Patients with IVF complicated by moderate-to-critical OHSS experience increased thrombosis,GDM and neonatal NICU admission but slightly shorter gestation compared with matched IVF counterparts: A retrospective Chinese cohort study

Patients with IVF complicated by moderate-to-critical OHSS experience increased thrombosis,GDM and neonatal NICU admission but slightly shorter gestation compared with matched IVF counterparts: A retrospective Chinese cohort study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Patients with IVF complicated by moderate-to-critical OHSS experience increased thrombosis,GDM and neonatal NICU admission but slightly shorter gestation compared with matched IVF counterparts: A retrospective Chinese cohort study Linli Hu, Rui Xie, Mengying Wang, Yingpu Sun This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.2.20287/v5 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 13 Jan, 2021 Read the published version in Reproductive Biology and Endocrinology → Version 5 posted 4 You are reading this latest preprint version Show more versions Abstract Background: Ovarian hyperstimulation syndrome (OHSS) is a common disease during controlled ovarian hyperstimulation treatment. However, the obstetric and neonatal outcomes of this group of patients are unknown. The aim of this study was to explore the effects of late moderate-to-critical OHSS on obstetric and neonatal outcomes. Methods: This prospective observational study included 17,537 patients who underwent IVF/ICSI-fresh embryo transfer (ET) between June 2012 and July 2016 and met the inclusion criteria, including 7,064 eligible patients diagnosed with clinical pregnancy. Ultimately, 6,356 patients were allocated to the control group, and 385 patients who were hospitalized and treated at the center for late moderate-to-critical OHSS were allocated to the OHSS group. Then, propensity score matching analysis was performed, matching nine maternal baseline covariates and the number of multiple gestations; 385 patients with late moderate-to-critical OHSS were compared with a matched control group of 1,540 patients. The primary outcomes were the live birth rate, preterm delivery rate, miscarriage rate, gestational age at birth (weeks), obstetric complications and neonatal complications. Results: The duration of gestation in the matched control group was significantly higher than that in the OHSS group. The live birth delivery rate did not significantly differ between the OHSS and matched control groups. The incidence rates of the obstetric complications venous thrombosis (VT) and gestational diabetes mellitus (GDM), neonatal complications and the number of neonates admitted to the NICU were significantly higher in the OHSS group than in the matched control group. Conclusions: Pregnant women undergoing IVF with fresh ET whose course is complicated by late moderate-to-critical OHSS appear to experience shortened gestation and increased obstetrical and neonatal complications compared with matched controls whose course is not complicated by OHSS. However, the live birth rate, average neonatal weight, and incidence rates of premature delivery, miscarriage, early abortion, hypertensive disorder of pregnancy (HDP), placenta previa (PP), intrahepatic cholestasis of pregnancy (ICP), and low neonatal birth weight (LBW) did not differ significantly between the two groups. Endocrinology & Metabolism OHSS pregnancy outcomes neonatal outcome in vitro fertilization infertility Figures Figure 1 Introduction The widespread use of assisted reproductive technology (ART) in the clinic to enhance the oocyte number has increased the prevalence of ovarian hyperstimulation syndrome (OHSS) [1, 2]. The etiopathogenesis of OHSS remains unclear, but hCG, VEGF, angiotensin, and interleukin seem to be the key players in OHSS. These factors increase capillary permeability and cause blood volume reduction, blood concentration, liver function damage, kidney function damage, water and electrolyte disorders, thrombosis, acute respiratory distress syndrome and other clinical manifestations, and the condition can be life-threatening [3-5]. Clinical studies indicate that the incidence of moderate-to-severe OHSS is approximately 2-3%, and milder forms may develop in up to 20– 30% of all in vitro fertilization (IVF) patients [5]. The clinical symptoms of OHSS are highly variable and difficult to precisely classify, and uniform standards are lacking, rendering accurate clinical data collection and unified classification difficult. Recently, numerous reports concerning the prevention and treatment of OHSS have been published. However, the pregnancy outcomes of OHSS are poorly understood and remain controversial likely because the impact of late OHSS on pregnancy outcomes is difficult to predict [6-10]. Earlier studies have demonstrated that pregnancy and abortion rates are significantly increased among OHSS patients and that these patients are more likely to develop adverse pregnancy outcomes, such as abortion, growth restriction, hypertensive disorder of pregnancy (HDP), gestational diabetes mellitus (GDM) and low neonatal birth weight (LBW) [1, 11-17]. In addition, one study reported that the hospitalization of OHSS patients who underwent IVF was not conducive to pregnancy or continued pregnancy [18]. The aim of this study was to investigate the effects of late moderate-to-critical OHSS on pregnancy and neonatal outcomes in pregnancies conceived following IVF/ICSI fresh embryo transfers. Materials And Methods This prospective observational study was approved by the Institutional Review Board of the First Affiliated Hospital of Zhengzhou University and the Institutional Ethics Committee Review Board of the First Affiliated Hospital of Zhengzhou University, Zhengzhou University (Scientific research-2019-LW-046). This study was retrospectively registered on May 26th, 2017 (ChiCTR-1800014655). The inclusion criteria in this study were as follows: IVF/ICSI-fresh embryo transfer (ET) and an age ≤40 years. The exclusion criteria included the following: preimplantation genetic testing (PGT), donor sperm and donor oocyte, female age > 40 years, missing clinical data, sperm extraction method for percutaneous epididymis/testicular puncture/testicular biopsy (PESA/TESA/TESE), parental chromosomal abnormalities, Mullerian tube abnormalities (uterine malformations), and other diseases that may affect pregnancy outcomes, including an adverse pregnancy history, diabetes, hyperprolactinemia, hypothyroidism, hyperthyroidism, cervix postoperative conization, pituitary tumor, pituitary microadenoma, premature ovarian failure, a history of pelvic tuberculosis, a history of rheumatic immune system disease, and a history of psychiatric diseases. The classification criteria for OHSS were as follows: early-onset OHSS indicated the occurrence of OHSS no later than 9 days after the hCG injection, and late OHSS indicated the occurrence of OHSS generally no earlier than 10 days after the hCG injection [5, 15]. The classification of OHSS symptoms were as follows: mild: abdominal distension/discomfort, mild nausea/vomiting, mild dyspnea, diarrhea, enlarged ovaries, and no important alterations; moderate: mild features, ultrasonographic evidence of ascites, hemoconcentration (Hct >41%), and elevated WBC (>15,000 mL); severe: mild and moderate features, clinical evidence of ascites, hydrothorax, severe dyspnea, oliguria/anuria, intractable nausea/vomiting, severe hemoconcentration (Hct >55%), WBC >25,000 mL, CrCl 1.6 mg/dL, Na+ 5 mEq/L, and elevated liver enzymes; critical: low blood/central venous pressure, pleural effusion, rapid weight gain (>1 kg in 24 h), syncope, severe abdominal pain, venous thrombosis, anuria/acute renal failure, arrhythmia, thromboembolism, pericardial effusion, massive hydrothorax, arterial thrombosis, adult respiratory distress syndrome, sepsis, and worsening of findings [19]. The control group included patients with no evidence of OHSS of any severity after undergoing fresh ET, and the OHSS group were patients who were hospitalized and treated at the center with late moderate-to-critical OHSS. Statistical analysis The incidences of the main outcome measures (obstetric complications and neonatal complications) were compared between the OHSS group and control group. First, we compared the baseline characteristics of the women according to the conception category. Potential confounders were selected based on the literature and clinical reasoning [3-10, 12-17]. The confounding baseline characteristics, including maternal age, infertility duration, body mass index (BMI), basal FSH, basal LH, antral follicle count (AFC), infertility cause, estradiol level on the hCG trigger day (pg/mL), number of oocytes retrieved from follicles with diameters ≥12 mm, and number of multiple gestations, were collected. We implemented a propensity score matching approach to identify the control group women who were most similar to the OHSS group women [20-25]. Propensity score matching was used to further validate the logistic regression analysis results. For the propensity score analysis, we performed one-to-four matching without replacement based on the nearest propensity scores of the OHSS and control groups [20-25]. Matching variables are presented in Table 1. The primary outcomes of our study were pregnancy outcomes, obstetric and neonatal complications, the live birth delivery rate, the miscarriage rate, gestational age at birth (weeks) and neonatal birth weight. Categorical data are represented as frequencies and percentages, and differences in these measures between the study groups were assessed by chi-square analysis with the Fisher’s exact test for expected frequencies less than 5. Continuous data are expressed as means ± standard deviations (SD) using IBM SPSS Statistics Version 22. Statistical analysis, including propensity score matching of data, was performed using R Statistical software version 3.2.5 (install.packages (“MatchIt”, R Foundation for Statistical Computing; https://www.r-project.org/). The significance testing was 2-sided, and P<0.05 was considered statistically significant. Results All 17,537 patients who met the inclusion and exclusion criteria were included, and 7,064 eligible patients who were diagnosed with clinical pregnancy after IVF/ICSI-fresh ET between June 2012 and July 2016 were evaluated. After meeting the inclusion and exclusion criteria, 6,356 patients who had no evidence of OHSS of any severity after undergoing fresh ET were allocated to the control group, and 385 (3.03%) patients who were hospitalized and treated at the center for late moderate-to-critical OHSS were allocated to the OHSS group. Then, the patients were grouped by propensity score matching as shown in the flow chart in Figure 1. In the OHSS group, 272 cases (70.7%) underwent fertilization by conventional IVF, and the control group included 4,646 cases (73.1%). On the day of embryonic development, the embryos were all transferred in fresh cycles. The OHSS group included the following patients: ex d3: 366 cases, 95.1%, d5/6: 18 cases, 4.9%; control group: ex d3: 5,907 cases, 90.4%, d5/6: 631 cases, 9.6%. Factors associated with OHSS Compared with the control group, the patients with moderate-to-critical OHSS in our center were characterized by a young age, a low BMI, ovulation disorders or PCOS, a low basal FSH level, a higher E 2 level on the hCG trigger day, and follicles ≥12 mm on the trigger day of final oocyte maturation (Table 1). Study patients The basic parameters of the patients in the two groups are presented in Table 1. A propensity score matching analysis was performed with matching based on multiple maternal baseline characteristics (one-to-four), and the analysis yielded 1,540 non-OHSS patients. The baseline patient characteristics and number of multiple gestation pregnancies were similar between the two study groups (Table 1). Characteristics of the moderate-to-critical OHSS patients The OHSS group comprised 385 patients (83 moderate OHSS; 289 severe OHSS; and 13 critical OHSS), with an average length of hospital stay of 12.7±6.9 days. The OHSS group included 302 (78.4%) patients who developed severe or critical OHSS. After admission, compared to the moderate group, the patients in the severe-to-critical group were hospitalized longer, and the percentage of those receiving puncture surgery was higher (9.3±4.7 vs. 13.8±7.2, (P<0.001) and 16.9% vs. 44.0%, (P<0.001), respectively). Furthermore, the HCT and WBC values in the severe-to-critical group were higher than those in the moderate group (42.0±4.1 vs. 44.9±5.7 (P<0.001) and 14.0±4.4 vs. 15.4±4.8 (P=0.012), respectively), as shown in Table 2. Compared with the matched control group with the same baseline characteristics, the incidence rates of miscarriages, live birth delivery, premature delivery and LBW did not significant differ between the groups. The incidence rate of obstetric complications was significantly higher in the severe and critical OHSS groups than in the matched control group; however, there were no significant differences between the moderate group and severe-to-critical group or between the moderate group and matched control group. The incidence rate of neonatal complications was significantly higher in the moderate group than in the matched control group; however, there were no significant differences between the moderate group and severe-to-critical group or between the severe-to-critical group and matched control group. The average neonatal weight in the severe-to-critical group and matched control group was significantly higher than that in the moderate group. The duration of gestation in the matched control group was significantly higher than those in the severe-to-critical group and moderate group. Pregnancy and neonatal outcomes A binary logistic regression analysis was first used to compare the perinatal outcomes of the OHSS group and unmatched control group. The pregnancy and neonatal outcomes are described