Hematologic malignancies among patients at Al-Amal Oncology Center in Ibb Governorate, Yemen

Hematologic malignancies among patients at Al-Amal Oncology Center in Ibb Governorate, Yemen | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Hematologic malignancies among patients at Al-Amal Oncology Center in Ibb Governorate, Yemen Baheej Abdullwahed Almuraisi, Sadeq Kaid Mohammed Al-Mohani This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6849395/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background: Hematologic malignancies (HMs) are a public health problem. The World Health Organization (WHO) reports that the incidence of these tumors will increase by approximately 48% in developing countries by 2030. Yemen is one of the developing countries that suffers from a lack of information about the frequency and patterns of hematologic malignancies. Methods: A retrospective descriptive study of all cancers detected at Al-Amal Oncology Center in Ibb Governorate, Yemen during the study period from 2008 to 2023. SPSS version 26 and Microsoft Excel version 16 were used for data analysis and graphing, respectively to identify the pattern and distribution of HMs in Ibb Governorate, Yemen. Results: Overall, 6,156 cancer cases were detected during period from 2008 to 2023. HMs represented 979 (15.9%) of all collected cases, and their ages between 1 and 108 years with a mean age of 40.5 years. A statistically association was detected between age and HMs. Of these, 549 (56.1%) were males and 430 (43.9%) were females, with a M:F Ratio of 1.2 :1. No statistical significance was detected. Married and illiterate individuals constituted 607 (62%) and 512 (52.3%), respectively. A statistical association was found between marital status and education level and HMs. Non-Hodgkin Lymphoma (NHL) which constituted 448 (46 %) of all the HMs, was the commonest, followed respectively by Leukemia 398 (41%), Hodgkin lymphoma (HL) 110 (11%), other malignancies 23 (2%). Conclusions: This study revealed a relatively high prevalence of HMs among diagnosed cancer cases in the study area. It also indicated that the pattern of HMs in the current study appears to be lower than some other studies carried out in different regions of Yemen. NHL is the most common type of HMs, followed by leukemia. Age, marital status, and educational level were strongly associated with HMs. Haematological malignancies Non-Hodgkin Lymphoma Leukemia and Ibb governorate Yemen Figures Figure 1 Figure 2 Introduction Cancer is considered one of the top three causes of mortality globally [16]. Cancer that develops from blood cells is called hematological malignancies (HMs) [9, 21] that arise primarily from the uncontrolled growth of hematopoietic and lymphoid tissues [7, 26] that differ in their incidence, prognosis, etiology, treatment and survival [15, 17] and were estimated to represent about 6.5% of all cancers worldwide in 2012 [9, 13]. HMs are classified according to four common subtypes: leukemia (acute and chronic), Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL), and multiple myeloma (MM) [14]. These disorders have significance impact on global health, posing challenges for health care systems worldwide [4]. The causes of HMs remain unclear, but are thought to be related to environmental exposure to ionizing radiation, chemicals such as benzene and pesticides, infectious agents, and smoking, as well as genetic factors [7]. The World Health Organization (WHO) reports that the incidence of HMs will increase by about 48% in developing countries by 2030. HMs represent the fourth most common cancer and the second leading cause of cancer death in developing countries and approximately 1.29 million people live with HMs [15]. A combination of factors, including limited diagnostic and clinical resources and lack of access to novel treatments, contribute to the increased incidence of these malignancies in Africa and Asia, although their prevalence in these countries is lower than in Western countries [7]. Although comprehensive cancer treatment is available in only 15% of developing countries, it is available in more than 90% of developed countries [16]. In high-income countries, HMs account for 1% of all deaths. They contribute to 6–10% of all causes of death from malignancies, with 50% among young people [4]. Yemen is one of the least developed countries in the Eastern Mediterranean region, and according to the WHO/Regional Office for the Eastern Mediterranean (2018), the health situation in Yemen is one of the least favorable in the world. Yemen has been facing a dirty, illegal and unjust war for 11 years and a blockade by the brutal aggression countries, which has led to a significant shortage of health facilities. The health system suffers from weakness and many problems that have been exacerbated by the ongoing conflict. The three-tier primary health care system, which relies on health units, health centers and hospitals, is insufficient to cover the health needs of the population, especially since the population growth rate is faster than the expansion of available health facilities [12]. Cancer is a significant public health problem in Yemen and the incidence of cancer in Yemen is not accurately known due to limited pathology resources, scarcity and poor quality of medical records, and limited epidemiology resources. Furthermore, the recent ongoing civil conflict has contributed to the obscurity of the cancer burden at the national level [12]. The distribution of HMs increased at National Oncology Center in Sana'a and increased in south-west Yemen [3]. Ibb governorate is located on the southwestern side of the escarpment of the Yemen highlands and it is one of the most densely populated governorates in Yemen. Ibb Governorate receives thousands of displaced persons from neighboring governorates due to the ongoing political conflict, which has increased the burden on the weak health system, especially the Al-Amal Center for Oncology, the only center in the governorate, which was opened on 5/22/2006 and provides its services to about (2000) cancer patients annually from Ibb governorate and neighboring governorates. Information on the epidemic of haematologic malignancies in Yemen, especially in Ibb governorate, are