RELATIONSHIP OF 25-HYDROXY-VITAMIN D3 SERUM LEVELS WITH CYCLOOXYGENASE-2 IN ADENOMIOSIS PATIENTS

Introduction: Adenomyosis is a condition in which endometrium is ectopically placed in the myometrium. The most frequent symptoms of adenomyosis is chronic pelvic pain. Pain is a sensoric stimuli that can be affected by COX-2. Some studies found that 25-Hidroxy-Vitamin D3 serum level has the ability to affect COX-2 serum level and modulate pain sensation. The aim of this study is to analyze correlation between 25-Hidroxy-Vitamin D3 and COX-2 serum level in patient with adenomyosis. Methods: This was an analytical observational study. Subjects were women diagnosed with adenomyosis who met the study criteria (n = 35). Their 25-Hidroxy-Vitamin D3 and COX-2 serum level were measured. The study was conducted at the Gynecologic Clinic of Obstetrics and Gynecology Department, Hasan Sadikin Hospital, Bandung Indonesia in June until November 2019. Results: There was a significant correlation between 25-Hidroxy-Vitamin D3 and COX-2 serum level in woman with adenomyosis. Conclusion: 25-Hidroxy-Vitamin D3 serum level can affect COX-2 serum level in woman with adenomyosis.