in detail in Table 3. All patients in the two groups had a clinical pregnancy, and the abortion rate of the unmatched control group was higher than that of the OHSS group, but there was no significant difference (12.2% vs. 15.4%, P=0.098). There was no difference in the abortion rate between the two groups after matching (12.2% vs. 13.6%, P=0.481). Before matching, several parameters differed between the patients in the OHSS group and the controls. However, after propensity score matching, the perinatal outcomes of the OHSS group and matched control group were compared. The live birth singleton delivery rate and preterm delivery rate did not significantly differ between the two groups. The incidence rate of obstetric complications of concern was significantly higher in the OHSS group than in the matched control group (7.0% vs. 3.2%; P=0.001). Moreover, the GDM and venous thrombosis (VT) rates were higher in the OHSS group than in the matched control group (1.8% vs. 0.6%; P=0.017 and 0.5% vs. 0%; P=0.04, respectively). The incidence rates of neonatal complications and number of neonates admitted to the NICU were significantly higher in the OHSS group than in the matched control group (3.6% vs. 2.1%; P=0.045 and 3.2% vs. 1.7%; P=0.034, respectively). The duration of gestation in the matched non-OHSS group was significantly higher than that in the OHSS group (38.7±2.1 vs. 38.0±2.2; P<0.001). However, no significant between-group differences were evident in the average neonatal weight (g) or LBW (2800.7±588.6 vs. 2853.6±659.6; P=0.081 and 25.5% vs. 27.1%; P=0.441, respectively). Discussion The occurrence of OHSS-associated hospitalizations increases the economic burden and affects patient mental wellbeing after IVF-ET [26]. However, different races, regions, hospitals or research methods may affect the impact of OHSS on pregnancy outcomes; for instance, the baseline characteristics or severity of OHSS in patients may affect interpretation of the results during the course of clinical research. The pregnancy outcomes of pregnancies effected by OHSS have not yet been investigated thoroughly, and further studies are needed [8, 12]. The results of our data in the OHSS group and unmatched control group showed that the rates of multiple live birth deliveries and LBW were significantly higher in the OHSS group after eliminating the impact of multiple pregnancies and nine baseline characteristics on perinatal complications using propensity score matching. Furthermore, the results of our data in the OHSS group and matched control group showed that the incidence rates of obstetric complications and neonatal complications were significantly higher in the OHSS group than in the control group, including the incidence of GDM, VT, congenital disorders and neonatal NICU hospitalization. No significant between-group differences in the rates of preterm delivery, miscarriage, and early miscarriage were observed. In our study, obstetric complications were significantly higher in the OHSS group than in the control group, but the incidence rates of PP, HDP, and ICP were not increased after OHSS, and the rates were consistent with previously reported post-IVF rates [27, 28]. Our results are similar to several previous reports that assessed this outcome [12, 14]. A previous symposium by Raziel et al. in 2009 and a previous case-control study indicated that the pregnancy rate is increased in OHSS patients and that the incidence rates of multiple pregnancies, GDM, premature birth, and LBW infants are significantly higher in OHSS patients [8]. We observed thrombosis only in the OHSS group. These results are rather inconsistent with previous findings because the obstetric complications examined here were not evaluated in previous studies [8, 13, 14]. A previous case-control study reported that the hospitalization duration of OHSS patients was positively related to increases in the rate of miscarriage and that OHSS hospitalization was not conducive to pregnancy or continued pregnancy in patients who underwent IVF [18]. It is possible that the occurrence and treatment of OHSS does not affect the abortion rate. At admission, the HCT and WBC values were positively correlated with the degree of OHSS and patient symptoms and were associated with an increased rate of surgical treatment. The number of hospital stays in the severe-critical group was higher than that in the moderate group, and the number of obstetric complications was decreased; however, the number of neonatal complications were increased, as shown in Table 2. The severity of OHSS increased the incidence rates of obstetrical complications and preterm delivery but had no effect on neonatal complications. Conclusions After eliminating the effects of confounding factors, late moderate-to-critical OHSS could reduce the gestational time and increase the number of obstetric complications and neonatal complications, including the incidence of GDM, VT, congenital disorders and neonatal NICU hospitalization. However, the live birth rate, average neonatal weight and incidence rates of premature delivery, miscarriage, early abortion, HDP, PP, ICP, and LBW were not statistically different between the two groups. Abbreviations IVF: in vitro fertilization; ICSI: intracytoplasmic sperm injection; BMI: body mass index; hCG: human chorionic gonadotropin; HDP: hypertensive disorder of pregnancy; GDM: gestational diabetes mellitus; LBW: low birth weight; OHSS: ovarian hyperstimulation syndrome. Declarations Author contributions All authors listed have made a substantial, direct and intellectual contribution to the work and approved the manuscript for publication. Acknowledgements The authors thank all patients included in this study Declaration Ethical approval and consent to participate The study received approval and was carried out in accordance with the approved guidelines of the Zhengzhou University Research Ethics Board. Consent for publication Not applicable Availability of data and material All data supporting the conclusions of this article are included. Competing interests The authors declare that they have no competing interests. Funding None. Author contributions LL. H. and R. X. contributed to the study design, data analysis and manuscript preparation. MY. W. performed the patient recruitment and data collection. All authors read and approved the final manuscript. References Sutter PD, Gerris J, Dhont M: Assisted reproductive technologies: How to minimize the risks and complications in developing countries? 2008, 2008 (1):73-76. 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Baseline characteristics OHSS group (n=385) Control group Unmatched (n=6356) P value Matched 1:4 (n=1540) P value Age (years), mean ±SD 29.3±3.8 30.3±4.3 < 0.001 29.4±4.0 0.585 BMI (kg/m 2 ) 21.8±2.7 22.5±3.0 < 0.001 21.8±2.7 0.997 Duration of infertility (years) 3.8±2.4 4.2±3.0 0.002 3.8±2.6 0.964 Baseline FSH (mIU/ml) 6.5±1.7 7.1±2.2 < 0.001 6.5±1.8 0.876 Baseline LH (mIU/ml) 6.0±4.3 5.4±3.3 0.005 6.0±4.0 0.939 AFC 14.7±5.8 12.8±6.0 < 0.001 14.5±6.4 0.588 Indications for IVF Unexplained factors (%) 10 (2.6) 320 (5.0) 0.031 42 (2.7) 0.888 Anovulatory disorders (includes PCOS) 67 (17.4) 563 (4.9) < 0.001 216 (14.0) 0.094 Tubal factors 157 (40.8) 2923 (46.0) 0.046 670 (43.5) 0.334 Endometriosis-associated 7 (1.8) 137 (2.2) 0.657 25 (1.6) 0.789 Male factors 111 (28.8) 2060 (32.4) 0.144 449 (29.2) 0.900 Pelvic inflammatory disease 3 (0.8) 56 (0.9) 1 13 (0.8) 1.000 Multiple factors 33 (8.6) 605 (9.5) 0.538 138 (9.0) 0.810 E 2 level on hCG trigger day (pg/ml) 4484.9±1905.8 4098.5±2715.2 < 0.001 4521.6±4030.0 0.795 No. of oocytes retrieved 12.2±2.9 10.5±3.8 < 0.001 12.2±4.0 0.906 Multiple gestations, no. (%) 179 (46.5) 1719 (27.1) < 0.001 725 (47.0) 0.837 Note: Data are expressed as n (%) unless otherwise indicated. Plus-minus values are the mean±SD; SD: Standard deviation. Statistically significant at P<0.05. OHSS, Ovarian hyperstimulation syndrome; IVF, In vitro fertilization; AFC, Antral follicle count; FSH, Follicle-stimulating hormone; LH, Luteinizing hormone; hCG, Human chorionic gonadotropin; BMI, Body mass index (the body mass index is the weight in kilograms divided by the square of the height in meters); PCOS, Polycystic ovary syndrome (polycystic ovaries were defined as the presence of an antral follicle count of 12 or more or a volume of more than 10 cm 3 in at least one ovary); Multiple factors, Infertility due to more than one infertility factor; Multiple gestations, diagnosis based on ultrasound during early pregnancy. Table 2. The characteristics of the OHSS group patients. Characteristic Moderate group (n=83) Severe-to-critical group (n=302) Matched control group 1:4 (n=1540) P1 value1-2 P2 value1-3 P3 value2-3 E 2 level on hCG trigger day (pg/ml) 4739.0±1754.6 4415.2±1935.7 / 0.171 / / Hospital days (days) 9.3±4.7 13.8±7.2 / <0.001 / / DT (days) 14.0+3.3 13.1+4.7 / 0.136 / / HCT (%) 42.0±4.1 44.9±5.7 / <0.001 / / WBC (×109) 14.0±4.4 15.4±4.8 / 0.012 / / Albumin (g/L) 37.0±4.2 36.7±5.0 / 0.574 / / Surgical treatment, no. (%) 14/83 ( 16.9) 133/303 ( 44.0 ) / <0.001 / / Miscarriages, no. (%) 9/83 ( 10.8) 38/302 ( 12.6) 209/1540 (13.6) 0.668 0.478 0.645 Live birth delivery rate, no.(%) 74/83 ( 89.2 ) 264/302 ( 87.4) 13 31 /1540 (8 6.4 ) 0.668 0.478 0.645 Obstetric complications 6/83 (7.2) 21/302 ( 7.0 ) 49/1540 ( 3.2 ) 0.931 0.058 0.002 Neonatal complications 6/108 ( 5.6 ) 12/395 ( 3.0 ) 40/1946 (2.1) 0.240 0.031 0.227 Premature delivery 15/74 ( 20.3 ) 52/264 (19.7) 262/1331 (19.7) 0.913 0.902 0.996 Average neonatal weight (g) 2698.8±666.2 2828.6±563.2 2853.6±659.6 0.042 0.018 0.436 Singletons 41 /74 (55.4) 133/264 (44.0) 721/1331 (54.2) 0.444 0.835 0.259 Multiples 33/74 (44.6) 131/264 (49.6) 610/1331 (45.8) 0.444 0.835 0.259 Duration of gestation (weeks) 37.8±2.8 38.1±2.0 38.7±2.1 0.435 <0.001 0.001 LBW, no.(%) 30/108 ( 27.8 ) 98/395 ( 24.8 ) 528/1946 (27.1) 0.530 0.883 0.342 Note : Data are n (%) unless otherwise indicated. Plus-minus values are the mean±SD; SD: Standard deviation. Statistically significant at P<0.05. Statistical analysis of baseline data in the above groups revealed no difference, and the results are not shown. P1 value was Moderate group vs. Severe-to-critical group, DT, Days after transplantation; OHSS patients were hospitalized for several days after transplantation. HCT, Red blood cell-specific volume. Normal range of values: 37-43%; pregnant: <35%. WBC, White blood cell count. Normal range of values: 15-22×10 9 /l, pregnant: 6-20×10 9 /l. Table 3. Pregnancy and neonatal outcomes of Logis tic and Propensity score matching. Outcomes OHSS group (n=385) Binary logistic regression analysis Propensity score matching Unmatched (n=6356) P value Matched 1:4 (n=1540) P value Live birth delivery rate, no. (%) 338/385 (87.8) 538 0 /6356 (84.6) 0.164 13 31 /1540 (8 6.4 ) 0.481 Singleton, no. (%) 174/338 (51.5) 3913/5380 (72.7) ＜ 0.001 721/1331 (54.2) 0.376 Multiple, no. (%) 164/338 (48.5) 1467/5380 (27.3) ＜ 0.001 610/1331 (45.8) 0.376 Preterm delivery, no. (%) 67/338 (19.8) 1456/5380 (27.1) ＜ 0.001 262/1331 (19.7) 0.955 Miscarriages, no. (%) 47/385 (12.2) 976/6356 (15.4) 0.164 209/1540 (13.6) 0.481 Early miscarriages, no. (%) 23/385 (6.0) 60 7 /6356 (9.6) 0.160 13 7 /1540 (8. 9 ) 0.063 Obstetric complications, no. (%) 27/385 ( 7.0 ) 414/6356 ( 6.5 ) 0.700 49/1540 ( 3.2 ) 0.001 PP, no. (%) 3/385 (0.8) 35/6356 (0.6) 0.404 5/1540 (0. 3 ) 0.215 GDM, no. (%) 7/385 (1. 8 ) 82/6356 (1.3) 0.178 9/1540 ( 0.6 ) 0.017 HDP, no. (%) 12/385 (3.1) 137/6356 (2 .2 ) 0.117 3 4 /1540 (2 .2 ) 0.184 ICP, no. (%) 2/385 (0.5) 7/6356 (0.1) 0.056 1/1540 (0.1) 0.104 VT, no. (%) 2/385 ( 0.5 ) 0 ＜ 0.001 0 0.040 Duration of gestation (weeks) (mean+SD) 38.0±2.2 38.7±2.0 0.020 38.7±2.1 ＜ 0.001 Neonatal births 503 6855 1946 Neonatal complications, no. (%) 18/503 (3.6) 193/6855 (2.8) 0.322 40/1946 (2.1) 0.045 NICU, no. (%) 16/503 (3.2) 143/6855 (2.1) 0.103 33/1946 (1.7) 0.034 Congenital diseases, no. (%) 2/503 (0.4) 15/6855 (0.2) 0.420 1/1946 (0.1) 0.048 Average neonatal weight (g) (mean+SD) 2800.7±588.6 3040.0±655.3 ＜ 0.001 2853.6±659.6 0.081 LBW, no. (%) 128/503 (25.5) 1228/6855 (17.9) ＜ 0.001 528/1946 (27.1) 0.441 Note: Data are n (%) unless otherwise indicated. Plus-minus values are the mean±SD; SD, Standard deviation. Statistically significant (P<0.05). OR, Odds ratio. Live birth delivery rate; the number of deliveries that resulted in at least one live birth, expressed per 100 cycle attempts. the denominator in our study is the number of pregnancies who were diagnosed with clinical pregnancy after IVF/ICSI- fresh ET. Premature delivery was defined as birth before 37 completed weeks and after 28 completed weeks of pregnancy. Miscarriage included early- and late-term miscarriages. Early miscarriages occurred before 12 gestational weeks, and late-term miscarriages occurred between 13 and 28 gestational weeks. Obstetric complications; PP, Placenta previa; GDM, Gestational diabetes mellitus; PROM, Premature rupture of the fetal membranes; HDP, hypertensive disorder of pregnancy ， including gestational hypertension, preeclampsia, and eclampsia; ICP, Intrahepatic cholestasis of pregnancy; VT, Venous thrombosis. Neonatal complications included prematurity, extremely low birth weight, perinatal asphyxia, major birth defects, sepsis, neonatal jaundice, and infant respiratory distress syndrome due to immaturity of the lungs. NICU, neonatal intensive care unit, which concentrates on the care of premature babies and sick newborns, due to extreme low birth weight (LBW), perinatal asphyxia, major birth defects, sepsis, neonatal jaundice, and infant respiratory distress syndrome due to immaturity of the lungs and other complications. Other neonatal complications: One neonatal death occurred in the NICU, and two congenital diseases occurred in the OHSS group. In the matched non-OHSS group, one death occurred within one year after birth, and one congenital disease, one chromosomal abnormality and five congenital diseases were present. LBW, Low