Optimized Fabrication and Enhanced Flexural Properties of PCL/F-BG Nanocomposites for Hard Tissue Engineering

Optimized Fabrication and Enhanced Flexural Properties of PCL/F-BG Nanocomposites for Hard Tissue Engineering | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Optimized Fabrication and Enhanced Flexural Properties of PCL/F-BG Nanocomposites for Hard Tissue Engineering Sanaz Toorani, Majid Sohrabian, Mahmood Sameezadeh, Mohadeseh Khalafi This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6641347/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 04 Nov, 2025 Read the published version in Journal of Polymers and the Environment → Version 1 posted 18 You are reading this latest preprint version Abstract To achieve bio-composites with optimal mechanical properties while considering biological aspects, neat PCL and PCL nanocomposites incorporating 15%, 27%, 30%, 32%, and 45% APTES-functionalized bioactive glass (F-BG) were developed using an innovative solvent casting method. The predominant particle size of 55 nm ensured well-distributed, non-agglomerated particles within the composites. Fine flexural specimens were prepared via melt molding with a hot press for mechanical property evaluations. Flexural testing revealed that the PCL/32% F-BG samples exhibited the highest flexural strength (25.8 MPa), whereas the PCL/45% F-BG samples showed the greatest flexural elastic modulus (1793 MPa). Consequently, PCL/32% F-BG was identified as the sample with optimal mechanical properties. Microstructural analysis of the samples and the fractography analysis were performed using FESEM and SEM, confirming the well-dispersed BG nanoparticles within the polymer matrix. To ensure comprehensive evaluations beyond mechanical properties, hydrophilicity tests, weight loss measurements, absorbed water, and pH changes were conducted over 3, 7, 14, and 28 days within the framework of degradation tests. Additionally, cytotoxicity tests were conducted over 24, 48, and 72 hours using mouse embryonic fibroblast cells (NIH3T3), enabling thorough assessments. PCL/F-BG nanocomposite flexural properties microstructure solvent casting polymer matrix nanocomposite Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 1. Introduction Achieving maximum mechanical properties in composites has widespread applications across various industries, from adhesive [ 1 ] and sealant [ 2 ] uses to other areas. In tissue engineering, the enhancement of the mechanical properties of polymer scaffolds is possible through various methods: by improving the materials via polymer composite creation [ 3 ], through the optimal selection of the best scaffold geometry [ 4 ], by optimizing and selecting appropriate manufacturing parameters [ 5 , 6 ], or even by thermal annealing treatments [ 7 ]. Over recent decades, aliphatic polyesters like Poly L-lactide (PLLA), Polycaprolactone (PCL), Poly Lactic-co-Glycolic Acid (PLGA), and Poly lactide-co-ε-caprolactone (PLCL) have been utilized in tissue engineering because of biodegradability and biocompatibility [ 8 – 13 ]. In recent years PCL has drawn renewed interest due to its remarkable properties, which make it suitable for various medical uses, particularly in tissue engineering. PCL is a semi-crystalline polymer with the chemical formula (C 6 H 10 O 2 ) n , known for its non-toxic nature, slow degradation rate, and high flexibility [ 14 , 15 ]. Excellent rheological and viscoelastic behavior of PCL allows for its easy processing into various medical implant forms. Most importantly, the biocompatibility of PCL is outstanding and is a significant requirement for scaffolds. Besides, it has tunable degradation rates; hence, it can be designed for specific functions and anatomical environments. In tissue engineering, PCL can act as the scaffold material for repairing and regenerating bone, cartilage, and other tissues. Among the merits that set PCL apart, one of the major ones is its relatively slow degradation rate compared to PLA and PGA. This makes PCL suitable for long-term drug delivery systems requiring controlled and sustained release. This property is very useful for medications whose therapeutic action must be prolonged. Moreover, PCL has demonstrated high permeability to small medicinal compounds, improving the solubility and bioavailability to enhance drug delivery performance. [ 16 , 17 ]. Several PCL-based drug delivery systems have received FDA approval, facilitating transition from laboratory research to clinical use. Its incorporation in drug delivery systems has proven effective, especially in cancer treatment, by enabling targeted therapy [ 18 ]. PCL has superior mechanical properties including flexibility and tensile strength, which surpass those of many other biodegradable polymers, making it versatile for various applications [ 16 ]. PCL has been effectively employed in 3D printing technologies, enabling the fabrication of complex structures for various biomedical applications [ 17 ]. It has excellent toughness, flexibility and easy fabrication. However, it has limitations in bone regeneration applications due to its low stiffness, hydrophobic nature, and lack of inherent biological activity [ 8 , 9 , 19 – 22 ]. PCL received FDA approval, but its use was briefly suspended due to its degradation time (3–4 years). PCL has low mechanical properties comparing to the host bone tissues which is addressed by reinforcing it with stiffener additives like bioactive glass (BG) to improve its mechanical properties. The addition of BG nanoparticles enhances both mechanical and biological characteristics. Without any reinforcement, PCL exhibits poor flexural properties [ 1 , 2 ]. As PCL is a biocompatible polymer with a low melting point, its mechanical properties are insufficient. Therefore, compositing it with BG can enhance its strength [ 23 – 25 ]. Addition of nanoparticles enhances not only mechanical characteristics but also solubility, melting point (59–64°C) and elasticity. Biodegradable polymer/BG composites, often used in scaffold, have been extensively researched for potential use in hard tissue regeneration due to favorable biocompatibility and bioactivity [ 21 , 22 ]. BG and its well-known type 45S5, can form strong bonds with bone tissue, significantly enhancing the integration and regeneration of hard tissues [ 26 ]. The composition of BG nanoparticles (nBG) enhances interaction with biological systems, which in turn promotes improved angiogenesis and osteogenesis [ 27 ]. The degradation kinetics of BGs align more closely with the rate of new tissue formation, enhancing integration and functional healing of bone defects. Additionally, the alkalinity of BG helps neutralize the acidic environment caused by polymer degradation, maintaining a favorable condition for cell growth and tissue regeneration [ 27 , 28 ]. It can also be used in dental implants, both in scaffolds and coatings, improving osseointegration in dental applications. With the possible release of bioactive ions and their stimulation of bone formation combined with antibacterial properties, they are considered a very promising solution for various dental procedures, including periodontal disease treatment and implant positioning [ 27 ]. The addition of BG into the composites has been proven to significantly enhance cell attachment and viability; there are many reports of higher than 70% cell viability within BG-containing biocomposites. The addition of BG particles usually increases the tensile strength and elastic modulus of polymer matrices, as reported in natural rubber-based composites [ 29 ]. BG composites demonstrate superior mechanical properties compared to conventional fillers, making them highly suitable for load-bearing applications [ 30 ]. Polymer nanocomposites, such as PCL/BG, are increasingly used as biodegradable materials in medical applications due to need for strong mechanical properties and high biocompatibility .