Plotting the Major Proteins of Borealpox Virus

Plotting the Major Proteins of Borealpox Virus | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Plotting the Major Proteins of Borealpox Virus Sunil Thomas This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4165453/v2 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 24 Nov, 2024 Read the published version in Frontiers in Virology → Version 2 posted You are reading this latest preprint version Show more versions Abstract In an era marked by rapid environmental transformations, the viability of numerous species hinges crucially on their ability to navigate and adjust to shifting climatic conditions through migration. Yet, amidst this natural quest for survival, a consequential and often overlooked consequence emerges: the inadvertent transportation of a diverse array of parasites and pathogens across landscapes. This phenomenon poses a substantial and tangible threat to global health, particularly in the wake of recent outbreaks and pandemics fueled by zoonotic viruses, which leap from animals to humans. These viruses, originating in animals but capable of infecting humans, serve as poignant reminders of the intricate relationship between human and wildlife health, and the potential dangers of disregarding this delicate balance. In 2015, the borealpox virus (BRPV) [formerly Alaskapox virus (AKPV)], classified as an Orthopoxvirus , was first identified in a woman living near Fairbanks, Alaska. The BRPV causes borealpox disease. The first recorded fatality attributed to BRPV infection occurred in January 2024. Current evidence suggests that BRPV primarily targets small mammals, particularly red-backed voles and shrews, as evidenced by sampling efforts in the Fairbanks North Star Borough. However, it is likely that the virus is more widespread among Alaska's small mammal populations, potentially leading to undiagnosed human infections. Additionally, domestic pets, such as cats and dogs, may also contribute to the transmission of the virus. To date, no instances of human-to-human transmission have been documented, but the lack of diagnostics and vaccines for BRPV remains a concerning gap. This paper aims to address this issue by reporting the structure and epitopes of the major proteins of BRPV. This data could serve as a foundation for the development of novel diagnostics and vaccines to combat BRPV, thereby mitigating its impact on both human and animal populations. Virology General Microbiology Bioinformatics Borealpox virus BRPV borealpox disease Alaskapox virus AKPV Alaska orthopoxvirus infectious disease zoonosis. Full Text Additional Declarations The authors declare no competing interests. Cite Share Download PDF Status: Published Journal Publication published 24 Nov, 2024 Read the published version in Frontiers in Virology → Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4165453","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":284046376,"identity":"aa20b16e-f401-4b51-a0c5-d2724c596f2a","order_by":0,"name":"Sunil Thomas","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA10lEQVRIiWNgGAWjYDACCSjNxt58gOFhAxE6eGBa+HmOJTAkkqRFckaOAXFa7KWbj2748aeOweBAztcNiTvqGPilj1/Ab4vMsbSbvW2HgVrObruReOYwg2RfTgEBh+WY3eBtOFC/4WAvUEvbAQaDMzwJBLXc/ANy2GGeZ0AtdcRpuc3Dxswg2cbDBtTCDNTCfgC/lhtpabdlgX7h52EzA2o5zCPZw4NXBwP7jORjN98AHcYm//jZjY9tdXL8POwP8OvBsBaIDEjTArKZRFtGwSgYBaNguAMAgRtKaB+WRp8AAAAASUVORK5CYII=","orcid":"","institution":"Lankenau Institute for Medical Research","correspondingAuthor":true,"prefix":"","firstName":"Sunil","middleName":"","lastName":"Thomas","suffix":""}],"badges":[],"createdAt":"2024-03-25 20:03:49","currentVersionCode":2,"declarations":{"humanSubjects":true,"vertebrateSubjects":true,"conflictsOfInterestStatement":false,"humanSubjectEthicalGuidelines":true,"humanSubjectConsent":true,"humanSubjectClinicalTrial":false,"humanSubjectCaseReport":false,"vertebrateSubjectEthicalGuidelines":true},"doi":"10.21203/rs.3.rs-4165453/v2","doiUrl":"https://doi.org/10.21203/rs.3.rs-4165453/v2","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.3389/fviro.2024.1451810","type":"published","date":"2024-11-25T00:00:00+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":81065956,"identity":"4b68dad4-bb60-45b4-befc-f4e8e7d269a3","added_by":"auto","created_at":"2025-04-21 21:25:27","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":3488525,"visible":true,"origin":"","legend":"","description":"","filename":"Borealpoxviruspaper1.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4165453/v2_covered_36c817c6-57ba-4395-9ccc-7d6c7c8389fe.pdf"}],"financialInterests":"The authors declare no competing interests.","formattedTitle":"\u003cp\u003ePlotting the Major Proteins of Borealpox Virus\u003c/p\u003e","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":false,"highlight":"","institution":"Lankenau Institute for Medical Research","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Borealpox virus, BRPV, borealpox disease, Alaskapox virus, AKPV, Alaska, orthopoxvirus, infectious disease, zoonosis.","lastPublishedDoi":"10.21203/rs.3.rs-4165453/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4165453/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eIn an era marked by rapid environmental transformations, the viability of numerous species hinges crucially on their ability to navigate and adjust to shifting climatic conditions through migration. 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