birth weight (birth weight <2500 g). Threatened abortion refers to a small amount of vaginal bleeding, often dark red or bloody leukorrhea and accompanying paroxysmal abdominal pain or lower back pain in the absence of pregnancy discharge at <28 weeks of pregnancy. Cite Share Download PDF Status: Published Journal Publication published 13 Jan, 2021 Read the published version in Reproductive Biology and Endocrinology → Version 5 posted Editorial decision: Accept 04 Dec, 2020 Editor assigned by journal 14 Nov, 2020 Submission checks completed at journal 14 Nov, 2020 Editor invited by journal 14 Nov, 2020 You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-10899","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research","associatedPublications":[],"authors":[{"id":4884957,"identity":"a817b484-ac84-43c2-8b76-be5695724c9f","order_by":0,"name":"Linli Hu","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAyklEQVRIiWNgGAWjYBACAwbmhgMMBRI8/OzNBx8kVNQQo4URqMVAQkay51iywYMzx4jTAiJtDG7kmEk+bGEmrMVcIrHxcIGBBQ9IS0ViAxsDf3t3Al4tljMSGw7PMJDgkTzzrOxG4g4ZBokzZzfgd9gNoBYeoBa+48nbbiSeYQP6K5dILQwHEswKEtuYSdAicCLFjIE4LWceQrSAAlki4cwxHsJ+OZ58+DNPRZ09KCo//qiokeNv78WvBQPwkKZ8FIyCUTAKRgFWAAAAQEw3dwDioQAAAABJRU5ErkJggg==","orcid":"","institution":"Zhengzhou University","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Linli","middleName":"","lastName":"Hu","suffix":""},{"id":4884958,"identity":"e780b5e3-7a5d-40fc-89e4-9633d7c4381d","order_by":1,"name":"Rui Xie","email":"","orcid":"","institution":"Zhengzhou University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Rui","middleName":"","lastName":"Xie","suffix":""},{"id":4884959,"identity":"a37b19b0-652d-4e45-88ac-33ff20115598","order_by":2,"name":"Mengying Wang","email":"","orcid":"","institution":"Zhengzhou University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Mengying","middleName":"","lastName":"Wang","suffix":""},{"id":4884960,"identity":"da69f170-5b4e-47ab-9e94-de49043b739c","order_by":3,"name":"Yingpu Sun","email":"","orcid":"","institution":"Zhengzhou University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Yingpu","middleName":"","lastName":"Sun","suffix":""}],"badges":[],"createdAt":"2020-01-06 06:00:24","currentVersionCode":5,"declarations":"","doi":"10.21203/rs.2.20287/v5","doiUrl":"https://doi.org/10.21203/rs.2.20287/v5","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s12958-020-00678-w","type":"published","date":"2021-01-13T15:01:32+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":3675068,"identity":"91bf0f75-19e8-4fe6-aeb0-9c5e1e06f5c0","added_by":"auto","created_at":"2020-11-18 20:14:05","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":207049,"visible":true,"origin":"","legend":"The patients were grouped by propensity score matching as shown in the flow chart .","description":"","filename":"FIGURE.jpg","url":"https://assets-eu.researchsquare.com/files/rs-10899/v5/1f97662985e9d0310d0218d7.jpg"},{"id":13616080,"identity":"caa3fb33-5d7e-4c30-a087-f4f663547cb3","added_by":"auto","created_at":"2021-09-17 06:48:09","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1022720,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-10899/v5/2a33be95-eadd-4e16-8392-3aeef04226e0.pdf"}],"financialInterests":"","formattedTitle":"Patients with IVF complicated by moderate-to-critical OHSS experience increased thrombosis,GDM and neonatal NICU admission but slightly shorter gestation compared with matched IVF counterparts: A retrospective Chinese cohort study","fulltext":[{"header":"Introduction","content":"\u003cp\u003eThe widespread use of assisted reproductive technology (ART) in the clinic to enhance the oocyte number has increased the prevalence of ovarian hyperstimulation syndrome (OHSS) [1, 2]. The etiopathogenesis of OHSS remains unclear, but hCG, VEGF, angiotensin, and interleukin seem to be the key players in OHSS. These factors increase capillary permeability and cause blood volume reduction, blood concentration, liver function damage, kidney function damage, water and electrolyte disorders, thrombosis, acute respiratory distress syndrome and other clinical manifestations, and the condition can be life-threatening [3-5]. Clinical studies indicate that the incidence of moderate-to-severe OHSS is approximately 2-3%, and milder forms may develop in up to 20\u0026ndash; 30% of all in vitro fertilization (IVF) patients [5]. The clinical symptoms of OHSS are highly variable and difficult to precisely classify, and uniform standards are lacking, rendering accurate clinical data collection and unified classification difficult.\u003c/p\u003e\n\u003cp\u003eRecently, numerous reports concerning the prevention and treatment of OHSS have been published. However, the pregnancy outcomes of OHSS are poorly understood and remain controversial likely because the impact of late OHSS on pregnancy outcomes is difficult to predict [6-10]. Earlier studies have demonstrated that pregnancy and abortion rates are significantly increased among OHSS patients and that these patients are more likely to develop adverse pregnancy outcomes, such as abortion, growth restriction, hypertensive disorder of pregnancy (HDP), gestational diabetes mellitus (GDM) and low neonatal birth weight (LBW) [1, 11-17]. In addition, one study reported that the hospitalization of OHSS patients who underwent IVF was not conducive to pregnancy or continued pregnancy [18]. The aim of this study was to investigate the effects of late moderate-to-critical OHSS on pregnancy and neonatal outcomes in pregnancies conceived following IVF/ICSI fresh embryo transfers.\u003c/p\u003e"},{"header":"Materials And Methods","content":"\u003cp\u003eThis prospective observational study was approved by the Institutional Review Board of the First Affiliated Hospital of Zhengzhou University and the Institutional Ethics Committee Review Board of the First Affiliated Hospital of Zhengzhou University, Zhengzhou University (Scientific research-2019-LW-046). This study was retrospectively registered on May 26th, 2017 (ChiCTR-1800014655).\u003c/p\u003e\n\u003cp\u003eThe inclusion criteria in this study were as follows: IVF/ICSI-fresh embryo transfer (ET) and an age \u0026le;40 years. The exclusion criteria included the following: preimplantation genetic testing (PGT), donor sperm and donor oocyte, female age \u0026gt; 40 years, missing clinical data, sperm extraction method for percutaneous epididymis/testicular puncture/testicular biopsy (PESA/TESA/TESE), parental chromosomal abnormalities, Mullerian tube abnormalities (uterine malformations), and other diseases that may affect pregnancy outcomes, including an adverse pregnancy history, diabetes, hyperprolactinemia, hypothyroidism, hyperthyroidism, cervix postoperative conization, pituitary tumor, pituitary microadenoma, premature ovarian failure, a history of pelvic tuberculosis, a history of rheumatic immune system disease, and a history of psychiatric diseases.\u003c/p\u003e\n\u003cp\u003eThe classification criteria for OHSS were as follows: early-onset OHSS indicated the occurrence of OHSS no later than 9 days after the hCG injection, and late OHSS indicated the occurrence of OHSS generally no earlier than 10 days after the hCG injection [5, 15].\u003c/p\u003e\n\u003cp\u003eThe classification of OHSS symptoms were as follows: mild: abdominal distension/discomfort, mild nausea/vomiting, mild dyspnea, diarrhea, enlarged ovaries, and no important alterations; moderate: mild features, ultrasonographic evidence of ascites, hemoconcentration (Hct \u0026gt;41%), and elevated WBC (\u0026gt;15,000 mL); severe: mild and moderate features, clinical evidence of ascites, hydrothorax, severe dyspnea, oliguria/anuria, intractable nausea/vomiting, severe hemoconcentration (Hct \u0026gt;55%), WBC \u0026gt;25,000 mL, CrCl \u0026lt;50 mL/min, Cr \u0026gt;1.6 mg/dL, Na+ \u0026lt;135 mEq/L, K+\u0026gt;5 mEq/L, and elevated liver enzymes; critical: low blood/central venous pressure, pleural effusion, rapid weight gain (\u0026gt;1 kg in 24 h), syncope, severe abdominal pain, venous thrombosis, anuria/acute renal failure, arrhythmia, thromboembolism, pericardial effusion, massive hydrothorax, arterial thrombosis, adult respiratory distress syndrome, sepsis, and worsening of findings [19].\u003c/p\u003e\n\u003cp\u003eThe control group included patients with no evidence of OHSS of any severity after undergoing fresh ET, and the OHSS group were patients who were hospitalized and treated at the center with late moderate-to-critical OHSS.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatistical analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe incidences of the main outcome measures (obstetric complications and neonatal complications) were compared between the OHSS group and control group. First, we compared the baseline characteristics of the women according to the conception category. Potential confounders were selected based on the literature and clinical reasoning [3-10, 12-17].\u003c/p\u003e\n\u003cp\u003eThe confounding baseline characteristics, including maternal age, infertility duration, body mass index (BMI), basal FSH, basal LH, antral follicle count (AFC), infertility cause, estradiol level on the hCG trigger day (pg/mL), number of oocytes retrieved from follicles with diameters \u0026ge;12 mm, and number of multiple gestations, were collected. We implemented a propensity score matching approach to identify the control group women who were most similar to the OHSS group women [20-25]. Propensity score matching was used to further validate the logistic regression analysis results. For the propensity score analysis, we performed one-to-four matching without replacement based on the nearest propensity scores of the OHSS and control groups [20-25]. Matching variables are presented in Table 1. The primary outcomes of our study were pregnancy outcomes, obstetric and neonatal complications, the live birth delivery rate, the miscarriage rate, gestational age at birth (weeks) and neonatal birth weight.\u003c/p\u003e\n\u003cp\u003eCategorical data are represented as frequencies and percentages, and differences in these measures between the study groups were assessed by chi-square analysis with the Fisher\u0026rsquo;s exact test for expected frequencies less than 5. Continuous data are expressed as means \u0026plusmn; standard deviations (SD) using IBM SPSS Statistics Version 22. Statistical analysis, including propensity score matching of data, was performed using R Statistical software version 3.2.5 (install.packages (\u0026ldquo;MatchIt\u0026rdquo;, R Foundation for Statistical Computing; https://www.r-project.org/). The significance testing was 2-sided, and P\u0026lt;0.05 was considered statistically significant.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eAll 17,537 patients who met the inclusion and exclusion criteria were included, and 7,064 eligible patients who were diagnosed with clinical pregnancy after IVF/ICSI-fresh ET between June 2012 and July 2016 were evaluated. After meeting the inclusion and exclusion criteria, 6,356 patients who had no evidence of OHSS of any severity after undergoing fresh ET were allocated to the control group, and 385 (3.03%) patients who were hospitalized and treated at the center for late moderate-to-critical OHSS were allocated to the OHSS group. Then, the patients were grouped by propensity score matching as shown in the flow chart in Figure 1.\u003c/p\u003e\n\u003cp\u003eIn the OHSS group, 272 cases (70.7%) underwent fertilization by conventional IVF, and the control group included 4,646 cases (73.1%). On the day of embryonic development, the embryos were all transferred in fresh cycles. The OHSS group included the following patients: ex d3: 366 cases, 95.1%, d5/6: 18 cases, 4.9%; control group: ex d3: 5,907 cases, 90.4%, d5/6: 631 cases, 9.6%.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFactors associated with OHSS\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eCompared with the control group, the patients with moderate-to-critical OHSS in our center were characterized by a young age, a low BMI, ovulation disorders or PCOS, a low basal FSH level, a higher E\u003csub\u003e2\u003c/sub\u003e level on the hCG trigger day, and follicles \u0026ge;12 mm on the trigger day of final oocyte maturation (Table 1).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStudy patients\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe basic parameters of the patients in the two groups are presented in Table 1. A propensity score matching analysis was performed with matching based on multiple maternal baseline characteristics (one-to-four), and the analysis yielded 1,540 non-OHSS patients. The baseline patient characteristics and number of multiple gestation pregnancies were similar between the two study groups (Table 1).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCharacteristics of the \u003c/strong\u003e\u003cstrong\u003emoderate-to-critical\u003c/strong\u003e\u003cstrong\u003eOHSS patients\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe OHSS group comprised 385 patients (83 moderate OHSS; 289 severe OHSS; and 13 critical OHSS), with an average length of hospital stay of 12.7\u0026plusmn;6.9 days.