limited. This information may be useful for planning and formulating policies for the prevention, control and treatment of these cancers. This study sought to determine the pattern and distribution of haematologic malignancies among patients attending Al-Amal Center for Oncology in Ibb Governorate, Yemen. Materials and methods Patients This is a retrospective descriptive study conducted in Al-Amal Cancer Center in Ibb governorate. A total of 6156 cancer patients were collected during period from 2008 to 2023. The collected data included details such as gender, age, place of residence, marital status, educational status, and family history of cancer. Statistical analysis. Data analysis was conducted using the SPSS software version 26 and Microsoft Excel version 16. The Chi-squared test was used to determine the statistical significance. P < 0.05 was considered to indicate a statistically significant difference. Results A total 6156 cancer patients were collected from Al-Amal Center for Oncology in Ibb Governorate. HMs represented 979 (15.9%) of collected cases (Fig. 1). Participated patients were aged between 1-108 years with a mean age of 40.5 years. The highest incidence of HMs was detected in the age group 22–43 years 293 (29.9%) followed by 270 (27.6%) and 255 (26.1%) in the patients aged between 1–21 years and 44–64 years, respectively. However, the lowest incidence rate was 20 (2.4%) in the patients aged 87 years and older. The current study indicated a significant relationship between the age of the studied cases and the incidence of the disease ( P < 0.00). In this study, males represented 549 (56.1%), while females represented 430 (43.9%), with a male: female ratio of 1.2:1. The present study showed no statistically significant relationship between gender and HMs ( P > 0.919). This study showed that, the most of HMs cases were from rural area 792 (80.9%). No statistically significant association was found ( P > 0. 944). Married subjects represented 607 (62%) and illiterate patients 512 (52.3%). A statistical association was found between HMs and marital status and educational level of the study population. Only 28 (2.86%) of HMs patients had relatives infected with HMs and insignificance association was detected between family history of HM and HM ( P > 0.827) (Table 1). Figure 2 shows the distribution of HMs by malignancy type, with the highest level of observed for NHL 448 (46%) followed by leukemia, HL and others types of malignancies, 398 (41%), 110 (11%) and 23 (2%) respectively. Discussion To our knowledge, this is the first epidemiological study on HMs in Ibb Governorate, Yemen. It was conducted using data collected from Al-Amal Oncology Centre, which is available to cancer patients. In this study, HM constituted 979 (15.9%) of all collected cancers cases, 6156 cases. This study revealed a relatively high prevalence of HMs among cancer cases diagnosed in the study area and lower than studies conducted in different regions in Yemen, such as studies conducted in Taiz, Hadramout and Aden which revealed that prevalence rates were 24.8%, 22.6%, 18.9%, respectively [6,8, 13]. The result of the current study was lower than the results conducted in Pakistan 45.36% [18], Iran 20% [8] and Indonesia [5]. The incidence of HMs in this study was higher than the findings of a studies conducted in USA 9.3% [25], Morocco 10.9% [8], Nigeria 12.34% [13], and in Madagascar 12.45% [22]. These variations in prevalence could be attributed to differences in sociodemographic factors, study population, type of study, type of sample, sample size, and availability facilities for diagnosis of HMs. The mean age of HM patients in this study was 40.5 years. This result was similar with the result reported by Abdul Hamid Gamal in Yemen [10] and in Aden, Yemen [2]. Similar result reported in Saudi Arabia [1]. However, the mean age of the present study was higher than that studies carried out in Taiz, Yemen [19] and Nigeria [13]. However, The mean age of HMs in the current study was lower than reported in Egypt [11], Madagascar [22], United Kingdom [22] and in Italia[17]. Thus, the median age at diagnosis of HMs in Yemen is younger than that found in Western countries, but it is similar to that in Asia. The present study indicated that significant relationship between age of studied cases and HMs ( P > 0.00). This study showed the higher frequency of HMs seen at age group between 22–43 years 293 (29.9%) and the lowest prevalence rate was in patients aged between 44–64 years 255 (26.1%). This could be attributed to people aged between 22–43 years are more active and worked than other people and prolonged exposure to carcinogens. Similar findings were reported by study conducted in Aden, Yemen, Nigeria, and in India [2,13]. In contrast, anther studies conducted in Morocco, Egypt, Chile, and Italia reported that HMs were prevalent among patients aged 60 years and older [8,11,17, 21]. Concerning sex, male predominance of HMs has been observed throughout the world. The current study reported that males represented 549 (56.1%), however, females 430 (43.9%), with a male: female ratio of 1.23:1 and there was no statistically significant was detected ( P > 0.919). Such a finding is consistent to that reported in Yemen, Italia, Eastern Morocco, Bangladesh, Pakistan, United Kingdom, France and in USA [8,10,15,17, 24]. The result of this study was the opposite trend to reports of HMs in Chile [21]. Regarding marital status, the results reported significance association between marital status and HMs ( P > 0.001). Married subjects represented 607 (62%) of HMs patients. This may be because married people are responsible for their families and therefore have more workloads and more susceptible to risk factors of HMs. Concerning educational level of study population, finding of this study revealed that statistical association between educational level of study population and HMs ( P > 0.001). More than half 512 (52.3%) of patients in the current study were illiterate, however, only 58 (5.9%) were graduate people. The higher prevalence of HMs in illiterate patients justifies the need to develop effective programs to educate people about risk factors of HMs and improve the management of HMs diseases in the