Single-cell analysis reveals that MXRA8 affected the progression of breast cancer via regulating ferroptosis

Single-cell analysis reveals that MXRA8 affected the progression of breast cancer via regulating ferroptosis | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Single-cell analysis reveals that MXRA8 affected the progression of breast cancer via regulating ferroptosis Yining Han, Zhihan Yao, Yue Xi, Xiaofeng Li This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7841320/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 02 Feb, 2026 Read the published version in Cancer Cell International → Version 1 posted 16 You are reading this latest preprint version Abstract Breast cancer is one of the most prevalent malignant tumors among women worldwide. The incidence of breast cancer in China has been steadily increasing, posing a significant public health concern that gravely jeopardizes women's well-being. Given the heterogeneity and drug resistance associated with breast cancer, conventional treatment methods are inadequate to meet current therapeutic demands, necessitating the urgent development of new biomarkers and therapeutic targets. Ferroptosis, characterized by iron-dependent lipid peroxidation-induced cell membrane rupture, represents a form of programmed cell death. As ferroptosis gains increasing attention for its role in cancer biology, its potential value as an anti-cancer therapy is being gradually explored. However, our understanding of tumor cell ferroptosis in breast cancer remains incomplete, particularly at the single-cell level where knowledge is limited. Therefore, delving into the heterogeneous response of breast cancer cells to ferroptosis and elucidating its regulatory mechanisms hold great significance for comprehending the biological behavior of breast cancer and devising novel therapeutic strategies. In this study, we reanalyzed single-cell RNA-seq data from 26 breast cancer patients using a non-negative matrix (NMF) algorithm. GSEA enrichment analysis was employed to identify tumor subsets most susceptible to ferroptosis while pseudotiming was utilized to pinpoint MXRA8 as a key gene regulating ferroptosis. CellChat was applied to explore relationships between different subsets and various immune cell populations. Finally, we conducted in vitro experiments to validate MXRA8's involvement in regulating ferroptosis in cancer cells. This study unveils the crucial role played by ferroptosis-related tumor subsets in breast cancer progression and tumor immunity. Single-cell RNA sequencing Breast cancer Ferroptosis TME MXRA8 Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 02 Feb, 2026 Read the published version in Cancer Cell International → Version 1 posted Editorial decision: Revision requested 21 Nov, 2025 Reviews received at journal 21 Nov, 2025 Reviews received at journal 20 Nov, 2025 Reviews received at journal 19 Nov, 2025 Reviews received at journal 19 Nov, 2025 Reviewers agreed at journal 14 Nov, 2025 Reviewers agreed at journal 12 Nov, 2025 Reviewers agreed at journal 12 Nov, 2025 Reviewers agreed at journal 12 Nov, 2025 Reviewers agreed at journal 12 Nov, 2025 Reviewers agreed at journal 12 Nov, 2025 Reviewers agreed at journal 09 Nov, 2025 Reviewers invited by journal 07 Nov, 2025 Editor assigned by journal 15 Oct, 2025 Submission checks completed at journal 15 Oct, 2025 First submitted to journal 12 Oct, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7841320","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":546207905,"identity":"bd04abd4-ce60-4b84-b20b-e47b69f8b01e","order_by":0,"name":"Yining Han","email":"","orcid":"","institution":"Dalian Medical University","correspondingAuthor":false,"prefix":"","firstName":"Yining","middleName":"","lastName":"Han","suffix":""},{"id":546207906,"identity":"d49ceafb-bc27-4e5b-a5b0-f9ead048b1ec","order_by":1,"name":"Zhihan Yao","email":"","orcid":"","institution":"Dalian Medical University","correspondingAuthor":false,"prefix":"","firstName":"Zhihan","middleName":"","lastName":"Yao","suffix":""},{"id":546207907,"identity":"d19c37fc-4109-44e5-8909-d3ea76a300a2","order_by":2,"name":"Yue Xi","email":"","orcid":"","institution":"Dalian Medical University","correspondingAuthor":false,"prefix":"","firstName":"Yue","middleName":"","lastName":"Xi","suffix":""},{"id":546207908,"identity":"83508846-52ef-45ff-b1bb-4f0c4dba9360","order_by":3,"name":"Xiaofeng Li","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAz0lEQVRIiWNgGAWjYBACPgbGBwyMDQwM/AwJID4zYS1sDMwGYC2SDSRrMThAtBaJZAaGnzts8oyPZ6dJMFRYJzawnz2AXwvPYQbG3jNpxWZn3m6TYDiTntjAk5eAXwt7/wFmxrbDidtu5G6TADEaJHgM8GthZmYAavmfuHkGSMs/YrSwN4O0HEjcIAHS0kCMFrBf2pITZ5x5u9ki4Vi6cRtPDn4t/OAQa7NL7G/P3XjjQ421bD/7GfxagID9B5yZALKXkPpRMApGwSgYBYQBAEDlQAI3tZsfAAAAAElFTkSuQmCC","orcid":"","institution":"Dalian Medical University","correspondingAuthor":true,"prefix":"","firstName":"Xiaofeng","middleName":"","lastName":"Li","suffix":""}],"badges":[],"createdAt":"2025-10-12 