Experimental Study on Cisplatin Injection into Endometrial Cysts

Objective:To investigate the therapeutic effect of cisplatin injection into endometrial implants.Methods:Rat was used as a model of endometriosis by surgically autotransplanting endometrium to the perˉtoneum.Four weeks after the autotransplantation,the rats with peritoneal implants were randomly assigned into3groups which included one group without treatment and two groups treated with cisplatin or absolute alcohol injection into the peritoneal endometrial implants respectively.After4weeks,the rats were laporotomized,and the volumes of endometrial implants were measured.The blood samples were collected for measuring serum E 2 ,P and EmAb levels.The ovary,heart,liver,brain,lung,and kidney were examined histologically together with the in situ endometrium and endometrial implants by microscopy and electromicroscopy.Four rats in each group had not been killed for observing the long_term effect.Results:Both cisplatin and alcohol group had smaller enˉdometrial implants,lower level of EmAb,and lower level of E 2 and P compared with the untreated group.All organs were not influenced.Compared with the alcohol group,the cisplatin group had less irritating effects,less adhesions,and lower recurrent rate.Conclusion:Local injection of cisplatin had an obvious effect in inhibiting endometrial implants.It was more effective than absolute alcohol.No obvious toxicity and side effect was found.