Contribution of LOC105371267 and MRPS30-DT Genetic Polymorphisms in IgA Nephropathy Among Chinese Han Population 

Background: : IgA nephropathy (IgAN) is the common primary glomerulonephritis worldwide. Genetic factors have been reported to take essential part in IgAN progression. This study was designed to investigate the association between LOC105371267 and MRPS30-DT with IgAN risk among Chinese. Methods: : 6 SNPs were genotyped. A logistic recession model was used to calculate the effects of candidate SNPs on IgAN. The SNP-SNP interaction was analyzed by MDR. Results: : We observed only LOC105371267 had relationships with IgAN. The results indicated an association between the genotype “CC” and the decreased IgAN risk (OR = 0.44, p = 0.014). The stratification analysis at age ≥ 35 showed that rs3931698 contributed to the IgAN susceptibility in “GT” (OR = 1.78, p = 0.038), while rs8044565 significantly showed a decreasing-risk effect with IgAN (“T”, OR = 0.59, p = 0.006; “CC”, OR = 0.15, p = 0.015; “CC-CT”, OR = 0.59, p = 0.023; Log-additive, OR = 0.56, p = 0.005). Rs8044565 was correlated with the decreased susceptibility of IgAN in male (“CC”, OR = 0.27, p = 0.006) and in Lee’s grade ≥ III (“CC”, OR = 0.46, p = 0.046). We found rs8044565 was related to systolic blood pressure and urinary casts, and rs3852740 had a relationship with Serum C3 and hemoglobin ( p < 0.05). Conclusion: : The present study first demonstrated that the SNPs in lncRNAs might be related to IgAN.