Investigating the contribution of the imprinted gene Asb4 to parental care

Investigating the contribution of the imprinted gene Asb4 to parental care | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 4 June 2025 V1 Latest version Share on Investigating the contribution of the imprinted gene Asb4 to parental care Authors : Rachel-Ann Jones 0000-0001-9792-7483 , Mathew Higgs , Rosalind John , and Anthony Isles [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174903147.72588165/v1 227 views 132 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Genomic imprinting is a form of epigenetic regulation that leads to expression from one parental allele only and, in animals, is unique to mammals. Imprinted gene expression is predominant in the brain and their roles in neural processes are becoming more appreciated. Recent analyses have indicated an enrichment of imprinted gene expression in the “parental hub” circuitry. Specifically, imprinted genes were over-represented in the transcriptomic profile of Galanin positive (Gal+) neurons in the medial preoptic area (MPOA) of the hypothalamus. One of those imprinted genes showing enriched expression in Gal+ neurons was the maternally expressed Asb4. Here, we hypothesise that Asb4 has a role in the function of the MPOA and influences parental behaviour. We aim to demonstrate abnormal parental behaviours and activity of MPOA Gal+ neurons in Asb4-brain specific knockout mice. Supplementary Material File (jones_ejnreport_stage1_final.pdf) Download 682.58 KB Information & Authors Information Version history V1 Version 1 04 June 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Authors Affiliations Rachel-Ann Jones 0000-0001-9792-7483 Cardiff University View all articles by this author Mathew Higgs Cardiff University View all articles by this author Rosalind John Cardiff University View all articles by this author Anthony Isles [email protected] Cardiff University View all articles by this author Metrics & Citations Metrics Article Usage 227 views 132 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Rachel-Ann Jones, Mathew Higgs, Rosalind John, et al. Investigating the contribution of the imprinted gene Asb4 to parental care. Authorea . 04 June 2025. DOI: https://doi.org/10.22541/au.174903147.72588165/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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