脂联素、肿瘤坏死因子-α及单核细胞趋化蛋白-1在大鼠子宫内膜异位症中的表达
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This study investigated the expression of adiponectin, tumor necrosis factor-alpha, and monocyte chemoattractant protein-1 in a rat model of endometriosis to explore their relationship with the disease.
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Abstract
子宫内膜异位症（EMT）简称EMT，为妇科常见疾病之一，主要症状为下腹痛与痛经、不孕及性交不适。EMT的发病机制普遍认为是逆行经血中的子宫内膜出现碎片粘附与腹膜腔被侵袭，从而使新血管形成，但是这并不能很好地解释大部分经血逆流女性为什么只有一小部分女性患EMT的现象。近年来，大量的研究证明EMT病患的腹腔微循环具有促进子宫内膜的碎片生长、粘附及形成血管的相关免疫因子，比如肿瘤的坏死因子-α（TNF-α）与单核细胞趋化蛋白1（MCP-1）。然而，脂联素（Acrp30）可以抑制TNF-α诱导的MCP-1的表达，本组研究的主要目的是为了从大鼠EMT模型模拟人EMT的发生、发展的全过程，进一步探讨细胞因子（TNF-α、MCP-1、Acrp30）与EMT之间的关系。
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- last seen: 2026-06-10T17:14:06.276822+00:00
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