community. In relation to the types of HMs, this study reported that NHL was the most common occurring HMs in this area and represented 448 (46%) of all cases followed by leukemia, HL and others types of malignancies, 398 (41%), 110 (11%) and 23 (2%) respectively. These findings are in agreement with literature review reported that NHL is the commonest HM globally [20]. The finding of the present study was in concordance with reports from local studies conducted in Aden and Hadramout with in Yemen [2,6] and studies carried out in Bangladesh, Nigeria, USA, and in Europe countries [7,20,23, 24]. Whereas, in contrast to the results of the current study, a studies conducted in Sana'a, Taiz and Ibb cities within Yemen [3, 19]. In addition to studies conducted in Saudi Arabia and Indonesia [1,5]. Study carried out in Africa also outlined that leukemia had the highest pooled prevalence (53.69%), followed by lymphoma 38.36% [18]. The variation in these results could be attributed to differences in type of sample, sample size, study population, sociodemographic factors, and methods of diagnosis. Leukemia was the second most common HMs in this study after NHL, representing for 398 (41%) of all HMs. This incidence rate was lower than that observed in the previous study done in Taiz, Ibb cities, Sana'a, Hadramout with in Yemen [3,6, 19] and studies in Egypt, Saudi Arabia, Nigeria, and in Chile [1,7,10, 21] but it was higher than those observed in Indonesia [5,8]. The limitations of the study Diagnosis of HMs in this center is based on clinical evaluation and primary tests due to absence of specialized diagnostic facilities as immunophenotype, cytochemical and other facilities required for current standard diagnosis of HMs. As result of using retrospective study, some information were lost. Conclusion This study revealed a relatively high prevalence of HMs among diagnosed cancer cases in the study area. The pattern of HMs in the current study appears to be lower than some other studies in different regions of Yemen, which showed that males are more affected, and that NHL is the most common type of hematological malignancy, followed by leukemia. Age, marital status and educational level were significantly associated with HMs. The present study highlighted the burden of HMs in the study area and could provide information for health policy planning and for future programs on HM control. Further studies on the various aspects of HMs are needed for better control and prevention system in Yemen. Declarations Acknowledgments We would like to thank the medical team and all the administrative staff at the Al Amal Oncology Center in Ibb Governorate for their cooperation during data collection. We also thank Dr. Mohammed Abduh Khoshafah for reviewing the English version of the manuscript. We also thank Professor Fahed Meqran for his role in the statistical analysis of the research. Authors contributions Al-Muraisi Baheej contributed to data collection, study design, manuscript writing, and formatting. Al-Mohani Sadeq performed statistical analyses and interpretation of results, and reviewed the final manuscript. Funding No funding was received for this study Data availability Data is provided within the manuscript. Ethics approval Ethical approval was obtained from Al-Amal Center for Oncology in Ibb Governorate. Patient consent was not required because the data used was anonymous and encrypted. All data is kept strictly confidential. Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. References Ahmed, Hussain Gadelkarim, et al. "Epidemiology of hematological malignancies in Hail region, Northern Saudi Arabia." Med Sci 24.102 (2020): 699-705. Al-Kahiry, Waiel. "Hematological Malignancies in Al-Amal Oncology Unit, Aden." Indian Journal of Hematology and Blood Transfusion 28 (2012): 19-23. Al-Nuzaili, Mohammed Abdulkader, et al. "Acute Myeloid Leukemia among Patients attending Sana’a Hospitals, Yemen: Prevalence, Subtypes and Hematological Patterns." Sana'a University Journal of Medicine and Health Sciences 18.3 (2024): 56-63. An, Zhuo-Yu, et al. "Projected global trends in hematological malignancies: incidence, mortality, and disability-adjusted life years from 2020 to 2030." Blood 142 (2023): 3810. Cahyadi, Andi, et al. "Region Variation of Hematological Malignancies and Solid Tumors in Children in East Java." Asian Journal of Health Research 2.1 (2023): 27-33. Daakeek AM, Bahashwan AA, Bakrman AA, Al-Zaazaai AA .Correlation Hematological malignancies in the Hadhramout Sector. Pattern and Distribution. J Blood Disord Med 5(1) (2022): dx.doi.org/10.16966/2471-5026.129. Egesie, Ochaka J., et al. "Prevalence and type of haematological malignancies among adults in a tertiary hospital in Jos-Nigeria: a sixteen-year retrospective analysis." Highland Medical Research Journal 17.2 (2017): 92-96. Elidrissi Errahhali, Mounia, et al. "Distribution and features of hematological malignancies in Eastern Morocco: a retrospective multicenter study over 5 years." BMC cancer 16 (2016): 1-10. ‏ Goswami P, Oliva EN, Ionova T, et al. Development of a Novel Hematological Malignancy Specific Patient-Reported Outcome Measure (HM-PRO): Content Validity. Front Pharmacol . 2020;11:209. Published 2020 Mar 5. doi:10.3389/fphar.2020.00209. Hamid, Gamal Abdul. "CANCER IN YEMEN: REPORT." ‏ Hussein, Safinaz, Doaa Mohamed, and Rania Hafez. "Risk factors of hematological malignancies in Upper Egypt: a case–control study." The Egyptian Journal of Internal Medicine 31 (2019): 171-177. Ibrahim, Amran, et al. "Cancer statistics in Yemen: incidence and mortality, in 2020." BMC Public Health 24.1 (2024): 962. James, Jasini, et al. "Pattern of Haematological Malignancies in A Tertiary Hospital in Yola, Nigeria: A Three Year Retrospective Review." Orient Journal of Medicine 34.3-4 (2022): 84-90. Keykhaei M, Masinaei M, Mohammadi E, et al. A global, regional, and national survey on burden and Quality of Care Index (QCI) of hematologic malignancies; global burden of disease systematic analysis 1990-2017. Exp Hematol Oncol . 2021;10(1):11. Published 2021 Feb 8. doi:10.1186/s40164-021-00198-2. Krok‐Schoen, Jessica L., et al. "Incidence and survival of hematological cancers among adults ages≥ 75 years." Cancer medicine 7.7 (2018): 3425-3433. Mahdi H, Mula-Hussain L, Ramzi ZS, et al. Cancer Burden Among Arab-World Females in 2020: Working Toward Improving Outcomes. JCO Glob Oncol . 