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At first I would like to thank the editor for publishing the review on a common benign Gynaecological disorder endometriosis. I have gone through the article and found the content of review is very nice & informative. Although I would like to share some of my observations and comments. Endometriosis is a disease of hypothesis as the definite cause remain unknown. Here the author mention the different theory of genesis including recent views, such as moleculer explanation of Sampsons theory, its familial inheritance and some diffect in immune response which is evidenced by altered T-cell mediated cytotoxicity, natural killer cell activity also B-cell dysfunction. In addition to these explanations several studies suggest that oxidative stress is a component of