The expressions of CYP1A1 genetic polymorphisms in endometriosis

Objective To investigate the expressions of CYP1A1 genetic polymorphisms in endometriosis, and to study the relationship between them.Methods CYP1A1 genetic polymorphisms were detected with method of Polymerase chain reaction (PCR) in 17 cases of endometriosis patents.Results The frequency of CYP1A1 I/I is 0.1176, and CYP1A1 V/V is 0.1765, then, CYP1A1 I/V is 0.7059. The frequency of CYP1A1 including no less then one Val gene mutation(I/V+V/V) is 0.8824. It's as 7.5 times high as the frequency of CYP1A1 I/I. Conclusion Genotype of Val gene mutation has a high proportion in endometriosis, and it maybe have a close relationship between endometriosis and CYP1A1 genetic polymorphisms.