2022;8:e2100415. doi:10.1200/GO.21.00415. Mangone, Lucia, et al. "Incidence, mortality, and survival of hematological malignancies in Northern Italian patients: an update to 2020." Frontiers in Oncology 13 (2023): 1182971. Mulatie, Zewudu, et al. "Prevalence of hematological malignancies in Africa: A systematic review and meta-analysis." Scientific reports 15.1 (2025): 9471. Nasher Saeed Thabet, Nooman Yousr Abdulhadi, Hady Saleh Abo, halimy Sadam Al. Characteristics Of Hematological Malignancies In South–West Yemen. Indian Journal Of Applied Research 11 (2021 | No. 2249 - 555X | DOI : 10.36106/ijar Otu, T. I., and U. G. Ejikeme. "The frequency and pattern of haematological malignancies in a Tertiary hospital In Abuja, federal capital territory, north central Nigeria: A sixteen year review." A sixteen year review 2021 (2021): 20. ‏ Pérez GB, Calaf GM, Villalba MTM, Prieto KS, Burgos FC. Frequency of hematologic malignancies in the population of Arica, Chile. Oncol Lett. 2019 Nov;18(5):5637-5643. doi: 10.3892/ol.2019.10858. Epub 2019 Sep 12. PMID: 31612068; PMCID: PMC6781717. Refeno, Valéry, et al. "Epidemiology and clinical aspects of hematological malignancies at the military hospital of Antananarivo." (2019) Sant, Milena, et al. "Incidence of hematologic malignancies in Europe by morphologic subtype: results of the HAEMACARE project." Blood, The Journal of the American Society of Hematology 116.19 (2010): 3724-3734. ‏ Sarwar, M. R., et al. "Hematological malignancies pattern among Bangladeshi adults." Journal of Medical Science and Clinical Research 5 (2020): 6-9. ‏ Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics. CA Cancer J Clin. 2014;64(1):9–29.) Tietsche de Moraes Hungria V, Chiattone C, Pavlovsky M, et al. Epidemiology of Hematologic Malignancies in Real-World Settings: Findings From the Hemato-Oncology Latin America Observational Registry Study. J Glob Oncol . 2019;5:1-19. doi:10.1200/JGO.19.00025 9. Table Table 1. Sociodemographic characteristics distribution of studied patients with haematological malignancies * p < 0.05 is considered as significant. Additional Declarations No competing interests reported. Supplementary Files table.docx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6849395","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":468345088,"identity":"056ffb4b-92c5-431b-bfdf-16694899cfac","order_by":0,"name":"Baheej Abdullwahed Almuraisi","email":"","orcid":"","institution":"","correspondingAuthor":false,"prefix":"","firstName":"Baheej","middleName":"Abdullwahed","lastName":"Almuraisi","suffix":""},{"id":468345089,"identity":"d5f6cd48-33ff-40b9-9e83-9769e94a433b","order_by":1,"name":"Sadeq Kaid Mohammed Al-Mohani","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA5UlEQVRIie3PsQrCMBCA4ZNAOnjFNdCir1ApiODQF/AhdHGK4AOIS6Gbzj6GInQWDtNF9w5uBQcnQehYbIuDU1s3wfxDstxHcgA63S9mALD8Qi/yj/kt7HrC3gTOalIQbEwA4rEDpa2r47enyWJ5tVtbfN7j5RDBoNOuiggyD+5W3ZBZ63AkVf4xnM3iymfIDC3khNy+hK7kORE4qCS9kmSEKOTNlVkD4hTEDAiFkCyZBw1Iv9jF3BA6qAZsvhHI63bpRut9gil5juEnT5muuh2DVPX6H3FRnk3Hi9jjm2mdTqf7n17vI0Kp4SbAbAAAAABJRU5ErkJggg==","orcid":"","institution":"","correspondingAuthor":true,"prefix":"","firstName":"Sadeq","middleName":"Kaid Mohammed","lastName":"Al-Mohani","suffix":""}],"badges":[],"createdAt":"2025-06-08 22:08:18","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-6849395/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6849395/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":84423371,"identity":"63dcf899-2078-487e-8752-89e2fe5abc7e","added_by":"auto","created_at":"2025-06-11 18:47:03","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":13765,"visible":true,"origin":"","legend":"\u003cp\u003ePercentage of HMs aming studied population\u003c/p\u003e","description":"","filename":"1.png","url":"https://assets-eu.researchsquare.com/files/rs-6849395/v1/3abcab1ec15ff9b8c8d4682d.png"},{"id":84423369,"identity":"69668daf-fff9-4821-8944-54ae9a76906c","added_by":"auto","created_at":"2025-06-11 18:47:03","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":23477,"visible":true,"origin":"","legend":"\u003cp\u003eDistribution of HMs cases according to the types of HMs in \u0026nbsp;the study area.\u003c/p\u003e","description":"","filename":"2.png","url":"https://assets-eu.researchsquare.com/files/rs-6849395/v1/58b805af5bb881c2a8ec7cab.png"},{"id":84596504,"identity":"fb444f8d-eac1-4b77-b29d-3c1218352269","added_by":"auto","created_at":"2025-06-14 06:46:50","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":472746,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6849395/v1/3d8723d5-df2b-4f67-aecc-4ea10fa1830a.pdf"},{"id":84424194,"identity":"93d46c66-779a-4c5d-b2c0-741b6a6c94ad","added_by":"auto","created_at":"2025-06-11 19:03:03","extension":"docx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":20714,"visible":true,"origin":"","legend":"","description":"","filename":"table.docx","url":"https://assets-eu.researchsquare.com/files/rs-6849395/v1/1ef0a0b764bc5d929496157f.docx"}],"financialInterests":"No competing interests reported.","formattedTitle":"Hematologic malignancies among patients at Al-Amal Oncology Center in Ibb Governorate, Yemen","fulltext":[{"header":"Introduction","content":"\u003cp\u003eCancer is considered one of the top three causes of mortality globally [16]. Cancer that develops from blood cells is called hematological malignancies (HMs) [9, 21] that arise primarily from the uncontrolled growth of hematopoietic and lymphoid tissues [7, 26] that differ in their incidence, prognosis, etiology, treatment and survival [15, 17] and were estimated to represent about 6.5% of all cancers worldwide in 2012 [9, 13]. HMs are classified according to four common subtypes: leukemia (acute and chronic), Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL), and multiple myeloma (MM) [14]. These disorders have significance impact on global health, posing challenges for health care systems worldwide [4]. The causes of HMs remain unclear, but are thought to be related to environmental exposure to ionizing radiation, chemicals such as benzene and pesticides, infectious agents, and smoking, as well as genetic factors [7]. The World Health Organization (WHO) reports that the incidence of HMs will increase by about 48% in developing countries by 2030. HMs represent the fourth most common cancer and the second leading cause of cancer death in developing countries and approximately 1.29\u0026nbsp;million people live with HMs [15]. A combination of factors, including limited diagnostic and clinical resources and lack of access to novel treatments, contribute to the increased incidence of these malignancies in Africa and Asia, although their prevalence in these countries is lower than in Western countries [7]. Although comprehensive cancer treatment is available in only 15% of developing countries, it is available in more than 90% of developed countries [16]. In high-income countries, HMs account for 1% of all deaths. They contribute to 6\u0026ndash;10% of all causes of death from malignancies, with 50% among young people [4].