Association of sleep quality and sleep duration with estimated Glomerular filtration rate（eGFR）in a secondary analysis based on a cross-sectional study

Background: Poor sleep conditions can cause many diseases. However, proof regarding the link of sleep status with renal function in general population is limited. This study was undertaken to investigate the association of sleep quality and sleep duration with estimated Glomerular filtration rate（eGFR）in Taiwanese participants. Methods: : The present study was a cross-sectional study. 5714 Taiwanese who visited a health center for a self-motivated general health assessment were collected in this study. The main outcome variables included Pittsburgh Sleep Quality Index（PSQI）and Self-reported sleep duration. The Independent variable is estimated glomerular filtration rate (eGFR). Multivariate linear regression model and two-piecewise linear model are employed to examine the association between outcomes and independent variables after adjusting for covariates involved in this study. Results: : After adjusting potential confounders, a non-linear relationship was detected between sleep quality and eGFR, which cut-point was 71. The effect sizes and the 95% confidence intervals on the right sides of inflection point were 0.982(0.967, 0.998) and1.006 (1.001, 1.010). Conclusion: The relationship between sleep quality and eGFR is non-linear. Sleep quality was negatively related to eGFR when eGFR is higher than 71points.