Influence of Chinese National Centralized Drug Procurement on the price of policy-related drugs: an interrupted time series analysis

Influence of Chinese National Centralized Drug Procurement on the price of policy-related drugs: an interrupted time series analysis | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Influence of Chinese National Centralized Drug Procurement on the price of policy-related drugs: an interrupted time series analysis Ni Wang, Ying Yang, Luxinyi Xu, Zongfu Mao, Dan Cui This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-403627/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 10 You are reading this latest preprint version Abstract Background: The Chinese government implemented the first round of National Centralized Drug Procurement (NCDP) pilot (so-called "4+7" policy) in mainland China in 2019. Under cross-price elasticity theory, the price behavior of pharmaceutical enterprises for policy-related drugs might change. This study aims to examine the impact of "4+7" policy on the price of policy-related drugs. Methods: This study used drug purchasing order data from the Centralized Drug Procurement Survey in Shenzhen 2019, covering 24 months from January 2018 to December 2019. Eighty-two drugs (by generic name) were selected as study samples, including "4+7" policy-related drugs (consisted of winning and non-winning products) and alternative drugs. Single-group Interruption Time Series (ITS) analysis was adopted to examine the change of Drug Price Index (DPI) for policy-related drugs. Results: The ITS analysis showed that the DPI of winning (-0.183 per month, p<0.0001) and non-winning (-0.034 per month, p=0.046) products significantly decreased after the implementation of "4+7" policy. No significant difference was found for the immediate change of DPI for alternative drugs (p=0.537), while a significant decrease in change trend was detected in the post-"4+7" policy period (-0.003 per month, p=0.014). The DPI of the overall policy-related drugs significantly decreased (-0.261 per month, p<0.0001) after "4+7" policy. Conclusions: These findings indicate that the price behavior of pharmaceutical enterprises changed under NCDP policy, while the price linkage effect is still limited. It is necessary to further expand the scope of centralized purchased drugs and strengthen the monitoring of related drugs regarding price change and consumption structure. Health Economics & Outcomes Research Health Policy National Centralized Drug Procurement "4+7" policy drug price interrupted time series volume-based procurement. Figures Figure 1 Figure 2 Figure 3 Introduction Worldwide, many countries are facing the challenge of ever-increasing pharmaceutical expenditures [1, 2], and the global pharmaceutical market reached $955 billion in 2019 [3]. In China, the total health expenditure increased from 145.4 billion yuan in 2008 to 5799.8 billion yuan in 2018, with an average compound annual growth rate of 13.4% [4]. In 2018, the total pharmaceutical expenditure was 1914.89 billion yuan in China, accounting for 32.39% of the total health expenditure [5], which was much higher than the average level of 17% in the Organization for Economic Co-operation and Development (OECD) countries [6]. It is common practice worldwide that lowering drug prices and reducing drug expenditures by volume-based drug procurement [7, 8]. Since 2000, the Chinese government has carried out drug centralized procurement, and gradually formed the centralized procurement model at the provincial level [9, 10]. In January 2019, the General Office of the State Council of the People’s Republic of China implemented the National Centralized Drug Procurement (NCDP) policy [11]. In the first round of the NCDP pilot, four municipalities and seven sub-provincial cities in mainland China were selected as pilot cities, thus, the first round of NCDP pilot is also known as “4+7” policy. Under NCDP policy, original branded drugs and generic drugs that passed the consistency evaluation of quality and efficacy were involved to conduct volume-based procurement, leading to a decline in drug prices by “group purchase” [12]. In the “4+7” policy, 25 drugs were centralized purchased (CP) with an average price decline of 52% [13]. According to the cross-price elasticity theory, in a group of drugs with substitution relationship, the percentage change in quantity demanded for one product in response to a percentage change in price of another product [14, 15]. Under the NCDP policy, the price behavior of pharmaceutical enterprises related to CP drugs would inevitably change. Previous studies reported the change of policy-related drugs after the implementation of “4+7” policy. Wang et al.’s [16] study in Shanghai found that the average daily cost of branded and generic cardiovascular drugs fell by 66.45% and 24.24% after the implementation of “4+7” policy. Chen et al. [17] reported that the price of winning products, non-winning products and basic alternative drugs decreased in Shenzhen. Yang et al. [18] indicated that the price of non-winning antipsychotic drugs decreased by more than 10% as the results of “4+7” policy, while the price of non-winning drugs in the same varieties dropped by less than 5%. However, Ye et al. [19] reported opposite results that the defined daily dose cost (DDDc) of non-winning products and alternative drugs increased by 17.43% and 7.68%, respectively. In summary, previous findings regarding the impact of NCDP policy on drug prices have been controversial. In the present study, we took the "4+7" policy as an example, using Drug Price Index (DPI) and single-group Interruption Time Series (ITS) to examine the impact of the NCDP policy on the change of policy-related drug prices in Shenzhen. Methods Data Sources This study used data from the Centralized Drug Procurement Survey in Shenzhen 2019 (CDPS-SZ 2019) [17]. In China, the CDPS-SZ 2019 was organized and conducted by the Global Health Institute of Wuhan University between December 2019 and January 2020. The survey aimed to evaluate the effect of drug-related policies in Shenzhen, China, and collected monthly drug purchase order data between 2018 and 2019. In the CDPS-SZ 2019 database, each purchase order record included purchase date, generic name, dosage form, specification, pharmaceutical manufacturer, price per unit, purchase volume, purchase expenditures, etc. A general database containing 963,127 monthly aggregated purchase order records was established, involving 1079 drug varieties (by generic name), 346 medical institutions, 857 pharmaceutical manufacturers. The total purchase expenditures reached RMB 20.87 billion. The purpose of this study is to examine the impact of NCDP policy on prices of policy-related drugs. Thus, we included samples with the following criteria: (a) the medication covered by “4+7” CP and their alternative drugs (Table A1). The CP drugs were sorted into winning and non-winning products based on the bidding results of "4+7" policy; (b) the time period between January 2018 and December 2019; and (c) the medical institutions purchasing drugs were from Shenzhen, China. Finally, 47,163 purchase order records of 82 drug varieties (by generic name) were included in the analysis. Figure 1 presents the flow chart of sample screening. Outcome Variables Drug Price Index was used as outcome variable in this study, which is a common indicator reflecting the trend of drug price change over different periods [20, 21]. This study applied three commonly used DPI: Laspeyres Price Index ( L P ), Paasche Price Index ( P P ), and Fisher Price Index ( F P ). L P is calculated as the ratio of price in reporting period and the price in baseline period, weighted by the quantity in baseline period. This method assumes that the consumption structure of drugs remains unchanged in different periods, and is applicable to reflect the pure price change of drugs. L P is calculated as follows: P P is calculated as the ratio of price in reporting period and the price in base-period, weighted by the quantity in reporting period. The index reflects the increase or decrease in drug costs due to the price change when the quantity and consumption structure has changed. P P is calculated as follows: F P is calculated as the geometric mean of L P and P P , which was weighted by the quantity in both baseline period and reporting period. Thus, F P can equalize and average the biases of L P and P P . Theoretical researches showed that F P is an optimal form of price index, and is called “the ideal index” [22]. F P is calculated as follows: In the above formula (1)-(3), P means the price, P 0 and P 1 refer to price per Defined Daily Doses (DDDs) of each product in baseline- and reporting period. Q means purchasing quantity, Q 0 and Q 1 refer to DDDs of each product in baseline- and reporting period. DDDs is the ratio of the quantity of drug utilization and Defined Daily Dose (DDD) [23]. If the drug price index > 1, it indicates the increase of drug price in the reporting period when compared with the base-period; If the drug price index =1, it means that drug prices remain unchanged over the two periods; If the drug price index < 1, it means that drug prices in the reporting period decrease compared with the base period. In this study, January to June 2018 was assigned as the baseline period, and July 2018 to December 2019 was assigned as the reporting periods to calculate drug price indexes of each month (18 months). Statistical Analysis Descriptive statistics were used. We first described the change of DPI of included drugs before (July 2018 to February 2019) and after (March to December 2019) the implementation of "4+7" policy. Interrupted time-series analysis was applied to assess the change of Fisher Price Index after the implementation of "4+7" policy. ITS is a commonly used approach for evaluating changes in longitudinal series following a quasi-experimental intervention occurring at a fixed point in time. The interrupted time series was constructed with DPI data in Shenzhen from July 2018 to December 2019. The time unit was set to 1 month and the intervention time point was set to March 2019, making 18 time points available for analysis, including 8 points as pre-"4+7" policy period and 10 points as post-"4+7" policy period. To estimate the effect of the intervention on the outcome variables, the following segmented linear regression model was developed [24-26]: Where, Y t is the independent outcome variable (i.e. Fisher Price Index) in month t . time is a continuous variable indicating time in months at time t from the start of the observation period. intervention is an indicator for time t in the pre-"4+7" policy period (intervention = 0) and post-"4+7" policy period (intervention = 1). time after intervention is a continuous variable indicating months in the post-"4+7" policy period (time in the pre-"4+7" policy period is coded 0). In this model, β 0 estimates the baseline level of the independent variable at the beginning of the observation period. β 1 estimates the linear trend during the pre-intervention period. β 2 estimates the level change in the outcome variable immediately following the intervention. β 3 estimates the trend change in the outcome variable in the post-intervention period compared with the pre-intervention period. ε t is an estimate of the random error at time t . Durbin-Watson test was performed to test the presence of first-order auto-correlation (a value around 2 indicates no sign of auto-correlation). If autocorrelation is detected, the Prais-Winsten method was applied to estimate the regression. Stata version 16.0 was used to perform the ITS analysis. A p -value <0.05 was considered statistically significant. Results Descriptive analysis Descriptive analysis was conducted to compare the change of L P , P P , and F P in the pre- and post-"4+7" policy periods. Table 1 lists the results of winning and non-winning products. After the implementation of "4+7" policy, the L P , P P , and F P of winning products decreased by 53.42%, 54.82%, and 79.02%, respectively. The F P of winning products declined from 0.44 ( SD = 0.08) in pre-"4+7" policy period to 0.09 ( SD = 0.01) in post-"4+7" policy period. The L P , P P , and F P of non-winning products decreased by 2.32%, 9.91%, and 11.96%, respectively. The F P of non-winning products declined from 0.49 ( SD = 0.01) in pre-"4+7" policy period to 0.43 ( SD = 0.03) in post-"4+7" policy period. Table 2 summarizes the results of CP drugs and alternative drugs. After the implementation of "4+7" policy, the L P , P P , and F P of CP drugs decreased by 58.95%, 60.68%, and 83.38%, respectively. The F P of CP drugs dropped from 0.48 ( SD = 0.02) in pre-"4+7" policy period to 0.08 ( SD = 0.03) in post-"4+7" policy period. The L P , P P , and F P of alternative drugs decreased by 2.30%, 2.11%, and 4.34%, respectively. The F P of alternative drugs dropped from 0.49 ( SD = 0.01) in pre-"4+7" policy period to 0.47 ( SD =0.02) in post-"4+7" policy period. For the overall of CP drugs and alternative drugs, the L P , P P , and F P decreased by 35.83%, 41.49%, and 62.21%, respectively. The F P of the overall drugs dropped from 0.48 ( SD = 0.01) in pre-"4+7" policy period to 0.18 ( SD = 0.03) in post-"4+7" policy period. ITS analysis Winning and non-winning products The ITS results of winning and non-winning products are presented in Table 3. The F P of winning products significantly declined (-0.183 per month, 95% CI = -0.248 to -0.118, p -value < 0.001) in the start of the "4+7" policy implementation, while significant increment (0.024 per month, 95% CI = 0.008 to 0.041, p -value = 0.007) in F P of winning products was found between the pre- and post-"4+7" policy slopes. In the start of the "4+7" policy implementation, significant decrease (-0.034 per month, 95% CI = -0.067 to -0.001, p -value = 0.046) was found in F P of non-winning products. However, the change in the pre- and post-"4+7" policy slopes had no significant difference ( p -value = 0.262) ( Figure 2 ). CP and alternative drugs The ITS results of CP drugs and alternative drugs are presented in Table 4. The F P of CP drugs significantly declined (-0.347 per month, 95% CI = -0.395 to -0.299, p -value < 0.001) in the start of the "4+7" policy implementation. However, no statistically significant difference was found in the trend change between the pre- and post-"4+7" policy periods ( p -value = 0.761). Significant decline (-0.003 per month, 95% CI = -0.006 to -0.001, p -value = 0.014) in F P of alternative drugs was found between the pre- and post-"4+7" policy slopes. For the overall of CP drugs and alternative drugs, the F P significantly decreased (-0.261 per month, 95% CI = -0.298 to -0.223, p -value < 0.001) at the start of the "4+7" policy implementation, while the change in the pre- and post-"4+7" policy slopes had no significant difference ( p -value = 0.268) ( Figure 3 ). Discussion This study aims to analyze the impact of NCDP on the prices of policy-related drugs. Overall, we found that the price of winning products decreased markedly and the prices of non-winning products dropped slightly after the implementation of "4+7" policy, while the price change of alternative products had no statistical difference. For the overall drugs of CP and alternative, the comprehensive effect of “4+7” policy on price reduction