Efficacy of Neuromodulation Therapy for Neuropathy Symptom Reduction and Functional Improvement

Background: /Objectives: Targeted neuromodulation therapies are increasingly used for the management of peripheral neuropathy; however, data on symptom and functional outcomes following standardized treatment courses remain limited. This report evaluates the efficacy of NeoGen Neuromodulation treatments administered at the National Neu-ropathy Center, focusing on changes in sensory symptoms and functional task perfor-mance from the first treatment (T1) to the twelfth treatment (T12) over a mean treatment duration of 36 sessions. Methods: Patients completing a standardized 12-treatment course using the NeoGen Neuromodulation device were analyzed. Outcomes included pa-tient-reported sensory symptoms (tingling, numbness, and pain) and measures of func-tional task performance. Changes from baseline (T1) to post-treatment (T12) were assessed to determine treatment effectiveness, response patterns, and areas for clinical optimiza-tion. Results: Patients demonstrated clear and measurable benefits following completion of 12 treatments. The greatest improvements were observed in sensory symptoms, with tingling, numbness, and pain each improving by approximately one point on the se-verity scale. Over half of patients achieved clinically meaningful relief in these sensory domains. Functional improvement was more modest, with meaningful gains observed in approximately one-quarter to one-third of patients. Non-response rates were low, alt-hough residual symptoms and functional limitations remained common. Conclusions: The standard NeoGen Neuromodulation treatment protocol provides substantial relief of sensory neuropathic symptoms, with consistent benefits across patients. While functional gains were less pronounced, the low non-response rate supports overall treatment ef-fectiveness. Persistent symptoms in some patients suggest a potential role for maintenance therapy and adjunctive interventions to optimize long-term outcomes.