\u003c/p\u003e\n\u003cp\u003eThe OHSS group included 302 (78.4%) patients who developed severe or critical OHSS. After admission, compared to the moderate group, the patients in the severe-to-critical group were hospitalized longer, and the percentage of those receiving puncture surgery was higher (9.3\u0026plusmn;4.7 vs. 13.8\u0026plusmn;7.2, (P\u0026lt;0.001) and 16.9% vs. 44.0%, (P\u0026lt;0.001), respectively). Furthermore, the HCT and WBC values in the severe-to-critical group were higher than those in the moderate group (42.0\u0026plusmn;4.1 vs. 44.9\u0026plusmn;5.7 (P\u0026lt;0.001) and 14.0\u0026plusmn;4.4 vs. 15.4\u0026plusmn;4.8 (P=0.012), respectively), as shown in Table 2. Compared with the matched control group with the same baseline characteristics, the incidence rates of miscarriages, live birth delivery, premature delivery and LBW did not significant differ between the groups. The incidence rate of obstetric complications was significantly higher in the severe and critical OHSS groups than in the matched control group; however, there were no significant differences between the moderate group and severe-to-critical group or between the moderate group and matched control group. The incidence rate of neonatal complications was significantly higher in the moderate group than in the matched control group; however, there were no significant differences between the moderate group and severe-to-critical group or between the severe-to-critical group and matched control group. The average neonatal weight in the severe-to-critical group and matched control group was significantly higher than that in the moderate group. The duration of gestation in the matched control group was significantly higher than those in the severe-to-critical group and moderate group.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePregnancy and neonatal outcomes \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eA binary logistic regression analysis was first used to compare the perinatal outcomes of the OHSS group and unmatched control group. The pregnancy and neonatal outcomes are described in detail in Table 3.\u003c/p\u003e\n\u003cp\u003eAll patients in the two groups had a clinical pregnancy, and the abortion rate of the unmatched control group was higher than that of the OHSS group, but there was no significant difference (12.2% vs. 15.4%, P=0.098). There was no difference in the abortion rate between the two groups after matching (12.2% vs. 13.6%, P=0.481).\u003c/p\u003e\n\u003cp\u003eBefore matching, several parameters differed between the patients in the OHSS group and the controls. However, after propensity score matching, the perinatal outcomes of the OHSS group and matched control group were compared. The live birth singleton delivery rate and preterm delivery rate did not significantly differ between the two groups. The incidence rate of obstetric complications of concern was significantly higher in the OHSS group than in the matched control group (7.0% vs. 3.2%; P=0.001). Moreover, the GDM and venous thrombosis (VT) rates were higher in the OHSS group than in the matched control group (1.8% vs. 0.6%; P=0.017 and 0.5% vs. 0%; P=0.04, respectively).\u003c/p\u003e\n\u003cp\u003eThe incidence rates of neonatal complications and number of neonates admitted to the NICU were significantly higher in the OHSS group than in the matched control group (3.6% vs. 2.1%; P=0.045 and 3.2% vs. 1.7%; P=0.034, respectively). The duration of gestation in the matched non-OHSS group was significantly higher than that in the OHSS group (38.7\u0026plusmn;2.1 vs. 38.0\u0026plusmn;2.2; P\u0026lt;0.001). However, no significant between-group differences were evident in the average neonatal weight (g) or LBW (2800.7\u0026plusmn;588.6 vs. 2853.6\u0026plusmn;659.6; P=0.081 and 25.5% vs. 27.1%; P=0.441, respectively).\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eThe occurrence of OHSS-associated hospitalizations increases the economic burden and affects patient mental wellbeing after IVF-ET [26]. However, different races, regions, hospitals or research methods may affect the impact of OHSS on pregnancy outcomes; for instance, the baseline characteristics or severity of OHSS in patients may affect interpretation of the results during the course of clinical research. The pregnancy outcomes of pregnancies effected by OHSS have not yet been investigated thoroughly, and further studies are needed [8, 12]. The results of our data in the OHSS group and unmatched control group showed that the rates of multiple live birth deliveries and LBW were significantly higher in the OHSS group after eliminating the impact of multiple pregnancies and nine baseline characteristics on perinatal complications using propensity score matching. Furthermore, the results of our data in the OHSS group and matched control group showed that the incidence rates of obstetric complications and neonatal complications were significantly higher in the OHSS group than in the control group, including the incidence of GDM, VT, congenital disorders and neonatal NICU hospitalization. No significant between-group differences in the rates of preterm delivery, miscarriage, and early miscarriage were observed.\u003c/p\u003e\n\u003cp\u003eIn our study, obstetric complications were significantly higher in the OHSS group than in the control group, but the incidence rates of PP, HDP, and ICP were not increased after OHSS, and the rates were consistent with previously reported post-IVF rates [27, 28]. Our results are similar to several previous reports that assessed this outcome [12, 14]. A previous symposium by Raziel et al. in 2009 and a previous case-control study indicated that the pregnancy rate is increased in OHSS patients and that the incidence rates of multiple pregnancies, GDM, premature birth, and LBW infants are significantly higher in OHSS patients [8]. We observed thrombosis only in the OHSS group. These results are rather inconsistent with previous findings because the obstetric complications examined here were not evaluated in previous studies [8, 13, 14].\u003c/p\u003e\n\u003cp\u003eA previous case-control study reported that the hospitalization duration of OHSS patients was positively related to increases in the rate of miscarriage and that OHSS hospitalization was not conducive to pregnancy or continued pregnancy in patients who underwent IVF [18]. It is possible that the occurrence and treatment of OHSS does not affect the abortion rate. At admission, the HCT and WBC values were positively correlated with the degree of OHSS and patient symptoms and were associated with an increased rate of surgical treatment. The number of hospital stays in the severe-critical group was higher than that in the moderate group, and the number of obstetric complications was decreased; however, the number of neonatal complications were increased, as shown in Table 2. The severity of OHSS increased the incidence rates of obstetrical complications and preterm delivery but had no effect on neonatal complications.\u003c/p\u003e"},{"header":"Conclusions","content":"\u003cp\u003eAfter eliminating the effects of confounding factors, late moderate-to-critical OHSS could reduce the gestational time and increase the number of obstetric complications and neonatal complications, including the incidence of GDM, VT, congenital disorders and neonatal NICU hospitalization. However, the live birth rate, average neonatal weight and incidence rates of premature delivery, miscarriage, early abortion, HDP, PP, ICP, and LBW were not statistically different between the two groups.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eIVF: in vitro fertilization; ICSI: intracytoplasmic sperm injection; BMI: body mass index; hCG: human chorionic gonadotropin; HDP: hypertensive disorder of pregnancy; GDM: gestational diabetes mellitus; LBW: low birth weight; OHSS: ovarian hyperstimulation syndrome.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eAuthor contributions \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll authors listed have made a substantial, direct and intellectual contribution to the work and approved the manuscript for publication.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors thank all patients included in this study\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eDeclaration\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthical approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe study received approval and was carried out in accordance with the approved guidelines of the Zhengzhou University Research Ethics Board.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and material \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll data supporting the conclusions of this article are included.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no competing interests.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNone.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eLL. H. and R. X. contributed to the study design, data analysis and manuscript preparation. MY. W. performed the patient recruitment and data collection. All authors read and approved the final manuscript.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eSutter PD, Gerris J, Dhont M: \u003cstrong\u003eAssisted reproductive technologies: How to minimize the risks and complications in developing countries?\u003c/strong\u003e 2008, \u003cstrong\u003e2008\u003c/strong\u003e(1):73-76.\u003c/li\u003e\n\u003cli\u003eToftager M, Bogstad J, Bryndorf T, L\u0026oslash;ssl K, Rosk\u0026aelig;r J, Holland T, Pr\u0026aelig;torius L, Zedeler A, Nilas L, Pinborg A: \u003cstrong\u003eRisk of severe ovarian hyperstimulation syndrome in GnRH antagonist versus GnRH agonist protocol: RCT including 1050 first IVF/ICSI cycles\u003c/strong\u003e. \u003cem\u003eHUM REPROD\u003c/em\u003e 2016, \u003cstrong\u003e80\u003c/strong\u003e(4):717.\u003c/li\u003e\n\u003cli\u003eElchalal U, Schenker JG: \u003cstrong\u003eThe pathophysiology of ovarian hyperstimulation syndrome--views and ideas.\u003c/strong\u003e \u003cem\u003eHUM REPROD\u003c/em\u003e 1997, \u003cstrong\u003e12\u003c/strong\u003e(6):1129.\u003c/li\u003e\n\u003cli\u003eCommittee JSOO, Shmorgun D, Claman P, Gysler M, Hemmings R, Cheung AP, Goodrow GJ, Hughes EG, Min JK, Roberts J: \u003cstrong\u003eThe diagnosis and management of ovarian hyperstimulation syndrome: No. 268, November 2011\u003c/strong\u003e. \u003cem\u003eInt J Gynaecol Obstet\u003c/em\u003e 2012, \u003cstrong\u003e116\u003c/strong\u003e(3):268-273.\u003c/li\u003e\n\u003cli\u003ePapanikolaou EG, Pozzobon C, Kolibianakis EM, Camus M, Tournaye H, Fatemi HM, Steirteghem AV, Devroey P: \u003cstrong\u003eIncidence and prediction of ovarian hyperstimulation syndrome in women undergoing gonadotropin-releasing hormone antagonist in vitro fertilization cycles\u003c/strong\u003e. \u003cem\u003eFertility \u0026amp; 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Sterility\u003c/em\u003e 2010, \u003cstrong\u003e94\u003c/strong\u003e(4):1399-1404.\u003c/li\u003e\n\u003cli\u003ePapanikolaou EG, Herman T, Willem V, Michel C, Val\u0026eacute;rie V, Andre VS, Paul D: \u003cstrong\u003eEarly and late ovarian hyperstimulation syndrome: early pregnancy outcome and profile\u003c/strong\u003e. \u003cem\u003eHUM REPROD\u003c/em\u003e 2005, \u003cstrong\u003e20\u003c/strong\u003e(3):636-641.\u003c/li\u003e\n\u003cli\u003eWiser A, Levron J, Kreizer D, Achiron R, Shrim A, Schiff E, Dor J, Shulman A: \u003cstrong\u003eOutcome of pregnancies complicated by severe ovarian hyperstimulation syndrome (OHSS): a follow-up beyond the second trimester\u003c/strong\u003e. \u003cem\u003eHUM REPROD\u003c/em\u003e 2005, \u003cstrong\u003e20\u003c/strong\u003e(4):910-914.\u003c/li\u003e\n\u003cli\u003eArieh R, Shevach F, Morey S, Deborah S, Eitan M, Raphael RE: \u003cstrong\u003eIncreased early pregnancy loss in IVF patients with severe ovarian hyperstimulation syndrome\u003c/strong\u003e. \u003cem\u003eHUM REPROD\u003c/em\u003e 2002, \u003cstrong\u003e17\u003c/strong\u003e(1):107-110.\u003c/li\u003e\n\u003cli\u003ePractice Committee of the American Society for Reproductive Medicine, 2016. 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Fertil Steril. 2016, 1634\u0026ndash;1647.\u003c/li\u003e\n\u003cli\u003eAustin PC: \u003cstrong\u003eAn Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies\u003c/strong\u003e. \u003cem\u003eMultivariate Behav Res\u003c/em\u003e 2011, \u003cstrong\u003e46\u003c/strong\u003e(3):399-424.\u003c/li\u003e\n\u003cli\u003eAxelsson KF, Nilsson AG, Wedel H, Lundh D, Lorentzon M: \u003cstrong\u003eAssociation Between Alendronate Use and Hip Fracture Risk in Older Patients Using Oral Prednisolone\u003c/strong\u003e. \u003cem\u003eJama\u003c/em\u003e 2017, \u003cstrong\u003e318\u003c/strong\u003e(2):146-155.\u003c/li\u003e\n\u003cli\u003eGuillaume D, Jean-Fran Ois H, Pierre-Emmanuel B, Guillaume L, Laurent V, Loic S: \u003cstrong\u003eMaternal and Neonatal Morbidity After Attempted Operative Vaginal Delivery According to Fetal Head Station\u003c/strong\u003e. \u003cem\u003eObstetrics \u0026amp; Gynecology\u003c/em\u003e 2015, \u003cstrong\u003e126\u003c/strong\u003e(3):521-529.\u003c/li\u003e\n\u003cli\u003eEnsing S, Abu-Hanna A, Roseboom TJ, Repping S, Veen FVD, Mol BWJ, Ravelli ACJ: \u003cstrong\u003eRisk of poor neonatal outcome at term after medically assisted reproduction: a propensity score-matched study.\u003c/strong\u003e \u003cem\u003eFertility \u0026amp; Sterility\u003c/em\u003e 2015, \u003cstrong\u003e104\u003c/strong\u003e(2):384-390.\u003c/li\u003e\n\u003cli\u003eLuo Z, Gardiner JC, Bradley CJ: \u003cstrong\u003eApplying propensity score methods in medical research: pitfalls and prospects\u003c/strong\u003e. \u003cem\u003eMedical Care Research \u0026amp; Review Mcrr\u003c/em\u003e 2010, \u003cstrong\u003e67\u003c/strong\u003e(5):528.\u003c/li\u003e\n\u003cli\u003eUppal S, Bazzi A, Reynolds RK, Harris J, Pearlman MD, Campbell DA, Morgan DM: \u003cstrong\u003eChlorhexidine-Alcohol Compared With Povidone-Iodine for Preoperative Topical Antisepsis for Abdominal Hysterectomy\u003c/strong\u003e. \u003cem\u003eObstetrics \u0026amp; Gynecology\u003c/em\u003e 2017, \u003cstrong\u003e130\u003c/strong\u003e(2):1.\u003c/li\u003e\n\u003cli\u003eCsokmay JM, Yauger BJ, Henne MB, Armstrong AY, Queenan JT, Segars JH: \u003cstrong\u003eCost Analysis Model of Outpatient Management of OHSS with Paracentesis: \u003c/strong\u003e\u003cstrong\u003e\u0026lsquo;\u003c/strong\u003e\u003cstrong\u003eTap Early and Often\u003c/strong\u003e\u003cstrong\u003e\u0026rsquo;\u003c/strong\u003e\u003cstrong\u003e Versus Hospitalization\u003c/strong\u003e. \u003cem\u003eFertility \u0026amp; Sterility\u003c/em\u003e 2010, \u003cstrong\u003e93\u003c/strong\u003e(1):167-173.