14:38:12","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-7841320/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-7841320/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s12935-026-04175-9","type":"published","date":"2026-02-02T15:57:35+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":96212350,"identity":"6b4af293-7fcc-49bd-b930-585838c5e1d2","added_by":"auto","created_at":"2025-11-18 19:05:54","extension":"docx","order_by":0,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":2242746,"visible":true,"origin":"","legend":"","description":"","filename":"Manuscript.docx","url":"https://assets-eu.researchsquare.com/files/rs-7841320/v1/bf4102f706e147071b31d345.docx"},{"id":96212345,"identity":"01eb3f75-d830-407f-a532-c05d9b56870f","added_by":"auto","created_at":"2025-11-18 19:05:54","extension":"json","order_by":1,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":6344,"visible":true,"origin":"","legend":"","description":"","filename":"1a108f08b87c4f488e78fc368a56d56f.json","url":"https://assets-eu.researchsquare.com/files/rs-7841320/v1/275e5b5d72a2d4d5116a3d26.json"},{"id":96212346,"identity":"a75e7639-a813-4b77-b7f7-4ff80d1f87f6","added_by":"auto","created_at":"2025-11-18 19:05:54","extension":"xml","order_by":2,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":124559,"visible":true,"origin":"","legend":"","description":"","filename":"1a108f08b87c4f488e78fc368a56d56f1enriched.xml","url":"https://assets-eu.researchsquare.com/files/rs-7841320/v1/4f3d9b8e642a9a952c646f1d.xml"},{"id":96252976,"identity":"22309893-a4fe-4b4a-9fa7-cafe2421497f","added_by":"auto","created_at":"2025-11-19 07:41:45","extension":"jpeg","order_by":3,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":655466,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage1.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-7841320/v1/4be604f149564a65c90c0e41.jpeg"},{"id":96212349,"identity":"e6d4a1dc-9237-46e7-8535-15946d0ccb1a","added_by":"auto","created_at":"2025-11-18 19:05:54","extension":"jpeg","order_by":4,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":427182,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage2.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-7841320/v1/5022d973762e695cf2e5621f.jpeg"},{"id":96251609,"identity":"a7e8d95f-de53-42eb-a731-8080afab7c4e","added_by":"auto","created_at":"2025-11-19 07:39:50","extension":"jpeg","order_by":5,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":333348,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage3.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-7841320/v1/b88adb104fda815d1a7b6bdf.jpeg"},{"id":96252906,"identity":"7987dcf2-9f8d-4673-9918-5b3942ca5840","added_by":"auto","created_at":"2025-11-19 07:41:38","extension":"jpeg","order_by":6,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":173116,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage4.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-7841320/v1/a62f735076d6be2b0d13133c.jpeg"},{"id":96212357,"identity":"84a2243a-3f7e-47b1-af45-e1b33ce5e34e","added_by":"auto","created_at":"2025-11-18 19:05:55","extension":"jpeg","order_by":7,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":105501,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage5.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-7841320/v1/b4644f60fe9d09b3aab792b4.jpeg"},{"id":96253096,"identity":"07fbb1fa-093b-4581-a95f-ff35a00d1518","added_by":"auto","created_at":"2025-11-19 07:41:57","extension":"jpeg","order_by":8,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":220297,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage6.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-7841320/v1/219b7edf0918d2575d4c2819.jpeg"},{"id":96212354,"identity":"8d0c2a7d-3363-4f69-98e7-5a14565d0424","added_by":"auto","created_at":"2025-11-18 19:05:55","extension":"jpeg","order_by":9,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":201749,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage7.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-7841320/v1/3195482eeca1550695db1e83.jpeg"},{"id":96212356,"identity":"be6e74e0-b620-4911-b81e-1a99f1ced1bc","added_by":"auto","created_at":"2025-11-18 19:05:55","extension":"jpeg","order_by":10,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":340908,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage8.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-7841320/v1/a33fcd315e6884cc02365b04.jpeg"},{"id":96212352,"identity":"af32b23c-211b-44db-b591-faee7d83b2f4","added_by":"auto","created_at":"2025-11-18 19:05:55","extension":"jpeg","order_by":11,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":88270,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage9.