[ 23 – 25 ] Despite the addition of bioactive particles like hydroxyapatite and BG, the mechanical properties of PCL composites still do not fully imitate the behavior of human bone [ 31 , 32 ]. Therefore, enhancing the mechanical properties of the composite to achieve maximum mechanical performance and approximating the mechanical properties of bone is crucial and inevitable. The use of BG nanofillers has become a promising approach in development of bio-composites. Compared to micro-fillers, BG nanofillers, with larger specific surface area, significantly enhance the bioactivity of organic and polymer-based composites, resulting in nanostructured composites with superior properties [ 33 ]. Tamjid et al. [ 34 ] fabricated a PCL composite containing 50 wt% BG particles, with particle sizes of 6 µm, 250 nm, and less than 100 nm, using the solvent casting method. They found that the 250 nm BG particles improved the bioactivity of the PCL polymer film. Addition of BG particles significantly enhanced the strength of the PCL/BG composite, and 100 nm particles had the most pronounced effect on mechanical strength. Similarly, Li et al. [ 35 ] prepared PCL/BG composite by the solvent casting method. They used 10 wt%, 20 wt%, and 30 wt% of BG in PCL. The neat PCL and 10% BG-loaded composite evidenced a ductile behavior characterized by remarkable elongation; on the other hand, 20% and 30% BG-loaded composites presented low values of toughness. It could be clearly observed that the elastic modulus increases as the amount of BG increases. Biocompatibility was enhanced with an increase in the concentration of BG. Moreover, spherical and finer BG particles contributed to greater increases in the elastic modulus. Sohrabian et al. demonstrated the effects of BG particle size and concentration on the composite’s mechanical properties [ 3 ], as well as the positive influence of APTES surface modification on enhancing mechanical properties and delaying the decline caused by agglomeration [ 36 ], using molecular dynamics simulations. Chen Zhang et al. [ 37 ] It also employed PCL and different concentration levels of 63s BG for the fabrication of PCL scaffolds by twin-screw extrusion and 3D printing. Indeed, they found enhanced mechanical properties with higher BG content; however, the final strength was below that of cortical bone. Addition of BG microspheres significantly improved elastic modulus of PCL composites, indeed showing good correspondence of filler content with mechanical strength [ 35 ]. Incorporation of nanosized BGs significantly enhanced the mechanical properties of PCL, particularly at low filler loadings, which could be ascribed to the strong interfacial interactions between nanofillers and polymer matrix. [ 38 ]. PCL composites containing BG exhibited increased hydrophilicity and enhanced apatite formation, both of which are vital for bone tissue regeneration [ 34 , 35 ]. In the present study, a completely new and accurate method of composite fabrication was carried out with due care. It involved the preparation of surface-modified nanosized BG particles by dissolution and uniform dispersion, avoiding particle agglomeration during fabrication by comprehensive stirring and appropriate sonication. The resulting nanocomposite exhibited significantly improved mechanical properties compared to those reported in previous researches. Various composite samples with different loadings of F-BG were fabricated and compared to determine the optimal composite with the best mechanical properties. The selection of flexural tests for fabricated samples, as an evaluation of the mechanical behavior of manufactured materials, is due to the presence of both tensile and compressive behavior within the flexural loading. To address common challenges like microcracks that often occur during flexural specimens machining, the melt molding technique was employed. This method enhanced fabrication precision and improved the overall quality of the produced samples. In addition to flexural tests, the microstructural, hydrophilic, degradation, and biological properties of PCL/F-BG (functionalized BG) nanocomposites were systematically analyzed. 2. Materials and Methods 2.1. Fabrication: The Sigma-Aldrich PCL of medical grade is used in this study, with the density of 1.145 g/ml and an average molecular weight of 80,000 g/mol. Additionally, the BG nanoparticles are also of medical grade 45S5 and surface modified with APTES (3-amino propyl triethoxysilane), a coupling agent that enhances bonding between bio-ceramic particles and polyester polymers. To reduce the size of the F-BG nanoparticles, mechanical grinding was performed. F-BG powder was ground using alumina balls for 30 minutes. After grinding, the nanoparticle size was analyzed using dynamic light scattering (DLS), but the size remained relatively large. Therefore, the F-BG powder was subjected to a drying procedure in vacuum oven at 70°C for 24 hours, followed by 24 hours at ambient temperature under vacuum. Additionally, nanoparticles were further ground for 7 minutes using an alumina-based hand grinder prior to composite preparation. After grinding, the nanoparticles were mixed with dichloromethane and the immersed powder was left for over 24 hours. They were then dispersed using ultrasonication for 15 minutes (in three intervals of 5 minutes) to break up potential agglomerates. For producing the solution neat samples, the dried PCL granules (25 minutes in 40°C) were added to dichloromethane to create a mixture containing of 10% PCL and 90% dichloromethane [ 14 , 35 , 39 ]. This mixture was stirred on a magnetic stirrer for 24 hours, during this period, 100 ml of the dichloromethane evaporated, so the evaporated volume was replenished, and the uniform solution was stirred for an additional 30 minutes. In order to produce the nanocomposite materials, the prepared F-BG nanoparticles were added to the PCL solution separately at weight ratios of 15%, 30%, and 45% as the first group and 27% and 32% as the second group (according to the output results). After adding nanoparticles to the PCL solution based on specified amount, stirring was continued for an additional 4 to 5 hours, followed by two cycles of 3-minutes sonication for resolving of possible formed aggregations. The solution was then stirred for an additional 20 hours (Fig. 1 ). As the dichloromethane evaporated, the lost volume was replenished before performing three more cycles of 3-minutes sonication. The mixture was further stirred on a magnetic stirrer for 30 minutes, then poured into petri dishes and left at room temperature for 4 hours to allow evaporation of the solvent. Finally, the samples were placed in a vacuum oven for 24 hours at room temperature under vacuum to ensure full evaporation of the remained solvent. Images of neat PCL and PCL/F-BG nanocomposites are shown in Fig. 2 (a-f). As it can be seen in Fig. 3 (a), the flexural test specimens mold was designed according to ASTM D790-17 (2 mm x 12.7 mm x 50 mm). The produced nanocomposite films were chopped, weighted and filled the cavities in the flexural test specimen mold. Thereafter they were subjected to hot pressing at temperatures of 180°C and 220°C for fabrication of flexural test specimens as illustrated in Figure. 3 (b). 2.2. Flexural Tests Flexural tests were conducted with three replicates for each case and with strain rate of 5 mm/min based on the mentioned standard. 2.3. Scanning Electron Microscope (SEM): To analyze the microstructure of the samples, SEM model VEGA/TESCAN-LMU, was employed. 2.4. Hydrophilicity Tests Hydrophilicity is a crucial factor for biomaterials and is a physical property that allows the material to temporarily form hydrogen bonds with water. This property increases liquid penetration across its wetted surface. This property is quantified using Young's equation, which measures the contact angle of a water droplet on the material's surface. For these bio composites, enhanced hydrophilicity is associated with improved biological performance and favorable outcomes. Hydrophilicity refers to the tendency of a substance to attract water, and this characteristic can significantly influence the behavior of cells in contact with the substance's surface. The hydrophilicity of materials plays a crucial role in cell adhesion to these surfaces. 2.5. Biodegradability Tests To assess the degradability of neat PCL and PCL/F-BG nanocomposites intended for internal body applications, biodegradability tests were conducted in accordance with the ISO 10993-13 standard. Bulk specimens with dimensions of 8 mm x 8 mm x 1 mm were sterilized using UV radiation for 10 minutes on each side and were immersed in 10 ml of phosphate-buffered saline (PBS) solution at 37°C with a pH of 7.4. The use of bulk material specimens, differing from the commonly employed porous scaffold forms in other research, was intended to ensure that the influencing and evaluated parameter was solely the material type. This approach allows for an accurate assessment of the material itself, without the influence of porosity, specific surface area, shape differences in printing, and potential hidden defects from scaffold fabrication and printing. It also avoids the complexities of scaffold structural failure impacting the interpretation of results, ensuring that these factors do not affect the material's degradation behavior. The samples which are demonstrated in Fig. 4 , were placed in an orbital shaker which set at 90 rpm and examined over periods of 3, 7, 14, 21, and 28 days, with at least three samples for each time point. At each interval, the samples were removed from the solution and the weight loss were calculated according to Equations (1) and (2). W A % = [(𝑊 𝑤 − 𝑊 𝑑 )/𝑊 𝑑 ] × 100 (1) W L % = \(\:{[W}_{i}-{W}_{d}]/{W}_{i}\:\times\:\:\) 100 (2) W A is weight of absorbed water, W w is wet weight, Subsequently, the samples were rinsed with distilled water and dried in vacuum condition at 37°C for 24 hours to determine dry weight (W d ). W L is weight loss and W i is initial weight. To maintain a constant pH level, the PBS solution was changed and refreshed weekly. To monitor pH changes, three samples tested over the three-day period were placed back into the same solution until the end of the experiment, ensuring that the solution was not replaced during the period. 