\u003c/li\u003e\n\u003cli\u003eMartin AS, Monsour M, Kissin DM, Jamieson DJ, Callaghan WM, Boulet SL: \u003cstrong\u003eTrends in Severe Maternal Morbidity After Assisted Reproductive Technology in the United States, 2008-2012.\u003c/strong\u003e \u003cem\u003eObstetrics \u0026amp; Gynecology\u003c/em\u003e 2016, \u003cstrong\u003e127\u003c/strong\u003e(1):59-66.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp style=\"margin-bottom: .0001pt; text-align: left; line-height: 200%;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 200%; color: #000000;\"\u003eTable 1.\u0026nbsp;\u003c/span\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u0026nbsp;\u003cspan style=\"font-size: 16px; line-height: 200%;\"\u003eCharacteristics of the patients at baseline and outcomes of controlled ovarian hyperstimulation.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none; padding: 0in 5.4pt; height: 18.3pt; vertical-align: top;\" rowspan=\"2\"\u003e\n\u003cp style=\"text-align: justify; line-height: 300%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 21.0pt; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eBaseline characteristics\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none; padding: 0in 5.4pt; height: 18.3pt; vertical-align: top;\" rowspan=\"2\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%; font-size: 14px; font-family: 'Times New Roman',serif; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eOHSS group (n=385)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 316.65pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none; padding: 0in 5.4pt; height: 18.3pt; vertical-align: top;\" colspan=\"4\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 73.5pt; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eControl group\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 101.6pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; height: 32.05pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eUnmatched \u0026nbsp;(n=6356)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none; padding: 0in 5.4pt; height: 32.05pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eP value\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none; padding: 0in 5.4pt; height: 32.05pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eMatched 1:4 (n=1540)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none; padding: 0in 5.4pt; height: 32.05pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eP value\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eAge (years), mean \u0026plusmn;SD\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; 29.3\u0026plusmn;3.8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; 30.3\u0026plusmn;4.3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026lt;\u003c/span\u003e0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; 29.4\u0026plusmn;4.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e0.585\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eBMI (kg/m\u003csup\u003e2\u003c/sup\u003e) \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; 21.8\u0026plusmn;2.7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; 22.5\u0026plusmn;3.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026lt;\u003c/span\u003e0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; 21.8\u0026plusmn;2.7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e0.997\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eDuration of infertility (years)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; \u0026nbsp;3.8\u0026plusmn;2.4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; \u0026nbsp;4.2\u0026plusmn;3.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e0.002\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; \u0026nbsp;3.8\u0026plusmn;2.6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e0.964\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eBaseline FSH (mIU/ml)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; \u0026nbsp;6.5\u0026plusmn;1.7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; \u0026nbsp;7.1\u0026plusmn;2.2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026lt;\u003c/span\u003e0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; \u0026nbsp;6.5\u0026plusmn;1.8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e0.876\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eBaseline LH (mIU/ml)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; \u0026nbsp;6.0\u0026plusmn;4.3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; \u0026nbsp;5.4\u0026plusmn;3.3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e0.005\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; \u0026nbsp;6.0\u0026plusmn;4.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e0.939\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eAFC\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; 14.7\u0026plusmn;5.8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; 12.8\u0026plusmn;6.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026lt;\u003c/span\u003e0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; 14.5\u0026plusmn;6.4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e0.588\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eIndications for IVF\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 10.5pt; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eUnexplained factors (%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; 10 (2.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;320 (5.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e0.031\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; 42 (2.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e0.888\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 10.5pt; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eAnovulatory disorders (includes PCOS)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; 67 (17.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;563 (4.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026lt;\u003c/span\u003e0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;216 (14.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e0.094\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 10.5pt; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eTubal factors\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;157 (40.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e2923 (46.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e0.046\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;670 (43.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e0.334\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 10.5pt; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eEndometriosis-associated\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; \u0026nbsp;7 (1.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;137 (2.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e0.657\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; 25 (1.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e0.789\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 10.5pt; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eMale factors\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;111 (28.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e2060 (32.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e0.144\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;449 (29.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e0.900\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 10.5pt; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003ePelvic inflammatory disease\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; \u0026nbsp;3 (0.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; 56 (0.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; 13 (0.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e1.000\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 10.5pt; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eMultiple factors\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; 33 (8.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;605 (9.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e0.538\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;138 (9.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e0.810\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eE\u003csub\u003e2\u003c/sub\u003e level on hCG trigger day (pg/ml)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e4484.9\u0026plusmn;1905.8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e4098.5\u0026plusmn;2715.2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026lt;\u003c/span\u003e0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e4521.6\u0026plusmn;4030.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e0.795\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eNo. of oocytes retrieved\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; 12.2\u0026plusmn;2.9\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; 10.5\u0026plusmn;3.8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026lt;\u003c/span\u003e0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp; 12.2\u0026plusmn;4.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e0.906\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eMultiple gestations,\u0026nbsp;no. (%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;179 (46.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;1719 (27.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026lt;\u003c/span\u003e0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;725 (47.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e0.837\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: left; line-height: 200%;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 200%;\"\u003eNote: Data are expressed as n (%) unless otherwise indicated. Plus-minus values are the mean\u0026plusmn;SD; SD: Standard deviation. Statistically significant at P\u0026lt;0.05.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: left; line-height: 200%;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 200%;\"\u003eOHSS, Ovarian hyperstimulation syndrome; IVF, In vitro fertilization; AFC, Antral follicle count; FSH, Follicle-stimulating hormone; LH, Luteinizing hormone; hCG, Human chorionic gonadotropin; BMI, Body mass index (the body mass index is the weight in kilograms divided by the square of the height in meters); PCOS, Polycystic ovary syndrome (polycystic ovaries were defined as the presence of an antral follicle count of 12 or more or a volume of more than 10 cm\u003csup\u003e3\u003c/sup\u003e in at least one ovary); Multiple factors, Infertility due to more than one infertility factor; \u0026nbsp; Multiple gestations, diagnosis based on ultrasound during early pregnancy.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: left; line-height: 200%;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: left; line-height: 200%;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 200%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left; line-height: normal; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px;\"\u003eTable 2.\u0026nbsp;The characteristics of the OHSS group patients.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 5.8e+2pt; border-collapse: collapse; border: none;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 132.7pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid black; border-right: none; padding: 0.75pt; height: 31.15pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eCharacteristic\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.5pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid black; border-right: none; padding: 0.75pt; height: 31.15pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eModerate group (n=83)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 93.75pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid black; border-right: none; padding: 0.75pt; height: 31.15pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eSevere-to-critical group (n=302)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.25pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid black; border-right: none; padding: 0.75pt; height: 31.15pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eMatched control group 1:4 (n=1540)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid black; border-right: none; padding: 0.75pt; height: 31.15pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eP1 value1-2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 53.6pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid black; border-right: none; padding: 0.75pt; height: 31.15pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eP2 value1-3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.9pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid black; border-right: none; padding: 0.75pt; height: 31.15pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eP3 value2-3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 132.7pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 20.0pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%;\"\u003eE\u003csub\u003e2\u003c/sub\u003e level on hCG trigger day (pg/ml)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.5pt; border: none; padding: 0.75pt; height: 20pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e4739.0\u0026plusmn;1754.6\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 93.75pt; border: none; padding: 0.75pt; height: 20pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e4415.2\u0026plusmn;1935.7\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.25pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 20.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e/\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.0pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 20.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.171\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 53.6pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 20.