The importance of epigenome research in the diagnosis and treatment of endometriosis
This review summarizes current knowledge on epigenetic mechanisms controlling gene expression and their role in the pathogenesis of endometriosis.
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This mini-review summarizes current knowledge on how epigenetic mechanisms that regulate gene expression contribute to the development of endometriosis, focusing on epigenomic processes such as DNA methylation, histone modifications, and microRNA-related gene control. It synthesizes published evidence from genome-wide methylation profiling studies and related experimental observations, highlighting that epigenetic dysregulation has been detected in endometriotic tissues and linked to gene regulation changes. A key limitation is that, as a review, it does not present new original data or resolve causality, and it summarizes a state of knowledge that remains incomplete given that the causes of endometriosis are still unexplained. This paper is centrally about endometriosis — it provides a focused review of epigenome research for endometriosis diagnosis and treatment.
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