Association of estrogen receptor gene restriction fragment length polymorphisms and endometriosis

Objective To study the relationship between estrogen receptor (ER) gene restriction fragment length polymorphisms (RFLPs) and endometriosis. Methods 50 Chinese women with endometriosis of stage I ~ IV ER gene RFLPs for PvuII restriction endonuclease were assessed and indicated P. - p ( uppercase letter signifying the absence and lowercase letter the presence of the restriction site) . 50 women without endometriosis were studied as control group. Results There was no significant difference between the patients and the control groups in the frequency of the two-allele PvuII polymorphisms (0.34 vs. 0.43) and in the frequency of PP, Pp and pp genotype (0.12 vs.0.2, 0.44 vs. 0.46, 0.44 vs.0.34, respectively) .Conclusions The genotype and the frequency of the two - allele Pvu II polymorphisms of the estrogen receptor gene probably do not related to the pathogenesis of endometriosis in Chinese people.