2.6. Cytotoxicity Tests The MTT assay is a widely used method to assess cell viability by measuring the toxicity of substances. It distinguishes between live and dead cells by examining the impact of compounds on cellular organelles. Mouse embryonic fibroblast cells (NIH3T3) were obtained from the Roshd Azma Company, Karaj. The cells were maintained at 37°C in a humidified environment with 5% CO2 using a mixture of DMEM/F12 culture medium supplemented with 5% fetal bovine serum, penicillin G, and streptomycin (100 mg/L). Cytotoxicity was assessed using the MTT assay, in accordance with the ISO 10993 standard. PCL/F-BG samples at concentrations of 27% and 32%, along with the neat samples, were fabricated into circular shapes with a cross-sectional area of 0.32 cm². Each sample was replicated three times. Following UV sterilization, the samples were placed into the wells of a 96-well plate. NIH3T3 cell line cells were cultured at a density of 1 × 104 cells/well and the microplate was incubated at 37°C in an atmosphere of 5% CO2. After 24, 48, and 72 h of incubation, 10% MTT dye solution was prepared in the culture medium, and 100 µl was pipetted into each well, followed by two additional hours of incubation. The medium was then removed and the formazan crystals in the living cells were dissolved in dimethyl sulfoxide (DMSO). The absorbance at 570 nm was measured using an ELISA reader (BioRad, US), and the percentage of cell viability was calculated using GraphPad prism software. 3. Results and Discussion 3.1. BG Size Distribution Field Emission Scanning Electron Microscopy (FESEM) images of the milled F-BG and the resulted particle size distribution chart is shown in Fig. 5. The particle distribution chart reveals that the predominant particle size is approximately 55 nm, indicating the success of achieving a small particle size with a high population density centered around 55 nm. The spherical shape, surface modification, and small size of BG particles facilitate dispersion within the polymer matrix, resulting in the enhancement of composite mechanical properties. 3.2. Mechanical Properties The results of the flexural tests on neat PCL and PCL/F-BG nanocomposites are shown in Fig. 6. As expected, an increase in the concentration of F-BG particles led to a significant improvement in both strength and elastic modulus of the composite. As previously mentioned, six points and states were used for sampling and evaluating the composite to identify and extract the general trend and behavioral path of the materials. In the first stage, sampling was conducted at four points: 0%, 15%, 30%, and 45%, and the mechanical properties were tested. Based on the mechanical properties obtained at each state, two additional points with finer grids, 27% and 32%, were selected on either side of the maximum point of the first stage (30%). These were chosen for the second stage to complete and enhance the quality of the results and analyses, enabling us to find the composite with the best mechanical properties. The mechanical properties derivatives elastic modulus and strength were extracted and gathered in Figs. 6 (a) & (b) respectively. Generally, the uneven distribution of nanoparticles within the composite results in variability in mechanical properties (the issue which can be seen in standard deviation of the composite containing 45% F-BG). However, the methodology applied for the composite fabrication in the current study could postpone the occurrence of this weakening effect of agglomeration at higher concentrations of reinforcement particles, allowing them to play strengthening role within the composite. This phenomenon is more likely to occur with the BG nanoparticles used in this study due to very small size and consequently high specific surface area and surface energy. This issue has been effectively addressed by surface modification of the particles and various processes to prevent agglomeration both before and after composite fabrication. Thus, the benefits of reducing the particle size can be maximized for enhancing the mechanical properties of the composite. The composites’ strength trend shows that increasing the amount of F-BG nanoparticles up to 32% enhances the flexural strength, but beyond this threshold, the flexural strength starts to decline significantly. This behavior can be attributed to the distribution challenges and agglomeration of BG nanoparticles within the polymer matrix composite (in B45 sample) which inhibits maximizing F-BG reinforcing effects. The formation of larger agglomerates of clustered particles leads to stress concentration sites, initiating cracks and subsequent fractures under load. This phenomenon reduces the flexural strength of the composites. However, the elastic modulus, being measured at low strain levels, is less affected by this phenomenon. The increase in the amount of the added ceramic component with a higher elastic modulus, results in a higher overall elastic modulus of the composite. Therefore, the more ceramic reinforcing particles are added to the composite, the higher the flexural elastic modulus of the samples, as observed in the Fig. 6(a). Despite the challenges of agglomeration, both the overall strength and elastic modulus of PCL/F-BG nanocomposites were significantly higher than those of neat PCL. This is illustrated in the Fig. 6, which shows a substantial and significant rise in mechanical properties from the neat polymer to the B32 sample. This demonstrates the effectiveness of F-BG nanoparticles as reinforcing agents and the composite fabrication procedure in improving the strength and elastic modulus of PCL, thereby enhancing the mechanical properties and obtaining superior characteristics. The PCL/32% F-BG sample exhibited the highest flexural strength (25.8 MPa), whereas the PCL/45% F-BG sample showed the highest elastic modulus (1793 MPa), surpassing the second-grade composite PCL/32% F-BG sample. Therefore, the PCL/32% F-BG sample can clearly be selected as having the best mechanical properties characteristics. 3.3. Microstructural Investigations For optimal performance of the PCL/F-BG nanocomposite, the polymer matrix must meet several criteria. These include shape and dimensional stability, proper distribution of reinforcements, mechanical and thermal stability, effective load transfer to the reinforcements, and chemical and physical stability, especially in biological environments. Microstructural images of neat PCL and PCL/F-BG nanocomposites, shown in Fig. 7 (a-f), were obtained from the fracture surfaces after the flexural test to evaluate both the fractography of the samples and to simultaneously examine the dispersion and morphology of the additive particles. The images of neat PCL and even to some extent PCL/15% F-BG shows some stretch fibrils on the fracture surfaces indicating a ductile fracture mode (shown in yellow circles), whereas, the serrated and sharp fracture lines formed on the fracture surfaces of high loadings of ceramic additives like 30%-45% demonstrate the brittle fractures (shown in green circles). As the proportion of additive particles increases, sharper fracture angles and voids become evident, indicating a shift toward brittle fracture behavior. Microscopic observations reveal that BG nanoparticles are nearly uniformly dispersed within the polymer matrix; however, this uniformity diminishes as the concentration of nanoparticles rises, leading to more agglomeration, particularly at higher F-BG percentages from 15–45% in the PCL/F-BG nanocomposites. Particle accumulation can serve as initiation points for fractures. The agglomerated particles, highlighted in pink circles in the images taken from the fractured surfaces of the specimens, do not appear to be very large in size. Surface modification of BGs enhances the interactions between particles and the polymer chains of the matrix, leading to improved mechanical properties of the PCL matrix. As indicated by the blue circles, some of the F-BGs extended beyond the fracture surface, demonstrating the bridging mechanism and the formation of a connection between the upper and lower surfaces of the crack by the particles during failure. This mechanism, resulting from the strong bonding between particles and polymer chains, contributed to an increase in flexural strength. The bridging particles were eventually pulled out from the upper or lower crack surfaces following interfacial debonding due to the applied stress. Upon the removal of BGs, an empty cavity remained in the fracture surface. The pores, highlighted by red arrows in Fig. 7, indicating the spaces left by the particles due to debonding and pull-out. Actually, there is a significant difference in surface energy between bio-ceramics and polymers. The high surface energy of the nanoparticles, resulting from large specific surface area, increases propensity for agglomeration. As a result, the reinforcing nanoparticles in polymer matrix composites tend to cluster together, forming interconnected networks. The Van der Waals forces among the nanoparticles further contribute to this agglomeration, hindering effective dispersion and limiting functionality within the composite [ 40 , 41 ]. The tendency for agglomeration also increases the viscosity of the polymer/nanoparticle mixture, which can impede the uniform distribution of nanoparticles within the polymer matrix and trap air bubbles formed during mixing. While BG nanoparticles can enhance the mechanical properties of the PCL polymer, achieving a consistent distribution remains a challenge. Optimal dispersion is observed mostly in the PCL/32% F-BG samples. 