\u003c/p\u003e \u003cp\u003eYemen is one of the least developed countries in the Eastern Mediterranean region, and according to the WHO/Regional Office for the Eastern Mediterranean (2018), the health situation in Yemen is one of the least favorable in the world. Yemen has been facing a dirty, illegal and unjust war for 11 years and a blockade by the brutal aggression countries, which has led to a significant shortage of health facilities. The health system suffers from weakness and many problems that have been exacerbated by the ongoing conflict. The three-tier primary health care system, which relies on health units, health centers and hospitals, is insufficient to cover the health needs of the population, especially since the population growth rate is faster than the expansion of available health facilities [12]. Cancer is a significant public health problem in Yemen and the incidence of cancer in Yemen is not accurately known due to limited pathology resources, scarcity and poor quality of medical records, and limited epidemiology resources. Furthermore, the recent ongoing civil conflict has contributed to the obscurity of the cancer burden at the national level [12]. The distribution of HMs increased at National Oncology Center in Sana'a and increased in south-west Yemen [3].\u003cdiv class=\"BlockQuote\"\u003e\u003cp\u003eIbb governorate is located on the southwestern side of the escarpment of the Yemen highlands and it is one of the most densely populated governorates in Yemen. Ibb Governorate receives thousands of displaced persons from neighboring governorates due to the ongoing political conflict, which has increased the burden on the weak health system, especially the Al-Amal Center for Oncology, the only center in the governorate, which was opened on 5/22/2006 and provides its services to about (2000) cancer patients annually from Ibb governorate and neighboring governorates. Information on the epidemic of haematologic malignancies in Yemen, especially in Ibb governorate, are limited. This information may be useful for planning and formulating policies for the prevention, control and treatment of these cancers. This study sought to determine the pattern and distribution of haematologic malignancies among patients attending Al-Amal Center for Oncology in Ibb Governorate, Yemen.\u003c/p\u003e\u003c/div\u003e\u003c/p\u003e"},{"header":"Materials and methods","content":"\u003cdiv id=\"Sec3\" class=\"Section2\"\u003e \u003ch2\u003ePatients\u003c/h2\u003e \u003cp\u003eThis is a retrospective descriptive study conducted in Al-Amal Cancer Center in Ibb governorate. A total of 6156 cancer patients were collected during period from 2008 to 2023. The collected data included details such as gender, age, place of residence, marital status, educational status, and family history of cancer.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec4\" class=\"Section2\"\u003e \u003ch2\u003eStatistical analysis.\u003c/h2\u003e \u003cp\u003eData analysis was conducted using the SPSS software version 26 and Microsoft Excel version 16. The Chi-squared test was used to determine the statistical significance. \u003cem\u003eP\u003c/em\u003e\u0026thinsp;\u0026lt;\u0026thinsp;0.05 was considered to indicate a statistically significant difference.\u003c/p\u003e \u003c/div\u003e"},{"header":"Results","content":"\u003cp\u003eA total 6156 cancer patients were collected from Al-Amal Center for Oncology in Ibb Governorate. HMs represented 979 (15.9%) of collected cases (Fig.\u0026nbsp;1). Participated patients were aged between 1-108 years with a mean age of 40.5 years. The highest incidence of HMs was detected in the age group 22\u0026ndash;43 years 293 (29.9%) followed by 270 (27.6%) and 255 (26.1%) in the patients aged between 1\u0026ndash;21 years and 44\u0026ndash;64 years, respectively. However, the lowest incidence rate was 20 (2.4%) in the patients aged 87 years and older. The current study indicated a significant relationship between the age of the studied cases and the incidence of the disease (\u003cem\u003eP\u003c/em\u003e\u0026thinsp;\u0026lt;\u0026thinsp;0.00). In this study, males represented 549 (56.1%), while females represented 430 (43.9%), with a male: female ratio of 1.2:1. The present study showed no statistically significant relationship between gender and HMs (\u003cem\u003eP\u003c/em\u003e\u0026thinsp;\u0026gt;\u0026thinsp;0.919). This study showed that, the most of HMs cases were from rural area 792 (80.9%). No statistically significant association was found (\u003cem\u003eP\u003c/em\u003e\u0026thinsp;\u0026gt;\u0026thinsp;0. 944). Married subjects represented 607 (62%) and illiterate patients 512 (52.3%). A statistical association was found between HMs and marital status and educational level of the study population. Only 28 (2.86%) of HMs patients had relatives infected with HMs and insignificance association was detected between family history of HM and HM (\u003cem\u003eP\u003c/em\u003e\u0026thinsp;\u0026gt;\u0026thinsp;0.827) (Table\u0026nbsp;1).\u003c/p\u003e \u003cp\u003eFigure 2 shows the distribution of HMs by malignancy type, with the highest level of observed for NHL 448 (46%) followed by leukemia, HL and others types of malignancies, 398 (41%), 110 (11%) and 23 (2%) respectively.