was significant, but the long-term effect of the policy was not obvious. In the NCDP policy, 60%-70% of the market in pilot cities was assigned to conduct volume-based procurement, so as to relieve the artificially high drug prices by “group purchase” [27]. In this study, a notably direct effect of price reduction for winning products was observed, the F P decreased by 79.02% and showed significant difference between the pre- and post-”4+7” policy periods. Tan et al. [28] reported similar results that 25 winning drugs dropped by 51.88% in Guangzhou when compared with the pre-intervention period, among which the price of atorvaststin (10mg*7 tablets) dropped by 85.7%. “4+7” winning products covered original branded drugs and generic drugs that had passed consistency evaluation of quality and efficacy, which had large clinical demand and quality assurance. Thus, the decline in drug prices might effectively alleviate the medication burden of patients. According to the cross-price elasticity theory, in a group of drugs with substitution relationship, the percentage change in quantity demanded for one product in response to a percentage change in price of another product [14, 15]. With the announcement of "4+7" bid winning results, pharmaceutical enterprises related to winning products made adjustments in pricing strategy and sales model [29]. It is reported that enterprises of non-winning products lowered the prices consciously to save the market [30]. In the present study, we found that the F P of non-winning products dropped by 11.96% after "4+7" policy in Shenzhen and showed statistically significant. Previous studies reported similar findings [18, 31]. Zhang & Wang [31] found that the price of non-winning antihypertensive drugs showed a gradient decline, with the fall ranging from 1% to 52%. Yang et al. [18] reported that the prices of three non-winning antidepressant drugs dropped by 12.67% on average. These findings indicated that the implementation of NCDP policy was conducive to improve market competitiveness and reshaping the competitive pattern of the pharmaceutical industry. However, ITS results of this study showed that there was no statistical difference in the changes of DPI slope of non-winning products between the pre- and post-”4+7” policy periods, indicating that the price reduction of non-winning products might just be a temporary response of pharmaceutical enterprises during the implementation of policy. In this study, the F P of alternative products fell slightly by 4.34% in Shenzhen, while ITS analysis showed no statistical difference. Chen et al. [17] and Yang et al. [18] reported consistent results as this study. On the one hand, the price of alternative drugs did not change significantly (such as price increase) during the implementation of “4+7” policy, indicating that the national monitoring did play an important role [32]. On the other hand, this study indicated that the effect of price reduction triggered by 25 CP drugs was limited, and could not make a further impact on the market pattern. Furthermore, this study also found that the DPI slope of alternative products dropped markedly after the implementation of “4+7” policy, indicating that the policy might help slow the growth of alternative drug prices and reduce the burden of patients. Several potential limitations should be mentioned regarding the present study. Firstly, this study designed a single-group ITS by using the drug purchasing data in Shenzhen, and potential confounding factors other than NCDP might not be controlled, so there may be some bias in the results. Secondly, only one of the 11 pilot cities was included in the study (i.e. Shenzhen City), the results of this study may not fully represent the overall implementation effect of NCDP policy in China, caution should be exercised in generalizing the findings. Conclusion This study analyzed the impact of NCDP on the price of policy-related drugs in Shenzhen. The F P of 25 winning products notably decreased by 79.02%. Under the NCDP policy, the market behavior of pharmaceutical enterprises of policy-related drugs changed. The F P of non-winning products dropped by 11.96% after the implementation of the policy, while the long-term trend of price reduction was not observed. In terms of alternative drugs, the price reduction at the start of the implementation of “4+7” policy had no statistical difference. However, a trend of price growth slowing down for alternative drugs was observed in the post-”4+7” policy period. In the future, on the one hand, it is necessary to expand the scope of CP drugs, so as to trigger the linkage effect of price reduction in a larger scope and to a greater extent. On the other hand, it is essential to strengthen the continuous monitoring of changes in the price and consumption structure of policy-related drugs, ensuring the accessibility and rationality of medications for patients. Abbreviations CDPS-SZ 2019: Centralized Drug Procurement Survey in Shenzhen 2019;CP: Centralized purchased; DDD: Defined Daily Dose; DDDc: Defined daily dose cost; DPI: Drug price index; ITS : Interruption Time Series; L P : Laspeyres Price Index; P P : Paasche Price Index; F P : Fisher Price Index; NCDP: National Centralized Drug Procurement; OECD: Organization for Economic Co-operation and Development. Declarations Author Contributions Conceptualization, Y.Y. and D.C.; methodology, N.W. and Y.Y.; software, Y.Y.; formal analysis, N.W. and Y.Y.; investigation, N.W., Y.Y., L.X. and Z.M.; resources, Z.M. and D.C.; data curation, Y.Y. and Z.M.; writing—original draft preparation, N.W., Y.Y. and L.X.; writing—review and editing, N.W., Y.Y., L.X., Z.M. and D.C.; supervision, Z.M. and D.C.; project administration, D.C.; funding acquisition, Z.M. and D.C. All authors have read and agreed to the published version of the manuscript. Funding This work was supported by the Global Health Institute, Wuhan University, China. The role of the funding body included designing the study, the analysis and interpretation of data, and writing the manuscript. Availability of data and materials The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request. Acknowledgements Not applicable. Ethics approval and consent to participate Not applicable. 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L P P P F P Pre- Post- GR (%) Pre- Post- GR (%) Pre- Post- GR (%) Winning products Mean 0.93 0.44 -53.42 0.94 0.42 -54.82 0.44 0.09 -79.02 SD 0.09 0.03 - 0.08 0.03 - 0.08 0.01 - Min 0.80 0.42 - 0.81 0.41 - 0.32 0.09 - Max 1.00 0.53 - 1.00 0.51 - 0.50 0.13 - Non-winning products Mean 0.99 0.96 -2.32 0.99 0.89 -9.91 0.49 0.43 -11.96 SD 0.01 0.02 - 0.01 0.04 - 0.01 0.03 - Min 0.97 0.94 - 0.97 0.85 - 0.47 0.41 - Max 1.00 1.00 - 1.00 1.00 - 0.50 0.50 - L P : Laspeyres Price Index; P P : Paasche Price Index; F P : Fisher Price Index; Pre-: pre-"4+7" policy, i.e. July 2018 to February 2019; Post-: post-"4+7" policy, i.e. March 2019 to December 2019; GR: growth rate; SD: standard deviation. Table 2. The change of drug price index for centralized purchased drugs and alternative drugs pre- and post-"4+7" policy. L P P P F P Pre- Post- GR (%) Pre- Post- GR (%) Pre- Post- GR (%) CP drugs Mean 0.98 0.40 -58.95 0.98 0.39 -60.68 0.48 0.08 -83.38 SD 0.02 0.07 - 0.01 0.07 - 0.02 0.03 - Min 0.95 0.35 - 0.96 0.34 - 0.46 0.06 - Max 1.00 0.60 - 0.99 0.59 - 0.50 0.18 - Alternatives Mean 0.99 0.97 -2.30 0.99 0.97 -2.11 0.49 0.47 -4.34 SD 0.01 0.02 - 0.01 0.02 - 0.01 0.02 - Min 0.98 0.95 - 0.97 0.95 - 0.48 0.45 - Max 1.02 1.00 - 1.00 1.00 - 0.51 0.50 - Overall Mean 0.98 0.63 -35.83 0.98 0.58 -41.49 0.48 0.18 -62.21 SD 0.01 0.05 - 0.01 0.06 - 0.01 0.03 - Min 0.97 0.60 - 0.97 0.52 - 0.47 0.16 - Max 1.00 0.77 - 1.00 0.72 - 0.50 0.28 - Note: L P , Laspeyres Price Index; P P , Paasche Price Index; F P , Fisher Price Index; Pre-, pre-"4+7" policy, i.e. July 2018 to February 2019; Post-, post-"4+7" policy, i.e. March 2019 to December 2019; GR, growth rate; CP, centralized purchased; SD, standard deviation. Table 3. ITS results of Fisher Price Index for winning and non-winning products. Item Coef. S.E t p -value 95% CI Lower Upper Winning products Baseline level, β 0 0.535 0.025 21.180 0.000 0.481 0.589 Baseline trend, β 1 -0.029 0.006 -5.240 0.000 -0.041 -0.017 Level change, β 2 -0.183 0.030 -6.050 0.000 -0.248 -0.118 Trend change, β 3 0.024 0.008 3.190 0.007 0.008 0.041 Non-winning products Baseline level, β 0 0.491 0.010 49.150 0.000 0.470 0.513 Baseline trend, β 1 -0.001 0.002 -0.500 0.628 -0.006 0.004 Level change, β 2 -0.034 0.015 -2.190 0.046 -0.067 -0.001 Trend change, β 3 -0.003 0.003 -1.170 0.262 -0.010 0.003 Table 4. ITS results of Fisher Price Index for centralized purchased drugs and alternative drugs. Item Coef. S.E t p -value 95% CI Lower Lower CP drugs Baseline level, β 0 0.498 0.015 33.670 0.000 0.466 0.530 Baseline trend, β 1 -0.005 0.004 -1.470 0.164 -0.013 0.002 Level change, β 2 -0.347 0.022 -15.480 0.000 -0.395 -0.299 Trend change, β 3 -0.001 0.004 -0.310 0.761 -0.011 0.008 Alternatives Baseline level, β 0 0.494 0.004 115.580 0.000 0.485 0.503 Baseline trend, β 1 -0.001 0.001 -1.270 0.225 -0.004 0.001 Level change, β 2 0.004 0.007 0.630 0.537 -0.010 0.018 Trend change, β 3 -0.003 0.001 -2.790 0.014 -0.006 -0.001 Overall Baseline level, β 0 0.495 0.011 44.240 0.000 0.471 0.519 Baseline trend, β 1 -0.003 0.003 -1.070 0.303 -0.009 0.003 Level change, β 2 -0.261 0.017 -15.020 0.000 -0.298 -0.223 Trend change, β 3 -0.004 0.003 -1.150 0.268 -0.011 0.003 Note: CP, centralized purchased. Supplementary Table Table A1. List of included drugs in this stuwdy. Drug Group Varieties CP drugs irbesartan and hydrochlorothiazide, irbesartan, losartan, montmorillonite, entecavir, cefuroxime, pemetrexed, atorvastatin, imatinib, olanzapine, escitalopram, fosinopril, enalapril, montelukast, rosuvastatin, lisinopril, risperidone, paroxetine, gefitinib, levetiracetam, clopidogrel, dexmedetomidine, tenofovir, amlodipine, flurbiprofen Alternative drugs adefovir, aspirin, oxcarbazepine, valproate, quetiapine, carbamazepine, captopril, lamivudine, risperidone, nilotinib, nitrendipine, cefprozil, cefaclor, cefixime, nifedipine, simvastatin, xuezhikang, icotinib, cefuroxime, chlorpromazine, haloperidol, fluoxetine, penfluridol, indomethacin, venlafaxine, perphenazine, sulpiride, cefalexin, cefdinir, afatinib, telmisartan, fluvastatin, candesartan, perindopril, sertraline, tiapride, lamotrigine, felodipine, aripiprazole, amlodipine and atorvastatin, valsartan, ticagrelor, losartan potassium and hydrochlorothiazide, valsartan and amlodipine, perindopril and indapamide Note. CP, centralized purchased. Additional Declarations No competing interests reported. Cite Share Download PDF Status: Under Review Version 1 posted Editorial decision: Major revision 08 Sep, 2021 Reviews received at journal 12 Jul, 2021 Reviewers agreed at journal 19 Jun, 2021 Reviews received at journal 25 May, 2021 Reviewers agreed at journal 30 Apr, 2021 Reviewers invited by journal 27 Apr, 2021 Editor assigned by journal 27 Apr, 2021 Editor invited by journal 19 Apr, 2021 Submission checks completed at journal 19 Apr, 2021 First submitted to journal 08 Apr, 2021 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-403627","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":20590992,"identity":"742bd756-4f40-4eac-9dad-c95ac9988128","order_by":0,"name":"Ni Wang","email":"","orcid":"","institution":"Wuhan University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Ni","middleName":"","lastName":"Wang","suffix":""},{"id":20590993,"identity":"c620a19c-565d-42a1-84b8-8a42aa14045d","order_by":1,"name":"Ying Yang","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA3klEQVRIiWNgGAWjYNACAwYGfgYeEIuZBC2SDaRpAek6QKwWg+NnD7/mKbhjt/lG7jEJhgrrxAb2swfwazmTl2bNY/AseduNvDQJhjPpiQ08eQkE3JNjZsxjcDjZ7HaOmQRj2+HEBgkeA/xazr+BaDGeDdLyjxgtN3KMHwO12BlIg7Q0EKFF8sYbM8Y5BocTJO6/MbZIOJZu3MaTg18L3/kc4w9v/hy25+85Y3jjQ421bD/7GfxaFA4wsEkBYySxAcRLAGI2vOqBQL6BgfnjDwYGe0IKR8EoGAWjYAQDAMWiRodAn2VmAAAAAElFTkSuQmCC","orcid":"","institution":"Wuhan University","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Ying","middleName":"","lastName":"Yang","suffix":""},{"id":20590994,"identity":"31393619-15d7-4cbc-9051-0368886dea29","order_by":2,"name":"Luxinyi Xu","email":"","orcid":"","institution":"Wuhan University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Luxinyi","middleName":"","lastName":"Xu","suffix":""},{"id":20590995,"identity":"bf9cf11d-78ac-41da-97c1-ea299132a2bd","order_by":3,"name":"Zongfu Mao","email":"","orcid":"","institution":"Wuhan University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Zongfu","middleName":"","lastName":"Mao","suffix":""},{"id":20590996,"identity":"3e92bb18-5bec-402d-a547-61bab22fcd81","order_by":4,"name":"Dan Cui","email":"","orcid":"","institution":"Wuhan University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Dan","middleName":"","lastName":"Cui","suffix":""}],"badges":[],"createdAt":"2021-04-09 03:44:06","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-403627/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-403627/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":7854334,"identity":"0452ca83-0149-42cf-b6f5-1c5157bf9dce","added_by":"auto","created_at":"2021-04-09 22:26:55","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":65880,"visible":true,"origin":"","legend":"Flow chart of sample screening. \nNote: CP, centralized purchased.","description":"","filename":"1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-403627/v1/4369d3a0b0f62e5357b2906c.jpg"},{"id":7854270,"identity":"cdce4c62-13c2-4387-af6b-aa84ed5b4380","added_by":"auto","created_at":"2021-04-09 22:23:55","extension":"jpg","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":35825,"visible":true,"origin":"","legend":"The Fisher Price Index of winning and non-winning products in the pre- and post-\"4+7\" policy periods. (a) winning products, (b) non-winning products. ","description":"","filename":"2.jpg","url":"https://assets-eu.researchsquare.com/files/rs-403627/v1/44c1ae837f5ea63d7f260f60.jpg"},{"id":7854272,"identity":"b1331666-5704-4808-8691-3b06242c0002","added_by":"auto","created_at":"2021-04-09 22:23:55","extension":"jpg","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":53112,"visible":true,"origin":"","legend":"The Fisher Price Index of CP drugs and alternative drugs in the pre- and post-\"4+7\" policy periods. (a) CP drugs, (b) alternative drugs, (c) overall.\nNote: CP, centralized purchased.\n","description":"","filename":"3.jpg","url":"https://assets-eu.researchsquare.com/files/rs-403627/v1/61f19ec8d53aba5ba05a1fc6.jpg"},{"id":13685189,"identity":"4f226511-28bc-4c29-a23f-cfbc8f3e25da","added_by":"auto","created_at":"2021-09-17 12:11:12","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":410332,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-403627/v1/047ef358-c8d4-4329-825e-a6c5e953590f.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Influence of Chinese National Centralized Drug Procurement on the price of policy-related drugs: an interrupted time series analysis","fulltext":[{"header":"Introduction","content":"\u003cp\u003eWorldwide, many countries are facing the challenge of ever-increasing pharmaceutical expenditures [1, 2], and the global pharmaceutical market reached $955 billion in 2019 [3]. In China, the total health expenditure increased from 145.4 billion yuan in 2008 to 5799.8 billion yuan in 2018, with an average compound annual growth rate of 13.4% [4]. In 2018, the total pharmaceutical expenditure was 1914.89 billion yuan in China, accounting for 32.39% of the total health expenditure [5], which was much higher than the average level of 17% in the Organization for Economic Co-operation and Development (OECD) countries [6].