Inflammatory Markers Related to Medical Nutritional Therapy in Critically Ill Patients in Intensive Care Unit: Study on CRP and Procalcitonin

Inflammatory Markers Related to Medical Nutritional Therapy in Critically Ill Patients in Intensive Care Unit: Study on CRP and Procalcitonin | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Inflammatory Markers Related to Medical Nutritional Therapy in Critically Ill Patients in Intensive Care Unit: Study on CRP and Procalcitonin Andi Yasmin Syauki, Nurhidayah Majid, Agussalim Bukhari, Nurpudji A. Taslim, and 4 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4576397/v2 This work is licensed under a CC BY 4.0 License Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Abstract Background and objectives : Malnutrition is the most frequent complication in patients in an intensive care unit (ICU). CRP and Procalcitonin are used as acute phase inflammatory markers, adversely affecting patient outcomes. This study aims to determine the effect of medical nutritional therapy on the level of CRP and procalcitonin in critically ill patients. Methods : This study was a retrospective cohort design on critically ill patients at Wahidin Sudirohusodo Teaching Hospital from 2020-2021, 250 subjects met the inclusion criteria by screening for malnutrition using the m-Nutric score, CRP assessment using Flouroscene immune assay, procalcitonin using chemiluminescent microparticle immune assay, nutrition intake by 24-hours food recall, all patients received medical nutrition therapy. Results : This study showed patients with low grade m-Nutric score s ignificantly decreased of CRP level (energy intake ≥ 600 kcal p=0.009) not for procalcitonin level (p=0.841), while procalcitonin tend to be significantly decreased (energy intake < 600 kcal p=0.054) not with CRP level (p=0.655). Patient with high-risk m-Nutric score showed significancy decreased procalcitonin level (energy intake ≥ 600 kcal p=0.011) while not for CRP (p=0.109) and procalciton (energy intake < 600 kcal p=0.138). Conclusion : Medical nutritional therapy with energy intake ≥ 600 kcal incritical ill decreased CRP level in a low risk m-Nutric score, and decreased procalcitonin level in a high risk m-Nutric score. Nutrition & Dietetics Malnutrition medical nutritional therapy CRP level Procalcitonin level m-Nutric score Full Text Additional Declarations The authors declare no competing interests. Cite Share Download PDF Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4576397","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":318880171,"identity":"28d7b693-d31a-42e4-a23d-a45931f74782","order_by":0,"name":"Andi Yasmin Syauki","email":"","orcid":"","institution":"Department of Nutrition, Faculty of Medicine, Hasanuddin University","correspondingAuthor":false,"prefix":"","firstName":"Andi","middleName":"Yasmin","lastName":"Syauki","suffix":""},{"id":318880168,"identity":"220f4fb4-b912-4cfd-aee9-330b7914e8d4","order_by":1,"name":"Nurhidayah Majid","email":"","orcid":"","institution":"Clinical Nutrition Specialist Program, Department of Nutrition, Faculty of Medicine, Hasanuddin University","correspondingAuthor":false,"prefix":"","firstName":"Nurhidayah","middleName":"","lastName":"Majid","suffix":""},{"id":318880169,"identity":"7167b891-2f64-4a02-9115-14203257cb05","order_by":2,"name":"Agussalim Bukhari","email":"","orcid":"","institution":"Department of Nutrition, Faculty of Medicine, Hasanuddin University","correspondingAuthor":false,"prefix":"","firstName":"Agussalim","middleName":"","lastName":"Bukhari","suffix":""},{"id":318880170,"identity":"d630b3d4-00f6-4614-94e7-187b3a660f04","order_by":3,"name":"Nurpudji A. 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CRP and Procalcitonin are used as acute phase inflammatory markers, adversely affecting patient outcomes. This study aims to determine the effect of medical nutritional therapy on the level of CRP and procalcitonin in critically ill patients.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods\u003c/strong\u003e: This study was a retrospective cohort design on critically ill patients at Wahidin Sudirohusodo Teaching Hospital from 2020-2021, 250 subjects met the inclusion criteria by screening for malnutrition using the m-Nutric score, CRP assessment using Flouroscene immune assay, procalcitonin using chemiluminescent microparticle immune assay, nutrition intake by 24-hours food recall, all patients received medical nutrition therapy.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults\u003c/strong\u003e: This study showed patients with \u0026nbsp;low grade m-Nutric score \u003cdel\u003es\u003c/del\u003eignificantly decreased of CRP level (energy intake ≥ 600 kcal \u0026nbsp;p=0.009) not for procalcitonin level (p=0.841), while procalcitonin tend to be significantly decreased (energy intake \u0026lt; 600 kcal p=0.054) not with CRP level (p=0.655). Patient with high-risk m-Nutric score showed significancy decreased procalcitonin level (energy intake ≥ 600 kcal p=0.011) while not for CRP (p=0.109) and procalciton (energy intake \u0026lt; 600 kcal p=0.138).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion\u003c/strong\u003e: Medical nutritional therapy with energy intake ≥ 600 kcal incritical ill decreased CRP level in a low risk m-Nutric score, and decreased procalcitonin level in a high risk m-Nutric score.\u003c/p\u003e","manuscriptTitle":"Inflammatory Markers Related to Medical Nutritional Therapy in Critically Ill Patients in Intensive Care Unit: Study on CRP and Procalcitonin","msid":"","msnumber":"","nonDraftVersions":[{"code":2,"date":"2024-06-27 19:20:47","doi":"10.21203/rs.3.rs-4576397/v2","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2024-06-25 14:00:07","doi":"10.21203/rs.3.rs-4576397/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"629b32ef-a9b6-4f24-bd88-7e10283e704b","owner":[],"postedDate":"June 27th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":33831894,"name":"Nutrition \u0026 Dietetics"}],"tags":[],"updatedAt":"2024-06-25T14:00:07+00:00","versionOfRecord":[],"versionCreatedAt":"2024-06-27 19:20:47","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v2","identity":"rs-4576397","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4576397","identity":"rs-4576397","version":["v2"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}