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e/\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.9pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 20.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e/\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 132.7pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"background: #fafafa;\"\u003eHospital days (days)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.5pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e9.3\u0026plusmn;4.7\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 93.75pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e13.8\u0026plusmn;7.2\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.25pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e/\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 53.6pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e/\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.9pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e/\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 132.7pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"background: #fafafa;\"\u003eDT (days)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.5pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e14.0+3.3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 93.75pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e13.1+4.7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.25pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e/\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e0.136\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 53.6pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e/\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.9pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e/\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 132.7pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"background: #fafafa;\"\u003eHCT (%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.5pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e42.0\u0026plusmn;4.1\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 93.75pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e44.9\u0026plusmn;5.7\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.25pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e/\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.0pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 53.6pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e/\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.9pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e/\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 132.7pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"background: #fafafa;\"\u003eWBC (\u0026times;109)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.5pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e14.0\u0026plusmn;4.4\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 93.75pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e15.4\u0026plusmn;4.8\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.25pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e/\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.0pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.012\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 53.6pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e/\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.9pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e/\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 132.7pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"background: #fafafa;\"\u003eAlbumin (g/L)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.5pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 24.0pt; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e37.0\u0026plusmn;4.2\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 93.75pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 24.0pt; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e36.7\u0026plusmn;5.0\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.25pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e/\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.0pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.574\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 53.6pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e/\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.9pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e/\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 132.7pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"background: #fafafa;\"\u003eSurgical treatment, no. (%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.5pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e14/83\u003c/span\u003e\u003cspan style=\"font-family: SimSun; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e(\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e16.9)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 93.75pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e133/303\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-family: SimSun; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e(\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e44.0\u003c/span\u003e\u003cspan style=\"font-family: SimSun; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.25pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e/\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 53.6pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e/\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.9pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e/\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 132.7pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"background: #fafafa;\"\u003eMiscarriages, no. (%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.5pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e9/83\u003c/span\u003e\u003cspan style=\"font-family: SimSun; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp;(\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e10.8)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 93.75pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e38/302\u003c/span\u003e\u003cspan style=\"font-family: SimSun; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp;(\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e12.6)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.25pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e209/1540 (13.6)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.668\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 53.6pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.478\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.9pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.645\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 132.7pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"background: #fafafa;\"\u003eLive birth delivery rate, no.(%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.5pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e74/83\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-family: SimSun; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e(\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e89.2\u003c/span\u003e\u003cspan style=\"font-family: SimSun; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 93.75pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e264/302\u003c/span\u003e\u003cspan style=\"font-family: SimSun; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp;(\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e87.4)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.25pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e13\u003c/span\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e31\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e/1540 (8\u003c/span\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e6.4\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.668\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 53.6pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.478\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.9pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.645\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 132.7pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"background: #fafafa;\"\u003eObstetric complications\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.5pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e6/83\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-family: SimSun; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e(7.2)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 93.75pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e21/302\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-family: SimSun; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e(\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e7.0\u003c/span\u003e\u003cspan style=\"font-family: SimSun; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.25pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e49/1540 (\u003c/span\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e3.2\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.931\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 53.6pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.058\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.9pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.002\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 132.7pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"background: #fafafa;\"\u003eNeonatal complications\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.5pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e6/108\u003c/span\u003e\u003cspan style=\"font-family: SimSun; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp;(\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e5.6\u003c/span\u003e\u003cspan style=\"font-family: SimSun; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 93.75pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e12/395\u003c/span\u003e\u003cspan style=\"font-family: SimSun; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp;(\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e3.0\u003c/span\u003e\u003cspan style=\"font-family: SimSun; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.25pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e40/1946 (2.1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.240\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 53.6pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.031\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.9pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.227\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 132.7pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"background: #fafafa;\"\u003ePremature delivery\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.5pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e15/74\u003c/span\u003e\u003cspan style=\"font-family: SimSun; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp;(\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e20.3\u003c/span\u003e\u003cspan style=\"font-family: SimSun; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 93.75pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e52/264\u003c/span\u003e\u003cspan style=\"font-family: SimSun; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp;(19.7)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.25pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e262/1331 (19.7)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.913\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 53.6pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.902\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.9pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.996\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 132.7pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"background: #fafafa;\"\u003eAverage neonatal weight (g)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.5pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e2698.8\u0026plusmn;666.2\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 93.75pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: bottom;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: bottom; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e2828.6\u0026plusmn;563.2\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.25pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e2853.6\u0026plusmn;659.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.042\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 53.6pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.018\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.9pt; border: none; padding: 0.75pt; height: 17pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.436\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 132.7pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"background: #fafafa;\"\u003eSingletons\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.5pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e41 /74 (55.4)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 93.75pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e133/264 (44.0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.25pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e721/1331 (54.