A sensitive and specific genetically encodable biosensor for potassium ions
preprint
OA: closed
CC-BY-NC-ND-4.0
Abstract
Potassium ions (K + ) play a critical role as an essential electrolyte in all biological systems. Here we report the crystal structure-guided optimization and directed evolution of an improved genetically encoded fluorescent K + biosensor, GINKO2. GINKO2 is highly sensitive and specific for K + and enables in vivo detection of K + dynamics in multiple species.
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- europepmc
- last seen: 2026-05-19T01:45:01.086888+00:00
- unpaywall
- last seen: 2026-05-24T02:00:01.246996+00:00
License: CC-BY-NC-ND-4.0