3.4. Hydrophobicity behavior Hydrophilicity test results for neat PCL and PCL/ F-BG nanocomposites are shown in Table 1 . Neat PCL exhibits a higher contact angle, indicating lower hydrophilicity compared to the PCL/ F-BG nanocomposites. This result highlights the influence of BG nanoparticles with hydrophilic properties. The PCL/15% F-BG nanocomposite has the highest wetting angle among the composites. As expected, with the increasing loadings of nanoparticles, the contact angle decreases, making the nanocomposites more hydrophilic [ 42 ]. The wetting angle continues to decline with the addition of BG nanoparticles, reaching its lowest value and highest hydrophilicity in the optimally selected PCL/32% F-BG sample with the best mechanical properties. In the PCL/45% F-BG nanocomposite, a slight increase in the contact angle is observed compared to PCL/32% F-BG. Although the PCL/45% F-BG composite contains more F-BG ceramic particles compared to the PCL/32% F-BG composite, the higher amount of particle agglomeration within the composite results in a higher contact angle. This agglomeration, which has previously been observed to diminish its composite’s mechanical properties, contributes to this phenomenon. 3.5. Biodegradability The degradation test results consist of pH changes of PBS solution, water absorption and weight changes of samples in PBS solution at 37 ℃ and in a period of 28 days are shown in Fig. 8. As mentioned, PCL and its composites require a significant amount of time to degrade. The adoption of bulk, non-porous samples with low specific surface area instead of porous scaffold samples with high specific surface area, alongside the interpretative advantages about the neat material under examination, has resulted in a much slower degradation rate. Furthermore, as stated, films prepared from the materials have been shaped in to bulk form under pressure and heat, which has led to the formation of microcracks or potential undetectable flash present on the surfaces of the bulk samples. Figure 8(a) illustrates the pH changes of the samples within the solution. As can be observed, due to the aforementioned reasons, there has been minimal degradation of the bulk samples within this time frame. The slight reduction in the pH of composite samples could be attributed to the detachment of agglomerated BG particles present on the bulk surfaces. This detachment may expose larger specific surface areas of the matrix polymer (created by the void spaces left from the detached clusters). Figure 8(b) shows the water absorption amount of the samples. As expected, the water absorption rate of composite samples has increased over time due to the presence of the hydrophilic component of BG, while the water absorption rate of neat polymer remains nearly zero and almost constant. Additionally, composites containing higher loadings of BG exhibit a higher water absorption rate compared to those with lower concentrations. The nearly zero weight loss of the bulk material samples from days 7 to 28, as shown in Fig. 8(c), indicates a very slow degradation process for the bulk specimens during this period. The greater positive and negative numerical values of weight loss observed on day 3 may be due to the presence of microcracks formed during the hot-pressing process and water penetration into them over the three-day period. Due to the bulk and compact nature of the samples, the vacuum process for drying the samples after removal from the pbs does not effectively remove the infiltrated liquid within the cracks. This results in weight gain in some samples with a low concentration of additives, or greater weight loss due to the detachment of flash or pieces of agglomerated BG from the surface in samples with higher loadings of additives. 3.6. Cytotoxicity Tests The MTT test samples and results are shown in Fig. 9. The MTT test samples and results are shown in Fig. 10. There was a notable difference between neat PCL and PCL/F-BG nanocomposites in terms of cell viability. After 24 h, the cell viability of neat PCL was approximately 84.040 ± 2.419%, whereas the PCL/27% F-BG and PCL/32% F-BG nanocomposites showed an increase to 89.074 ± 0.939 and 92.490 ± 1.310, respectively. This indicates that the addition of the current paper’s F-BG nanoparticles decreases toxicity compared to that of neat PCL. Over time, the cytotoxicity of PCL increased and the addition of the nanocomposite counteracted this increase. The lowest lethality was observed in the 24-hour period for PCL/32% F-BG nanocomposites. The results of this study showed that the addition of 32% F-BG significantly reduced the cytotoxicity of neat PCL such that the survival rate was above 87%. With extended exposure, there is a possibility that the cells may adapt to environment, improve adhesion to the composite surface, and begin to proliferate. This adaptation period is a crucial consideration when assessing the biocompatibility of PCL/BG nanocomposites in future studies [ 43 ]. 4. Conclusion Enhancing the mechanical properties of biodegradable polymer composites implanted within bone tissue to match the mechanical properties of the host bone is crucial for maximizing the biocompatibility of the implanted scaffolds for the patient. In this study, efforts were made to optimize production process parameters and material selection. 45S5 BG was surface-modified using APTES, meticulously reduced to approximately 55 nanometers, and incorporated into the composite production while preventing agglomeration. A novel solution casting process was designed, and composite samples with 15%, 30%, 45% wt% and two other derived points of 27% and 32% wt% according to the later point’s results were fabricated. To produce flawless, homogeneous, and uniform samples, hot pressing was utilized in designed molds to prepare flexural test samples, which allowed the mechanical properties of various particle loadings to be evaluated. The 32% composite sample, with an excellent elastic modulus of 1193 MPa and a flexural strength of 25.8 MPa, was selected as the optimal BG loading. Comprehensive assessments beyond mechanical properties were also conducted: Microscopic evaluation of the fracture surface indicated good quality of particle-to-matrix bonding, composite formation, and uniform distribution of non-agglomerated particles, as well as brittle and ductile fracture assessments of the samples. To evaluate the degradation model of the composite in all scenarios, samples were exposed to PBS in an orbital shaker for 3, 7, 14, 21, and 28 days, assessing water absorption weight, weight loss, and pH changes. To assess the hydrophilicity of the composites, indicative of suitable cell adhesion in the body, the samples were examined, with the optimal 32% sample exhibiting the best hydrophilicity at 69 degrees. Cytotoxicity tests conducted on the samples over 1, 2, and 3 days indicated not only good cell viability of the 32% F-BG composite at 92.490 ± 1.310%, but also an improvement in cell viability compared to neat polymer. Declarations The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. On behalf of all authors, the corresponding author states that there is no conflict of interest. Funding Declaration This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Author Contribution All authors contributed to the study’s conception and design.All authors read and approved the final manuscript.Sanaz Toorani: Writing – original draft, Validation, Investigation, Data curation.Majid Sohrabian: Writing – review & editing, Consulting, Methodology, Investigation.Mahmood Sameezadeh: Writing – review & editing, Supervision, Methodology, Conceptualization.Mohadeseh Khalafi: Writing – editing, Software, Data curation. Data availability statement The raw/processed data required to reproduce these findings cannot be shared at this time as the data also forms part of an ongoing study and can be shared if only part of the research data required to reproduce these findings. References Nikkhah Varkani M et al (2023) Design, preparation and characterization of a high-performance epoxy adhesive with Poly (butylacrylate-block-styrene) Block Copolymer and Zirconia nano particles in aluminum-aluminum bonded joints. J Inorg Organomet Polym Mater 33(11):3595–3616 Haramshahi SA, Moini Jazani O, Sohrabian M (2022) Designing a novel polythioether/multiwall carbon nanotube nanocomposites: A complete overview of mechanical, thermal, and morphological properties. Polym Adv Technol 33(6):1944–1955 Sohrabian M et al (2024) Molecular dynamics study on mechanical properties of polycaprolactone/bioactive glass nanocomposites. 