MK2206 and U0126 synergistically inhibit proliferation of deep endometriotic stromal cells and autophagy inhibition enhances the therapeutic effects of the combination therapy in vitro

This conference report examines how combining the AKT inhibitor MK2206 with the MEK inhibitor U0126 affects deep endometriotic stromal cells in vitro, focusing on cell proliferation and autophagy-related mechanisms. The authors report that the two inhibitors synergistically suppress proliferation, and that blocking autophagy increases the therapeutic impact of the combination in these cells. A stated limitation is that the work is conducted in vitro (deep endometriotic stromal cells), without reported in vivo validation. This paper is centrally about endometriosis — it specifically tests MK2206 and U0126, and autophagy inhibition, in deep endometriotic stromal cells.

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