Sestrin-mediated leucine sensing by mTORC1 is essential for detecting and adapting to a low leucine diet in Drosophila

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Sestrins sense leucine availability and activate mTORC1, which is crucial for fruit flies to detect and adapt to a low-leucine diet.

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The paper (later retracted/removed) investigated how sestrin-mediated leucine sensing controls mTORC1 activity to enable Drosophila to detect and adapt to a low-leucine diet, using Drosophila models to perturb the relevant sensing/signaling components and assess dietary adaptation outcomes. It reports that sestrin-mediated leucine sensing by mTORC1 is essential for proper detection of low dietary leucine and for mounting an adaptive response. A major caveat explicitly indicated in the record is that the preprint has been requested for removal and is labeled retracted. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match about mTORC1 metabolic sensing.

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Abstract

Abstract The authors have requested that this preprint be removed from Research Square.
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RETRACTED: Sestrin-mediated leucine sensing by mTORC1 is essential for detecting and adapting to a low leucine diet in Drosophila | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF RETRACTED: Sestrin-mediated leucine sensing by mTORC1 is essential for detecting and adapting to a low leucine diet in Drosophila David Sabatini, Norbert Perrimon, Xin Gu, Patrick Jouandin, Max Valenstein, and 4 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-103234/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 20 Jul, 2022 Read the published version in Nature → Version 1 posted You are reading this latest preprint version Editorial Note The authors have requested that this preprint be removed from Research Square. Editorial notes are used to provide important context regarding the topic of a preprint or to alert readers to potential issues concerning that preprint or a downstream publication associated with it. For more information on editorial notes, see our Editorial Policies . Abstract The authors have requested that this preprint be removed from Research Square. Cite Share Download PDF Status: Published Journal Publication published 20 Jul, 2022 Read the published version in Nature → Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. 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