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eTo our knowledge, this is the first epidemiological study on HMs in Ibb Governorate, Yemen. It was conducted using data collected from Al-Amal Oncology Centre, which is available to cancer patients.\u003c/p\u003e \u003cp\u003eIn this study, HM constituted 979 (15.9%) of all collected cancers cases, 6156 cases.\u003c/p\u003e \u003cp\u003eThis study revealed a relatively high prevalence of HMs among cancer cases diagnosed in the study area and lower than studies conducted in different regions in Yemen, such as studies conducted in Taiz, Hadramout and Aden which revealed that prevalence rates were 24.8%, 22.6%, 18.9%, respectively [6,8, 13]. The result of the current study was lower than the results conducted in Pakistan 45.36% [18], Iran 20% [8] and Indonesia [5]. The incidence of HMs in this study was higher than the findings of a studies conducted in USA 9.3% [25], Morocco 10.9% [8], Nigeria 12.34% [13], and in Madagascar 12.45% [22]. These variations in prevalence could be attributed to differences in sociodemographic factors, study population, type of study, type of sample, sample size, and availability facilities for diagnosis of HMs.\u003c/p\u003e \u003cp\u003eThe mean age of HM patients in this study was 40.5 years. This result was similar with the result reported by Abdul Hamid Gamal in Yemen [10] and in Aden, Yemen [2]. Similar result reported in Saudi Arabia [1]. However, the mean age of the present study was higher than that studies carried out in Taiz, Yemen [19] and Nigeria [13]. However, The mean age of HMs in the current study was lower than reported in Egypt [11], Madagascar [22], United Kingdom [22] and in Italia[17]. Thus, the median age at diagnosis of HMs in Yemen is younger than that found in Western countries, but it is similar to that in Asia. The present study indicated that significant relationship between age of studied cases and HMs (\u003cem\u003eP\u003c/em\u003e\u0026thinsp;\u0026gt;\u0026thinsp;0.00). This study showed the higher frequency of HMs seen at age group between 22\u0026ndash;43 years 293 (29.9%) and the lowest prevalence rate was in patients aged between 44\u0026ndash;64 years 255 (26.1%). This could be attributed to people aged between 22\u0026ndash;43 years are more active and worked than other people and prolonged exposure to carcinogens. Similar findings were reported by study conducted in Aden, Yemen, Nigeria, and in India [2,13]. In contrast, anther studies conducted in Morocco, Egypt, Chile, and Italia reported that HMs were prevalent among patients aged 60 years and older [8,11,17, 21].\u003c/p\u003e \u003cp\u003eConcerning sex, male predominance of HMs has been observed throughout the world. The current study reported that males represented 549 (56.1%), however, females 430 (43.9%), with a male: female ratio of 1.23:1 and there was no statistically significant was detected (\u003cem\u003eP\u003c/em\u003e\u0026thinsp;\u0026gt;\u0026thinsp;0.919). Such a finding is consistent to that reported in Yemen, Italia, Eastern Morocco, Bangladesh, Pakistan, United Kingdom, France and in USA [8,10,15,17, 24]. The result of this study was the opposite trend to reports of HMs in Chile [21].\u003c/p\u003e \u003cp\u003eRegarding marital status, the results reported significance association between marital status and HMs (\u003cem\u003eP\u003c/em\u003e\u0026thinsp;\u0026gt;\u0026thinsp;0.001). Married subjects represented 607 (62%) of HMs patients. This may be because married people are responsible for their families and therefore have more workloads and more susceptible to risk factors of HMs.\u003c/p\u003e \u003cp\u003eConcerning educational level of study population, finding of this study revealed that statistical association between educational level of study population and HMs (\u003cem\u003eP\u003c/em\u003e\u0026thinsp;\u0026gt;\u0026thinsp;0.001). More than half 512 (52.3%) of patients in the current study were illiterate, however, only 58 (5.9%) were graduate people. The higher prevalence of HMs in illiterate patients justifies the need to develop effective programs to educate people about risk factors of HMs and improve the management of HMs diseases in the community.\u003c/p\u003e \u003cp\u003eIn relation to the types of HMs, this study reported that NHL was the most common occurring HMs in this area and represented 448 (46%) of all cases followed by leukemia, HL and others types of malignancies, 398 (41%), 110 (11%) and 23 (2%) respectively. These findings are in agreement with literature review reported that NHL is the commonest HM globally [20]. The finding of the present study was in concordance with reports from local studies conducted in Aden and Hadramout with in Yemen [2,6] and studies carried out in Bangladesh, Nigeria, USA, and in Europe countries [7,20,23, 24]. Whereas, in contrast to the results of the current study, a studies conducted in Sana'a, Taiz and Ibb cities within Yemen [3, 19]. In addition to studies conducted in Saudi Arabia and Indonesia [1,5]. Study carried out in Africa also outlined that leukemia had the highest pooled prevalence (53.69%), followed by lymphoma 38.36% [18]. The variation in these results could be attributed to differences in type of sample, sample size, study population, sociodemographic factors, and methods of diagnosis.\u003c/p\u003e \u003cp\u003eLeukemia was the second most common HMs in this study after NHL, representing for 398 (41%) of all HMs. This incidence rate was lower than that observed in the previous study done in Taiz, Ibb cities, Sana'a, Hadramout with in Yemen [3,6, 19] and studies in Egypt, Saudi Arabia, Nigeria, and in Chile [1,7,10, 21] but it was higher than those observed in Indonesia [5,8].\u003c/p\u003e\n\u003ch3\u003eThe limitations of the study\u003c/h3\u003e\n\u003cp\u003eDiagnosis of HMs in this center is based on clinical evaluation and primary tests due to absence of specialized diagnostic facilities as immunophenotype, cytochemical and other facilities required for current standard diagnosis of HMs. As result of using retrospective study, some information were lost.