Acute upsurge of tumour markers in ruptured ovarian endometrioma: a false alarm for malignancy: a case report

Deepika Theresa Thomas, G. Usha Rani
In: International Journal of Reproduction, Contraception, Obstetrics and Gynecology · 2024 · vol. 13(12) , pp. 3724–3726 · doi:10.18203/2320-1770.ijrcog20243435 · W4404327889
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⚙ AI-generated summary by qwen3.7-flash, 2026-10-05 ⓘ

This case report describes a 21-year-old woman with extremely high CA 125 levels who was diagnosed with a ruptured ovarian endometrioma, demonstrating that such marker elevations can mimic malignancy in this condition.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-22 · read from full text ⓘ

This paper reports a case of a 21-year-old nulliparous woman who presented with an extremely high acute rise in CA-125 and was suspected of having malignancy. Laparoscopy identified a ruptured ovarian endometrioma, and histopathology confirmed the diagnosis, with the authors discussing possible pathogenesis and the evaluation/management approach for ruptured endometriotic cysts. The main limitation is that it is a single case report, so the conclusions about mechanisms and evaluation are not based on a broader patient cohort. This paper is centrally about endometriosis—specifically, CA-125 upsurge following rupture of an ovarian endometrioma that initially mimicked malignancy.

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Abstract

CA 125, in gynaecological practice, is seen to be elevated in both benign and malignant conditions. Higher values, usually raise the suspicion of malignancy. Here we report a case of a 21-year-old nulliparous female, with extremely high evels of CA 125, suspected malignancy, but laparoscopy revealed a ruptured ovarian endometrioma, which was confirmed by histopathology. We discuss the pathogenesis of the same, evaluation and approach to management of ruptured endometriotic cysts.
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Acute upsurge of tumour markers in ruptured ovarian endometrioma: a false alarm for malignancy: a case report DOI: https://doi.org/10.18203/2320-1770.ijrcog20243435Keywords: CA125, Endometriosis, MalignancyAbstract CA 125, in gynaecological practice, is seen to be elevated in both benign and malignant conditions. Higher values, usually raise the suspicion of malignancy. Here we report a case of a 21-year-old nulliparous female, with extremely high evels of CA 125, suspected malignancy, but laparoscopy revealed a ruptured ovarian endometrioma, which was confirmed by histopathology. We discuss the pathogenesis of the same, evaluation and approach to management of ruptured endometriotic cysts. Metrics References Handa V, Van Le L. Te Linde's Operative Gynecology. Lippincott Williams & Wilkins; 2019. Kurata H, Sasaki M, Kase H, Yamamoto Y, Yoichi Aoki Y, Tanaka K. Elevated serum CA125 and CA19-9 due to the spontaneous rupture of ovarian endometrioma. Eur J Obst Gynecol Reprod Bio. 2002;105(1):75-6. Halvorson LM. First Trimester Abortion In: Hoffman BL, Schorge JO, Bradshaw KD, Halvorson LM, Schaffer JI, Corton MM, editors. Williams Gynecology. 2016. J Johansson, M Santala, A Kauppila, Explosive rise of serum CA 125 following the rupture of ovarian endometrioma. Human Rep. 1998;13(12):3503–4. Nezhat C, Nezhat F, Nezhat C. Nezhat’s Operative Gynecologic Laparoscopy and Hysteroscopy. 3rd ed. Cambridge University Press; 2008. Rao S, Kapurubandara, S, Anpalagan A. Elevated CA 125 in a case of leaking endometrioma. Case Reports in Obstetrics and Gynecology. 2018;23:850.

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