\u003c/p\u003e\n\u003cp\u003eIt is common practice worldwide that lowering drug prices and reducing drug expenditures by volume-based drug procurement [7, 8]. Since 2000, the Chinese government has carried out drug centralized procurement, and gradually formed the centralized procurement model at the provincial level [9, 10]. In January 2019, the General Office of the State Council of the People\u0026rsquo;s Republic of China implemented the National Centralized Drug Procurement (NCDP) policy [11]. In the first round of the NCDP pilot, four municipalities and seven sub-provincial cities in mainland China were selected as pilot cities, thus, the first round of NCDP pilot is also known as \u0026ldquo;4+7\u0026rdquo; policy. Under NCDP policy, original branded drugs and generic drugs that passed the consistency evaluation of quality and efficacy were involved to conduct volume-based procurement, leading to a decline in drug prices by \u0026ldquo;group purchase\u0026rdquo; [12]. In the \u0026ldquo;4+7\u0026rdquo; policy, 25 drugs were centralized purchased (CP) with an average price decline of 52% [13].\u003c/p\u003e\n\u003cp\u003eAccording to the cross-price elasticity theory, in a group of drugs with substitution relationship, the percentage change in quantity demanded for one product in response to a percentage change in price of another product [14, 15]. Under the NCDP policy, the price behavior of pharmaceutical enterprises related to CP drugs would inevitably change. Previous studies reported the change of policy-related drugs after the implementation of \u0026ldquo;4+7\u0026rdquo; policy. Wang et al.\u0026rsquo;s [16] study in Shanghai found that the average daily cost of branded and generic cardiovascular drugs fell by 66.45% and 24.24% after the implementation of \u0026ldquo;4+7\u0026rdquo; policy. Chen et al. [17] reported that the price of winning products, non-winning products and basic alternative drugs decreased in Shenzhen. Yang et al. [18] indicated that the price of non-winning antipsychotic drugs decreased by more than 10% as the results of \u0026ldquo;4+7\u0026rdquo; policy, while the price of non-winning drugs in the same varieties dropped by less than 5%. However, Ye et al. [19] reported opposite results that the defined daily dose cost (DDDc) of non-winning products and alternative drugs increased by 17.43% and 7.68%, respectively.\u003c/p\u003e\n\u003cp\u003eIn summary, previous findings regarding the impact of NCDP policy on drug prices have been controversial. In the present study, we took the \"4+7\" policy as an example, using Drug Price Index (DPI) and single-group Interruption Time Series (ITS) to examine the impact of the NCDP policy on the change of policy-related drug prices in Shenzhen.\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003e\u003cstrong\u003eData Sources\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study used data from the Centralized Drug Procurement Survey in Shenzhen 2019 (CDPS-SZ 2019) [17]. In China, the CDPS-SZ 2019 was organized and conducted by the Global Health Institute of Wuhan University between December 2019 and January 2020. The survey aimed to evaluate the effect of drug-related policies in Shenzhen, China, and collected monthly drug purchase order data between 2018 and 2019. In the CDPS-SZ 2019 database, each purchase order record included purchase date, generic name, dosage form, specification, pharmaceutical manufacturer, price per unit, purchase volume, purchase expenditures, etc. A general database containing 963,127 monthly aggregated purchase order records was established, involving 1079 drug varieties (by generic name), 346 medical institutions, 857 pharmaceutical manufacturers. The total purchase expenditures reached RMB 20.87 billion.\u003c/p\u003e\n\u003cp\u003eThe purpose of this study is to examine the impact of NCDP policy on prices of policy-related drugs. Thus, we included samples with the following criteria: (a) the medication covered by \u0026ldquo;4+7\u0026rdquo; CP and their alternative drugs (Table A1). The CP drugs were sorted into winning and non-winning products based on the bidding results of \"4+7\" policy; (b) the time period between January 2018 and December 2019; and (c) the medical institutions purchasing drugs were from Shenzhen, China. Finally, 47,163 purchase order records of 82 drug varieties (by generic name) were included in the analysis. \u003cstrong\u003eFigure 1\u003c/strong\u003e presents the flow chart of sample screening.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eOutcome Variables\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eDrug Price Index was used as outcome variable in this study, which is a common indicator reflecting the trend of drug price change over different periods [20, 21]. This study applied three commonly used DPI: Laspeyres Price Index (\u003cem\u003eL\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e), Paasche Price Index (\u003cem\u003eP\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e), and Fisher Price Index (\u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e).\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eL\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e is calculated as the ratio of price in reporting period and the price in baseline period, weighted by the quantity in baseline period. This method assumes that the consumption structure of drugs remains unchanged in different periods, and is applicable to reflect the pure price change of drugs. \u003cem\u003eL\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e is calculated as follows:\u003c/p\u003e\u003cp\u003e\u003cimg src=\"data:image/jpeg;base64,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\"\u003e\u003c/p\u003e\u003cp\u003e\u003cem\u003eP\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e is calculated as the ratio of price in reporting period and the price in base-period, weighted by the quantity in reporting period. The index reflects the increase or decrease in drug costs due to the price change when the quantity and consumption structure has changed. \u003cem\u003eP\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e is calculated as follows:\u003c/p\u003e\u003cp\u003e\u003cimg src=\"data:image/jpeg;base64,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\"\u003e\u003c/p\u003e\u003cp\u003e\u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e is calculated as the geometric mean of \u003cem\u003eL\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e and \u003cem\u003eP\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e, which was weighted by the quantity in both baseline period and reporting period. Thus, \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e can equalize and average the biases of \u003cem\u003eL\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e and \u003cem\u003eP\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e. Theoretical researches showed that \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e is an optimal form of price index, and is called \u0026ldquo;the ideal index\u0026rdquo; [22]. \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e is calculated as follows:\u003c/p\u003e\u003cp\u003e\u003cimg src=\"data:image/jpeg;base64,/9j/4AAQSkZJRgABAQEAYABgAAD/4QAiRXhpZgAATU0AKgAAAAgAAQESAAMAAAABAAEAAAAAAAD/2wBDAAIBAQIBAQICAgICAgICAwUDAwMDAwYEBAMFBwYHBwcGBwcICQsJCAgKCAcHCg0KCgsMDAwMBwkODw0MDgsMDAz/2wBDAQICAgMDAwYDAwYMCAcIDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAz/wAARCAA/AaIDASIAAhEBAxEB/8QAHwAAAQUBAQEBAQEAAAAAAAAAAAECAwQFBgcICQoL/8QAtRAAAgEDAwIEAwUFBAQAAAF9AQIDAAQRBRIhMUEGE1FhByJxFDKBkaEII0KxwRVS0fAkM2JyggkKFhcYGRolJicoKSo0NTY3ODk6Q0RFRkdISUpTVFVWV1hZWmNkZWZnaGlqc3R1dnd4eXqDhIWGh4iJipKTlJWWl5iZmqKjpKWmp6ipqrKztLW2t7i5usLDxMXGx8jJytLT1NXW19jZ2uHi4+Tl5ufo6erx8vP09fb3+Pn6/8QAHwEAAwEBAQEBAQEBAQAAAAAAAAECAwQFBgcICQoL/8QAtREAAgECBAQDBAcFBAQAAQJ3AAECAxEEBSExBhJBUQdhcRMiMoEIFEKRobHBCSMzUvAVYnLRChYkNOEl8RcYGRomJygpKjU2Nzg5OkNERUZHSElKU1RVVldYWVpjZGVmZ2hpanN0dXZ3eHl6goOEhYaHiImKkpOUlZaXmJmaoqOkpaanqKmqsrO0tba3uLm6wsPExcbHyMnK0tPU1dbX2Nna4uPk5ebn6Onq8vP09fb3+Pn6/9oADAMBAAIRAxEAPwD9/KKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACivlfxz+2d8ab39pj4reA/hx8GfAfjDS/hbp2m3surar8RLvSJtUlvLWScWcdvFo10q3KeXkqZSpSe2bcDIyJ9CfBzxfq3xA+EXhXXvEGgSeFde1zR7S/1LRJJzO2j3MsKSS2pkZIy5idmTcY0J252rnAAOkormPi78bfBn7P3gyTxJ498XeGPBHh2GVIJNU1/VYNNskkc4RDNMyoGY8AZye1ebeE/+Cm37Nvj3xVpuhaF+0H8D9a1vWruKw0/T7Dx1pdzdX9xK4SKGKJJy8kjuyqqKCWJAAJNAHuFUfE3ibTfBXhvUNZ1nULHSdH0m2kvb6+vZ1t7aygjUvJLLI5CoiKpZmYgAAkkAVerxH9usjxZ8PfC/wAPF+aT4qeKtP8ADsyfwy2CF9Q1KNvaTTrG9jz6yL16EAzf+HsX7LP/AEct+z//AOHD0j/5Io/4exfss/8ARy37P/8A4cPSP/kirnxH/aw8R+E/29/h58GNH8F6VrmmeMPDWp+J9W15/EEltceHraymgg5sxaOswlluoEQ/aEyRNkDyxv8AdKAPn/8A4exfss/9HLfs/wD/AIcPSP8A5Io/4exfss/9HLfs/wD/AIcPSP8A5Iruj+1R4P0/40+I/AWsXkvhrXvDuljXg2sKtpa6ppgRTNe2szNslhgc+XNyGhYKXVUkieTT+AXxz0j9pD4ZWfjDw/a6xDoGqSy/2bcahZm1bU7dJGRLuJG+f7PMB5kTMFLxsrbQGGQDzL/h7F+yz/0ct+z/AP8Ahw9I/wDkiuw+Cn7bvwX/AGlPFVxoXw5+L3wv8f63aWjX8+n+G/FVjqt1Dbq6I0zRQSu6xh5I1LkYBkUZywzznwt/av8AEnxJ/bx+Knwm/wCEK0m38J/DLR9Kv38VReIJJri8u9QQyR2TWJtFWJkSKd3YXMmENsduZ2WL3OgAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigD4V/YR/YJ0/4pfET4hfGL49/s/wCl+G/jBqfxRufFfh/UtcOk6lq2n2EMNvb6UsN5ZXE5RYreCMNC0gUTiRgpG1zjfs5ftRfFr46ft0aw3hjxd8SfE3gG1+JmtaDeaXf+B7a18I6V4esLJ7Z54NY+wQvdXn9tQSRosN5cYiYrJECjS1+gdc38K/g34Q+BXhX+wfBHhXw34N0Pz5Lr+ztD0yHT7XzpDukk8qFVTex5ZsZJ5OaAGfF3wDq3xJ8GSaXo3jbxR8P755UkGsaBBp017GqnJQLf2t1BtbocxFvQqea828J/sn+PPDnirTdQvP2m/jhr1nYXcVxPpl/pfg9LXUURwzQStBoUUwjkAKsYpI5AGO11bDD3CigDif2idE8d+Ivgz4gs/hrr2j+GvG01lMNJ1DVNNOoW0Nx5beXuj8xBjzNmWO4AZ+U9vnP9if8Aacj/AOCgPxZ8GeMXs5dKvPhz4Jmh8S6NKg/4k/ia+vWs7u0Y5yJrNtHvo+2Y75W5DrX2FXI/DH4D+EPgzr/jHVPC+g2ejX/xA1o+IfEEsG7OpX5t4bczsCSFJjt4gQgVSwZyN7uzAHyfqupeMvhD+1T+1p8eviF4N13wb4R8K/D6y0bwRr51HTLo3un6emoXl5LDBHNNJHLLdTqyLPD86xQgruzGPoT9i/xJrdx8DNE8O+NfGTeOPif4T06ytfG9+9nBaNHqs1rFdSRmO3ijhjwsybURciMx7iWJZu++JXww8M/GfwRf+GfGHh3Q/FnhvVVVL3SdZsIr6xvFV1dRJDKrI4DqrAMDgqD1ArN+C37PvgL9m3wpNoPw78EeEfAOh3F019Lp3hzRrfSrSW4ZURpmigREMhWNFLEZIRRnAFAHzf8At4fsEeIP+Ck/xAt/Dviqa18F/Dn4eyLqvh7ULaC11DU9f1p7cqssiSqyR6bAJGjktmw1429X2Qovn/RH7PereN9V+FliPiLoukaH4vs3ls75NJufP0+98pyiXdvn544plCyLFJ88e/YxYrubtqKAPzTvPGnxV/Zd/Yo/aJ+JPijw54x+DXxf+MHxYg/sE20OmeKNV8i6n03TNL8i2tDqEdw0VjEBJAI2kLR3HlqcxufrD/gnr4p+IXi74Z+Krrx1f+MNY01fE08fg7VPF2gQ6D4h1PRRa2pWa+soYLZYZPthvkQG2gcwpAzRhmJPq/xK+DPg/wCM0GkR+MPCfhrxZH4f1KLWdLTWdMgvl02+i3CK6gEqt5c6bm2yJhl3HBGTXS0AFFFFABRRRQAUUUUAFFFFABRRRQAUUUUAFFFFABRRRQAUUUUAFFFFABRRRQAUUUUAFFFFABRRRQAUUUUAFFFFABXzj8ZNbt9X/wCCjPw70zWLyLTtG8IfD3xJ4tgnmdFjt703Gm2P2zMgKK1va3F2m85AW9cHg4P0dXGeN/gXovjv4s+D/Gl011BrnguLULO2eHy9l5Z30UaXNpOHRiYXkgtZsIUbzLSH5iu9HAPhLRvAuveH9I/aU+GXjfXPEMK6p8JrbxRo0X/CxNR8c2tgY31VBrUepaksNxa3sk0du4tobaO0h+wxSQySO8qw/enwD8bXnxK+BXgvxHqEXk6h4g0Gx1K5jxjy5ZreORx0HRmI6D6CuHuP2A/hLpXwG8Y/Dfwj4H8M/DXwr4+tns9et/Bmj2eiHUYZF8uVH8mIKTJCXiL43hHbaythh7Ba2sVjaxwQRxwwwqEjjRQqooGAABwABxgUASUUUUAFFFFABRRRQAUUUUAFFFFABRRRQAUUUUAFFFFABRRRQAUUUUAFFFFABRRRQAUUUUAFFFFABRRRQAUUUUAFFFFABRRRQAUUUUAFFFFABRRRQAUUUUAFFFFABRRRQAUUUUAFFFFABRRRQAUUUUAFFFFAH//Z\"\u003e\u003c/p\u003e\u003cp\u003eIn the above formula (1)-(3), P means the price, P\u003csub\u003e0\u003c/sub\u003e and P\u003csub\u003e1\u003c/sub\u003e refer to price per Defined Daily Doses (DDDs) of each product in baseline- and reporting period. Q means purchasing quantity, Q\u003csub\u003e0\u003c/sub\u003e and Q\u003csub\u003e1\u003c/sub\u003e refer to DDDs of each product in baseline- and reporting period. DDDs is the ratio of the quantity of drug utilization and Defined Daily Dose (DDD) [23]. If the drug price index \u0026gt; 1, it indicates the increase of drug price in the reporting period when compared with the base-period; If the drug price index =1, it means that drug prices remain unchanged over the two periods; If the drug price index \u0026lt; 1, it means that drug prices in the reporting period decrease compared with the base period.\u003c/p\u003e\n\u003cp\u003eIn this study, January to June 2018 was assigned as the baseline period, and July 2018 to December 2019 was assigned as the reporting periods to calculate drug price indexes of each month (18 months).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatistical Analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eDescriptive statistics were used. We first described the change of DPI of included drugs before (July 2018 to February 2019) and after (March to December 2019) the implementation of \"4+7\" policy.\u003c/p\u003e\n\u003cp\u003eInterrupted time-series analysis was applied to assess the change of Fisher Price Index after the implementation of \"4+7\" policy. ITS is a commonly used approach for evaluating changes in longitudinal series following a quasi-experimental intervention occurring at a fixed point in time. The interrupted time series was constructed with DPI data in Shenzhen from July 2018 to December 2019. The time unit was set to 1 month and the intervention time point was set to March 2019, making 18 time points available for analysis, including 8 points as pre-\"4+7\" policy period and 10 points as post-\"4+7\" policy period. To estimate the effect of the intervention on the outcome variables, the following segmented linear regression model was developed [24-26]:\u003c/p\u003e\u003cp\u003e\u003cimg