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-7841320/v1/8deb48576344010625074374.jpeg"},{"id":96253095,"identity":"beba29f3-22a9-458f-adba-f622eaceedf1","added_by":"auto","created_at":"2025-11-19 07:41:57","extension":"png","order_by":13,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":167560,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage2.png","url":"https://assets-eu.researchsquare.com/files/rs-7841320/v1/bc4bd6247e45c4816a380b9c.png"},{"id":96252792,"identity":"41a1c415-81e8-41ad-a576-be08edc4df1e","added_by":"auto","created_at":"2025-11-19 07:41:29","extension":"png","order_by":14,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":97094,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage3.png","url":"https://assets-eu.researchsquare.com/files/rs-7841320/v1/77a376208dcc63fed8bc52fa.png"},{"id":96212361,"identity":"3c5d2db2-42ce-47fa-b911-60b9af69207d","added_by":"auto","created_at":"2025-11-18 19:05:55","extension":"png","order_by":15,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":125373,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage4.png","url":"https://assets-eu.researchsquare.com/files/rs-7841320/v1/3186b145f07b4ee0910ebb2e.png"},{"id":96212363,"identity":"c32be483-c152-4552-9cf2-b93c913c76e0","added_by":"auto","created_at":"2025-11-18 19:05:55","extension":"png","order_by":16,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":89736,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage5.png","url":"https://assets-eu.researchsquare.com/files/rs-7841320/v1/bee4ad905ec35bbee6d10bff.png"},{"id":96212366,"identity":"cadd6e55-87ca-47f4-8c4d-5cbcf82cf699","added_by":"auto","created_at":"2025-11-18 19:05:55","extension":"png","order_by":17,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":50126,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage6.png","url":"https://assets-eu.researchsquare.com/files/rs-7841320/v1/a6412b29040bf676d1433e40.png"},{"id":96212359,"identity":"946fb7d9-e356-4b94-af62-e533db0f6f0f","added_by":"auto","created_at":"2025-11-18 19:05:55","extension":"png","order_by":18,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":45876,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage7.png","url":"https://assets-eu.researchsquare.com/files/rs-7841320/v1/ccfec88d1947cc1477d0e00b.png"},{"id":96212364,"identity":"f5b610b8-2874-4eed-916b-0a60f20f23dd","added_by":"auto","created_at":"2025-11-18 19:05:55","extension":"png","order_by":19,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":105926,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage8.png","url":"https://assets-eu.researchsquare.com/files/rs-7841320/v1/400cb275963038b84935e47b.png"},{"id":96212358,"identity":"4e242d14-056e-4069-9cf3-83c9169a9f5b","added_by":"auto","created_at":"2025-11-18 19:05:55","extension":"png","order_by":20,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":75684,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage9.png","url":"https://assets-eu.researchsquare.com/files/rs-7841320/v1/182a8b18f5eb4bd922437f0b.png"},{"id":96212355,"identity":"c66a53d0-587b-4baf-95bf-818c1e43a6bc","added_by":"auto","created_at":"2025-11-18 19:05:55","extension":"xml","order_by":21,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":123241,"visible":true,"origin":"","legend":"","description":"","filename":"1a108f08b87c4f488e78fc368a56d56f1structuring.xml","url":"https://assets-eu.researchsquare.com/files/rs-7841320/v1/02e46e2971bc724c720d5af0.xml"},{"id":96252975,"identity":"f12d5110-8f26-4113-9d1c-05da8f95a642","added_by":"auto","created_at":"2025-11-19 07:41:45","extension":"html","order_by":22,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":131292,"visible":true,"origin":"","legend":"","description":"","filename":"earlyproof.html","url":"https://assets-eu.researchsquare.com/files/rs-7841320/v1/55114b072ff87033fc65abbf.html"},{"id":102235607,"identity":"41b80dd8-e064-45dd-8360-7c962584d0ea","added_by":"auto","created_at":"2026-02-09 16:17:15","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1669452,"visible":true,"origin":"","legend":"","description":"","filename":"Manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7841320/v1_covered_6a431f14-4e97-43e1-945e-8c93a147ae94.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Single-cell analysis reveals that MXRA8 affected the progression of breast cancer via regulating ferroptosis","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"cancer-cell-international","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"ccin","sideBox":"Learn more about [Cancer Cell International](http://cancerci.biomedcentral.com/)","snPcode":"12935","submissionUrl":"https://submission.nature.com/new-submission/12935/3","title":"Cancer Cell International","twitterHandle":"@OncoBioMed","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Single-cell RNA sequencing, Breast cancer, Ferroptosis, TME, MXRA8","lastPublishedDoi":"10.21203/rs.3.rs-7841320/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7841320/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Breast