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Int J Appl Glass Sci 4(2):149–161 Jin G, Kim G (2013) The effect of sinusoidal AC electric stimulation of 3D PCL/CNT and PCL/β-TCP based bio-composites on cellular activities for bone tissue regeneration. J Mater Chem B 1(10):1439–1452 Sharifianjazi F, Parvin N, Tahriri M (2017) Formation of apatite nano-needles on novel gel derived SiO2-P2O5-CaO-SrO-Ag2O bioactive glasses. Ceram Int 43(17):15214–15220 Hashemi M et al (2025) Biodegradable Shape Memory Nanocomposites Based on PCL/PPC/Graphene: As a Proposal Material for Cardiovascular Stent. J Polym Environ 33(5):2464–2479 Noori F et al (2025) Fabrication and in vivo evaluation of hybrid squalene-loaded nanofiber scaffolds based on poly (ε-caprolactone)/polyvinyl alcohol/chitosan for wound healing applications. J Polym Environ, : p. 1–22 Zadehnajar P et al (2025) Hybrid Nano-Micro Scaffolds for Cartilage Tissue Engineering: Integrating PCL-DWJM-MWCNTs on Chemically Modified Silk Fibroin. J Polym Environ, : p. 1–22 Dziadek M et al (2016) The role of solvent type, size and chemical composition of bioactive glass particles in modulating material properties of poly (ε-caprolactone) based composites. Compos Part A: Appl Sci Manufac 90:90–99 Wang C et al (2022) 3D printing of polycaprolactone/bioactive glass composite scaffolds for in situ bone repair. Ceram Int 48(6):7491–7499 Hosseini A et al A Review on Synthesis, Characterization and Applications of Polycaprolactone as a Novel Drug Delivery System and Tissue Engineering. J Inflamm Dis 27(3) Ramanujam R et al (2018) Biodegradable polycaprolactone nanoparticles based drug delivery systems: a short review. Biosci Biotechnol Res Asia 15(3):679–685 Woodruff MA, Hutmacher DW (2010) The return of a forgotten polymer—Polycaprolactone in the 21st century. Progress in polymer science, 35(10): pp. 1217–1256 Behtaj S et al (2021) Electrospun PGS/PCL, PLLA/PCL, PLGA/PCL and pure PCL scaffolds for retinal progenitor cell cultivation. Biochem Eng J 166:107846 de Melo F et al (2020) Minimally invasive aesthetic treatment of the face and neck using combinations of a PCL-based collagen stimulator, PLLA/PLGA suspension sutures, and cross-linked hyaluronic acid. Clinical, cosmetic and investigational dermatology, : pp. 333–344 Goncalves EM et al (2016) Three-dimensional printed PCL‐hydroxyapatite scaffolds filled with CNT s for bone cell growth stimulation. J Biomedical Mater Res Part B: Appl Biomaterials 104(6):1210–1219 Lebedev SM (2020) PCL-CNT nanocomposites prepared by melt compounding and evaluation of their basic properties. Polym Compos 41(5):1830–1840 Cannillo V et al (2022) Bioactive glasses in periodontal regeneration: existing strategies and future prospects—a literature review. Materials 15(6):2194 Sadeghinia Z, Emadi R, Shamoradi F (2022) A study of the electrophoretic deposition of polycaprolactone-chitosan-bioglass nanocomposite coating on stainless steel (316L) substrates. J Bioactive Compatible Polym 37(1):53–71 Sun L et al (2022) Polycaprolactone strengthening keratin/bioactive glass composite scaffolds with double cross-linking networks for potential application in bone repair. J Leather Sci Eng 4:1–13 Doostmohammadi A et al (2011) A comparative physico-chemical study of bioactive glass and bone-derived hydroxyapatite. Ceram Int 37(5):1601–1607 Yousefi A-M et al (2014) Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering. Nanatechnol Reviews 3(6):527–552 Piatti E, Miola M, Verné E (2024) Tailoring of bioactive glass and glass-ceramics properties for in vitro and in vivo response optimization: a review. Biomaterials Sci Lima LR et al (2023) Evaluation of tensile, thermal, and biological properties of natural rubber-based biocomposite with biosilicate and 45S5‐K bioglass. J Appl Polym Sci 140(22):e53894 Naseri S, Boccaccini AR, Nazhat SN (2016) Bioactive Glass Particulate-incorporated Polymer Composites. Baier RV et al (2022) Shape fidelity, mechanical and biological performance of 3D printed polycaprolactone-bioactive glass composite scaffolds. Biomaterials Adv 134:112540 Mohammed MR (2022) Mechanical and biological behaviour of 3D printed PCL-based scaffolds fabricated by fused deposition modelling for bone tissue engineering: a review of recent advances. Misan J Eng Sci 1(1):33–46 Malekahmadi B et al (2022) In vitro study of the recruitment and expansion of mesenchymal stem cells at the interface of a Cu-doped PCL-bioglass scaffold. Biomimetics 7(1):19 Tamjid E et al (2011) Effect of particle size on the in vitro bioactivity, hydrophilicity and mechanical properties of bioactive glass-reinforced polycaprolactone composites. Mater Sci Engineering: C 31(7):1526–1533 Lei B et al (2012) Bioactive glass microspheres as reinforcement for improving the mechanical properties and biological performance of poly (ε-caprolactone) polymer for bone tissue regeneration. J Biomedical Mater Res Part B: Appl Biomaterials 100(4):967–975 Sohrabian M et al (2025) Enhancing mechanical properties of PCL Biopolymers with APTES-Functionalized Bioactive Glass Nanoparticles: A molecular dynamics study. Comput Mater Sci 255:113930 Zhang C et al (2023) Effect of Different Contents of 63s Bioglass on the Performance of Bioglass-PCL Composite Bone Scaffolds. Inventions 8(6):138 Terzopoulou Z et al (2018) Biocompatible nanobioglass reinforced poly (ε-caprolactone) composites synthesized via in situ ring opening polymerization. Polymers 10(4):381 Ataie M, Nourmohammadi J, Seyedjafari E (2022) Carboxymethyl carrageenan immobilized on 3D-printed polycaprolactone scaffold for the adsorption of calcium phosphate/strontium phosphate adapted to bone regeneration. Int J Biol Macromol 206:861–874 Su J et al (2022) Three-dimensional printing of gyroid-structured composite bioceramic scaffolds with tuneable degradability. Biomaterials Adv 133:112595 Yuan X et al (2022) Enhancing the bioactivity of hydroxyapatite bioceramic via encapsulating with silica-based bioactive glass sol. J Mech Behav Biomed Mater 128:105104 Ou Y, Wu W, Zhou Z (2022) In-Vitro Degradation Behaviors of Composite Scaffolds Based on Poly (Lactide-co-Glycolide-co-ε-Caprolactone), 1, 4-Butanediamine Modified Poly (Lactide-co-Glycolide) and Bioceramics. Journal of Macromolecular Science, Part B, 61(6): pp. 776–787 Canales D et al (2020) Effect of bioglass nanoparticles on the properties and bioactivity of poly (lactic acid) films. J Biomedical Mater Res Part A 108(10):2032–2043 Additional Declarations No competing interests reported. Supplementary Files GraphicalAbstractPCLnBGFlexural040204.png Cite Share Download PDF Status: Published Journal Publication published 04 Nov, 2025 Read the published version in Journal of Polymers and the Environment → Version 1 posted Editorial decision: Revision requested 03 Jun, 2025 Reviews received at journal 02 Jun, 2025 Reviews received at journal 01 Jun, 2025 Reviews received at journal 25 May, 2025 Reviewers agreed at journal 23 May, 2025 Reviews received at journal 23 May, 2025 Reviews received at journal 20 May, 2025 Reviews received at journal 17 May, 2025 Reviewers agreed at journal 17 May, 2025 Reviewers agreed at journal 16 May, 2025 Reviewers agreed at journal 16 May, 2025 Reviewers agreed at journal 15 May, 2025 Reviewers agreed at journal 15 May, 2025 Reviewers agreed at journal 15 May, 2025 Reviewers invited by journal 15 May, 2025 Editor assigned by journal 13 May, 2025 Submission checks completed at journal 13 May, 2025 First submitted to journal 11 May, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6641347","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":458037102,"identity":"3c59ef72-395b-4719-818e-434b9e36f792","order_by":0,"name":"Sanaz Toorani","email":"","orcid":"","institution":"Shahid Beheshti University","correspondingAuthor":false,"prefix":"","firstName":"Sanaz","middleName":"","lastName":"Toorani","suffix":""},{"id":458037103,"identity":"aa6dc048-b8eb-46ee-b454-2a03964ef924","order_by":1,"name":"Majid Sohrabian","email":"","orcid":"","institution":"Shahid Beheshti University","correspondingAuthor":false,"prefix":"","firstName":"Majid","middleName":"","lastName":"Sohrabian","suffix":""},{"id":458037104,"identity":"501e87da-50c9-4234-8691-1905d0d66237","order_by":2,"name":"Mahmood