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eThis study revealed a relatively high prevalence of HMs among diagnosed cancer cases in the study area. The pattern of HMs in the current study appears to be lower than some other studies in different regions of Yemen, which showed that males are more affected, and that NHL is the most common type of hematological malignancy, followed by leukemia. Age, marital status and educational level were significantly associated with HMs. The present study highlighted the burden of HMs in the study area and could provide information for health policy planning and for future programs on HM control. Further studies on the various aspects of HMs are needed for better control and prevention system in Yemen.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eAcknowledgments\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe would like to thank the medical team and all the administrative staff at the Al Amal Oncology Center in Ibb Governorate for their cooperation during data collection. We also thank Dr. Mohammed Abduh Khoshafah for reviewing the English version of the manuscript. We also thank Professor Fahed Meqran for his role in the statistical analysis of the research.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAl-Muraisi Baheej contributed to data collection, study design, manuscript writing, and formatting. Al-Mohani Sadeq performed statistical analyses and interpretation of results, and reviewed the final manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNo funding was received for this study\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eData availability\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eData is provided within the manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthics approval\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eEthical approval was obtained from Al-Amal Center for Oncology in Ibb Governorate.\u0026nbsp;Patient consent was not required because the data used was anonymous and encrypted. All data is kept strictly confidential.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConflict of interest\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eAhmed, Hussain Gadelkarim, et al. \u0026quot;Epidemiology of hematological malignancies in Hail region, Northern Saudi Arabia.\u0026quot; \u003cem\u003eMed Sci\u003c/em\u003e 24.102 (2020): 699-705.\u003c/li\u003e\n\u003cli\u003eAl-Kahiry, Waiel. \u0026quot;Hematological Malignancies in Al-Amal Oncology Unit, Aden.\u0026quot; \u003cem\u003eIndian Journal of Hematology and Blood Transfusion\u003c/em\u003e 28 (2012): 19-23.\u003c/li\u003e\n\u003cli\u003eAl-Nuzaili, Mohammed Abdulkader, et al. \u0026quot;Acute Myeloid Leukemia among Patients attending Sana\u0026rsquo;a Hospitals, Yemen: Prevalence, Subtypes and Hematological Patterns.\u0026quot; \u003cem\u003eSana\u0026apos;a University Journal of Medicine and Health Sciences\u003c/em\u003e 18.3 (2024): 56-63. \u003c/li\u003e\n\u003cli\u003eAn, Zhuo-Yu, et al. \u0026quot;Projected global trends in hematological malignancies: incidence, mortality, and disability-adjusted life years from 2020 to 2030.\u0026quot; \u003cem\u003eBlood\u003c/em\u003e 142 (2023): 3810.\u003c/li\u003e\n\u003cli\u003eCahyadi, Andi, et al. \u0026quot;Region Variation of Hematological Malignancies and Solid Tumors in Children in East Java.\u0026quot; \u003cem\u003eAsian Journal of Health Research\u003c/em\u003e 2.1 (2023): 27-33. \u003c/li\u003e\n\u003cli\u003eDaakeek AM, Bahashwan AA, Bakrman AA, Al-Zaazaai AA .Correlation Hematological malignancies in the Hadhramout Sector. Pattern and Distribution. J Blood Disord Med 5(1) (2022): dx.doi.org/10.16966/2471-5026.129.\u003c/li\u003e\n\u003cli\u003eEgesie, Ochaka J., et al. \u0026quot;Prevalence and type of haematological malignancies among adults in a tertiary hospital in Jos-Nigeria: a sixteen-year retrospective analysis.\u0026quot; \u003cem\u003eHighland Medical Research Journal\u003c/em\u003e 17.2 (2017): 92-96.\u003c/li\u003e\n\u003cli\u003eElidrissi Errahhali, Mounia, et al. \u0026quot;Distribution and features of hematological malignancies in Eastern Morocco: a retrospective multicenter study over 5 years.\u0026quot; \u003cem\u003eBMC cancer\u003c/em\u003e 16 (2016): 1-10.\u003cspan dir=\"RTL\"\u003e\u0026rlm; \u003c/span\u003e\u003c/li\u003e\n\u003cli\u003eGoswami P, Oliva EN, Ionova T, et al. Development of a Novel Hematological Malignancy Specific Patient-Reported Outcome Measure (HM-PRO): Content Validity. \u003cem\u003eFront Pharmacol\u003c/em\u003e. 2020;11:209. Published 2020 Mar 5. doi:10.3389/fphar.2020.00209.\u003c/li\u003e\n\u003cli\u003eHamid, Gamal Abdul. \u0026quot;CANCER IN YEMEN: REPORT.\u0026quot;\u003cspan dir=\"RTL\"\u003e\u0026rlm;\u003c/span\u003e\u003c/li\u003e\n\u003cli\u003eHussein, Safinaz, Doaa Mohamed, and Rania Hafez. \u0026quot;Risk factors of hematological malignancies in Upper Egypt: a case\u0026ndash;control study.\u0026quot; \u003cem\u003eThe Egyptian Journal of Internal Medicine\u003c/em\u003e 31 (2019): 171-177.\u003c/li\u003e\n\u003cli\u003eIbrahim, Amran, et al. \u0026quot;Cancer statistics in Yemen: incidence and mortality, in 2020.\u0026quot; \u003cem\u003eBMC Public Health\u003c/em\u003e 24.1 (2024): 962. \u003c/li\u003e\n\u003cli\u003eJames, Jasini, et al. \u0026quot;Pattern of Haematological Malignancies in A Tertiary Hospital in Yola, Nigeria: A Three Year Retrospective Review.\u0026quot; \u003cem\u003eOrient Journal of Medicine\u003c/em\u003e 34.3-4 (2022): 84-90.\u003c/li\u003e\n\u003cli\u003eKeykhaei M, Masinaei M, Mohammadi E, et al. A global, regional, and national survey on burden and Quality of Care Index (QCI) of hematologic malignancies; global burden of disease systematic analysis 1990-2017. \u003cem\u003eExp Hematol Oncol\u003c/em\u003e. 2021;10(1):11. Published 2021 Feb 8. doi:10.1186/s40164-021-00198-2.\u003c/li\u003e\n\u003cli\u003eKrok‐Schoen, Jessica L., et al. \u0026quot;Incidence and survival of hematological cancers among adults ages\u0026ge; 75 years.\u0026quot; \u003cem\u003eCancer medicine\u003c/em\u003e 7.7 (2018): 3425-3433.\u003c/li\u003e\n\u003cli\u003eMahdi H, Mula-Hussain L, Ramzi ZS, et al. Cancer Burden Among Arab-World Females in 2020: Working Toward Improving Outcomes. \u003cem\u003eJCO Glob Oncol\u003c/em\u003e. 2022;8:e2100415. doi:10.1200/GO.21.00415.\u003c/li\u003e\n\u003cli\u003eMangone, Lucia, et al. \u0026quot;Incidence, mortality, and survival of hematological malignancies in Northern Italian patients: an update to 2020.