Transient heat transfer in human endometrium during cryoablation

This paper presents an experimental study and numerical prediction of the transient heat transfer behavior inside the uterus during application of a PFC fluid into the endometrium cavity in order to achieve cryoablation. The numerical prediction is based on a 1-D finite difference method of the bio-heat equation using the Crank Nicolson scheme. The numerical method is first validated by a 1-D physical model by measuring temperature history at several locations within a silicone rubber sheet. Good comparisons are obtained by comparing numerical predictions with the experimental data obtained from eight intact, hysterectomized uteri during cryoablation.