The clinical analysis of levonorgestrel-releasing intrauterine system in eighty patients with adenomyosis

Objective To investigate the chnical effect of levonorgestrel-releasing intrauterine system(LNG-IUS) in patients with adenomyosis.Methods A total of eighty patients with adenomyosis were enrolled and underwent LNG-IUS insertion.The degree of dysmenorrhea,amount of menorrhea,size of the uterus,endometrial thickness,hemoglobin as well as hormonal changes and adverse reaction before treatment and after treatment for 3,6,12 months were compared.Results After treatment for3,6,12months,the amount of menorrhea was reduced [(52.4 ± 8.4)％,(22.6 ± 9.8)％,(14.8 ± 8.6)％ vs.(100.0 ±0.0)％],the scores of dysmenorrhea was reduced [(1.2 ± 0.5),(0.8 ± 0.4),(0.3 ± 0.2) scores vs.(2.4 ±0.6) scores],the level of hemoglobin was increased [(104.4 ± 11.4),(109.2 ± 12.6),(118.8 ± 13.4) g/L vs.(88.6 ± 16.5) g/L],the endometrial thickness was thinner [(6.3 ± 1.4),(3.6 ± 0.8),(1.8 ± 0.5) mm vs.(9.2 ± 2.8) mm],the size of the uterus was reduced [(156.8 ± 56.8),(142.4 ± 48.9),(126.6 ± 36.5)cm3 vs.(172.6 ± 62.5) cm3],there was significant difference compared with that before treatment (P ＜ 0.05).After treatment for 3,6,12 months,the levels of folhcle-stimulating hormone,luteinizing hormone and estradiol had no significant difference compared with those before treatment (P ＞ 0.05).After treatment for 3,6,12 months,the level of cancer antigen 125 was significantly reduced compared with that before treatment [(34.6 ± 11.6),(16.6 ± 9.8),(11.7 ± 6.4) kU/L vs.(62.4 ± 24.3) kU/L].Conclusiom The LNG-IUS has exact therapeutic effect in treatment of adenomyosis,and has little influence on ovarian function.It is worth of using in clinic. Key words: Levonorgestrel;  Adenomyosis;  Clinical analysis