Sameezadeh","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA4ElEQVRIiWNgGAWjYHCDBDaGDwwHoGxitTDOIFkLMw9MCz6g28D+8NONCht7/vbkY49t/txJbGA//IDh4R7cWswO8BhL55xJY5Y48yzdOLftWWIDT5oBQ8IzvFoYpHPbDrMx3Mgxk85tOJzYwJADdCQeB5odYH/8O/fffx75G/nfpC3+ALXwvyGkhQFk+AEJgxs5bNIMbEAtEgRt4TGzzjmWbGB45pmZZG/bM+M2iWcGBwg57HZOjZ293PHkZxI//tyR7edPfvjwBx4tDPIP0ATYgBifhlEwCkbBKBgFRAAAcbRU5MO/tpIAAAAASUVORK5CYII=","orcid":"","institution":"Shahid Beheshti University","correspondingAuthor":true,"prefix":"","firstName":"Mahmood","middleName":"","lastName":"Sameezadeh","suffix":""},{"id":458037105,"identity":"cf1aa89f-763a-43ff-bdcd-337a83f2070d","order_by":3,"name":"Mohadeseh Khalafi","email":"","orcid":"","institution":"Shahid Beheshti University","correspondingAuthor":false,"prefix":"","firstName":"Mohadeseh","middleName":"","lastName":"Khalafi","suffix":""}],"badges":[],"createdAt":"2025-05-11 19:53:11","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-6641347/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6641347/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1007/s10924-025-03710-5","type":"published","date":"2025-11-04T15:57:12+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":83074418,"identity":"acdd6524-407f-4e1f-824f-e66306c558b7","added_by":"auto","created_at":"2025-05-19 17:46:22","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":149198,"visible":true,"origin":"","legend":"\u003cp\u003ePCL/F-BG Stirring\u003c/p\u003e","description":"","filename":"1.png","url":"https://assets-eu.researchsquare.com/files/rs-6641347/v1/6cca574fec2cfdd4ba78d1f5.png"},{"id":83076279,"identity":"a5960fc3-528c-499c-99fa-9ae056690365","added_by":"auto","created_at":"2025-05-19 18:10:22","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":416469,"visible":true,"origin":"","legend":"\u003cp\u003eImages of the fabricated nanocomposite films in various additive concentrations\u003cem\u003e.\u003c/em\u003e\u003c/p\u003e","description":"","filename":"2.png","url":"https://assets-eu.researchsquare.com/files/rs-6641347/v1/36dbdd1e76458d0655cb188b.png"},{"id":83075229,"identity":"2547c64a-6a18-4318-8d19-e4182ca71faa","added_by":"auto","created_at":"2025-05-19 17:54:22","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":360933,"visible":true,"origin":"","legend":"\u003cp\u003e(a) Flexural test specimen molds (b) Fabricated flexural tests specimens\u003c/p\u003e","description":"","filename":"3.png","url":"https://assets-eu.researchsquare.com/files/rs-6641347/v1/32cd1205fd4ec16beae8bf77.png"},{"id":83075239,"identity":"23a3e3bd-6cf6-43f0-98ad-22a04b3a12c3","added_by":"auto","created_at":"2025-05-19 17:54:22","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":346872,"visible":true,"origin":"","legend":"\u003cp\u003eDegradability Tests Bulk Samples.\u003c/p\u003e","description":"","filename":"4.png","url":"https://assets-eu.researchsquare.com/files/rs-6641347/v1/d549c0263bc564146285efe8.png"},{"id":83075688,"identity":"b3b6c0e1-430f-4dec-a9f1-6111aadeb7aa","added_by":"auto","created_at":"2025-05-19 18:02:22","extension":"png","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":215873,"visible":true,"origin":"","legend":"\u003cp\u003e(a) FESEM images of the F-BG nanoparticles (b) Particle size distribution.\u003c/p\u003e","description":"","filename":"5.png","url":"https://assets-eu.researchsquare.com/files/rs-6641347/v1/5186f3dd529fb0a68337732f.png"},{"id":83075686,"identity":"ecd55221-917c-4a68-8aad-51bef2f1ef8e","added_by":"auto","created_at":"2025-05-19 18:02:22","extension":"png","order_by":6,"title":"Figure 6","display":"","copyAsset":false,"role":"figure","size":37459,"visible":true,"origin":"","legend":"\u003cp\u003ea) Elastic Modulus\u003cem\u003e \u003c/em\u003eand b) Flexural Strength of Samples (*P \u0026lt; 0.05\u003cem\u003e، \u003c/em\u003e** p ≤ 0.001\u003cem\u003e، \u003c/em\u003e*** P = 0.0001, ****P \u0026lt; 0.0001)\u003c/p\u003e","description":"","filename":"6.png","url":"https://assets-eu.researchsquare.com/files/rs-6641347/v1/d99151683b2041f66a7da100.png"},{"id":83074422,"identity":"8c7da182-f51b-45ed-af6d-deb82fd20eda","added_by":"auto","created_at":"2025-05-19 17:46:22","extension":"png","order_by":7,"title":"Figure 7","display":"","copyAsset":false,"role":"figure","size":260684,"visible":true,"origin":"","legend":"\u003cp\u003eSEM images of samples after flexural fracture (magnification 100 µm)\u003c/p\u003e","description":"","filename":"7.png","url":"https://assets-eu.researchsquare.com/files/rs-6641347/v1/47ee74f14fbf0595c0e615ab.png"},{"id":83074424,"identity":"a1a061a8-67f6-4eda-b33f-4d46d555a175","added_by":"auto","created_at":"2025-05-19 17:46:22","extension":"png","order_by":8,"title":"Figure 8","display":"","copyAsset":false,"role":"figure","size":53714,"visible":true,"origin":"","legend":"\u003cp\u003e(a) pH changes of PBS solution, (b) weight of absorbed water and (c) weight loss of samples in PBS solution at 37 ℃ in a period of 28 days.\u003c/p\u003e","description":"","filename":"8.png","url":"https://assets-eu.researchsquare.com/files/rs-6641347/v1/521e36c3ffdb23126b3de4d2.png"},{"id":83075255,"identity":"b28814c1-6096-48b1-b2c1-79760df3149d","added_by":"auto","created_at":"2025-05-19 17:54:22","extension":"png","order_by":9,"title":"Figure 9","display":"","copyAsset":false,"role":"figure","size":84085,"visible":true,"origin":"","legend":"\u003cp\u003eMTT test results (a Samples through time, (b Viability improvement through rising of BG loadings. (*P \u0026lt; 0.05\u003cem\u003e، \u003c/em\u003e** p ≤ 0.001\u003cem\u003e، \u003c/em\u003e*** P = 0.0001\u003cem\u003e, \u003c/em\u003e****P \u0026lt; 0.0001)\u003cem\u003e.\u003c/em\u003e\u003c/p\u003e","description":"","filename":"9.png","url":"https://assets-eu.researchsquare.com/files/rs-6641347/v1/8553971bf729eaa8893d720e.png"},{"id":95564071,"identity":"df46c2bd-6360-4b94-a35b-ed8d0f7f5c20","added_by":"auto","created_at":"2025-11-10 16:07:22","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":3012981,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6641347/v1/e663abf8-b53e-4d1d-ae3f-2d173c3634c0.pdf"},{"id":83075687,"identity":"b9476d4f-e123-4452-a0c8-457c5214daf4","added_by":"auto","created_at":"2025-05-19 18:02:22","extension":"png","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":508576,"visible":true,"origin":"","legend":"","description":"","filename":"GraphicalAbstractPCLnBGFlexural040204.png","url":"https://assets-eu.researchsquare.com/files/rs-6641347/v1/74381139b417a42f4bd69940.png"}],"financialInterests":"No competing interests reported.","formattedTitle":"Optimized Fabrication and Enhanced Flexural Properties of PCL/F-BG Nanocomposites for Hard Tissue Engineering","fulltext":[{"header":"1. Introduction","content":"\u003cp\u003eAchieving maximum mechanical properties in composites has widespread applications across various industries, from adhesive [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e] and sealant [\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e] uses to other areas. In tissue engineering, the enhancement of the mechanical properties of polymer scaffolds is possible through various methods: by improving the materials via polymer composite creation [\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e], through the optimal selection of the best scaffold geometry [\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e], by optimizing and selecting appropriate manufacturing parameters [\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e, \u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e], or even by thermal annealing treatments [\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e]. Over recent decades, aliphatic polyesters like Poly L-lactide (PLLA), Polycaprolactone (PCL), Poly Lactic-co-Glycolic Acid (PLGA), and Poly lactide-co-ε-caprolactone (PLCL) have been utilized in tissue engineering because of biodegradability and biocompatibility [\u003cspan additionalcitationids=\"CR9 CR10 CR11 CR12\" citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e]. In recent years PCL has drawn renewed interest due to its remarkable properties, which make it suitable for various medical uses, particularly in tissue engineering. PCL is a semi-crystalline polymer with the chemical formula (C\u003csub\u003e6\u003c/sub\u003eH\u003csub\u003e10\u003c/sub\u003eO\u003csub\u003e2\u003c/sub\u003e) \u003csub\u003en\u003c/sub\u003e, known for its non-toxic nature, slow degradation rate, and high flexibility [\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e, \u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eExcellent rheological and viscoelastic behavior of PCL allows for its easy processing into various medical implant forms. Most importantly, the biocompatibility of PCL is outstanding and is a significant requirement for scaffolds. Besides, it has tunable degradation rates; hence, it can be designed for specific functions and anatomical environments. In tissue engineering, PCL can act as the scaffold material for repairing and regenerating bone, cartilage, and other tissues. Among the merits that set PCL apart, one of the major ones is its relatively slow degradation rate compared to PLA and PGA. This makes PCL suitable for long-term drug delivery systems requiring controlled and sustained release. This property is very useful for medications whose therapeutic action must be prolonged. Moreover, PCL has demonstrated high permeability to small medicinal compounds, improving the solubility and bioavailability to enhance drug delivery performance. [\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e, \u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eSeveral PCL-based drug delivery systems have received FDA approval, facilitating transition from laboratory research to clinical use. Its incorporation in drug delivery systems has proven effective, especially in cancer treatment, by enabling targeted therapy [\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e].