The Full-Term Delivery of a Normal Female Infant by a Woman with a Levonorgestrel Intrauterine System in Situ and Identified as Having Uterine Adenomyosis: A Case Report
A woman with adenomyosis delivered a normal female infant with a levonorgestrel intrauterine system in situ following multiple failed IVF cycles, suggesting LNG-IUS may alter the adenomyosis uterine environment.
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This 2017 case report describes a 38-year-old woman with uterine adenomyosis and infertility who underwent two IVF cycles and three frozen embryo transfer (FET) cycles without success, followed by identification of adenomyosis on MRI. After insertion of a levonorgestrel-releasing intrauterine system (Mirena®) during the luteal phase, she became pregnant despite the IUD in situ and had a normally progressing singleton pregnancy culminating in an uncomplicated elective Caesarean delivery at 39 weeks; the IUD was found in the placenta and the postpartum course was uneventful, with a healthy female infant and no observed masculinization or congenital abnormalities. The paper’s main limitation is that it is a single-patient report, with no control group to determine causality or generalizability. This paper is centrally about endometriosis and/or adenomyosis — it focuses specifically on uterine adenomyosis and the delivery of a healthy infant while an LNG-IUS remained in place.
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