Pharmacodynamic study of Kaiyuan granules in experimental rat endometriosis

Objective To evaluate the inhibiting effect of Kaiyuan granules on ectopic endometrial implants in rats. Methods Endometriosis models in rats were developed by surgical operations.Rats were sacrificed;volumes and pathological changes of endometrial transplant were observed after 2 weeks of treatments with Kaiyuan granules.Results Transplant volumes were significantly reduced in the moderate-dose and high-dose Kaiyuan granules group.Histologic examination of the explants showed an atrophy of epithelium and a decrease of endometrial glands.Conclusions The growth of ectopic endometrium can be inhibited with a moderate or high dose Kaiyuan granules.