\u0026quot;\u003cem\u003e Frontiers in Oncology\u003c/em\u003e 13 (2023): 1182971.\u003c/li\u003e\n\u003cli\u003eMulatie, Zewudu, et al. \u0026quot;Prevalence of hematological malignancies in Africa: A systematic review and meta-analysis.\u0026quot; \u003cem\u003eScientific reports\u003c/em\u003e 15.1 (2025): 9471. \u003c/li\u003e\n\u003cli\u003eNasher Saeed Thabet, Nooman Yousr Abdulhadi, Hady Saleh Abo, halimy Sadam Al. Characteristics Of Hematological Malignancies In South\u0026ndash;West Yemen. Indian Journal Of Applied Research 11 (2021 | No. 2249 - 555X | DOI : 10.36106/ijar\u003c/li\u003e\n\u003cli\u003eOtu, T. I., and U. G. Ejikeme. \u0026quot;The frequency and pattern of haematological malignancies in a Tertiary hospital In Abuja, federal capital territory, north central Nigeria: A sixteen year review.\u0026quot; \u003cem\u003eA sixteen year review\u003c/em\u003e 2021 (2021): 20.\u003cspan dir=\"RTL\"\u003e\u0026rlm; \u003c/span\u003e\u003c/li\u003e\n\u003cli\u003eP\u0026eacute;rez GB, Calaf GM, Villalba MTM, Prieto KS, Burgos FC. Frequency of hematologic malignancies in the population of Arica, Chile. Oncol Lett. 2019 Nov;18(5):5637-5643. doi: 10.3892/ol.2019.10858. Epub 2019 Sep 12. PMID: 31612068; PMCID: PMC6781717.\u003c/li\u003e\n\u003cli\u003eRefeno, Val\u0026eacute;ry, et al. \u0026quot;Epidemiology and clinical aspects of hematological malignancies at the military hospital of Antananarivo.\u0026quot; (2019)\u003c/li\u003e\n\u003cli\u003eSant, Milena, et al. \u0026quot;Incidence of hematologic malignancies in Europe by morphologic subtype: results of the HAEMACARE project.\u0026quot; \u003cem\u003eBlood, The Journal of the American Society of Hematology\u003c/em\u003e 116.19 (2010): 3724-3734.\u003cspan dir=\"RTL\"\u003e\u0026rlm; \u003c/span\u003e\u003c/li\u003e\n\u003cli\u003eSarwar, M. R., et al. \u0026quot;Hematological malignancies pattern among Bangladeshi adults.\u0026quot; \u003cem\u003eJournal of Medical Science and Clinical Research\u003c/em\u003e 5 (2020): 6-9.\u003cspan dir=\"RTL\"\u003e\u0026rlm;\u003c/span\u003e\u003c/li\u003e\n\u003cli\u003eSiegel R, Ma J, Zou Z, Jemal A. Cancer statistics. CA Cancer J Clin. 2014;64(1):9\u0026ndash;29.)\u003c/li\u003e\n\u003cli\u003eTietsche de Moraes Hungria V, Chiattone C, Pavlovsky M, et al. Epidemiology of Hematologic Malignancies in Real-World Settings: Findings From the Hemato-Oncology Latin America Observational Registry Study. \u003cem\u003eJ Glob Oncol\u003c/em\u003e. 2019;5:1-19. doi:10.1200/JGO.19.00025 9.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Table","content":"\u003cp\u003eTable 1. Sociodemographic characteristics distribution of \u0026nbsp;studied patients with haematological malignancies\u003c/p\u003e\n\u003cp\u003e\u003cimg src=\"data:image/png;base64,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\" style=\"width: 667px; height: 754.586px;\" width=\"667\" height=\"754.586\"\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp\u003e* p \u0026lt; 0.05 is considered as significant.\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Haematological malignancies, Non-Hodgkin Lymphoma, Leukemia and Ibb governorate, Yemen","lastPublishedDoi":"10.21203/rs.3.rs-6849395/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6849395/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground:\u003c/strong\u003e Hematologic malignancies (HMs) are a public health problem. The World Health Organization (WHO) reports that the incidence of these tumors will increase by approximately 48% in developing countries by 2030. Yemen is one of the developing countries that suffers from a lack of information about the frequency and patterns of hematologic malignancies.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods:\u003c/strong\u003e A retrospective descriptive study of all cancers detected at Al-Amal Oncology Center in Ibb Governorate, Yemen during the study period from 2008 to 2023. SPSS version 26 and Microsoft Excel version 16 were used for data analysis and graphing, respectively to identify the pattern and distribution of HMs in Ibb Governorate, Yemen.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults: \u003c/strong\u003eOverall, 6,156 cancer cases were detected during period from 2008 to 2023. HMs represented 979 (15.9%) of all collected cases, and their ages between 1 and 108 years with a mean age of 40.5 years. A statistically association was detected between age and HMs. Of these, 549 (56.1%) were males and 430 (43.9%) were females, \u003cem\u003ewith \u003c/em\u003ea\u003cem\u003e \u003c/em\u003eM:F Ratio of 1.2 :1. No statistical significance was detected. Married and illiterate individuals constituted 607 (62%) and 512 (52.3%), respectively. A statistical association was found between marital status and education level and HMs. Non-Hodgkin Lymphoma (NHL) which constituted 448 (46 %) of all the HMs, was the commonest, followed respectively by Leukemia 398 (41%), Hodgkin lymphoma (HL) 110 (11%), other malignancies 23 (2%).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusions:\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study revealed a relatively high prevalence of HMs among diagnosed cancer cases in the study area. It also indicated that the pattern of HMs in the current study appears to be lower than some other studies carried out in different regions of Yemen. NHL is the most common type of HMs, followed by leukemia. Age, marital status, and educational level were strongly associated with HMs.\u003c/p\u003e","manuscriptTitle":"Hematologic malignancies among patients at Al-Amal Oncology Center in Ibb Governorate, Yemen","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-06-11 18:46:58","doi":"10.21203/rs.3.rs-6849395/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"5150df3f-b02b-4a45-880d-d63288a61ef3","owner":[],"postedDate":"June 11th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2025-06-14T06:38:32+00:00","versionOfRecord":[],"versionCreatedAt":"2025-06-11 18:46:58","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-6849395","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6849395","identity":"rs-6849395","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}