src=\"data:image/jpeg;base64,/9j/4AAQSkZJRgABAQEAYABgAAD/4QAiRXhpZgAATU0AKgAAAAgAAQESAAMAAAABAAEAAAAAAAD/2wBDAAIBAQIBAQICAgICAgICAwUDAwMDAwYEBAMFBwYHBwcGBwcICQsJCAgKCAcHCg0KCgsMDAwMBwkODw0MDgsMDAz/2wBDAQICAgMDAwYDAwYMCAcIDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAz/wAARCAA9AnMDASIAAhEBAxEB/8QAHwAAAQUBAQEBAQEAAAAAAAAAAAECAwQFBgcICQoL/8QAtRAAAgEDAwIEAwUFBAQAAAF9AQIDAAQRBRIhMUEGE1FhByJxFDKBkaEII0KxwRVS0fAkM2JyggkKFhcYGRolJicoKSo0NTY3ODk6Q0RFRkdISUpTVFVWV1hZWmNkZWZnaGlqc3R1dnd4eXqDhIWGh4iJipKTlJWWl5iZmqKjpKWmp6ipqrKztLW2t7i5usLDxMXGx8jJytLT1NXW19jZ2uHi4+Tl5ufo6erx8vP09fb3+Pn6/8QAHwEAAwEBAQEBAQEBAQAAAAAAAAECAwQFBgcICQoL/8QAtREAAgECBAQDBAcFBAQAAQJ3AAECAxEEBSExBhJBUQdhcRMiMoEIFEKRobHBCSMzUvAVYnLRChYkNOEl8RcYGRomJygpKjU2Nzg5OkNERUZHSElKU1RVVldYWVpjZGVmZ2hpanN0dXZ3eHl6goOEhYaHiImKkpOUlZaXmJmaoqOkpaanqKmqsrO0tba3uLm6wsPExcbHyMnK0tPU1dbX2Nna4uPk5ebn6Onq8vP09fb3+Pn6/9oADAMBAAIRAxEAPwD9/KKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiivh/9t3xf4j/AGWv+ClfwZ8faXcfEjxjpPxK0TV/Atv4E0/xJdRaRP4gSOO8sLxrRpfsyA28V/HNO0ZWJVSUgsuaAPuCivgX4y+HvjR/wTu/ZT8D+Gfh/wCLZPiJ8VPi18RbDTLzVvHHjPUbtNPlu5vPmttNW6gvSlpFawXCKGG6KGNpis8oKt9t+Fta17/hXVvf+KNO0DRfEC2hmv7Ox1eS9061kAJKrdyW8DvGMDMjQIQM/LxyAb9FfAH/AA+o/wCpy/YA/wDEp/8A7wV9r/BX4hf8LY+EnhvxN9o8L3X9vafDfed4c1r+2tIl3qGza3vlRfaYTn5ZfKTcMHaM4oA6iivyQ+PXhKH9t7VvFOu+INDa41D4wfE69+HXw6+I2psG074V2Wk3QsI5NMC754dSu7u01CaKZEijlleKOS4VVjjf9RvBnxy8E/Ebxp4h8N+HvGHhbXvEXhGVYNd0vTtVgur3RZGztS5hRy8LHBwJApODQB1NFed/HH9p/wAN/s9XWmw69pvxE1BtUWR4T4Z8A674nVAhUHzW02zuBCTuGBKVLYO3O048Q/4JI/tl6f8AtAfsZ/BHSb7/AIWpqXjM/DfQ7zWNY8ReCfEFpZ6ncjT7YXE41a8tEtbt5JGLiSOeQzAl1LrlqAPrOivjr/gpbrN38U/jf8KfhBDo2veLvD95Y634/wDF/hbRZoobrxTp2kxQQ22mO00sUXk3GoX9qWSSRUlFsY2OxmBsf8EmtO8K/Cn9mpdWtdU8I+GdH+Mni6/1/wAL+EdOmNpYeGkeOOH+xbKGZIW8yL7HLLNEkKBJ5LragUAkA+vaKwvidoWueJ/h5rWn+GteHhjxBeWckenasbJL1dPuCp8uVoX+WRQ2CUJG4ZAKnBHyN+zR+3/46/bS/aDuPhbpMPh3wVr3wdvY2+KeoW93DqdvqciTyxJZ6KpJZoJ3gfzriZVe2Gbfabjc8AB9rUV81/8ABV748fEr4A/siXF58Io/D/8AwsDxTrul+EdHuNVvDD/Z9zqd3HZQ3MEf2W5S4mjlmjbypUWMIJJGL+X5MuL8Uviz8RPEn7SPwB8AeJvDv/CN6xqI1rxzq8XgT4hSzxiPSUECWU4uNMtvt1lcNqVkWV2tds4UHekZaQA+rqK+IB/wVq8Z2uiNqVz8D2ksdK+KUfwv1b7B4rFzNJdS3cVqr6chs0F7JE0jG4Rmgji8qQJPMUfb1M3/AAVRs/hZ8D/jj42+LHhSz8E23wU8UxeFpV0/xDHqVvrlxPbWE9usVzPFaxxyFtQhhkEmIoXWQtKY0LgA+tqK+df2B/25NW/bQu/GpuvCOhaXo3hmWyXTPEXhzxMfEeg+IRcRvI8dvefZbZJJrfagmEImhBmQJPIdwXhv+ClX7eGj/CHwdaaDYR/GTTtf074heCIru90f4deJ5bGe0fxPpBu4I9Qt7Fra4E1o00BhimczmU24V5JBEwB9h0VxfwS+POh/tAeH7rUtBsfGlhb2dx9lkTxJ4P1bwzcM+1WykOpW1vLImGHzopTORnIIH55/t7+IdP8Ajn8Yfjvr/jDwPZ/ErwP8MZtL+GHh6LXCr+FPBurXlnHeX+v38eHlZom1DToPOt4JZYBAcGFXllUA/UCivIf2evGngz4LaH4H+BV58U/D/ij4l+EvC1jZz2V7rVu3iHVo7W2jhe/ltTIZj5hQuzkEZY8nrWx+1I3jzTfhVLrHw71bQdP8QeG511WS01wLHpuuWsSP51jPOQWtVkU5W4TJieNGZZIw8bgHo1FfKX/BPr9t/Wv+Ck+oyfEzwv5fhb4P6VA2kwaNeC3uNc1nVGWGSWe5Mbutrbwq22FEYtcCQzEiIw7+l/ax8e61fftV/AH4b2MetWem+KdYvfEeoapoviltLvLeLSIFn8i4tfssgvLCeWa3ilQTwnMkYO5SwIB9EUV8Q6z/AMFZfGmiW3xAmm+CdtDH8NfiBo3gjVjJ4zU+cdU/ssW62xjtHWa/jfVIkltVPkoYZNt3JlN/WeH/ANon46eNv+CpPjTwLougfD+6+EPw/wBB0hdUkl8TTwX32jUZJpftAjGmSb7qKC2I+yefHFsuIpGmZpAsIB9ZUV8O/Db/AILS6f8AtBftCaf4X+FvgzS/iP4butd1DQJrrR/F0Muv2Zs4blmv5tNWFobWwkltvKjlvLy3kczQsIiJFz3X7NH7d/xO/aTnim0/4H20ei6P4y1vwf4n1ODxpFLDYPpzXUf2mxEltEb+Nri2S3fPkeXLcKFMqRzPGAfVFFfJHhT/AIKOeOPF/gK21az+D9lcXafFW5+Gl/bQ+MFdEW31WLTpry2c2qvcSR7rid4PLREi0+7LTgogk5jwt/wWe034xftLWvgv4Y+EdJ+Imjx+K7nwlqMumeLIm8RWUlv56z6gdLSB0i09JIGQT3l1amTKtGkivGXAPt6ivivw3/wVW8Za1cWhuPg3Z2tnb/FmH4UaxcJ4w85Yrma7itvOsh9iH2xoN7vco3kpEIZAk05RgvSfDX9oj45fEX/gpn8TvB9poXw9m+D/AMO7PSNMu3/4SaePUILu7jlvGuBGNMbzLgW7Woa2NxFHGksbiWVpCIwD6wor4h+A/wC3BqHw9/ZMb4p654f8Va14z+N/xKudE8LeDD4vGtWz33nPp0Ftp13La2q22mNDpk1/l4cpG88p3s22pPiX/wAFXPGnwd+EPxs1HXvg3pcvjT4D3Fl/wkGl6Z40Nxo89td2S3kDW9/JYxTSXDKyQiD7ID50sQLLG/nAA+2qK8L+AP7W3iD4t/tQ/EH4ca34Dj8Lr4P0PR/ENpfJrP26a4t9Slvo4oLuHyI1tbpfsLu0SSzrskQ+ZnKjgP8Agrd+2Xp/7P8A+xn8btJsf+Fqab4zHw31y80fWPDvgnxBd2emXJ0+5FvOdWs7R7W0eORQ5kknjMIAdii4agD6zorzv4HftP8Ahv8AaFutSh0HTfiJp7aWsbzHxN4B13wwrhywHlNqVnbiYjaciIsVyN2Nwz8jf8FGPGlt8SP2p9a0fxB4F1L4ufDX4D/D6Pxjr3gi3WKSw1nVNTu5oLOS/ilJW4hs7TT76fyRHM/78OkMsiRoQD79or5Z/wCCefjL4e/sw/s8fCv4P6p8Xfh3qnjbWNPl1jR9Ig1+JZ7u2vZ5r+GDT7aZxcyWcEMwhgJQHyII8quCB798adA8VeJvhhq1n4I8QWfhfxY8ayaXqN3YrfWsUyOrhJoSQXhk2mN9rK4SRijI4VgAdRRXxp+xr/wUB8V/8FCPjFNpPhy20jwPpPwkvJLL4iL9st9Wm1rVFM9uLPTXU4OmiSJ5ftzKryGNYURHWfy+t/4KafH74s/B7TPhPoHwdtPB8/in4leO7DQPM1vVpLN1gj3X91HEq2V0pWWzs7yOSZlzArB0SV9oUA+nqK+VfHvxY8feIv22fhl4T1DwzqNpeeFvAup/EPULPwj49JsdS1BQdOXR7uC4sbcXdu7Xfm200k1uDNbM7xIIVLcT4Q/4K2+MvEfh7wDq0vwRVrHxl8Q9W+Gh/s7xb9qmudSsptSiWfTleziF3Zt/ZkrSTzNaiFXztcRyFQD7gor5B1D/AIKz6X8Kf2T/ABj8SPih4b0nwbfeFfHdz8PINPtfE8Nzp+r6lHcLboYtQuorSOOHzDJ5skyIIRbTk7tnPon7BX7Y+sftkeGfFupal4R0vQLTw7rC6bp+raJrsmuaH4lia2hnNxZXclpatMiNKYnZYjGJI3CySbWwAe9UV8dfGT/gqT4g8JHxhrXgv4V2vi/wF4K8YW/w9uNYvPFQ0u71jxBPfQacLbT7QWs3nRQ31ykE0sssJUxzmNJvLw2B/wAFUdV+I3xY/aY+A/wT8K+GvAvijwn4wudQ8UeJ9I13xPd6VH4gstKiXdY3Yh0+6AsTcXdi7ZEgnZRC0axlnIB9yUV8T+KvEfxM/Zr/AGy/hJ+z/wDs++B/hrafC/w94Q1LxNqemX/ie504i2FzFaxW5I027a3RZrppYVjYmYwSqzQJFiVPEv8AwWX0rV/2rLr4Z/DnwzofxCm8P+NbbwRr8Nt4sjj8Q29w08cV5dW2lRQTM9pZF386e7ls0zbThC4QFgD7Zor5T8Dft7fFH4ofFz4geDvD3wJhvdQ+G/ivSdF1eaXxrDDbwWF9DaXDz+Z9mKNe21td+dLZxl02RELcs7xI/Sf8FH/HutaH8OfA/hHRY9ahk+K/jXS/B0+paF4pbw/rWjQzO0813Zyi1uPMeOG2mZ4/3RMQk2yK2DQB9EUV8VfHz/gqv4y+Cup/tA20fwZtb/8A4UPodr4onmufGK28OpafMt43lu0dpN5N862ivDbL5qyLcxeZLA25V2/j1+0r8eD/AMFBPhj8O/hr4Z8BXfhuXwhfeMfE1trfiabTbqWMSwWcUEpTTLrydstwZI/LJM7W8oZoVjxKAfXVFfE3iX/gsvpWr/tWXXwz+HPhnQ/iFN4f8a23gjX4bbxZHH4ht7hp44ry6ttKigmZ7SyLv5093LZpm2nCFwgLdb4G/b2+KPxQ+LnxA8HeHvgTDe6h8N/Fek6Lq80vjWGG3gsL6G0uHn8z7MUa9tra786WzjLpsiIW5Z3iRwD6sor5D1//AIKS+OrPwr8arrTPgzbanq3wi8YWfhWOzPjGOGLWWudPsb2NRN9mOy8J1C2thbRrMpuJEXzgh80YXxW/4LL6TpP7T2qfDP4d+GdD+I2q+FfE+n+FdesYvFaW2vm5uJYEnew0yK3nknhtFnDTz3L2kK+VMBI3lsQAfbNFfEvxs/4KveNfhK/x0S3+CcGpSfA37Bd34l8YrAt7aXkQkhhDJaShdScNGUtEMsZEqF7mIuqt1Hjv9on45ap/wVNtfhv4J0X4eah8OPCvg2HXfEaX3iaezvpjqF6sFtOwXTJ9ksK2Oo+VbJKqzh98k0e1EAB9ZUV8X6N+2m3wnvv2lvi54w07xdJY+E/F1j8NtA8O2Hif+2LHxBcwNGlo+m2r21utpd3lzqsVvcBnlUSW2DL5cO86Gtf8FJfH3w/vPip4e8WfCHQdM8c/DXwRafEE2lj45+2aK+lzvfIftd+9jE9rNEbCYvHHb3GQVKNIu4qAfYFFfM/7Mv7fHiL4+fHjwz4U1X4ZP4R0rxj8Ox8QNNvZ9c+0ahbxie0g+z3lmLdRbmRrlmhYTOzpbyb44XBQd1+1d+1T4f8A2evC95a6pY/Ee4vtQ0u5mtJ/DXgPXvEMUBVCAZJ9Os544GDYI81kOBkcDNAHr1FfNf8AwTV/bA0n9oT9nT4a6T5PxQuPE8PgbS77U9S8SeBvEGl2t/KLa3SaRdSvrSK2upHkk3AxzO0o3SLuUMwj/bb/AOCgN5+yv8XvA/gXR/D/AIK1DXvHVnd3Vhc+MvGyeEdKu5oZYIo9Otrk2tyZtQneceVBsQMqOd4xigD6YorP8I6lqGseFNLvNW03+xtUurSKa80/7Qtx9hmZAXh81flk2MSu5eGxkcGtCgAooooAKKKKACisHxB8TtD8LeOPD3hu+vvL1zxV9pOmWiQySPcLbxiSeQlVIjjQMgLuVXdLGmd8iK2D4w/ah+HfgW18aSaj4y0EP8N47abxZb210t3deGo7hBJDJewRbpLdHiPmh5FVfKDSEhFZgAd5RRRQAUUUUAFeN/F79jKx+Mf7V3wx+LV3438daXf/AApjvF0rQbCWxGi3bXcTQ3EtwktrJM8jxERhkmTYq/JtLOX9kooA8m/ak/ZH039qS88C303irxf4M1r4d62+vaNqnh2SzW4inksrmxkVlu7e4iZHt7uZc7A6lgyMrAGvTfDuiR+GvD9jpsU15dR6fbx2yTXdw9xcShFChpJXJaRzjJZiSxJJJJq5RQAVj/ETUtW0b4fa7eeH9P8A7X1610+4m02xEiR/bblY2MUW6RlRd7hVyzKozkkDJrYooA+NP2N/+CUcfwt+EnwTt/iB4++Iviy6+GMFrrsfha/vrE6FY+I2hZrm9Bgtkubhlup7mSNZ7maONnBRRtXGV/wT6/Za+JHwu+N3g2Txd4On8O2Pwp8GeJfCU+vTajZXK+OrjU9csL+G9gSCZ5VjSOymd/tSRSebfOArDc5+4KKACvP/ANk74Gf8Mv8A7LHw0+Gf9qf25/wrvwrpfhj+0vs32X+0PsVpFbef5W9/L3+Vu2b227sbmxk+gUUAfJvjn9i7xv8AHP8Abw+IHj668c/ED4W6PZ+EtJ8H+F9Q8L3eltNqVuZLq71Nmjure6Ee6aW0jEnlxTKbQlGCnc3P/HD9ma4/Zvk/Zt8L/CH4GeKPG2gfCvxFHqF3q9hqejLdWNktlqEDq8uo30FxPPJPfee20FWzKxbeQjfaVFAGF8TvAq/E74ea14dbVta0KPW7OSyfUNHuvst/aK6lS8EuCY5ACcOBlTyMEAjgG/Ye+HWmQfDceHtHbwfN8J5VHhu50KT7LNa2pK/aLKRsHzrW5C/vo5N3mNtkyJkSVfXKKAPMP2qv2W9P/at8IaBpt54k8UeEb7wrr9r4l0nV9Aa0+2WV7biQRsFu7e4gddsjgq8TdQRggEY6/sS6Mnx38E/EIeMPiGdY8E+HG8L+S+rrJDrlsZ4bgveO0ZneQzQRuxjljWTG2RXTCj2eigDwXwb/AME7fBPgzw58NdLi1PxReWnwz8Z6n4+thc3MDNrOr3/9otLNelYV8wJJqdxKgTy8OkWdwTacHXv+CWvgnxF4N8ZaPP4r+Ia/8JV44HxEsbtdRtvP8K6yt+uoR3FiDbmI+XcqCoukuPkAjJMYCD6YooA434JfCK4+D3hu6s77xn4y8ealf3Ru7rVvEl1BJcyuVVAqRW0MFtBGFQYjghjTJZiCzMxo/tLfAz/hoj4dab4f/tT+x/7P8V+HPE/n/ZvtHmf2Rrljq3kbd64877F5W/J2ebv2vt2N6BRQAV8N/AD/AIJa6l8RfhXqEvxg8XfEazXx5431Lx34q+HsGpaa2h3tzJqslxZwzyxW73TRR20VjG0MV4IHMHzK2Wz9yUUAfL974e1/xV+3xoL3fwD13T/CfhPWLvVNN8Zw3egxafLfz6RLbTarOqXp1CSVo2FgkRtR8srSyOQsaxezftB/s8+H/wBpzwVbeGfFTalceGxfxXuo6Xb3Hk22vRx7iLO8AGZbVnKs8IKrJ5ao+6NnjfuqKAPP7L9mrwxovx//AOFk6TFd6L4iutJGi6pHYSiGz1yBCptzdQ42ySW+GWKQYdEldMlCFGT8SP2SdH+JX7Tfgv4qTeIvF+k654J0u70WGy029jhsdStLm5s7qSO4UxNLgzWFsT5Uke9UMb742ZD6tRQB87eJv+Ca/hLxD8Lrrw1D4q8e6VNdfEd/ii+tWV5aDUf7Wa9a7VTvtmha3jJSJEaJiscMXzb0Elbvw7/Yd0j4X/tM+JPiXpfjT4iLJ4rmtbzUvD0upQvpF1d22mRaXFcyHyftcrC1hTKS3DwmQeb5fmAOPbKKAPBf2U/2BdL/AGQk0vTPDvxA+JeoeC/DUU9v4d8I6hfWa6PoEMrs3lRi3tYbi4VN5VBeTXBQY2kEAjvv2Zf2eNF/ZU+CWjeBPD91ql9pujtczfa9SkjkvL2e4uZbqeeZo0RDJJNNI7FUUZY8Cu8ooA8U/Zq/YR8I/sxareXmm6p4n8QSSaxrGs6amt3cU0Wgvqt9NfXiWqRRRr8008gEsoknEbeX5pT5ao/s1fsC6X+yzq9pD4d+IHxMuPBuj3V9d6J4Nur6zTRNFa7kmklVPItYrm4jDTyFEvJ7hYyVKhSqke80UAfN15/wTE8Gv8KPAnhOy8V/ELR18A+M7/x3bapY6jbx6jqOo3z6g92blzblGWT+07oBo0jljyhjkRkDV0/w6/Yj0n4X/tCeNvH+l+NPiAq+PdT/ALb1Hw6b+3TSBf8A9nwacbkbIFuXb7PbQgRzXEkSuu9Y1f5h7VRQB8u+G/8AglN4S8H/ALOPw++Hum+PfihbzfCnV4da8JeKHvrGfWtDmhtJLKNIxJaNZmL7LLJEyPbMJN7SSb5WMh3Lf/gmp4DX4MXngu61TxhqSa94x0/x14m1i9v45tU8W6jZ3lrdx/bZDFsMLGztojFCkSLDEscYjAFfQ1FAHlngT9k/Sfh9+0946+KVn4i8YTah8QI7MX+iz30Z0eCW1tktkmijWMS7jEgBV5XjDF3VFZ2Y6f7WPwM/4ag/ZY+Jfwz/ALU/sP8A4WJ4V1Twx/aX2b7V/Z/220ltvP8AK3p5mzzd2zeu7bjcucj0CigAr4ssP+CcXiT49/FH9oHxD468dfEzwHpvxW8RjS5ND8OanpqW+ueGrPT7ezto5JGt557bzmF7KTbTW82262uQQAPtOigD4w+Nn7Nni6+/ap+F+m+C/hndaX4D8Ca3o14L2O60NvDF9ZWkAi8y8hYJqw1C0jLx2ax+bbgiN3KniP6n+NPwptfjj8MNW8J3+p69pGn65Gtvd3GjXrWN60G9WkiSZRvjEqBo2ZCrhJG2MjbXXqKKAPLj+x14D03xn8P9f0HSR4R1L4a2h0nSG0HbYxtpZjKHTJo1XbLZ52SLEw+SSJHQq2San7Tn7IWn/tN+IvAutSeLvGfgrXPh7f3N/peo+HJrOOf/AEm1ktLiJ/tVvOu14JZF3IqSoTuR0YA165RQB5BB+xro9n+1ND8WLfxV46t9Yj8MWnhaXTBqaPpt3BavdvBNMHjaeSVWvbgkNMY3Yo7xu8aOuN8Kf+Cengn4Q6Z8ErSx1LxNew/AeC/GhfbbmCRtQury2e2nvrwrCvmXJSa5+aPy1zdTEqcqF94ooA+Xk/4JSeDbX4U2vhi18bfEqzm0TxxN8QfDmspfWUl94X1SW6vbp2tkktWtnUvqN6rG5gneRJ9sjvsj2e7/AAc+F8nwk8GjS7jxR4q8ZXkk73Nzq3iG7jnvLqR8ZOIo4oIlAAAjgijjXkhASSeqooA+V2/4JLeC4LO8s7Hxx8TdN0z/AITl/iHo9hBfWLW3hrVZL03s7WivaNuWWZpM/aDM8azSCF4d1anwS+BnirxB/wAFAfGnxY8TaBfeG9B8N+E7f4c+CbfUNRhvr7UbZb2W6v8AU3aOWYpHcvHYCMSv5zJbBpUjclB9KUUAeN+Nv2LtL8Y/tZWPxeh8Y+PNB1iHR7DQtQ0rSry2g03W7WyvLi9tkuCYGuQFmupSywzxLKhCSrImVOT8Gf2BNJ+A3xFvtU8O/ED4lWvhW98QX/ihfBS39pFoVvqF9LJPcyBo7ZL2SN5pZJPIlupIQzcRhQqj3qigDg/gV+zxov7Pz+NJNJutUvrnx74ovPFuq3F/JG8jXdyI02KURAIooYYYowQWCRIGZjlji/tK/sk6P+074g+H+qaj4i8X+HL74c6zNremzaDex2rzSTWNzYTRyF4nIVre7nUPEY5Yy+6ORGAavVqKAPn/AOJn/BOfwf8AFHwP8Y9HuvEHjSxuPjZr9j4h1jVbO8t1vtPmsorCK1htS8DRrBGNPiPlzRyhvMmDblfaLdz+wbpMn7Ruh/Ey38ffEyy1jTdB07w7qNrBqlv9n8SW1jeXF7b/AGx2tzc58+6mZ1gmhjlVvLdHjGyvdaKAPBfgz+wJpPwG+It9qnh34gfEq18K3viC/wDFC+Clv7SLQrfUL6WSe5kDR2yXskbzSySeRLdSQhm4jChVHffAr9njRf2fn8aSaTdapfXPj3xReeLdVuL+SN5Gu7kRpsUoiARRQwwxRggsEiQMzHLHvKKAPFvhl+wr4T+GXxo8UeNk1TxNrFx4l8RzeLE0vUbqJtM0jUprWG1luLeKOJCzmGFFVrhpmjDOIygdgc74afsC6X8Ifi5rXiHw98QPiXpnh3xB4mu/GN54Nt76zh0OTVbp/MuZy6WovmSSXMrQNdtAWZv3e07a96ooA+e/iH/wTf8AB/xD+HXxK0B/EXjbS7j4o+NbLx7qer2V1a/b7bULN7BrVIfMt3hNvENNtVEU0UoKq27cWzWn4Y/YU0nwd+0fN8SdP8dfEmG61HTdL07VtIOpwPY64dOSdLSa5kaA3juouJiyi5WKQtl42IFe40UAfMs3/BLLwXc/Dbxh4Zl8X/EiaDxR41HxAsbt9Tt2uPCmrrqratHNp4Nv5QKXjs+bhJ2Zdsbs8aIi3Lr/AIJleDde+C3xV8J694o8e+JNU+NltHY+M/FmoX1t/bmrWqIYktgYrdLWCBYnljWKC3jjUTzMFDuzn6OooA8nT9kLRbf9rj/hcFt4g8XWerP4dtfDU2iW95FHotxb2st1JA7RCLzdyG9n+RZRExKM0bPGjL6T4q0T/hJvDGpab5nk/wBoWstt5m3d5e9Cu7GRnGc4yKv0UAcj+z/8LP8AhRfwH8E+Cft39qf8IdoFjof23yPI+1/ZreOHzfL3Ns3bN23c2M4yeteZ/Ej9gLSfHX7SOr/E7TfH3xI8F6x4m0a00DX7Xw/eWUMOs2dq8zwxmaW1lu7XaZ5Dusri3JJySW5r3qigD5f/AGcP2c9c8O/8FAvjf8QvEHhzxtp6a5d2ltoGr3Hjm4udGv8AS47C0VII9LW7eNZEvG1KQtNbxeUJ0WHcJJWr6goooAKKKKACiiigD5k+NFx4isf+Ci2itocOlyeILn4O+JI/B51jzE03+0V1HSnmimkjUuiOf7PZwgLlIWZVPlmvlj4UfBb4hfs0aT+1t/wtnwH4W0rwlefBezk13xJZeI7zWv8AhKtSSPXZLycvJpVlHcT3BuriW4VNvkM9siI6TAQ/pnqnhXS9c1bTNQvdNsLy+0WV59PuZ7dJJrCR42id4mIJjZo3dCVIJV2B4JFHiXwtpfjTRpNO1jTbDVtPmdJHtby3SeF2R1kQlGBBKuqsDjhlBHIFAHPfs8abrGjfADwNZ+IRIuv2vh+wh1MOMMLlbaMS5xjneGrsKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooAKKKKACiiigAooooA//9k=\"\u003e\u003c/p\u003e\u003cp\u003eWhere, \u003cem\u003eY\u003csub\u003et\u003c/sub\u003e\u003c/em\u003e is the independent outcome variable (i.e. Fisher Price Index) in month \u003cem\u003et\u003c/em\u003e. \u003cem\u003etime\u003c/em\u003e is a continuous variable indicating time in months at time \u003cem\u003et\u003c/em\u003e from the start of the observation period. \u003cem\u003eintervention\u003c/em\u003e is an indicator for time \u003cem\u003et\u003c/em\u003e in the pre-\"4+7\" policy period (intervention = 0) and post-\"4+7\" policy period (intervention = 1). \u003cem\u003etime after intervention\u003c/em\u003e is a continuous variable indicating months in the post-\"4+7\" policy period (time in the pre-\"4+7\" policy period is coded 0).\u003c/p\u003e\n\u003cp\u003eIn this model, \u0026beta;\u003csub\u003e0\u003c/sub\u003e estimates the baseline level of the independent variable at the beginning of the observation period. \u0026beta;\u003csub\u003e1\u003c/sub\u003e estimates the linear trend during the pre-intervention period. \u0026beta;\u003csub\u003e2\u003c/sub\u003e estimates the level change in the outcome variable immediately following the intervention. \u0026beta;\u003csub\u003e3\u003c/sub\u003e estimates the trend change in the outcome variable in the post-intervention period compared with the pre-intervention period. \u003cem\u003e\u0026epsilon;\u003csub\u003et\u003c/sub\u003e\u003c/em\u003e is an estimate of the random error at time \u003cem\u003et\u003c/em\u003e. Durbin-Watson test was performed to test the presence of first-order auto-correlation (a value around 2 indicates no sign of auto-correlation). If autocorrelation is detected, the Prais-Winsten method was applied to estimate the regression. Stata version 16.0 was used to perform the ITS analysis. A \u003cem\u003ep\u003c/em\u003e-value \u0026lt;0.05 was considered statistically significant.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cstrong\u003eDescriptive analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eDescriptive analysis was conducted to compare the change of \u003cem\u003eL\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e, \u003cem\u003eP\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e, and \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e in the pre- and post-\"4+7\" policy periods. \u003cstrong\u003eTable 1\u003c/strong\u003e lists the results of winning and non-winning products. After the implementation of \"4+7\" policy, the \u003cem\u003eL\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e, \u003cem\u003eP\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e, and \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e of winning products decreased by 53.42%, 54.82%, and 79.02%, respectively. The\u003cem\u003e F\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e of winning products declined from 0.44 (\u003cem\u003eSD\u003c/em\u003e = 0.08) in pre-\"4+7\" policy period to 0.09 (\u003cem\u003eSD\u003c/em\u003e = 0.01) in post-\"4+7\" policy period. The \u003cem\u003eL\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e, \u003cem\u003eP\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e, and \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e of non-winning products decreased by 2.32%, 9.91%, and 11.96%, respectively. The\u003cem\u003e F\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e of non-winning products declined from 0.49 (\u003cem\u003eSD\u003c/em\u003e = 0.01) in pre-\"4+7\" policy period to 0.43 (\u003cem\u003eSD\u003c/em\u003e = 0.03) in post-\"4+7\" policy period.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 2\u003c/strong\u003e summarizes the results of CP drugs and alternative drugs. After the implementation of \"4+7\" policy, the \u003cem\u003eL\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e, \u003cem\u003eP\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e, and \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e of CP drugs decreased by 58.95%, 60.68%, and 83.38%, respectively. The \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e of CP drugs dropped from 0.48 (\u003cem\u003eSD\u003c/em\u003e = 0.02) in pre-\"4+7\" policy period to 0.08 (\u003cem\u003eSD\u003c/em\u003e = 0.03) in post-\"4+7\" policy period. The \u003cem\u003eL\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e, \u003cem\u003eP\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e, and \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e of alternative drugs decreased by 2.30%, 2.11%, and 4.34%, respectively. The \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e of alternative drugs dropped from 0.49 (\u003cem\u003eSD\u003c/em\u003e = 0.01) in pre-\"4+7\" policy period to 0.47 (\u003cem\u003eSD\u003c/em\u003e =0.02) in post-\"4+7\" policy period. For the overall of CP drugs and alternative drugs, the \u003cem\u003eL\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e, \u003cem\u003eP\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e, and \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e decreased by 35.83%, 41.49%, and 62.21%, respectively. The \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e of the overall drugs dropped from 0.48 (\u003cem\u003eSD\u003c/em\u003e = 0.01) in pre-\"4+7\" policy period to 0.18 (\u003cem\u003eSD\u003c/em\u003e = 0.03) in post-\"4+7\" policy period.