Comparison of pre-operative inflammation parameters of adenomyosis and leiomyoma patients after hysterectomy

Cemile Dayangan Sayan, Funda Tüzün, M. Ilkin Yeral, Zehra Sema Özkan, Nevin Sağsöz
In: Ortadoğu Tıp Dergisi · 2018 · vol. 11(4) , pp. 555–560 · doi:10.21601/ortadogutipdergisi.449994 · W2897689767
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study found that mean platelet volume and neutrophil count were higher in patients with leiomyoma compared to adenomyosis before hysterectomy.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-11 · read from full text ⓘ

This retrospective study evaluated pre-operative complete blood count (CBC) inflammation-related parameters in 640 patients with histopathologically confirmed adenomyosis (n=247) or leiomyoma (n=393) after hysterectomy, comparing white blood cell count, neutrophil/lymphocyte and platelet/lymphocyte ratios, platelet count, platelet distribution width, mean platelet volume, plateletcrit, and neutrophil measures. The authors found no between-group differences for white cells and platelet count, platelet distribution width, plateletcrit, platelet/lymphocyte ratio, or neutrophil/lymphocyte ratio. Mean platelet volume and neutrophil counts (neutrophilia percentage) were significantly higher in the leiomyoma group than in the adenomyosis group. The paper’s main caveat is that it is based on retrospective chart review and concludes that results need support from prospective controlled studies. This paper is centrally about adenomyosis—specifically comparing pre-operative inflammatory CBC parameters between adenomyosis and leiomyoma patients.

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Abstract

Aim: The purpose of the research is evaluation of pre-operative white blood cell, neutrophil, lymphocyte, platelet, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, platelet distribution width, mean platelet volume and plateletcrit values of patients who diagnosed with adenomyosis or leiomyoma histopathologically.Material and Method: The research group consist of 640 patients. For gathering data, we review the patients’ files retrospectively and we use patients’ complete blood count (CBC) results.Results: The mean age of the patients are 54.89±5.11 years. 61.40% (n=393) of them are diagnosed with leiomyoma and 38.60% (n=247) of them are diagnosed with adenomyosis histopathologically. There was no difference between the groups in terms of white cell and platelet count, platelet distribution width, platelet crit, platelet / lymphocyte ratios, and neutrophil / lymphocyte ratios. Mean platelet volume and neutrophil counts in the leiomyoma group were significantly higher than in the adenomyosis group.Conclusions: The mean platelet volume and neutrophilia percentage values are promising as an adjunctive method in differential diagnosis of leiomyoma and adenomyosis diseases, but these findings should be supported by prospective controlled studies.
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Abstract

Aim: The purpose of the research is evaluation of pre-operative white blood cell, neutrophil, lymphocyte, platelet, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, platelet distribution width, mean platelet volume and plateletcrit values of patients who diagnosed with adenomyosis or leiomyoma histopathologically.

Material

and Method: The research group consist of 640 patients. For gathering data, we review the patients’ files retrospectively and we use patients’ complete blood count (CBC) results.

Results

The mean age of the patients are 54.89±5.11 years. 61.40% (n=393) of them are diagnosed with leiomyoma and 38.60% (n=247) of them are diagnosed with adenomyosis histopathologically. There was no difference between the groups in terms of white cell and platelet count, platelet distribution width, platelet crit, platelet / lymphocyte ratios, and neutrophil / lymphocyte ratios. Mean platelet volume and neutrophil counts in the leiomyoma group were significantly higher than in the adenomyosis group.

Conclusions

The mean platelet volume and neutrophilia percentage values are promising as an adjunctive method in differential diagnosis of leiomyoma and adenomyosis diseases, but these findings should be supported by prospective controlled studies. Öz Amaç: Bu çalışmada histerektomi sonrası, adenomiyosis ya da leiomyoma histopatolojik tanısı alan hastaların pre-operatif beyaz küre ve platelet sayısı, nötrofili, nötrofil/lenfosit oranı, platelet/lenfosit oranı, platelet dağılım genişliği, ortalama platelet hacmi ve plateletcrit değerlerinin değerlendirilmesi ve iki hastalık arasında bu değerler açısından fark olup olmadığının araştırılması amaçlanmıştır. Gereç ve Yöntem: Post-operatif histopatolojik tanıları leiomyoma ya da adenomyosis olan 640 hasta çalışmaya dahil edildi. Hastaların demografik özellikleri ve hemogram testi sonuçları retrospektif olarak incelendi. Bulgular: Toplam 640 hastanın, %61,40’ı (n=393) leiomyoma ve %38,60’ı (n=247) adenomyosis histopatolojik tanısı almıştı. Gruplar arasında beyaz küre ve platelet sayısı, platelet dağılım genişliği, platelet crit, platelet/lenfosit oranları ve nötrofil/lenfosit oranları açısından fark yoktu. Leiomyoma grubunda ortalama platelet hacmi değerleri ve nötrofil yüzdeleri anlamalı olarak adenomiyozis grubuna göre yüksekti. Sonuçlar: Ortalama platelet hacmi ve nötrofili yüzdesi değerleri leiomyoma ve adenomyozis hastalıkları ayırıcı tanısında yardımcı bir yöntem olarak kullanılabileceği konusunda umut vericidir ancak bu bulguların prospektif kontrollü çalışmalarla desteklenmesi gerekmektedir.

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adenomyosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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