The Expression of P450arom in Human Ovarian Endometriosis and its Eutopic

Objective To study the expression of P450arom (P450A) protein and mRNA in human ovarian endometriosis, eutopic and normal endometrium. Methods PT - PCR was used to assess P450arom messenger RNA(mRNA) expression of 45 ovarian endometriosis and 35 normal eutopic endometrium; immunohistochemical assay was performed to locate and examin the protein expression of P450arom in the above cases. Results P450A mRNA level was higher in the ectopic endometrium than that in eutopic endometrium( P 0.01) ; P450A mRNA was present in only 2 of 35 normal uterine endometrium samples; The expression characteristic of P450A protein is the same as one of P450A mRNA in ectopic endometrium. Conclusion The abnormal expression of P450arom probably play an important role in the development and growth of endometriosis.