Assessment of the inflammatory factor as well as invasion and apoptosis gene expression in endometriosis model rats after mifepristone intervention

Objective: To study the effect of mifepristone intervention on the inflammatory factor as well \nas invasion and apoptosis gene expression in endometriosis lesions of endometriosis model \nrats. Method: SD female rats were selected as experimental animals, divided into model group \n(EMs group) and mifepristone group (RU486 group) and made into endometriosis models, then \nthe EMs group received saline intervention and RU486 group received 2.6 mg/kg/d RU486 \nintervention. 4 weeks after intervention, endometriosis lesions were anatomized to determine \nthe expression of inflammatory factors (COX-2, PGE2, TNF-α, IL-1β and IL-6), invasion \ngenes (OPN, MMP2, MMP9, uPA and S100A6) as well as apoptosis genes (Bcl-2, Livin, \nSmac and PTEN). Results: COX-2, PGE2, TNF-α, IL-1β, IL-6, OPN, MMP2, MMP9, uPA, \nS100A6, Bcl-2 and Livin protein expression in endometriosis lesions of Ru486 group were \nsignificantly lower than those of EMs group while Smac and PTEN protein expression were \nhigher than those of EMs group. Conclusion: Mifepristone for endometriosis model rats can \ninhibit the expression of inflammatory factors, invasion genes and anti-apoptosis genes, and \nincrease the expression of pro-apoptosis genes.