Serum Copper and Vascular Endothelial Growth Factor (VEGF-A) in Dysfunctional Uterine Bleeding

Afshan Rafi, D. Ramakrishn, K. Sabitha, Sujata Mohanty, Pragna Rao
In: American Journal of Biochemistry and Molecular Biology · 2011 · vol. 1(3) , pp. 284–290 · doi:10.3923/ajbmb.2011.284.290 · W2061372703
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This study found significantly increased serum copper and VEGF-A levels in dysfunctional uterine bleeding patients, correlating strongly with endometrial thickness and suggesting copper stimulates VEGF-A for abnormal angiogenesis.

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This paper measured serum copper and vascular endothelial growth factor (VEGF-A) levels in individuals with dysfunctional uterine bleeding, using comparative analysis between affected patients and controls. The authors reported differences in copper and VEGF-A associated with dysfunctional uterine bleeding, linking these biochemical variables to altered vascular/endometrial signaling. A key limitation noted implicitly through the study design is that it evaluates serum biomarkers in a specific uterine bleeding category without establishing causal mechanisms. Relevance to endometriosis: the paper focuses on dysfunctional uterine bleeding and uterine vascular signaling rather than directly studying endometriosis, though it is included in the corpus because uterine bleeding disorders and related VEGF-associated endometrial processes overlap with pathways implicated in endometriosis.

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Abstract

Over the past 20 years there has been an upsurge of interest proper cause of abnormal angiogenesis of DUB. This study particularly focused on the association of serum copper and vascular endothelial growth factor (VEGF-A) in patients with Dysfunctional Uterine Bleeding (DUB). Blood samples were collected from female patients suffering with DUB (n = 50) as well as healthy females as controls (n = 50). Serum copper levels were estimated by spectrophotometric method and serum VEGF-A by ELISA technique and compared with ultrasonographic measurement of endometrial thickness in both patients and controls. A significant increase in serum copper levels and an almost two fold increase in serum VEGF-A was observed in DUB patients when compared with controls. Correlation(r) between serum VEGF-A levels and endometrial thickness was 0.97. Odd Ratio for copper, VEGF-A and combination of copper and VEGF-A was 0.0426, 0.0947 and 0.0313, respectively, in all these cases odds ratio was less than one. The abnormal angiogenesis in DUB could be due to increased serum copper levels, which in turn stimulates factors like VEGF-A, thereby causing an increase in endometrial growth.
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Afshan Rafi Kamineni Institute of Medical Sciences, Sreepuram, Narketpally, Nalgonda 508254, Andhra Pradesh, India D. Ramakrishna Kamineni Institute of Medical Sciences, Sreepuram, Narketpally, Nalgonda 508254, Andhra Pradesh, India LiveDNA: 91.1232 K. Sabitha Chalmeda Anandrao Institute of Medical Sciences, Bommakal, Karimnagar, Andhra Pradesh, India S. Mohanty Kamineni Institute of Medical Sciences, Sreepuram, Narketpally, Nalgonda 508254, Andhra Pradesh, India Pragna Rao Department of Biochemistry, Kasturba Medical College, Manipal University, Manipal-576104, Karnataka, India PDF Fulltext XML References Citation How to cite this article Afshan Rafi, D. Ramakrishna, K. Sabitha, S. Mohanty and Pragna Rao, 2011. Serum Copper and Vascular Endothelial Growth Factor (VEGF-A) in Dysfunctional Uterine Bleeding. American Journal of Biochemistry and Molecular Biology, 1: 284-290. DOI: 10.3923/ajbmb.2011.284.290 URL: https://scialert.net/abstract/?doi=ajbmb.2011.284.290 DOI: 10.3923/ajbmb.2011.284.290 URL: https://scialert.net/abstract/?doi=ajbmb.2011.284.290

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