and severe cases may lead to suicidal ideation. Our research found that suicidal ideation can affect MCS and could consequently predict HRQoL of MM patients. Many scholars agreed that migraine patients are associated with a poor quality of life and a higher likelihood of suicidal ideation[\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e, \u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e, \u003cspan citationid=\"CR29\" class=\"CitationRef\"\u003e29\u003c/span\u003e, \u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e30\u003c/span\u003e]. This study demonstrated, for the first time to our knowledge, the correlation between HRQoL and suicidal ideation among MM patients. Providing psychological treatment to MM patients with suicidal ideation may help to reduce suicide risk, as can the application of active treatment, improving their mental health and HRQoL.\u003c/p\u003e \u003cp\u003eSleep disturbance, as a clinical triggers for migraine, is associated with migraine, creating a vicious cycle[\u003cspan citationid=\"CR31\" class=\"CitationRef\"\u003e31\u003c/span\u003e]. Although sleep quality is associated with the PCS and MCS of patients with MM in the univariate analysis, it is no longer a significant associated factor after adjusting for the potential confounders in the multivariate model. Thus, we cannot consider sleep quality as a predictor for HRQoL in MM patients. In the current study, the evidence describing the relationship between sleep quality and HRQoL was still insufficient among migraine patients[\u003cspan citationid=\"CR32\" class=\"CitationRef\"\u003e32\u003c/span\u003e],and this result was in line with the previous study.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eConsidering HRQoL by migraine subtype, we found that MM patients had a worse HRQoL with statistically significantly lower mean scores in many domains than NMM patients. Depression symptoms are closely linked to physical and mental health in MM patients. For MM patients, PCS is related to the headache frequency and the impact of headaches on daily life, and MCS is related to the social support and suicidal ideation. Moreover, sleep quality did not have a significant impact on the HRQoL among MM patients. The early application of individualized treatment may help improve the HRQoL in patients with MM.\u003c/p\u003e \u003cp\u003eThere were some limitations to this study. The sample representativeness was limited because the sample was derived from the outpatient population of a hospital in southwest China. A multicenter study would be needed with a larger sample size and more associated factors to determine the factors that had an association with HRQoL of MM patients.\u003c/p\u003e"},{"header":"List Of Abbreviations","content":"\u003cp\u003eHRQoL: Health-related quality of life; MM: Menstrual migraine; NMM: non-menstrual migraine; SIOSS: Self-rating Idea of Suicide Scale; HAMD: Hamilton Depression Scale; HAMA: Hamilton Anxiety Scale; HIT-6: Headache Impact Test-6; PSSS: Perceived Social Support Scale; PSQI: Pittsburgh Sleep Quality Index; SF-36: 36-Item Short Form Survey; ICHD-3: International Classification of Headache Disorders, Third Edition; BMI: Body mass index; PF: Physical functioning; RP: Role-physical; BP: Bodily pain; GH:General health; VT:Vitality; SF:Social functioning; RE: Role-emotional; MH: Mental health; PCS: Physical component summary; MCS: Mental component summary; SD: Standard deviation.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eApproval was obtained from the ethics committee of Affiliated Hospital of North Sichuan Medical College.The procedures used in this study adhere to the tenets of the Declaration of Helsinki. An informed consent was obtained from each participant.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe datasets used or analysed during the current study are available from the corresponding author on reasonable request.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConflicts of interest\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no competing interests\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe research received funding from the Bureau of Science and Technology and Intellectual Property of Nanchong City (No. NSMC20170420).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors\u0026rsquo; contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eMaterial preparation, data collection and analysis were performed by Wenxiu Luo, Xing Cao and Jiaming Luo. The first draft of the manuscript was written by Wenxiu Luo and Xing Cao, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript. All authors certify responsibility of the paper.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe thank all the patients for their support in this research.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e\u003cspan\u003eDisease GBD, Injury I, Prevalence C: Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. \u003cem\u003eLancet.\u003c/em\u003e 2017;\u003cb\u003e390\u003c/b\u003e:1211\u0026ndash;1259. doi: \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/S0140-6736(17)32154-2\u003c/span\u003e\u003c/span\u003e.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eHeadache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 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(article in Chinese\u003c/b\u003e) \u003cem\u003eJournal of Neuroscience and Mental Health.\u003c/em\u003e 2018;\u003cb\u003e18\u003c/b\u003e:28\u0026ndash;31.\u003c/span\u003e\u003c/li\u003e\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Menstrual migraine, Health related quality of life, Associated factors, SF-36","lastPublishedDoi":"10.21203/rs.3.rs-1055240/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-1055240/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eBackground\u003c/h2\u003e \u003cp\u003eMenstrual migraine is a special form of migraine with significant impact on quality of life for those women afflicted. Presently, there is no study reported on quality of life in menstrual migraine patients. The study reported here aimed to assess the health-related quality of life and identify its associated factors among Chinese menstrual migraine patients.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e \u003cp\u003eThe cross-sectional study group consisted of 109 patients with menstrual migraine and the control group consisted of 397 female patients with non-menstrual migraine. In total, 506 patients completed questionnaires for demographic and clinical information, Self-rating Idea of Suicide Scale, Hamilton Depression Scale, Hamilton Anxiety Scale, Headache Impact Test-6, Perceived Social Support Scale, Pittsburgh Sleep Quality Index. Health-related quality of life was measured using the 36-Item Short Form Survey.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003eCompared with non-menstrual migraine patients, five dimensions of health-related quality of life were all found to be significantly impaired in menstrual migraine patients. Headache frequency (\u0026szlig;=-0.218, P=0.014), the impact of headache on daily life (\u0026szlig;=-0.270, P=0.002), depression symptoms (\u0026szlig;=-0.345, P\u0026lt;0.001) were significantly associated with physical component summary, depression symptoms (\u0026szlig;= -0.379, P\u0026lt;0.001), social support (\u0026szlig;=0.270, P\u0026lt;0.001), suicidal ideation (\u0026szlig;=-0.344, P\u0026lt;0.001) were closely related to mental component summary.\u003c/p\u003e\u003ch2\u003eConclusion\u003c/h2\u003e \u003cp\u003eMenstrual migraine patients had significantly poorer health-related quality of life in many domains than non-menstrual migraine patients. Headache frequency, the impact of headache on daily life, depression symptoms, social support and suicidal ideation were significantly associated with health-related quality of life in menstrual migraine patients.\u003c/p\u003e\u003ch2\u003eTrial registration:\u003c/h2\u003e \u003cp\u003eChiCTR1800014343. Registered 01 July 2018 at Chinese Clinical Trial registry. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttp://www.chictr.org.cns\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e","manuscriptTitle":"Health-Related Quality of Life and Associated Factors in Chinese Menstrual Migraine Patients","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2021-11-30 15:18:09","doi":"10.21203/rs.3.rs-1055240/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"358ed300-17f1-4077-884d-39f04a2bb0cf","owner":[],"postedDate":"November 30th, 2021","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":8737509,"name":"Health Economics \u0026 Outcomes Research"}],"tags":[],"updatedAt":"2021-12-14T22:35:41+00:00","versionOfRecord":[],"versionCreatedAt":"2021-11-30 15:18:09","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-1055240","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-1055240","identity":"rs-1055240","version":["v1"]},"buildId":"cBFmMYwuxLRRLfASyISRj","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}