Study on the correlation between controlling nutritional status score and clinical biochemical indicators in patients with colorectal cancer

Purpose: The controlling nutritional status (CONUT) score is an important tool for predicting the prognosis of colorectal cancer (CRC), but its effectiveness is relatively insufficient. This study aims to screen more effective clinical indicators as supplements to the CONUT scoring system and improve the predictive value of CRC prognosis. Methods: Retrospective collection of clinical information from all CRC patients in our unit from 2014 to 2020, and calculation of CONUT scores based on serum albumin, lymphocyte, and total cholesterol levels. Divide the included patients into three groups: the normal nutrition group (0-1), the mild malnutrition group (2-4), and the moderate to severe malnutrition group (5-12). Evaluate the correlation between CONUT score and baseline characteristics and clinical indicators. Results: This study ultimately included 5014 CRC patients. The higher the values of neutrophil (NE), monocyte (MC), eosinophil (EOS), alkaline phase, lactate dehydrogenase, carboxylic antigen in patients, as well as the lower the values of white blood cell (WBC), basil (BAS), hemoglobin, total protein, triglycerides, low density lipoprotein (LDL), aspartate transaminase, blood urea nitrogen in patients, all indicate poorer nutritional status, with statistical significance ( P <0.05). The indicators significantly correlated with the CONUT score all reflect immune nutritional status, including WBC (OR=0.036, P =000), NE (OR=30.815, P =0.000), MC (OR=41.388, P =0.000), EOS (OR=27.577, P =0.000), BAS (OR=0.006, P =0.046), and LDL (OR=0.319, P =0.000). Conclusion: WBC, NE, MC, EOS, BAS, and LDL may be used as supplementary indicators in the CONUT scoring system to more effectively predict the clinical prognosis of CRC patients.