\u003c/p\u003e \u003cp\u003ePCL has superior mechanical properties including flexibility and tensile strength, which surpass those of many other biodegradable polymers, making it versatile for various applications [\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e]. PCL has been effectively employed in 3D printing technologies, enabling the fabrication of complex structures for various biomedical applications [\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e]. It has excellent toughness, flexibility and easy fabrication. However, it has limitations in bone regeneration applications due to its low stiffness, hydrophobic nature, and lack of inherent biological activity [\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e, \u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e, \u003cspan additionalcitationids=\"CR20 CR21\" citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e]. PCL received FDA approval, but its use was briefly suspended due to its degradation time (3\u0026ndash;4 years). PCL has low mechanical properties comparing to the host bone tissues which is addressed by reinforcing it with stiffener additives like bioactive glass (BG) to improve its mechanical properties. The addition of BG nanoparticles enhances both mechanical and biological characteristics. Without any reinforcement, PCL exhibits poor flexural properties [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e, \u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]. As PCL is a biocompatible polymer with a low melting point, its mechanical properties are insufficient. Therefore, compositing it with BG can enhance its strength [\u003cspan additionalcitationids=\"CR24\" citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e]. Addition of nanoparticles enhances not only mechanical characteristics but also solubility, melting point (59\u0026ndash;64\u0026deg;C) and elasticity. Biodegradable polymer/BG composites, often used in scaffold, have been extensively researched for potential use in hard tissue regeneration due to favorable biocompatibility and bioactivity [\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e, \u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e]. BG and its well-known type 45S5, can form strong bonds with bone tissue, significantly enhancing the integration and regeneration of hard tissues [\u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e26\u003c/span\u003e]. The composition of BG nanoparticles (nBG) enhances interaction with biological systems, which in turn promotes improved angiogenesis and osteogenesis [\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e]. The degradation kinetics of BGs align more closely with the rate of new tissue formation, enhancing integration and functional healing of bone defects. Additionally, the alkalinity of BG helps neutralize the acidic environment caused by polymer degradation, maintaining a favorable condition for cell growth and tissue regeneration [\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e, \u003cspan citationid=\"CR28\" class=\"CitationRef\"\u003e28\u003c/span\u003e]. It can also be used in dental implants, both in scaffolds and coatings, improving osseointegration in dental applications. With the possible release of bioactive ions and their stimulation of bone formation combined with antibacterial properties, they are considered a very promising solution for various dental procedures, including periodontal disease treatment and implant positioning [\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e]. The addition of BG into the composites has been proven to significantly enhance cell attachment and viability; there are many reports of higher than 70% cell viability within BG-containing biocomposites. The addition of BG particles usually increases the tensile strength and elastic modulus of polymer matrices, as reported in natural rubber-based composites [\u003cspan citationid=\"CR29\" class=\"CitationRef\"\u003e29\u003c/span\u003e]. BG composites demonstrate superior mechanical properties compared to conventional fillers, making them highly suitable for load-bearing applications [\u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e30\u003c/span\u003e].\u003c/p\u003e \u003cp\u003ePolymer nanocomposites, such as PCL/BG, are increasingly used as biodegradable materials in medical applications due to need for strong mechanical properties and high biocompatibility .[\u003cspan additionalcitationids=\"CR24\" citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e] Despite the addition of bioactive particles like hydroxyapatite and BG, the mechanical properties of PCL composites still do not fully imitate the behavior of human bone [\u003cspan citationid=\"CR31\" class=\"CitationRef\"\u003e31\u003c/span\u003e, \u003cspan citationid=\"CR32\" class=\"CitationRef\"\u003e32\u003c/span\u003e]. Therefore, enhancing the mechanical properties of the composite to achieve maximum mechanical performance and approximating the mechanical properties of bone is crucial and inevitable. The use of BG nanofillers has become a promising approach in development of bio-composites. Compared to micro-fillers, BG nanofillers, with larger specific surface area, significantly enhance the bioactivity of organic and polymer-based composites, resulting in nanostructured composites with superior properties [\u003cspan citationid=\"CR33\" class=\"CitationRef\"\u003e33\u003c/span\u003e]. Tamjid et al. [\u003cspan citationid=\"CR34\" class=\"CitationRef\"\u003e34\u003c/span\u003e] fabricated a PCL composite containing 50 wt% BG particles, with particle sizes of 6 \u0026micro;m, 250 nm, and less than 100 nm, using the solvent casting method. They found that the 250 nm BG particles improved the bioactivity of the PCL polymer film. Addition of BG particles significantly enhanced the strength of the PCL/BG composite, and 100 nm particles had the most pronounced effect on mechanical strength. Similarly, Li et al. [\u003cspan citationid=\"CR35\" class=\"CitationRef\"\u003e35\u003c/span\u003e] prepared PCL/BG composite by the solvent casting method. They used 10 wt%, 20 wt%, and 30 wt% of BG in PCL. The neat PCL and 10% BG-loaded composite evidenced a ductile behavior characterized by remarkable elongation; on the other hand, 20% and 30% BG-loaded composites presented low values of toughness. It could be clearly observed that the elastic modulus increases as the amount of BG increases. Biocompatibility was enhanced with an increase in the concentration of BG. Moreover, spherical and finer BG particles contributed to greater increases in the elastic modulus. Sohrabian et al. demonstrated the effects of BG particle size and concentration on the composite\u0026rsquo;s mechanical properties [\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e], as well as the positive influence of APTES surface modification on enhancing mechanical properties and delaying the decline caused by agglomeration [\u003cspan citationid=\"CR36\" class=\"CitationRef\"\u003e36\u003c/span\u003e], using molecular dynamics simulations. Chen Zhang et al. [\u003cspan citationid=\"CR37\" class=\"CitationRef\"\u003e37\u003c/span\u003e] It also employed PCL and different concentration levels of 63s BG for the fabrication of PCL scaffolds by twin-screw extrusion and 3D printing. Indeed, they found enhanced mechanical properties with higher BG content; however, the final strength was below that of cortical bone. Addition of BG microspheres significantly improved elastic modulus of PCL composites, indeed showing good correspondence of filler content with mechanical strength [\u003cspan citationid=\"CR35\" class=\"CitationRef\"\u003e35\u003c/span\u003e]. Incorporation of nanosized BGs significantly enhanced the mechanical properties of PCL, particularly at low filler loadings, which could be ascribed to the strong interfacial interactions