Determining prescriptions in electronic healthcare record (EHR) data: methods for development of standardized, reproducible drug codelists

ABSTRACT Objective Epidemiological research using electronic healthcare records(EHR) informing everyday patient care uses combinations of codes (“codelists”) to define diseases and prescriptions (or phenotypes). Yet methodology for codelist generation varies, manifesting in misclassification bias, while there are drug-specific codelist considerations. Materials and Methods We developed methods to generate drug codelists, testing this using the Clinical Practice Research Datalink (CPRD) Aurum database, accounting for missing data in “attribute” search variables. We generated codelists for 1)cardiovascular disease and 2)inhaled Chronic Obstructive Pulmonary Disease (COPD) therapies, applying them to a sample cohort of 335,931 COPD patients. We compared searching on all search variables (A,”gold standard”) to B) chemical and C) ontological information only. Results In Search A we determined 165,150 patients prescribed cardiovascular drugs(49.2% of cohort), and 317,963 prescribed COPD inhalers (94.7% of cohort). Considering output per value set, Search C missed substantial prescriptions, including vasodilator anti-hypertensives (A and B:19,696 prescriptions; C:1,145) and SAMA inhalers (A and B:35,310; C:564). Discussion We recommend the full methods (A) for comprehensiveness. There are special considerations when generating adaptable and generalizable drug codelists, including fluctuating status, cohort-specific drug indications, underlying hierarchical ontology, and statistical analyses. Conclusions Methods: must have end-to-end clinical input, and be standardizable, reproducible, and understandable to all researchers across data contexts. LAY ABSTRACT Health research using patient records informs everyday medicine, using groups of codes (“codelists”) to define diseases and drugs. Yet methods to create drug codelists are inconsistent, may not include physician expertise, nor be reported. We developed a reproducible method to create drug codelists, testing it using de-identified healthcare records. We generated codelists for 1) heart conditions and 2) inhalers to identify prescriptions in a sample group of 335,931 patients with chronic lung disease. We compared our full methods (Search A) to two restricted searches to show prescriptions can be missed if necessary considerations are not made. In search A, we determined 165,150 people (49.2% of sample group) prescribed drugs from the heart codelist. For lung inhalers, we determined 317,963 prescriptions (94.7% of group). Search C missed substantial prescriptions, for drugs lowering blood pressure by opening vessels (A and B:19,696 prescriptions; C: 1,145), and short-term inhalers opening airways (A and B: 35,310; C:564). We recommend full methods(A) for completeness. Drug codelist methods must be consistent, duplicable, and include physician input at all research stages, and have special considerations including status (eg, new, taken off market), disease, and drug categorical system. Quality methods should be freely accessible and usable across study contexts.