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eITS analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eWinning and non-winning products\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe ITS results of winning and non-winning products are presented in\u003cstrong\u003e Table 3.\u003c/strong\u003e The \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e of winning products significantly declined (-0.183 per month, 95% \u003cem\u003eCI\u003c/em\u003e = -0.248 to -0.118, \u003cem\u003ep\u003c/em\u003e-value \u0026lt; 0.001) in the start of the \"4+7\" policy implementation, while significant increment (0.024 per month, 95% \u003cem\u003eCI\u003c/em\u003e = 0.008 to 0.041, \u003cem\u003ep\u003c/em\u003e-value = 0.007) in \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e of winning products was found between the pre- and post-\"4+7\" policy slopes. In the start of the \"4+7\" policy implementation, significant decrease (-0.034 per month, 95% \u003cem\u003eCI\u003c/em\u003e = -0.067 to -0.001, \u003cem\u003ep\u003c/em\u003e-value = 0.046) was found in \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e of non-winning products. However, the change in the pre- and post-\"4+7\" policy slopes had no significant difference (\u003cem\u003ep\u003c/em\u003e-value = 0.262) (\u003cstrong\u003eFigure 2\u003c/strong\u003e).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eCP and alternative drugs\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe ITS results of CP drugs and alternative drugs are presented in\u003cstrong\u003e Table 4.\u003c/strong\u003e The \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e of CP drugs significantly declined (-0.347 per month, 95% \u003cem\u003eCI\u003c/em\u003e = -0.395 to -0.299, \u003cem\u003ep\u003c/em\u003e-value \u0026lt; 0.001) in the start of the \"4+7\" policy implementation. However, no statistically significant difference was found in the trend change between the pre- and post-\"4+7\" policy periods (\u003cem\u003ep\u003c/em\u003e-value = 0.761). Significant decline (-0.003 per month, 95% \u003cem\u003eCI\u003c/em\u003e = -0.006 to -0.001, \u003cem\u003ep\u003c/em\u003e-value = 0.014) in \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e of alternative drugs was found between the pre- and post-\"4+7\" policy slopes. For the overall of CP drugs and alternative drugs, the \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e significantly decreased (-0.261 per month, 95% \u003cem\u003eCI\u003c/em\u003e = -0.298 to -0.223, \u003cem\u003ep\u003c/em\u003e-value \u0026lt; 0.001) at the start of the \"4+7\" policy implementation, while the change in the pre- and post-\"4+7\" policy slopes had no significant difference (\u003cem\u003ep\u003c/em\u003e-value = 0.268) (\u003cstrong\u003eFigure 3\u003c/strong\u003e).\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eThis study aims to analyze the impact of NCDP on the prices of policy-related drugs. Overall, we found that the price of winning products decreased markedly and the prices of non-winning products dropped slightly after the implementation of \"4+7\" policy, while the price change of alternative products had no statistical difference. For the overall drugs of CP and alternative, the comprehensive effect of \u0026ldquo;4+7\u0026rdquo; policy on price reduction was significant, but the long-term effect of the policy was not obvious.\u003c/p\u003e\n\u003cp\u003eIn the NCDP policy, 60%-70% of the market in pilot cities was assigned to conduct volume-based procurement, so as to relieve the artificially high drug prices by \u0026ldquo;group purchase\u0026rdquo; [27]. In this study, a notably direct effect of price reduction for winning products was observed, the \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e decreased by 79.02% and showed significant difference between the pre- and post-\u0026rdquo;4+7\u0026rdquo; policy periods. Tan et al. [28] reported similar results that 25 winning drugs dropped by 51.88% in Guangzhou when compared with the pre-intervention period, among which the price of atorvaststin (10mg*7 tablets) dropped by 85.7%. \u0026ldquo;4+7\u0026rdquo; winning products covered original branded drugs and generic drugs that had passed consistency evaluation of quality and efficacy, which had large clinical demand and quality assurance. Thus, the decline in drug prices might effectively alleviate the medication burden of patients.\u003c/p\u003e\n\u003cp\u003eAccording to the cross-price elasticity theory, in a group of drugs with substitution relationship, the percentage change in quantity demanded for one product in response to a percentage change in price of another product [14, 15]. With the announcement of \"4+7\" bid winning results, pharmaceutical enterprises related to winning products made adjustments in pricing strategy and sales model [29]. It is reported that enterprises of non-winning products lowered the prices consciously to save the market [30]. In the present study, we found that the \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e of non-winning products dropped by 11.96% after \"4+7\" policy in Shenzhen and showed statistically significant. Previous studies reported similar findings [18, 31]. Zhang \u0026amp; Wang [31] found that the price of non-winning antihypertensive drugs showed a gradient decline, with the fall ranging from 1% to 52%. Yang et al. [18] reported that the prices of three non-winning antidepressant drugs dropped by 12.67% on average. These findings indicated that the implementation of NCDP policy was conducive to improve market competitiveness and reshaping the competitive pattern of the pharmaceutical industry. However, ITS results of this study showed that there was no statistical difference in the changes of DPI slope of non-winning products between the pre- and post-\u0026rdquo;4+7\u0026rdquo; policy periods, indicating that the price reduction of non-winning products might just be a temporary response of pharmaceutical enterprises during the implementation of policy.\u003c/p\u003e\n\u003cp\u003eIn this study, the \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e of alternative products fell slightly by 4.34% in Shenzhen, while ITS analysis showed no statistical difference. Chen et al. [17] and Yang et al. [18] reported consistent results as this study. On the one hand, the price of alternative drugs did not change significantly (such as price increase) during the implementation of \u0026ldquo;4+7\u0026rdquo; policy, indicating that the national monitoring did play an important role [32]. On the other hand, this study indicated that the effect of price reduction triggered by 25 CP drugs was limited, and could not make a further impact on the market pattern. Furthermore, this study also found that the DPI slope of alternative products dropped markedly after the implementation of \u0026ldquo;4+7\u0026rdquo; policy, indicating that the policy might help slow the growth of alternative drug prices and reduce the burden of patients.\u003c/p\u003e\n\u003cp\u003eSeveral potential limitations should be mentioned regarding the present study. Firstly, this study designed a single-group ITS by using the drug purchasing data in Shenzhen, and potential confounding factors other than NCDP might not be controlled, so there may be some bias in the results. Secondly, only one of the 11 pilot cities was included in the study (i.e. Shenzhen City), the results of this study may not fully represent the overall implementation effect of NCDP policy in China, caution should be exercised in generalizing the findings.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eThis study analyzed the impact of NCDP on the price of policy-related drugs in Shenzhen. The \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e of 25 winning products notably decreased by 79.02%. Under the NCDP policy, the market behavior of pharmaceutical enterprises of policy-related drugs changed. The \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e of non-winning products dropped by 11.96% after the implementation of the policy, while the long-term trend of price reduction was not observed. In terms of alternative drugs, the price reduction at the start of the implementation of \u0026ldquo;4+7\u0026rdquo; policy had no statistical difference. However, a trend of price growth slowing down for alternative drugs was observed in the post-\u0026rdquo;4+7\u0026rdquo; policy period. In the future, on the one hand, it is necessary to expand the scope of CP drugs, so as to trigger the linkage effect of price reduction in a larger scope and to a greater extent. On the other hand, it is essential to strengthen the continuous monitoring of changes in the price and consumption structure of policy-related drugs, ensuring the accessibility and rationality of medications for patients.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eCDPS-SZ 2019: Centralized Drug Procurement Survey in Shenzhen 2019;CP: Centralized purchased; DDD: Defined Daily Dose; DDDc: Defined daily dose cost; DPI: Drug price index; ITS : Interruption Time Series; \u003cem\u003eL\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e: Laspeyres Price Index; \u003cem\u003eP\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e: Paasche Price Index; \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e: Fisher Price Index; NCDP: National Centralized Drug Procurement; OECD: Organization for Economic Co-operation and Development.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eAuthor Contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eConceptualization, Y.Y. and D.C.; methodology, N.W. and Y.Y.; software, Y.Y.; formal analysis, N.W. and Y.Y.; investigation, N.W., Y.Y., L.X. and Z.M.; resources, Z.M. and D.C.; data curation, Y.Y. and Z.M.; writing\u0026mdash;original draft preparation, N.W., Y.Y. and L.X.; writing\u0026mdash;review and editing, N.W., Y.Y., L.X., Z.M. and D.C.; supervision, Z.M. and D.C.; project administration, D.C.; funding acquisition, Z.M. and D.C. All authors have read and agreed to the published version of the manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis work was supported by the Global Health Institute, Wuhan University, China. The role of the funding body included designing the study, the analysis and interpretation of data, and writing the manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConflicts of interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare no conflict of interest.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eParkinson B, Sermet C, Clement F, Crausaz S, Godman B, Garner S, et al. 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China Pharmacy 2019, 30(17):2317-2322. doi: 10.6039/j.issn.1001-0408.2019.17.03.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003ch2 style='margin:0in;text-align:justify;text-indent:0in;line-height:150%;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-family: Calibri, sans-serif; color: rgb(0, 0, 0);\"\u003eTable 1.\u003c/span\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;font-weight:normal;'\u003e\u0026nbsp;The change of drug price index for winning and non-winning products pre- and post-\u0026quot;4+7\u0026quot; policy.\u003c/span\u003e\u003c/span\u003e\u003c/h2\u003e\n\u003ctable style=\"width:100.0%;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:27.5%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:23.16%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eL\u003csub\u003eP\u003c/sub\u003e\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.56%;border-right: none;border-bottom: none;border-left: none;border-image: initial;border-top: 1pt solid windowtext;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:23.12%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eP\u003csub\u003eP\u003c/sub\u003e\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.56%;border-right: none;border-bottom: none;border-left: none;border-image: initial;border-top: 1pt solid windowtext;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:23.1%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:6.4%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003ePre-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.46%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003ePost-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.3%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eGR (%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.56%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.36%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003ePre-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.46%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003ePost-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.3%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eGR (%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.56%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.36%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003ePre-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.46%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003ePost-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.28%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eGR (%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:27.5%;border:none;padding:0in 2.85pt 0in 2.85pt;height:4.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eWinning products\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.4%;border:none;padding:0in 2.85pt 0in 2.85pt;height:4.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.46%;border:none;padding:0in 2.85pt 0in 2.85pt;height:4.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.3%;border:none;padding:0in 2.85pt 0in 2.85pt;height:4.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.56%;border: none;padding: 0in 2.85pt;height: 4.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.36%;border:none;padding:0in 2.85pt 0in 2.85pt;height:4.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.46%;border:none;padding:0in 2.85pt 0in 2.85pt;height:4.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.3%;border:none;padding:0in 2.85pt 0in 2.85pt;height:4.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.56%;border: none;padding: 0in 2.85pt;height: 4.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.36%;border:none;padding:0in 2.85pt 0in 2.85pt;height:4.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.46%;border:none;padding:0in 2.85pt 0in 2.85pt;height:4.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.28%;border:none;padding:0in 2.85pt 0in 2.85pt;height:4.