Intervention mechanism of Traditional Chinese medicine on the expression of TGF - β 1, IL-10 and MAdCAM-1 in ulcerative colitis

Background: Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease that invades the colonic mucosa and is characterized by ulceration. It has been listed as one of the modern refractory diseases by the World Health Organization, and has become a hot issue in the field of Gastroenterology of Traditional Chinese medicine. This study aimed to determine the intervention mechanism of Traditional Chinese medicine in the treatment of UC. Methods: : The pathological changes of intestines were observed. TGF - β1, IL-10 and MadCAM-1 in the intestinal tissue or in the serum of UC rats were detected in order to explore the intervention mechanism of the Chinese medicine (Sodium Houttuynia, Matrine and HQHLD) in an immune-TNBS-ethanol rat model. Results: : Sodium Houttuynia, Matrine and HQHLD could alleviate intestinal inflammation reaction in the UC by lessening the pathological changes and fibrosis of the intestine, regulating the expression of TGF - β1, IL-10 and MadCAM-1 in the intestine or in the serum, and by reducing lymphocyte homing to intestinal tissues. Conclusions: : This study revealed the intervention mechanism of Traditional Chinese medicine in the treatment of UC, which provided further theoretical and scientific basis for the treatment of clinical ulcerative colitis. Our results will likely help expand clinical practice using HQHLD, Matrine and Sodium Houttuynia as effective Chinese medicines to treat ulcerative colitis.