OP07.05: Recurrence rate after ultrasound‐guided transvaginal aspiration of benign adnexal masses with and without sclerotherapy: a systematic review and meta‐analysis

To determine the pooled recurrence rate of benign adnexal masses/cysts (namely simple cyst, endometrioma, hydrosapinx, peritoneal cyst) after transvaginal ultrasound-guided aspiration, with or without sclerotherapy. A search of studies published in PubMed and Web of Science (WoS) databases between January 1990 and December 2020. A systematic search strategy was done using medical subject heading (MeSH) terms. Only randomised trials and prospective studies published in English language were included. A total of 395 papers were identified. After applying inclusion and exclusion criteria, 20 studies were included in this review comprising data from 1420 patients. The overall pooled rate of recurrence of adnexal masses was 27%, (CI 95%: 18-39%). Recurrence rate was significantly higher after only aspiration than after sclerotherapy (53%, CI 95%: 46-60%, vs 14%, CI 95%: 8-22%, p < .0001). However, a high heterogeneity across the studies was found. 10 major complications were recorded in the different publications. Only 1 cyst was positive for malignancy cells in a patient with previous records of ovarian cancer. In selected population, aspiration with sclerotherapy has a lower recurrence rate as compared without sclerotherapy. However, these results should be interpreted with caution given the heterogeneity of the studies.