cancer is one of the most prevalent malignant tumors among women worldwide. The incidence of breast cancer in China has been steadily increasing, posing a significant public health concern that gravely jeopardizes women's well-being. Given the heterogeneity and drug resistance associated with breast cancer, conventional treatment methods are inadequate to meet current therapeutic demands, necessitating the urgent development of new biomarkers and therapeutic targets. Ferroptosis, characterized by iron-dependent lipid peroxidation-induced cell membrane rupture, represents a form of programmed cell death. As ferroptosis gains increasing attention for its role in cancer biology, its potential value as an anti-cancer therapy is being gradually explored. However, our understanding of tumor cell ferroptosis in breast cancer remains incomplete, particularly at the single-cell level where knowledge is limited. Therefore, delving into the heterogeneous response of breast cancer cells to ferroptosis and elucidating its regulatory mechanisms hold great significance for comprehending the biological behavior of breast cancer and devising novel therapeutic strategies. In this study, we reanalyzed single-cell RNA-seq data from 26 breast cancer patients using a non-negative matrix (NMF) algorithm. GSEA enrichment analysis was employed to identify tumor subsets most susceptible to ferroptosis while pseudotiming was utilized to pinpoint MXRA8 as a key gene regulating ferroptosis. CellChat was applied to explore relationships between different subsets and various immune cell populations. Finally, we conducted in vitro experiments to validate MXRA8's involvement in regulating ferroptosis in cancer cells. This study unveils the crucial role played by ferroptosis-related tumor subsets in breast cancer progression and tumor immunity.","manuscriptTitle":"Single-cell analysis reveals that MXRA8 affected the progression of breast cancer via regulating ferroptosis","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-11-18 19:05:50","doi":"10.21203/rs.3.rs-7841320/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2025-11-21T11:25:27+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-11-21T10:20:04+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-11-20T20:45:32+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-11-20T02:09:10+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-11-19T07:39:11+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"120997387495752764965999261497127969658","date":"2025-11-14T15:21:57+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"256483170906693078890348021773044732301","date":"2025-11-13T01:40:47+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"87231040957919481829795201646793548855","date":"2025-11-12T15:21:24+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"167486018942072839034562212959302863439","date":"2025-11-12T13:35:46+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"168211666369017291540596643070522063125","date":"2025-11-12T06:45:13+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"248998379405379788748230096597755968160","date":"2025-11-12T06:40:16+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"76213844532615567605118561832319740746","date":"2025-11-09T14:00:59+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2025-11-07T10:24:35+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-10-16T01:12:35+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2025-10-15T09:39:33+00:00","index":"","fulltext":""},{"type":"submitted","content":"Cancer Cell International","date":"2025-10-12T14:24:41+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"cancer-cell-international","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"ccin","sideBox":"Learn more about [Cancer Cell International](http://cancerci.biomedcentral.com/)","snPcode":"12935","submissionUrl":"https://submission.nature.com/new-submission/12935/3","title":"Cancer Cell International","twitterHandle":"@OncoBioMed","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"eab096c9-3d56-446c-a7b1-88cd308ea7f8","owner":[],"postedDate":"November 18th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[],"tags":[],"updatedAt":"2026-02-09T16:16:10+00:00","versionOfRecord":{"articleIdentity":"rs-7841320","link":"https://doi.org/10.1186/s12935-026-04175-9","journal":{"identity":"cancer-cell-international","isVorOnly":false,"title":"Cancer Cell International"},"publishedOn":"2026-02-02 15:57:35","publishedOnDateReadable":"February 2nd, 2026"},"versionCreatedAt":"2025-11-18 19:05:50","video":"","vorDoi":"10.1186/s12935-026-04175-9","vorDoiUrl":"https://doi.org/10.1186/s12935-026-04175-9","workflowStages":[]},"version":"v1","identity":"rs-7841320","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7841320","identity":"rs-7841320","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}