Effects of Huoxue-xiaozheng Capsule on VEGF and Bcl-2 protein expression of ectopic endometrinm in Adenomyosis Rats

Objective To discuss the effects of Huoxue-xiaozheng Capsule on blood rheology, serum CA125, and expression of vascular endothelial growth factor （VEGF） and Bcl-2 Protein （Bcl-2） of endometriosis tissue. Methods Establish the rat models of adenomyosis using surgical induction, and divide them into 4 groups stochastically. 1 group was not filled stomach, and the other 3 groups were filled with normal saline, Huoxue-xiaozheng capsule and mifepriston separately. After 8 weeks, examine the indicator of blood rheology and serum CA125, and the expression of VEGF, Bcl-2 in rats＇endometriosis tissue. Results Huoxue-xiaozheng capsule has the function of lowing the value of blood rheology, serum CA125, and weakening tissue expression of VEGF and Bcl-2. Condusions Huoxue-xiaozheng capsules had the function of lowing the value of blood rheology and weakening the expression of VEGF, Bcl-2 in rats＇ endometriosis tissue, inhibiting growth of ectopic endometrium and promoting its atrophy. Key words: Adenomyosis;  HuoxuexiaozhengCapsule;  VEGF;  Bcl-2