Research on the Mechanics of Thrombosis Interface Damage Evolution

Research on the Mechanics of Thrombosis Interface Damage Evolution | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Research on the Mechanics of Thrombosis Interface Damage Evolution Zhen Zhou, Jiaxuan Chen, Chaoyue Ji, Dongyang Hou, Shunyong Jiang, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4112702/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract The shedding of thrombosis can pose diagnostic difficulties for clinicians as it results in risks of damage. Determining the appropriate treatment, drug thrombolysis, implanted vascular stents, clinical research, or surgical cutting is often challenging. To better understand the interfacial mechanical mechanism of thrombus shedding, a fluid-solid coupling finite element model was created based on viscoelasticity-based blood vessels, line elastic thrombosis, and Euler fluid blood to establish a connective interface between blood vessels and thrombosis. Under hypertension conditions, the interface mechanics model calculated the finite element interface performance of thrombosis with different degrees of calcification, thicknesses, and coverage angles, using the mechanical parameters to assess damage for the interface of different structural thromboses. The study analyzed and clarified the evolution mechanism of damage and exfoliation of the thrombotic interface in blood vessels under various conditions. The results revealed that the mechanics of damage and the shedding mechanism of the thrombosis were significantly affected by the different coverage angles. Based on these analyses, this study determined that the finite element method based on the Coupled Eulerian–Lagrangian method, including the interface model of the cohesive zone volume element layer, could well simulate the mechanics of damage and the shedding mechanism of the thrombotic interface under the impact of hypertension. This study is the first to explore the finite element interface damage model of thrombosis and the vessel wall using interfacial mechanics. Thrombosis shedding Interface damage Fluid-solid coupling Cohesive model Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4112702","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":281095742,"identity":"7aa79fce-bc02-422f-8d82-fd3c6f74169c","order_by":0,"name":"Zhen Zhou","email":"","orcid":"","institution":"The Institute of Technological Sciences, Wuhan University","correspondingAuthor":false,"prefix":"","firstName":"Zhen","middleName":"","lastName":"Zhou","suffix":""},{"id":281095743,"identity":"0e9541a1-59b2-4931-863e-061a05739d48","order_by":1,"name":"Jiaxuan Chen","email":"","orcid":"","institution":"The Institute of Technological Sciences, 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Determining the appropriate treatment, drug thrombolysis, implanted vascular stents, clinical research, or surgical cutting is often challenging. To better understand the interfacial mechanical mechanism of thrombus shedding, a fluid-solid coupling finite element model was created based on viscoelasticity-based blood vessels, line elastic thrombosis, and Euler fluid blood to establish a connective interface between blood vessels and thrombosis. Under hypertension conditions, the interface mechanics model calculated the finite element interface performance of thrombosis with different degrees of calcification, thicknesses, and coverage angles, using the mechanical parameters to assess damage for the interface of different structural thromboses. The study analyzed and clarified the evolution mechanism of damage and exfoliation of the thrombotic interface in blood vessels under various conditions. 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