The known and the unknown

Vol.VI�Issue: 3: (JSRM Code: 006030100103) The known and the unknown Dear Friends, The blue print readers of the DNA, a group of proteins so called the transcription factors play a major role in interpreting the genetic information on the DNA and helps in transcription of the information from DNA to mRNA. Their clinical significance includes that their mutations are associated with many diseases and they can be targets for drug delivery for genetic disorders in the future. These are being used in the process of reprogramming cells from one state to another .Their significance in the present scenario cannot be further emphasized other than the fact that they play a major role in the production of iPS cells ,the cells which is believed ,will rule the stem cell world for the next decade. They are essential for the reprogramming of the somatic cells to the induced pluripotency state. The generation of iPS cells requires complete nuclear reprogramming and to date iPS cells have been generated from the adult somatic cells but not been generated from immortalized cells .Dr. Hideyuki Kobayashi and his team have analysed the efficacy of reprogramming of an immortalized cell line using the four transcription factors OCT4, SOX2, NANOG, and LIN28 and have come out with several significant findings which are highlighted in their article in this issue. In the year when Nobel Prize in Physiology or Medicine has been awarded to a person who has brought life and smiles in many women with infertility it is most appropriate that in an article in this issue Dr.Tamer Taha and their team have postulated the existence of a novel Endometrial Inducing Factor (EIF) in the serum of women with endometriosis and they have described the same in their article. This study the first of its kind with a postulation of the existence of a new Endometrial Inducing Factor is likely to open up a new era in the management and therapy of endometriosis which is a common finding in women with infertility The abstracts of the proceedings of the annual plenary session and symposium of regenerative Medicine gives a glimpse of the stem cell research being pursued in a variety of fields including cancer biology, neurology ,dentistry etc. The abstract on enteric neural stem cells throws light on the stem cell research in the pursuit of therapies for Hirschprung’s disease or the congenital megacolon. The abstracts on Microgravity cell culture, stem cells in spinal cord injury, imaging techniques and lot more is surely a must-read for the researchers, scholars and those interested in this ever exciting field of Stem cell Research. Stem Cell field continues to grow leaving further branches of research into minute aspects ranging from research of the complex interplay of transcription factors, epigenetics, reprogramming and so on. As the field continues to grow it is the duty of such journals to make the scientific community aware of the various ongoing researches in order to contemplate the known and to explore the unknown. With that thought in mind we present to you this interesting Vol 6 Issue III of JSRM. Happy reading! Yours sincerely, The Editorial team.