Експресія транскрипційних факторів регуляції диференціювання Т-хелперів Т-bet та GATA-3 у тканині ендометрія в жінок з ендометріозом, асоційованим з безпліддям

The expression and correlation of transcription regulation factors in differentiation of T-helpers of 1st and 2nd types in the endometrium have been determined at women with endometriosis associated with infertility. Expression of mRNA T-bet and GATA-3 was examined by the method of polymerase chain reaction in the endometrium of 42 women with endometriosis associated with infertility and 12 women with infertility of tubal genesis. Increase of expression of mRNA T-bet and GATA-3 with prevailing expression of mRNA T-bet has been ascertained. Changes of transcription factors expression found indicative about the imbalance of T-helpers of 1st and 2nd types which can be one of the causes of endometriosis and play a negative role in the development of infertility in case of this disease.