Validating a questionnaire to identify women in first trimester of pregnancy during preventive chemotherapy interventions against soil-transmitted helminths in North-western Tanzania

Abstract Background Women of reproductive age carry a large burden of disease from soil-transmitted helminths infections. Preventive chemotherapy with anthelminthic is an effective treatment to control soil-transmitted helminths morbidity. However, as a precautionary measure, the treatment of pregnant women is recommended only after the first trimester. This has resulted in many women of reproductive age be denied treatment because of doubt on their pregnancy status. The standard assessments of the pregnancy status (i.e. urine pregnancy rapid test or blood test) are too expensive to be used in mass drug administration campaigns. Thus, use of a simple alternative approach is recommended. The present study was conducted to evaluate the performances of a questionnaire in assessing the pregnancy status of women of reproductive age during preventive chemotherapy interventions. Methodology A questionnaire (20 questions) followed by rapid pregnancy test (RPT) were administered to a group of women of reproductive age in two districts in North-western Tanzania. Results A total of 1,217 women of reproductive age participated in the study. Overall, 10.8% of the women reported to be pregnant at the specific question in the questionnaire. The rapid pregnancy test identified 15.1% (184/1217) of the women to be pregnant. In total, 86.4% (114/1,217) of the women who reported to be pregnant during the interview were confirmed to be pregnant using the RPT. The question on pregnancy demonstrated an overall sensitivity of 62% and specificity 98.3%. Conclusion The questionnaire can be used to identify pregnant women in first trimester during preventive chemotherapy campaigns. The question on last date of start of menstrual period yield the highest sensitivity and appeared to be the key one to be used in combination with other questions. However, validation of these results in other countries with different cultures are needed to fully evaluate performance of this method.