The importance of epigenome research in the diagnosis and treatment of endometriosis

In: Journal of Medical Science · 2017 · vol. 86(4) , pp. 325–327 · doi:10.20883/jms.2017.202 · W2790423783
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This review summarizes current knowledge on epigenetic mechanisms controlling gene expression and their role in the pathogenesis of endometriosis.

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This mini-review summarizes current knowledge on how epigenetic mechanisms that regulate gene expression contribute to the development of endometriosis, focusing on epigenomic processes such as DNA methylation, histone modifications, and microRNA-related gene control. It synthesizes published evidence from genome-wide methylation profiling studies and related experimental observations, highlighting that epigenetic dysregulation has been detected in endometriotic tissues and linked to gene regulation changes. A key limitation is that, as a review, it does not present new original data or resolve causality, and it summarizes a state of knowledge that remains incomplete given that the causes of endometriosis are still unexplained. This paper is centrally about endometriosis — it provides a focused review of epigenome research for endometriosis diagnosis and treatment.

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Abstract

The causes of endometriosis remain unexplained. Studying the molecular mechanisms at the origin of the lesions leads to conclusions about the important role of the epigenome. This mini-review is a summary of the current state of knowledge about the processes of epigenetic control of gene expression involved in the pathogenesis of endometriosis.
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The importance of epigenome research in the diagnosis and treatment of endometriosis DOI: https://doi.org/10.20883/jms.2017.202Keywords: endometriosis, gene expression, methylationAbstract The causes of endometriosis remain unexplained. Studying the molecular mechanisms at the origin of the lesions leads to conclusions about the important role of the epigenome. This mini-review is a summary of the current state of knowledge about the processes of epigenetic control of gene expression involved in the pathogenesis of endometriosis.Downloads References Giudice LC, Kao LC. Endometriosis. Lancet. 2004;364: 1789–1799. Vercellini P, Fedele L, Aimi G, Pietropaolo G, Consonni D, Crosignani PG. Association between endometriosis stage, lesion type, patient characteristics and severity of pelvic pain symptoms: a multivariate analysis of over 1000 patients. Hum Reprod. 2007;22:266–271. Scarselli G, Rizzello F, Cammilli F, Ginocchini L. Diagnosis and treatment of endometriosis. A review. 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Downloads Published Issue Section License Copyright (c) 2017 Przemysław Krzysztof Wirstlein, Paweł P. Jagodziński, Małgorzata Szczepańska This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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endometriosis

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