⚙
AI-generated deep summary
by claude@2026-06, 2026-06-10
· read from full text
ⓘ
This study used immune complexome analysis with nano-liquid chromatography-tandem mass spectrometry to comprehensively identify antigens incorporated into immune complexes in seminal plasma and follicular fluid from infertile couples undergoing assisted reproduction. Forty-two male participants included oligozoospermia, asthenozoospermia, and normal semen analysis groups, while fifty-eight female participants included women with ovarian endometriosis and controls without disease; the researchers identified four disease-specific antigens in oligozoospermia, five in asthenozoospermia (some related to spermatogenesis), and eight antigens detected only in endometriosis. The authors conclude that immune complex formation may contribute to spermatogenic dysfunction and endometriosis-related infertility through loss of function of the associated proteins, but they also frame the work as identifying antigens rather than directly proving causality. Relevance to endometriosis: the paper reports that eight antigens were detected only in subjects with endometriosis and links immune complex antigen function to endometriosis-related infertility, though the main focus is immune complex antigen identification across male and female infertility subtypes.
Abstract
BACKGROUND: Autoimmune reactions and subsequent inflammation may underlie spermatogenic dysfunction and endometriosis-related infertility. The aim of this study is to identify disease-specific antigens in immune complexes (ICs) in seminal plasma (SP) and in follicular fluid (FF).
METHODS: Immune complexome analysis, in which nano-liquid chromatography-tandem mass spectrometry is employed to comprehensively identify antigens incorporated into ICs in biological fluids, was performed for specimens collected from infertile couples undergoing assisted reproduction. Forty-two male patients consisting of subjects with oligozoospermia (n = 6), asthenozoospermia (n = 8), and normal semen analysis (n = 28). Fifty-eight female patients consisting of subjects with ovarian endometriosis (n = 10) and control women without disease (n = 48).
RESULTS: Four disease-specific antigens were identified in subjects with oligozoospermia, while five disease-specific antigens were detected in subjects with asthenozoospermia, some of which are involved in sprematogenesis. Eight antigens were detected only in subjects with endometriosis.
CONCLUSION: Functional characteristics of disease-specific antigens were found to correspond to the pathogenesis of male and female infertility. The formation of ICs may contribute to spermatogenic dysfunction and endometriosis-related infertility via loss of function of the related proteins. Immune complexome analysis is expected to be a valuable tool for the investigation of novel diagnostic methods and treatment strategies for infertility.
Full text
4,725 characters
· extracted from
oa-html
· click to expand
WEKO3
アイテム
Comprehensive immune complexome analysis detects disease-specific immune complex antigens in seminal plasma and follicular fluids derived from infertile men and women
http://hdl.handle.net/10069/39283
http://hdl.handle.net/10069/3928347441d4d-afe7-4864-a0fe-e187e17a0066
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
|
CCA495_545.pdf (274.7 kB)
|
|
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2020-05-31 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Comprehensive immune complexome analysis detects disease-specific immune complex antigens in seminal plasma and follicular fluids derived from infertile men and women | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||||
| 主題 | immune complex antigen | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||||
| 主題 | immune complexome analysis | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||||
| 主題 | infertility | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||||
| 主題 | spermatogenic dysfunction | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||||
| 主題 | spermatogenic dysfunction | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||||
| 主題 | endometriosis | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 著者 |
Murakami, Naoko
× Murakami, Naoko
× Kitajima, Michio
× Ohyama, Kaname
× Aibara, Nozomi
× Taniguchi, Ken
× Wei, Mian
× Kitajima, Yuriko
× Miura, Kiyonori
× Masuzaki, Hideaki
|
|||||||||||||||||||||||
| 抄録 | ||||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||||
| 内容記述 | Background: Autoimmune reactions and subsequent inflammation may underlie spermatogenic dysfunction and endometriosis-related infertility.The aim of this study is to identify disease-specific antigens in immune complexes (ICs) in seminal plasma (SP) and in follicular fluid (FF). Methods: Immune complexome analysis, in which nano-liquid chromatography-tandem mass spectrometry is employed to comprehensively identify antigens incorporated into ICs in biological fluids, was performed for specimens collected from infertile couples undergoing assisted reproduction.Forty-two male patients consisting of subjects with oligozoospermia (n=6), asthenozoospermia (n=8), and normal semen analysis (n=28). Fifty-eight female patients consisting of subjects with ovarian endometriosis (n=10) and control women without disease (n=48). Results: Four disease-specific antigens were identified in subjects with oligozoospermia, while five disease-specific antigens were detected in subjects with asthenozoospermia, some of which are involved in sprematogenesis. Eight antigens were detected only in subjects with endometriosis. Conclusion: Functional characteristics of disease-specific antigens were found to correspond to the pathogenesis of male and female infertility. The formation of ICs may contribute to spermatogenic dysfunction and endometriosis-related infertility via loss of function of the related proteins. Immune complexome analysis is expected to be a valuable tool for the investigation of novel diagnostic methods and treatment strategies for infertility. |
|||||||||||||||||||||||
| 書誌情報 |
Clinica Chimica Acta 巻 495, p. 545-551, 発行日 2019-05-31 |
|||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | Elsevier B.V. | |||||||||||||||||||||||
| ISSN | ||||||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 0009-8981 | |||||||||||||||||||||||
| DOI | ||||||||||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||||
| 関連識別子 | 10.1016/j.cca.2019.05.031 | |||||||||||||||||||||||
| 権利 | ||||||||||||||||||||||||
| 権利情報 | c 2019 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||||
| 引用 | ||||||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||||||
| 内容記述 | Clinica Chimica Acta, 495, pp.545-551; 2019 |
Text is read by the "Ask this paper" AI Q&A widget below.
Extraction quality varies by source — PMC NXML preserves structure
cleanly, OA-HTML may include some navigation residue, and OA-PDF can
have broken hyphenation. The publisher copy
(via DOI)
is the canonical version.