Trajectories of selective serotonin reuptake inhibitor use in pregnancy and neonatal outcomes: a longitudinal register study

Trajectories of selective serotonin reuptake inhibitor use in pregnancy and neonatal outcomes: a longitudinal register study | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL BJOG: An International Journal of Obstetrics and Gynaecology This is a preprint and has not been peer reviewed. Data may be preliminary. 15 January 2025 V1 Latest version Share on Trajectories of selective serotonin reuptake inhibitor use in pregnancy and neonatal outcomes: a longitudinal register study Authors : Guro Pauck Bernhardsen 0000-0003-1622-2911 [email protected] , Maiju Pesonen , Leea Keski-Nisula , Hedvig Nordeng 0000-0001-6361-2918 , and Soili Marianne Lehto Authors Info & Affiliations https://doi.org/10.22541/au.173696407.78909605/v1 305 views 138 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Objective: We examined the possible impact of selective serotonin reuptake inhibitor (SSRI)-trajectories describing the timing of different SSRI dosages on adverse neonatal outcomes. Design: Longitudinal register study Setting: Population based study from Kuopio University Hospital Birth Register. Population or Sample : Altogether 508 mothers who reported using SSRIs in pregnancy, where matched to a five-fold comparison group (n=2540), based on maternal depression, psychiatric diagnoses and age. Methods: We applied unsupervised k-Means longitudinal clustering method to identify four distinct patterns of SSRI use, and propensity score adjusted generalized estimating equations to examine the associations between the exposure groups and the neonatal outcomes, using the unexposed group as reference. Main Outcome Measures: Birth weight, placenta weight, placenta-to-birth-weight ratio (PBWR), umbilical cord length, gestational length, premature birth, low 5-min Apgar score, neonatal intensive care unit (NICU) admission. Results : Compared to the no SSRI group, we found no associations between the use of SSRI up to standard doses and the neonatal outcomes. However, the sustained high dose group (~twice the standard dose) displayed significantly higher mean PBWR (B=1.65, 95% CI=0.83, 2.47). In addition, the odds of low Apgar score for the high dose group were about 3.2-fold (OR=3.2; 95%CI=1.04, 9.79), and the odds of NICU admission 2.6-fold (OR=2.6; 95%CI=1.10,6.03), compared with no SSRI group. Conclusions: Sustained, increasing, or decreasing use of SSRI up to standard doses were not associated with adverse neonatal outcomes. However, caution is advised as sustained higher doses may be linked to reduced placental efficacy and higher risk of adverse neonatal health. Supplementary Material File (bernhardsen_ssri_bjog.docx) Download 43.85 KB File (table 1.docx) Download 24.18 KB File (table 2.docx) Download 16.89 KB Information & Authors Information Version history V1 Version 1 15 January 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Collection BJOG: An International Journal of Obstetrics and Gynaecology Keywords epidemiology epidemiology: paediatric paediatrics: neonatal psychiatry Authors Affiliations Guro Pauck Bernhardsen 0000-0003-1622-2911 [email protected] Akershus Universitetssykehus HF View all articles by this author Maiju Pesonen Oslo universitetssykehus View all articles by this author Leea Keski-Nisula University of Eastern Finland View all articles by this author Hedvig Nordeng 0000-0001-6361-2918 Universitetet i Oslo Det matematisk-naturvitenskapelige fakultet View all articles by this author Soili Marianne Lehto Akershus Universitetssykehus HF View all articles by this author Metrics & Citations Metrics Article Usage 305 views 138 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Guro Pauck Bernhardsen, Maiju Pesonen, Leea Keski-Nisula, et al. Trajectories of selective serotonin reuptake inhibitor use in pregnancy and neonatal outcomes: a longitudinal register study. 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