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:27.5%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:11.0pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eMean\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.4%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.93\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.46%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New 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style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.02\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.3%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.56%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New 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sans-serif;\"\u003e0.04\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.3%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.56%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.36%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.01\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.46%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.03\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.28%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:27.5%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:11.0pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eMin\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.4%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.97\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.46%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.94\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.3%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, 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style=\"width:7.46%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.85\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.3%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.56%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.36%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.47\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.46%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.41\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.28%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:27.5%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:11.0pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eMax\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.4%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e1.00\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.46%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e1.00\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.3%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.56%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.36%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e1.00\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.46%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e1.00\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.3%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.56%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.36%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.50\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.46%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.50\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.28%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;text-align:justify;text-indent:0in;line-height:150%;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 15px; line-height: 150%; font-family: Calibri, sans-serif;\"\u003eL\u003c/span\u003e\u003c/em\u003e\u003cem\u003e\u003csub\u003e\u003cspan style='font-size:15px;line-height:150%;font-family:\"Calibri\",sans-serif;'\u003eP\u003c/span\u003e\u003c/sub\u003e\u003c/em\u003e\u003cspan style='font-size:15px;line-height:150%;font-family:\"Calibri\",sans-serif;'\u003e: Laspeyres Price Index; \u003cem\u003eP\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e: Paasche Price Index; \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e: Fisher Price Index; Pre-: pre-\u0026quot;4+7\u0026quot; policy, i.e. July 2018 to February 2019; Post-: post-\u0026quot;4+7\u0026quot; policy, i.e. March 2019 to December 2019; GR: growth rate; SD: standard deviation.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ch2 style='margin:0in;text-align:justify;text-indent:0in;line-height:150%;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;'\u003eTable 2.\u0026nbsp;\u003c/span\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;font-weight:normal;'\u003eThe change of drug price index for centralized purchased drugs and alternative drugs pre- and post-\u0026quot;4+7\u0026quot; policy.\u003c/span\u003e\u003c/span\u003e\u003c/h2\u003e\n\u003ctable style=\"width:100.0%;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:15.16%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:13px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:28.9%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eL\u003csub\u003eP\u003c/sub\u003e\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border-right: none;border-bottom: none;border-left: none;border-image: initial;border-top: 1pt solid windowtext;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width:27.06%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eP\u003csub\u003eP\u003c/sub\u003e\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border-right: none;border-bottom: none;border-left: none;border-image: initial;border-top: 1pt solid windowtext;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"5\" style=\"width:25.2%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:7.44%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003ePre-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.72%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003ePost-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.9%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eGR (%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003ePre-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003ePost-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:10.9%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eGR (%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003ePre-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003ePost-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:10.88%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eGR (%)\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:15.16%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eCP drugs\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:12.74%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:10.9%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.04%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:15.16%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:11.0pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eMean\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.98\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.40\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:12.74%;border:none;padding: 0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-58.95\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.98\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.39\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:10.9%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-60.68\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.48\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.08\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.04%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-83.38\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:15.16%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:11.0pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eSD\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.02\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.07\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:12.74%;border:none;padding: 0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.01\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.07\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:10.9%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.02\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.03\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.04%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:15.16%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:11.0pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eMin\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.95\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.35\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:12.74%;border:none;padding: 0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.96\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.34\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:10.9%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.46\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.06\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.04%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:15.16%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:11.0pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eMax\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e1.00\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.60\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:12.74%;border:none;padding: 0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.99\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.59\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:10.9%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.50\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.18\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.04%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:15.16%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eAlternatives\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:12.74%;border:none;padding: 0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:10.9%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.04%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:15.16%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:11.0pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eMean\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.99\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.97\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:12.74%;border:none;padding: 0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-2.30\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.99\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.97\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:10.9%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-2.11\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.49\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.47\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.04%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-4.34\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:15.16%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:11.0pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eSD\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.01\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.02\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:12.74%;border:none;padding: 0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.01\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.02\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:10.9%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.01\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.02\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.04%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:15.16%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:11.0pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eMin\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.98\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.95\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:12.74%;border:none;padding: 0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.97\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.95\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:10.9%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.48\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.45\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.04%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:15.16%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:11.0pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eMax\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e1.02\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e1.00\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:12.74%;border:none;padding: 0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e1.00\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e1.00\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:10.9%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.51\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.50\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.04%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:15.16%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eOverall\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:12.74%;border:none;padding: 0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:10.9%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.04%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:15.16%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:11.0pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eMean\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.98\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.63\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:12.74%;border:none;padding: 0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-35.83\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.98\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.58\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:10.9%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-41.49\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.48\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.18\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.04%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-62.21\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:15.16%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:11.0pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eSD\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.01\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.05\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:12.74%;border:none;padding: 0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.01\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.06\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:10.9%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.01\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.03\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.04%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:15.16%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:11.0pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eMin\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.97\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.60\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:12.74%;border:none;padding: 0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.97\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.52\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:10.9%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border: none;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.47\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.16\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.04%;border:none;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:15.16%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:11.0pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; font-family: Calibri, sans-serif;\"\u003eMax\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.44%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e1.00\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.72%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.77\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:12.74%;border:none;border-bottom: solid windowtext 1.0pt;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e1.00\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.72\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:10.9%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.84%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 2.85pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:7.44%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.50\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:8.72%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e0.28\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.04%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 2.85pt 0in 2.85pt;height:14.