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.0pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.444\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 53.6pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.835\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.9pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.259\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 132.7pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"background: #fafafa;\"\u003eMultiples\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.5pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e33/74 (44.6)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 93.75pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e131/264 (49.6)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.25pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e610/1331 (45.8)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.0pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.444\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 53.6pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.835\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.9pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.259\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 132.7pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"background: #fafafa;\"\u003eDuration of gestation (weeks)\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.5pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e37.8\u0026plusmn;2.8\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 93.75pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e38.1\u0026plusmn;2.0\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.25pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e38.7\u0026plusmn;2.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.0pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.435\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 53.6pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.9pt; border: none; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 132.7pt; border: none; border-bottom: solid black 1.0pt; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: top; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"background: #fafafa;\"\u003eLBW, no.(%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.5pt; border: none; border-bottom: solid black 1.0pt; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e30/108\u003c/span\u003e\u003cspan style=\"font-family: SimSun; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp;(\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e27.8\u003c/span\u003e\u003cspan style=\"font-family: SimSun; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 93.75pt; border: none; border-bottom: solid black 1.0pt; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e98/395\u003c/span\u003e\u003cspan style=\"font-family: SimSun; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp;(\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e24.8\u003c/span\u003e\u003cspan style=\"font-family: SimSun; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 91.25pt; border: none; border-bottom: solid black 1.0pt; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e528/1946 (27.1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 61.0pt; border: none; border-bottom: solid black 1.0pt; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.530\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 53.6pt; border: none; border-bottom: solid black 1.0pt; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.883\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.9pt; border: none; border-bottom: solid black 1.0pt; padding: .75pt .75pt .75pt .75pt; height: 17.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.342\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: left; line-height: normal;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: 'Times New Roman',serif;\"\u003e\u003cspan style=\"font-size: 16px;\"\u003eNote\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px;\"\u003e: Data are n (%) unless otherwise indicated. Plus-minus values are the mean\u0026plusmn;SD; SD: Standard deviation. Statistically significant at P\u0026lt;0.05.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: left; line-height: normal; vertical-align: middle;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px;\"\u003eStatistical analysis of baseline data in the above groups revealed no difference, and the results are not shown.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: left; line-height: normal;\"\u003e\u003cspan style=\"color: #000000;\"\u003eP1 value was Moderate group vs. Severe-to-critical group,\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: left; line-height: normal;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px;\"\u003eDT, Days after transplantation; OHSS patients were hospitalized for several days after transplantation.\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: left; line-height: normal;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px;\"\u003eHCT, Red blood cell-specific volume. Normal range of values: 37-43%; pregnant: \u0026lt;35%.\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: left; line-height: normal;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px;\"\u003eWBC, White blood cell count. Normal range of values: 15-22\u0026times;10\u003csup\u003e9\u003c/sup\u003e/l, pregnant: 6-20\u0026times;10\u003csup\u003e9\u003c/sup\u003e/l.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: left; line-height: normal;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: left; line-height: normal;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: left; line-height: 200%;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 200%;\"\u003eTable 3.\u003c/span\u003e\u0026nbsp; \u0026nbsp;\u0026nbsp;\u003cspan style=\"font-size: 16px; line-height: 200%;\"\u003e\u0026nbsp;Pregnancy and neonatal outcomes of\u003c/span\u003e Logis\u003cspan style=\"font-size: 16px; line-height: 200%;\"\u003etic and Propensity score matching.\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none; padding: 0in 5.4pt; height: 15.85pt; vertical-align: top;\" rowspan=\"2\"\u003e\n\u003cp style=\"text-align: justify; line-height: 300%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 24.0pt; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 300%;\"\u003eOutcomes\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none; padding: 0in 5.4pt; height: 15.85pt; vertical-align: top;\" rowspan=\"2\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%; font-size: 14px; font-family: 'Times New Roman',serif; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eOHSS group (n=385)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 316.65pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none; padding: 0in 5.4pt; height: 15.85pt; vertical-align: top;\" colspan=\"4\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eBinary logistic regression analysis \u0026nbsp; Propensity score matching\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 101.6pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; height: 29.55pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 60%; font-size: 14px; font-family: 'Times New Roman',serif; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eUnmatched \u0026nbsp;(n=6356)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none; padding: 0in 5.4pt; height: 29.55pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eP value\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none; padding: 0in 5.4pt; height: 29.55pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 80%; font-size: 14px; font-family: 'Times New Roman',serif; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eMatched 1:4 (n=1540)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none; padding: 0in 5.4pt; height: 29.55pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003eP value\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt; height: 14.15pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 12.0pt; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003eLive birth delivery rate, no. (%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp;338/385 (87.8)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e538\u003c/span\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e/6356 (84.6)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.164\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e13\u003c/span\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e31\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e/1540 (8\u003c/span\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e6.4\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.481\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 24.0pt; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003eSingleton, no. (%)\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp;174/338 (51.5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e3913/5380 (72.7)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp;721/1331 (54.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.376\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 24.0pt; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003eMultiple, no. (%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp;164/338 (48.5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e1467/5380 (27.3)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp;610/1331 (45.8)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.376\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 12.0pt; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003ePreterm delivery, no. (%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp; 67/338 (19.8)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e1456/5380 (27.1)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp;262/1331 (19.7)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.955\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 12.0pt; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003eMiscarriages, no. (%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp; 47/385 (12.2)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e976/6356 (15.4)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.164\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp;209/1540 (13.6)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.481\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp; Early miscarriages, no. (%)\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp; 23/385 (6.0)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp;60\u003c/span\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e7\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e/6356 (9.6)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.160\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp;13\u003c/span\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e7\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e/1540 (8.\u003c/span\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e9\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.063\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 12.0pt; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003eObstetric complications, no. (%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;27/385 (\u003c/span\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e7.0\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp;414/6356 (\u003c/span\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e6.5\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.700\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;49/1540 (\u003c/span\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e3.2\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 24.0pt; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003ePP, no. (%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; 3/385 (0.8)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;35/6356 (0.6)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.404\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; 5/1540 (0.\u003c/span\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e3\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.215\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 24.0pt; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003eGDM, no. (%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; 7/385 (1.\u003c/span\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e8\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;82/6356 (1.3)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.178\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; 9/1540 (\u003c/span\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e0.6\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.017\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 24.0pt; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003eHDP, no. (%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;12/385 (3.1)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp;137/6356 (2\u003c/span\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e.2\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.117\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;3\u003c/span\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e4\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e/1540 (2\u003c/span\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e.2\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.184\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 24.0pt; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003eICP, no. (%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; 2/385 (0.5)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; 7/6356 (0.1)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.056\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; 1/1540 (0.1)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.104\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 24.0pt; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003eVT, no. (%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; 2/385 (\u003c/span\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e0.5\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.040\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003eDuration of gestation (weeks) (mean+SD)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 12.0pt; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e38.0\u0026plusmn;2.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 12.0pt; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e38.7\u0026plusmn;2.