KAI1, MMP9 in endometriosis sickness expression and significance

Xuemei Zhang, MA Feng-ying, Lei Liang, Ding Ding, Li-shu Wu, Meisong Lu
In: Zhongguo yishi zazhi · 2011 · vol. 13(11) , pp. 1473–1475 · doi:10.3760/cma.j.issn.1008-1372.2011.11.009 · W2587937465
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This study found that KAI1 was lowly expressed and MMP-9 was highly expressed in endometriosis patients compared to controls, indicating a potential negative correlation and role in disease prognosis.

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This study investigated the expression levels of the tumor metastasis suppressor gene KAI1 and matrix metalloproteinase 9 (MMP-9) in endometriosis tissue compared to normal endometrium. Researchers analyzed samples from 53 patients with endometriosis and 30 healthy controls using immunohistochemistry, finding that KAI1 was significantly downregulated while MMP-9 was upregulated in the disease group. The analysis revealed a significant negative correlation between KAI1 and MMP-9 expression levels within both groups, suggesting their potential involvement in the invasion and progression of ectopic endometrial lesions. This paper is centrally about endometriosis — specifically examining molecular markers associated with its pathogenesis and potential prognosis.

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Abstract

Objective To discuss the expression of tumor shift suppressor gene KAI1,matrix metal proteinase 9 (MMP-9) in endometriosis sickness in dystopia internal membrane and its significance.Methods In 53 patients and 30 healthy controls,the expression of KAI1,MMP-9 in the endometriosis was detected with immunohistochemistry SP method,and the relationship was analyzed.Results KAI1 had low expression in EMS patients,while MMP-9 was highly expressed.In the control group,KAI1 was highly expressed while MMP-9 lowly expressed,and the differences between two groups were remarkably significant (P ＜0.05).KAI1 and the MMP-9 expression showed negative correlation between two groups.Conclusions KAI1 and MMP-9 was negatively expressed in EMS,which may play a role in the EMS prognosis.KAI1 and MMP-9 may be served as the prognosis and monitor markers for EMS. Key words: Proto-oncogene proteins/ME;  Matrix metalloproteinase 9 ;  Genes, tumor suppressor; Endometriosis/ME
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摘要目的 探讨肿瘤转移抑制基因KAI1、基质金属蛋白酶9(MMP-9)在子宫内膜异位症(Endometriosis,EMS;内异症)组织中的表达及意义.方法 对本院53例内异症者(研究组)及30例正常子宫内膜者(对照组),应用免疫组化SP法检测不同子宫内膜组织中KAI1及MMP-9的表达,分析两组KAI1及MMP-9表达水平及相关性.结果 KAI1在研究组中呈低表达,而MMP-9呈高表达；KAI1对照组中呈高表达,而MMP-9呈低表达,两组KAI1及MMP-9表达水平比较差异均统计学有意义(P＜0.05).内异症和正常子宫内膜组织中KAI1与MMP-9水平均呈负相关(r=-0.402,-0.550,P＜0.05).结论 KAI1及MMP-9在内异症组织中表达呈负相关,其可能参与了EMS异位内膜的转移和侵袭中作用,促进内异症的发生和发展.可成为EMS预后和复发的监测指标之一. 更多相关知识 abstractsObjective To discuss the expression of tumor shift suppressor gene KAI1,matrix metal proteinase 9 (MMP-9) in endometriosis sickness in dystopia internal membrane and its significance.Methods In 53 patients and 30 healthy controls,the expression of KAI1,MMP-9 in the endometriosis was detected with immunohistochemistry SP method,and the relationship was analyzed.Results KAI1 had low expression in EMS patients,while MMP-9 was highly expressed.In the control group,KAI1 was highly expressed while MMP-9 lowly expressed,and the differences between two groups were remarkably significant (P ＜0.05).KAI1 and the MMP-9 expression showed negative correlation between two groups.Conclusions KAI1 and MMP-9 was negatively expressed in EMS,which may play a role in the EMS prognosis.KAI1 and MMP-9 may be served as the prognosis and monitor markers for EMS. More相关知识 - 浏览0 - 被引3 - 下载0 相似文献 - 中文期刊 - 外文期刊 - 学位论文 - 会议论文

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