Composition for treating dysmenorrhea endometriosis and fibroids

Compounds having thromboxane antagonist activity are of use in the treatment of dysmenorrhea, endometriosis and fibroids. Thromboxane antagonists of particular value are compounds of formula (I> wherein is e.g. a bicyclo-heptane, -heptene, -octane or -octene group; R is a 6-carboxyhex-2-enyl group or a modification thereof; V and V' either each separately is hydrogen or together are the second bond of a carbon-nitrogen double bond; R is hydrogen, an aliphatic hydrocarbon group or an aliphatic hydrocarbon group substituted by an aromatic group directly or through an oxygen or sulphur atom; and R is a group -NH, CO, NH-R or -NH, CS, NH-R wherein R is an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted by one or more groups directly or through an oxygen or sulphur atom. A preferred compound is 5-endo-(6'-carboxyhex-2'Z-enyl)-6-exo-(1'-[N- (phenylthiocarbamoyl)-hydrazino]- ethyl)-bicyclo [2,2,1]-heptane