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e0.020\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 12.0pt; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e38.7\u0026plusmn;2.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003eNeonatal births\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 12.0pt; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e503\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 12.0pt; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e6855\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; text-indent: 12.0pt; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e1946\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003eNeonatal complications, no. (%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;18/503 (3.6)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;193/6855 (2.8)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e0.322\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; 40/1946 (2.1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e0.045\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;NICU, no. (%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;16/503 (3.2)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;143/6855 (2.1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e0.103\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;33/1946 (1.7)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e0.034\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003eCongenital diseases, no. (%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; 2/503 (0.4)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;15/6855 (0.2)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e0.420\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; 1/1946 (0.1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e0.048\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.0pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003eAverage neonatal weight (g) (mean+SD)\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.0pt;\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e2800.7\u0026plusmn;588.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.0pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e3040.0\u0026plusmn;655.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.0pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.0pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e2853.6\u0026plusmn;659.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 16.0pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e0.081\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 189.5pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003eLBW, no. (%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.25in; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;128/503 (25.5)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 101.6pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;1228/6855 (17.9)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.95pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: SimSun;\"\u003e＜\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 107%;\"\u003e0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.8pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e\u0026nbsp;528/1946 (27.1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.3pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 14.15pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Times New Roman',serif; vertical-align: middle; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-family: Calibri, sans-serif; text-decoration: none;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 107%; font-family: 'Times New Roman', serif;\"\u003e0.441\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: left; line-height: 200%;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px; line-height: 150%;\"\u003eNote: Data are n (%) unless otherwise indicated. Plus-minus values are the mean\u0026plusmn;SD; SD, Standard deviation. Statistically significant (P\u0026lt;0.05). OR, Odds ratio.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: left; line-height: normal;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px;\"\u003eLive birth delivery rate; the number of deliveries that resulted in at least one live birth, expressed per 100 cycle attempts. the denominator in our study is the number of pregnancies who were diagnosed with clinical pregnancy after IVF/ICSI- fresh ET.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: left; line-height: normal;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px;\"\u003ePremature delivery was defined as birth before 37 completed weeks and after 28 completed weeks of pregnancy.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: left; line-height: normal;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px;\"\u003eMiscarriage included early- and late-term miscarriages. Early miscarriages occurred before 12 gestational weeks, and late-term miscarriages occurred between 13 and 28 gestational weeks.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: left; line-height: normal;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px;\"\u003eObstetric complications; PP, Placenta previa; GDM, Gestational diabetes mellitus; PROM, Premature rupture of the fetal membranes;\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size: 16px;\"\u003eHDP,\u0026nbsp;hypertensive disorder of pregnancy\u003c/span\u003e\u003cspan style=\"font-size: 16px; font-family: SimSun;\"\u003e，\u003c/span\u003e\u003cspan style=\"font-size: 16px;\"\u003eincluding gestational hypertension, preeclampsia, and eclampsia;\u003c/span\u003e\u003cspan style=\"font-size: 16px;\"\u003e\u0026nbsp;ICP, Intrahepatic cholestasis of pregnancy; VT, Venous thrombosis.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: left; line-height: normal;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px;\"\u003eNeonatal complications included prematurity, extremely low birth weight, perinatal asphyxia, major birth defects, sepsis, neonatal jaundice, and infant respiratory distress syndrome due to immaturity of the lungs.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: left; line-height: normal;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px;\"\u003eNICU, neonatal intensive care unit, which concentrates on the care of premature babies and sick newborns, due to extreme low birth weight (LBW), perinatal asphyxia, major birth defects, sepsis, neonatal jaundice, and infant respiratory distress syndrome due to immaturity of the lungs and other complications.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: left; line-height: normal;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px;\"\u003eOther neonatal complications: One neonatal death occurred in the NICU, and two congenital diseases occurred in the OHSS group. In the matched non-OHSS group, one death occurred within one year after birth, and one congenital disease, one chromosomal abnormality and five congenital diseases were present.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: left; line-height: normal;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"font-size: 16px;\"\u003eLBW, Low birth weight (birth weight \u0026lt;2500 g).\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: left; line-height: normal;\"\u003e\u003cspan style=\"font-size: 16px; color: #000000;\"\u003eThreatened abortion refers to a small amount of vaginal bleeding, often dark red or bloody leukorrhea and accompanying paroxysmal abdominal pain or lower back pain in the absence of pregnancy discharge at \u0026lt;28 weeks of pregnancy.\u003c/span\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"reproductive-biology-and-endocrinology","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"rbej","sideBox":"Learn more about [Reproductive Biology and Endocrinology](http://rbej.biomedcentral.com)","snPcode":"12958","submissionUrl":"https://submission.nature.com/new-submission/12958/3","title":"Reproductive Biology and Endocrinology","twitterHandle":"@BioMedCentral","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"OHSS, pregnancy outcomes, neonatal outcome, in vitro fertilization, infertility","lastPublishedDoi":"10.21203/rs.2.20287/v5","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.2.20287/v5","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground:\u003c/strong\u003e Ovarian hyperstimulation syndrome (OHSS) is a common disease during controlled ovarian hyperstimulation treatment. However, the obstetric and neonatal outcomes of this group of patients are unknown. The aim of this study was to explore the effects of late moderate-to-critical OHSS on obstetric and neonatal outcomes.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMethods: \u003c/strong\u003eThis prospective observational study included 17,537 patients who underwent IVF/ICSI-fresh embryo transfer (ET) between June 2012 and July 2016 and met the inclusion criteria, including 7,064 eligible patients diagnosed with clinical pregnancy. Ultimately, 6,356 patients were allocated to the control group, and 385 patients who were hospitalized and treated at the center for late moderate-to-critical OHSS were allocated to the OHSS group. Then, propensity score matching analysis was performed, matching nine maternal baseline covariates and the number of multiple gestations; 385 patients with late moderate-to-critical OHSS were compared with a matched control group of 1,540 patients. The primary outcomes were the live birth rate, preterm delivery rate, miscarriage rate, gestational age at birth (weeks), obstetric complications and neonatal complications.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults: \u003c/strong\u003eThe duration of gestation in the matched control group was significantly higher than that in the OHSS group. The live birth delivery rate did not significantly differ between the OHSS and matched control groups. The incidence rates of the obstetric complications venous thrombosis (VT) and gestational diabetes mellitus (GDM), neonatal complications and the number of neonates admitted to the NICU were significantly higher in the OHSS group than in the matched control group.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eConclusions: \u003c/strong\u003ePregnant women undergoing IVF with fresh ET whose course is complicated by late moderate-to-critical OHSS appear to experience shortened gestation and increased obstetrical and neonatal complications compared with matched controls whose course is not complicated by OHSS. However, the live birth rate, average neonatal weight, and incidence rates of premature delivery, miscarriage, early abortion, hypertensive disorder of pregnancy (HDP), placenta previa (PP), intrahepatic cholestasis of pregnancy (ICP), and low neonatal birth weight (LBW) did not differ significantly between the two groups.\u003c/p\u003e","manuscriptTitle":"Patients with IVF complicated by moderate-to-critical OHSS experience increased thrombosis,GDM and neonatal NICU admission but slightly shorter gestation compared with matched IVF counterparts: A retrospective Chinese cohort study","msid":"","msnumber":"","nonDraftVersions":[{"code":5,"date":"2020-11-18 20:14:04","doi":"10.21203/rs.2.20287/v5","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Accept","date":"2020-12-05T00:00:00+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2020-11-15T00:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-11-14T23:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-11-14T23:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"reproductive-biology-and-endocrinology","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"rbej","sideBox":"Learn more about [Reproductive Biology and Endocrinology](http://rbej.biomedcentral.com)","snPcode":"12958","submissionUrl":"https://submission.nature.com/new-submission/12958/3","title":"Reproductive Biology and Endocrinology","twitterHandle":"@BioMedCentral","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":4,"date":"2020-10-15 21:36:51","doi":"10.21203/rs.2.20287/v4","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Minor revision","date":"2020-10-17T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-10-12T12:00:00+00:00","index":1,"fulltext":"Recommendation: Reviewer's comments unavailable due to the journal's policy.\n"},{"type":"reviewersInvited","content":"","date":"2020-10-09T12:00:00+00:00","index":"","fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-10-09T12:00:00+00:00","index":1,"fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-10-09T12:00:00+00:00","index":2,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-10-09T12:00:00+00:00","index":2,"fulltext":"Recommendation: Reviewer's comments unavailable due to the journal's policy.\n"},{"type":"editorAssigned","content":"","date":"2020-10-06T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-10-05T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-10-05T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"reproductive-biology-and-endocrinology","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"rbej","sideBox":"Learn more about [Reproductive Biology and Endocrinology](http://rbej.biomedcentral.com)","snPcode":"12958","submissionUrl":"https://submission.nature.com/new-submission/12958/3","title":"Reproductive Biology and Endocrinology","twitterHandle":"@BioMedCentral","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":3,"date":"2020-06-03 14:13:43","doi":"10.21203/rs.2.20287/v3","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Major revision","date":"2020-09-11T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-09-10T12:00:00+00:00","index":2,"fulltext":"Recommendation: Reviewer's comments unavailable due to the journal's policy.\n"},{"type":"reviewerAgreed","content":"","date":"2020-09-09T12:00:00+00:00","index":2,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-06-07T12:00:00+00:00","index":1,"fulltext":"Recommendation: Reviewer's comments unavailable due to the journal's 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