A Correlative Study of Hemodynamically Significant Patent Ductus Arteriosus and Platelets within 24 hours of Birth in Preterm Infants

Objective: To investigate the correlation between the hemodynamically significant patent ductus arteriosus (hsPDA) of preterm infants and the platelet count (PLT), plateletocrit within 24 h of birth.Methods The clinical data of 1270 preterm infants were retrospectively studied. The patients were divided into the non-PDA group, no hsPDA group, and hsPDA group.Results The smaller gestational age and the lower birth weight, PLT, plateletocrit were associated with the greater likelihood of PDA ( P < 0.05). The receiver operating characteristic (ROC) curve showed that the predictive values of PLT and plateletocrit were 0.703 and 0.748, respectively, with the best critical values of 241.5 × 10 9 /L and 0.245%. For the preterm infants with PLT < 241.5 × 10 9 /L, < 150 × 10 9 /L and < 100 × 10 9 /L as well as plateletocrit < 0.245% and 0.09%, the risks of hsPDA were 1.876, 2.169, 6.216, 1.749 and 5.407 times of preterm infants with PLT ≥ 241.5 × 10 9 /L, ≥ 150 × 10 9 /L and ≥ 100 × 10 9 /L as well as plateletocrit ≥ 0.245% and ≥0.09%. The logistic regression analysis showed that plateletocrit was an independent risk factor for preterm infants with hsPDA ( P = 0.000).Conclusions The decrease in plateletocrit of the preterm infants within 24 h of birth was the independent risk factor of hsPDA on the 4th-7th day of birth.