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px; font-family: Calibri, sans-serif;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;text-align:justify;text-indent:0in;line-height:150%;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 15px; line-height: 150%; font-family: Calibri, sans-serif;\"\u003eNote:\u0026nbsp;\u003c/span\u003e\u003cem\u003e\u003cspan style='font-size:15px;line-height:150%;font-family:\"Calibri\",sans-serif;'\u003eL\u003csub\u003eP\u003c/sub\u003e\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:15px;line-height:150%;font-family:\"Calibri\",sans-serif;'\u003e, Laspeyres Price Index; \u003cem\u003eP\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e, Paasche Price Index; \u003cem\u003eF\u003csub\u003eP\u003c/sub\u003e\u003c/em\u003e, Fisher Price Index; Pre-, pre-\u0026quot;4+7\u0026quot; policy, i.e. July 2018 to February 2019; Post-, post-\u0026quot;4+7\u0026quot; policy, i.e. March 2019 to December 2019; GR, growth rate; CP, centralized purchased; SD, standard deviation.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ch2 style='margin:0in;text-align:justify;text-indent:0in;line-height:150%;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;'\u003eTable 3.\u003c/span\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;font-weight:normal;'\u003e\u0026nbsp;ITS results of Fisher Price Index for winning and non-winning products.\u003c/span\u003e\u003c/span\u003e\u003c/h2\u003e\n\u003ctable style=\"width:100.0%;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:27.38%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eItem\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:11.94%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eCoef.\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:10.92%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eS.E\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:12.62%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003et\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:13.26%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003ep\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-value\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:23.86%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e95% \u003cem\u003eCI\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:11.94%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eLower\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.92%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eUpper\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:27.38%;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;text-indent:0in;line-height: normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eWinning products\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.94%;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.92%;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:12.62%;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.26%;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.94%;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.92%;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:27.38%;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:5.5pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eBaseline level, \u0026beta;\u003csub\u003e0\u003c/sub\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.94%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.535\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.92%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.025\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.62%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e21.180\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.26%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.000\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.94%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.481\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.92%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.589\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:27.38%;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:5.5pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eBaseline trend, \u0026beta;\u003csub\u003e1\u003c/sub\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.94%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.029\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.92%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.006\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.62%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-5.240\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.26%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.000\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.94%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.041\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.92%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.017\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:27.38%;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:5.5pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eLevel change, \u0026beta;\u003csub\u003e2\u003c/sub\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.94%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.183\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.92%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.030\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.62%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-6.050\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.26%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.000\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.94%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.248\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.92%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan 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style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.041\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:27.38%;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eNon-winning products\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.94%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New 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style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.26%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.94%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n 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none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.491\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.92%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.010\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.62%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e49.150\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.26%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.000\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.94%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.470\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.92%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.513\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:27.38%;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:5.5pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eBaseline 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12.62%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.500\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.26%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.628\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.94%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.006\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.92%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.004\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:27.38%;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:5.5pt;line-height:normal;font-size:16px;font-family:\"Times New 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style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.015\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.62%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-2.190\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.26%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.046\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:5.5pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eTrend change, \u0026beta;\u003csub\u003e3\u003c/sub\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.94%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.003\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.92%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.003\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.62%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-1.170\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.26%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.262\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.94%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.010\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.92%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.003\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ch2 style='margin:0in;text-align:justify;text-indent:0in;line-height:150%;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;'\u003eTable 4.\u003c/span\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;font-weight:normal;'\u003e\u0026nbsp;ITS results of Fisher Price Index for centralized purchased drugs and alternative drugs.\u003c/span\u003e\u003c/span\u003e\u003c/h2\u003e\n\u003ctable style=\"width:100.0%;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:28.06%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eItem\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:11.56%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eCoef.\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:10.58%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eS.E\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:13.86%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003et\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:12.84%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003ep\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-value\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:23.1%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e95% \u003cem\u003eCI\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:11.56%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eLower\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.54%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eLower\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:28.06%;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eCP drugs\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.56%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.58%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.86%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.84%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.56%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.54%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:28.06%;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:5.5pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eBaseline level, \u0026beta;\u003csub\u003e0\u003c/sub\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.56%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.498\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.58%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.015\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.86%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e33.670\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.530\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:28.06%;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:5.5pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eBaseline trend, \u0026beta;\u003csub\u003e1\u003c/sub\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.56%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.005\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.58%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.004\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.86%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-1.470\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.84%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.164\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.56%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.013\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.54%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.002\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:28.06%;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:5.5pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eLevel change, 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13.86%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-15.480\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.84%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.000\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.56%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.395\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.54%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.299\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:28.06%;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:5.5pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eTrend change, \u0026beta;\u003csub\u003e3\u003c/sub\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.56%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.58%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.004\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.86%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.310\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.84%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.761\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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style='margin:0in;text-align:left;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eAlternatives\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.56%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.58%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.86%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.84%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.56%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.54%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n 