Repurposing ramipril to mitigate EMT-like transition in endometriosis by PI3K/AKT/S6K1 signalling pathway: a study in endometriosis induced rats

Piyali Mazumdar, Shampa Sarkar Biswas
Naunyn-Schmiedeberg's archives of pharmacology · 2026 · vol. 399(7) , pp. 9923–9936 · doi:10.1007/s00210-026-05030-4 · PMID:41603922 · W7125955025
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Ramipril administration reversed the EMT-like process in endometriosis rats by disrupting the MMP9/PI3K/AKT/S6K1 pathway.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This study examined whether ramipril modulates epithelial-mesenchymal transition (EMT)-like changes in a rat model of endometriosis, using peritoneal uterine tissue transplantation across sham, vehicle, and ramipril-treated groups, with evaluation of ectopic lesion morphology and EMT markers. The authors measured MMP9 and MMP2 activity (zymography) and assessed EMT-related proteins and regulators—including MMP9, TIMP1, RECK, snail, E-cadherin, N-cadherin, vimentin, and the PI3K/AKT/mTOR/S6K1 axis with HIF-1α—in uterine and ectopic tissues, finding that ramipril (group 3) reduced ectopic gland quantity and decreased MMP9:TIMP1-related ratios and the phosphorylation/activation markers of PI3K/AKT/mTOR/S6K1 as well as snail and HIF-1α, alongside increased E-cadherin to N-cadherin/vimentin ratios. A key limitation is the very small donor number (five donor rats) and the lack of detailed effect-size reporting beyond statistical significance, alongside an animal-only design. This paper is centrally about endometriosis — it tests ramipril’s ability to reverse EMT-like processes in endometriosis-induced rats via the MMP9/PI3K/AKT/S6K1 signaling pathway.

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Condition tags

endometriosis

MeSH descriptors

Angiotensin-Converting Enzyme Inhibitors Angiotensin-Converting Enzyme Inhibitors Angiotensin-Converting Enzyme Inhibitors Angiotensin-Converting Enzyme Inhibitors Angiotensin-Converting Enzyme Inhibitors Angiotensin-Converting Enzyme Inhibitors Angiotensin-Converting Enzyme Inhibitors Angiotensin-Converting Enzyme Inhibitors Angiotensin-Converting Enzyme Inhibitors Angiotensin-Converting Enzyme Inhibitors Angiotensin-Converting Enzyme Inhibitors Angiotensin-Converting Enzyme Inhibitors Angiotensin-Converting Enzyme Inhibitors Angiotensin-Converting Enzyme Inhibitors Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

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References (39)

SciLite annotations

chemicals 5
ramipril ramipril ramipril haematoxylin ramipril
organisms 6
rattus sp. rattus sp. zitter rats rattus sp. rattus sp. rattus sp.

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