Endometriosis associated with hemothorax

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This case study describes a 40-year-old woman with right-sided hemothorax, likely caused by pelvic endometriosis seeping through the diaphragm during menstruation, which resolved with hormonal therapy after surgical intervention.

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This case report describes a 40-year-old woman presenting with right-sided hemothorax and cyclic symptoms that coincided with her menstrual period. Diagnostic procedures revealed multiple small pores in the right hemidiaphragm, through which blood from pelvic endometriosis seeped into the pleural space during menstruation. Although initial surgical intervention failed to resolve the effusion, treatment with danazol successfully prevented recurrence over one year of follow-up. This paper is centrally about endometriosis — specifically thoracic endometriosis syndrome manifesting as catamenial hemothorax due to diaphragmatic defects.

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Abstract

Bloody pleural effusion is rarely associated with endometriosis. To effectively treat this condition, it is important to differentiate the malady from other common diseases such as malignancy or tuberculosis. We describe the case of a 40-year-old multiparous female featuring right-sided hemothorax presenting with right shoulder pain and progressive shortness of breath for the preceding 2 months. Thoracoscopy disclosed grossly negative findings apart from multiple small pores in the right hemi-diaphragm with blood clots within them. Examination of the thoracoscopic biopsy specimens showed chronic pleuritis without evidence of malignancy or tuberculosis. Pelvic endometriosis was considered a possible diagnosis according to the results of abdominal computed tomography (CT) scan, transvaginal sonography, and the results of dilatation and curettage. Periodic episodes of symptoms concurrent with menstruation led to the suspicion of a relationship between these conditions in our patient. Despite the patient undergoing an abdominal total hysterectomy and adhesiolysis without salpingo-oophorectomy, recurrent right-sided bloody pleural effusion developed 1.5 months subsequent to surgery. As a consequence, danazol (400 mg/day) was maintained because of the endometriosis associated with pleural effusion. One year of regular follow-up later, there was no evidence of recurrent pleural effusion. We considered that the bloody pleural fluid arose via seepage from the pelvic endometriosis through the pores of the right hemi-diaphragm during menstruation.
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Endometriosis Associated with Hemothorax - Hung-Tsung Lee - Hong-Chung Wang - Ia-Tang Huang - Huang-Chou Chang - Jau-Yeong Lu Bloody pleural effusion is rarely associated with endometriosis. To effectively treat this condition, it is important to differentiate the malady from other common diseases such as malignancy or tuberculosis. We describe the case of a 40-year-old multiparous female featuring right-sided hemothorax presenting with right shoulder pain and progressive shortness of breath for the preceding 2 months. Thoracoscopy disclosed grossly negative findings apart from multiple small pores in the right hemi-diaphragm with blood clots within them. Examination of the thoracoscopic biopsy specimens showed chronic pleuritis without evidence of malignancy or tuberculosis. Pelvic endometriosis was considered a possible diagnosis according to the results of abdominal computed tomography (CT) scan, transvaginal sonography, and the results of dilatation and curettage. Periodic episodes of symptoms concurrent with menstruation led to the suspicion of a relationship between these conditions in our patient. Despite the patient undergoing an abdominal total hysterectomy and adhesiolysis without salpingo-oophorectomy, recurrent right-sided bloody pleural effusion developed 1.5 months subsequent to surgery. As a consequence, danazol (400 mg/day) was maintained because of the endometriosis associated with pleural effusion. One year of regular follow-up later, there was no evidence of recurrent pleural effusion. We considered that the bloody pleural fluid arose via seepage from the pelvic endometriosis through the pores of the right hemi-diaphragm during menstruation.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Hemothorax Adult CA-125 Antigen CA-125 Antigen Endometriosis Female Hemothorax Humans Pleural Effusion Pleural Effusion

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europepmc
last seen: 2026-10-06T06:14:42.462031+00:00
pubmed
last seen: 2026-05-13T22:15:23.967219+00:00
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