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none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.004\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.86%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e115.580\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.84%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.000\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.56%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.485\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.54%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.503\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:28.06%;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:5.5pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eBaseline trend, \u0026beta;\u003csub\u003e1\u003c/sub\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.56%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.58%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.86%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-1.270\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.84%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.225\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.56%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.004\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.54%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:28.06%;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:5.5pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eLevel change, \u0026beta;\u003csub\u003e2\u003c/sub\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.56%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.004\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.58%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.007\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.86%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.630\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.84%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.537\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.56%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.010\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.54%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.018\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:28.06%;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:5.5pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eTrend change, 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13.86%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-2.790\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.84%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.014\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.56%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.006\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.54%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.001\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:28.06%;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eOverall\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.56%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.58%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.86%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.84%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.56%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.54%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:28.06%;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:5.5pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eBaseline level, \u0026beta;\u003csub\u003e0\u003c/sub\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.56%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.495\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.58%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.011\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.86%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e44.240\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.84%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.000\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.56%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.471\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.54%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.519\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:28.06%;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:5.5pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eBaseline trend, \u0026beta;\u003csub\u003e1\u003c/sub\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.56%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.003\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.58%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.003\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.86%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-1.070\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.84%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.303\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.56%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.009\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.54%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.003\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:28.06%;border:none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:5.5pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eLevel change, \u0026beta;\u003csub\u003e2\u003c/sub\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.56%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.261\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.58%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.017\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.86%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-15.020\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.84%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.000\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.56%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.298\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.54%;border: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.223\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:28.06%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:5.5pt;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003eTrend change, \u0026beta;\u003csub\u003e3\u003c/sub\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.56%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.004\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.58%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.003\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.86%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-1.150\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.84%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.268\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.56%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e-0.011\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.54%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:right;text-indent:0in;line-height:normal;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style='font-size:15px;font-family:\"Calibri\",sans-serif;'\u003e0.003\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 15px; line-height: 150%; font-family: Calibri, sans-serif; color: rgb(0, 0, 0);\"\u003eNote: CP, centralized purchased.\u003c/span\u003e\u003c/p\u003e"},{"header":"Supplementary Table","content":"\u003ch2 style='margin:0in;text-align:justify;text-indent:0in;line-height:150%;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;'\u003eTable A1.\u003c/span\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;font-weight:normal;'\u003e\u0026nbsp;List of included drugs in this stuwdy.\u003c/span\u003e\u003c/h2\u003e\n\u003ctable style=\"width:100.0%;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:23.54%;border:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:24.1pt;line-height:120%;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:15px;line-height:120%;font-family:\"Calibri\",sans-serif;'\u003eDrug Group\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.46%;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:24.1pt;line-height:120%;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:15px;line-height:120%;font-family:\"Calibri\",sans-serif;'\u003eVarieties\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:23.54%;border:solid windowtext 1.0pt;border-top: none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:120%;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:15px;line-height:120%;font-family:\"Calibri\",sans-serif;'\u003eCP drugs\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.46%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:0in;line-height:120%;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:15px;line-height:120%;font-family:\"Calibri\",sans-serif;'\u003eirbesartan and hydrochlorothiazide, irbesartan, losartan, montmorillonite, entecavir, cefuroxime, pemetrexed, atorvastatin, imatinib, olanzapine, escitalopram, fosinopril, enalapril, montelukast, rosuvastatin, lisinopril, risperidone, paroxetine, gefitinib, levetiracetam, clopidogrel, dexmedetomidine, tenofovir, amlodipine, flurbiprofen\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:23.54%;border:solid windowtext 1.0pt;border-top: none;padding:0in 5.4pt 0in 5.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;text-indent:0in;line-height:120%;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:15px;line-height:120%;font-family:\"Calibri\",sans-serif;'\u003eAlternative drugs\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.46%;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:left;text-indent:0in;line-height:120%;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:15px;line-height:120%;font-family:\"Calibri\",sans-serif;'\u003eadefovir, aspirin, oxcarbazepine, valproate, quetiapine, carbamazepine, captopril, lamivudine, risperidone, nilotinib, nitrendipine, cefprozil, cefaclor, cefixime, nifedipine, simvastatin, xuezhikang, icotinib, cefuroxime, chlorpromazine, haloperidol, fluoxetine, penfluridol, indomethacin, venlafaxine, perphenazine, sulpiride, cefalexin, cefdinir, afatinib, telmisartan, fluvastatin, candesartan, perindopril, sertraline, tiapride, lamotrigine, felodipine, aripiprazole, amlodipine and atorvastatin, valsartan, ticagrelor, losartan potassium and hydrochlorothiazide, valsartan and amlodipine, perindopril and indapamide\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;text-align:justify;text-indent:0in;line-height:150%;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-size:15px;line-height:150%;font-family:\"Calibri\",sans-serif;'\u003eNote. CP, centralized purchased.\u003c/span\u003e\u003c/p\u003e\u003cbr\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-public-health","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"pubh","sideBox":"Learn more about [BMC Public Health](http://bmcpublichealth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/pubh/default.aspx","title":"BMC Public Health","twitterHandle":"@BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"National Centralized Drug Procurement, \"4+7\" policy, drug price, interrupted time series, volume-based procurement.","lastPublishedDoi":"10.21203/rs.3.rs-403627/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-403627/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eBackground: The Chinese government implemented the first round of National Centralized Drug Procurement (NCDP) pilot (so-called \"4+7\" policy) in mainland China in 2019. Under cross-price elasticity theory, the price behavior of pharmaceutical enterprises for policy-related drugs might change. This study aims to examine the impact of \"4+7\" policy on the price of policy-related drugs.\u003c/p\u003e\u003cp\u003eMethods: This study used drug purchasing order data from the Centralized Drug Procurement Survey in Shenzhen 2019, covering 24 months from January 2018 to December 2019. Eighty-two drugs (by generic name) were selected as study samples, including \"4+7\" policy-related drugs (consisted of winning and non-winning products) and alternative drugs. Single-group Interruption Time Series (ITS) analysis was adopted to examine the change of Drug Price Index (DPI) for policy-related drugs.\u003c/p\u003e\u003cp\u003eResults: The ITS analysis showed that the DPI of winning (-0.183 per month, p\u0026lt;0.0001) and non-winning (-0.034 per month, p=0.046) products significantly decreased after the implementation of \"4+7\" policy. No significant difference was found for the immediate change of DPI for alternative drugs (p=0.537), while a significant decrease in change trend was detected in the post-\"4+7\" policy period (-0.003 per month, p=0.014). The DPI of the overall policy-related drugs significantly decreased (-0.261 per month, p\u0026lt;0.0001) after \"4+7\" policy.\u003c/p\u003e\u003cp\u003eConclusions: These findings indicate that the price behavior of pharmaceutical enterprises changed under NCDP policy, while the price linkage effect is still limited. It is necessary to further expand the scope of centralized purchased drugs and strengthen the monitoring of related drugs regarding price change and consumption structure.\u003c/p\u003e","manuscriptTitle":"Influence of Chinese National Centralized Drug Procurement on the price of policy-related drugs: an interrupted time series analysis","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2021-04-09 22:23:53","doi":"10.21203/rs.3.rs-403627/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Major revision","date":"2021-09-08T13:13:26+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2021-07-12T21:14:30+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"d041d2b9-40d7-4b7d-b88d-e5b0bcca0265","date":"2021-06-19T18:44:38+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2021-05-25T17:37:52+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"b9a8ed07-e696-4068-a10c-ac265e356ff2","date":"2021-05-01T02:27:03+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2021-04-28T02:09:29+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2021-04-28T01:58:29+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2021-04-19T07:13:05+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2021-04-19T06:54:58+00:00","index":"","fulltext":""},{"type":"submitted","content":"BMC Public Health","date":"2021-04-09T03:36:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-public-health","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"pubh","sideBox":"Learn more about [BMC Public Health](http://bmcpublichealth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/pubh/default.aspx","title":"BMC Public Health","twitterHandle":"@BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"88220291-6645-43b6-acd7-944bd26aa0f8","owner":[],"postedDate":"April 9th, 2021","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[{"id":3542836,"name":"Health Economics \u0026 Outcomes Research"},{"id":3542837,"name":"Health Policy"}],"tags":[],"updatedAt":"2021-09-28T16:59:09+00:00","versionOfRecord":[],"versionCreatedAt":"2021-04-09 22:23:53","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-403627","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-403627","identity":"rs-403627","version":["v1"]},"buildId":"ApUGefWb6u5IBVtyqm6d5","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}