between nanofillers and polymer matrix. [\u003cspan citationid=\"CR38\" class=\"CitationRef\"\u003e38\u003c/span\u003e]. PCL composites containing BG exhibited increased hydrophilicity and enhanced apatite formation, both of which are vital for bone tissue regeneration [\u003cspan citationid=\"CR34\" class=\"CitationRef\"\u003e34\u003c/span\u003e, \u003cspan citationid=\"CR35\" class=\"CitationRef\"\u003e35\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eIn the present study, a completely new and accurate method of composite fabrication was carried out with due care. It involved the preparation of surface-modified nanosized BG particles by dissolution and uniform dispersion, avoiding particle agglomeration during fabrication by comprehensive stirring and appropriate sonication. The resulting nanocomposite exhibited significantly improved mechanical properties compared to those reported in previous researches. Various composite samples with different loadings of F-BG were fabricated and compared to determine the optimal composite with the best mechanical properties. The selection of flexural tests for fabricated samples, as an evaluation of the mechanical behavior of manufactured materials, is due to the presence of both tensile and compressive behavior within the flexural loading. To address common challenges like microcracks that often occur during flexural specimens machining, the melt molding technique was employed. This method enhanced fabrication precision and improved the overall quality of the produced samples. In addition to flexural tests, the microstructural, hydrophilic, degradation, and biological properties of PCL/F-BG (functionalized BG) nanocomposites were systematically analyzed.\u003c/p\u003e"},{"header":"2. Materials and Methods","content":"\u003cdiv id=\"Sec3\" class=\"Section2\"\u003e\n \u003ch2\u003e2.1. Fabrication:\u003c/h2\u003e\n \u003cp\u003eThe Sigma-Aldrich PCL of medical grade is used in this study, with the density of 1.145 g/ml and an average molecular weight of 80,000 g/mol. Additionally, the BG nanoparticles are also of medical grade 45S5 and surface modified with APTES (3-amino propyl triethoxysilane), a coupling agent that enhances bonding between bio-ceramic particles and polyester polymers. To reduce the size of the F-BG nanoparticles, mechanical grinding was performed. F-BG powder was ground using alumina balls for 30 minutes. After grinding, the nanoparticle size was analyzed using dynamic light scattering (DLS), but the size remained relatively large. Therefore, the F-BG powder was subjected to a drying procedure in vacuum oven at 70\u0026deg;C for 24 hours, followed by 24 hours at ambient temperature under vacuum. Additionally, nanoparticles were further ground for 7 minutes using an alumina-based hand grinder prior to composite preparation. After grinding, the nanoparticles were mixed with dichloromethane and the immersed powder was left for over 24 hours. They were then dispersed using ultrasonication for 15 minutes (in three intervals of 5 minutes) to break up potential agglomerates.\u003c/p\u003e\n \u003cp\u003eFor producing the solution neat samples, the dried PCL granules (25 minutes in 40\u0026deg;C) were added to dichloromethane to create a mixture containing of 10% PCL and 90% dichloromethane [\u003cspan class=\"CitationRef\"\u003e14\u003c/span\u003e, \u003cspan class=\"CitationRef\"\u003e35\u003c/span\u003e, \u003cspan class=\"CitationRef\"\u003e39\u003c/span\u003e]. This mixture was stirred on a magnetic stirrer for 24 hours, during this period, 100 ml of the dichloromethane evaporated, so the evaporated volume was replenished, and the uniform solution was stirred for an additional 30 minutes. In order to produce the nanocomposite materials, the prepared F-BG nanoparticles were added to the PCL solution separately at weight ratios of 15%, 30%, and 45% as the first group and 27% and 32% as the second group (according to the output results). After adding nanoparticles to the PCL solution based on specified amount, stirring was continued for an additional 4 to 5 hours, followed by two cycles of 3-minutes sonication for resolving of possible formed aggregations. The solution was then stirred for an additional 20 hours (Fig. \u003cspan class=\"InternalRef\"\u003e1\u003c/span\u003e).\u003c/p\u003e\n \u003cp\u003eAs the dichloromethane evaporated, the lost volume was replenished before performing three more cycles of 3-minutes sonication. The mixture was further stirred on a magnetic stirrer for 30 minutes, then poured into petri dishes and left at room temperature for 4 hours to allow evaporation of the solvent. Finally, the samples were placed in a vacuum oven for 24 hours at room temperature under vacuum to ensure full evaporation of the remained solvent. Images of neat PCL and PCL/F-BG nanocomposites are shown in Fig. 2 (a-f).\u003c/p\u003e\n \u003cp\u003eAs it can be seen in Fig. 3 (a), the flexural test specimens mold was designed according to ASTM D790-17 (2 mm x 12.7 mm x 50 mm). The produced nanocomposite films were chopped, weighted and filled the cavities in the flexural test specimen mold. Thereafter they were subjected to hot pressing at temperatures of 180\u0026deg;C and 220\u0026deg;C for fabrication of flexural test specimens as illustrated in Figure. 3 (b).\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec4\" class=\"Section2\"\u003e\n \u003ch2\u003e2.2. Flexural Tests\u003c/h2\u003e\n \u003cp\u003eFlexural tests were conducted with three replicates for each case and with strain rate of 5 mm/min based on the mentioned standard.\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec5\" class=\"Section2\"\u003e\n \u003ch2\u003e2.3. Scanning Electron Microscope (SEM):\u003c/h2\u003e\n \u003cp\u003eTo analyze the microstructure of the samples, SEM model VEGA/TESCAN-LMU, was employed.\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec6\" class=\"Section2\"\u003e\n \u003ch2\u003e2.4. Hydrophilicity Tests\u003c/h2\u003e\n \u003cp\u003eHydrophilicity is a crucial factor for biomaterials and is a physical property that allows the material to temporarily form hydrogen bonds with water. This property increases liquid penetration across its wetted surface. This property is quantified using Young\u0026apos;s equation, which measures the contact angle of a water droplet on the material\u0026apos;s surface. For these bio composites, enhanced hydrophilicity is associated with improved biological performance and favorable outcomes. Hydrophilicity refers to the tendency of a substance to attract water, and this characteristic can significantly influence the behavior of cells in contact with the substance\u0026apos;s surface. The hydrophilicity of materials plays a crucial role in cell adhesion to these surfaces.\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec7\" class=\"Section2\"\u003e\n \u003ch2\u003e2.5. Biodegradability Tests\u003c/h2\u003e\n \u003cp\u003eTo assess the degradability of neat PCL and PCL/F-BG nanocomposites intended for internal body applications, biodegradability tests were conducted in accordance with the ISO 10993-13 standard. Bulk specimens with dimensions of 8 mm x 8 mm x 1 mm were sterilized using UV radiation for 10 minutes on each side and were immersed in 10 ml of phosphate-buffered saline (PBS) solution at 37\u0026deg;C with a pH of 7.4. The use of bulk material specimens, differing from the commonly employed porous scaffold forms in other research, was intended to ensure that the influencing and evaluated parameter was solely the material type. This approach allows for an accurate assessment of the material itself, without the influence of porosity, specific surface area, shape differences in printing, and potential hidden defects from scaffold fabrication and printing. It also avoids the complexities of scaffold structural failure impacting the interpretation of results, ensuring that these factors do not affect the material\u0026apos;s degradation behavior.\u003c/p\u003e\n \u003cp\u003eThe samples which are demonstrated in Fig. \u003cspan class=\"InternalRef\"\u003e4\u003c/span\u003e, were placed in an orbital shaker which set at 90 rpm and examined over periods of 3, 7, 14, 21, and 28 days, with at least three samples for each time point. At each interval, the samples were removed from the solution and the weight loss were calculated according to Equations (1) and (2).\u003c/p\u003e\n \u003cp\u003e\u003cem\u003eW\u003c/em\u003e \u003csub\u003e\u0026nbsp;\u003cem\u003eA\u003c/em\u003e\u0026nbsp;\u003c/sub\u003e \u003cem\u003e%\u003c/em\u003e = [(𝑊\u003csub\u003e𝑤\u003c/sub\u003e \u0026minus; 𝑊\u003csub\u003e𝑑\u003c/sub\u003e)/𝑊\u003csub\u003e𝑑\u003c/sub\u003e] \u0026times; \u003cem\u003e100\u003c/em\u003e (1)\u003c/p\u003e\n \u003cp\u003e\u003cem\u003eW\u003c/em\u003e \u003csub\u003e\u0026nbsp;\u003cem\u003eL\u003c/em\u003e\u0026nbsp;\u003c/sub\u003e \u003cem\u003e% =\u003c/em\u003e \u003cspan class=\"InlineEquation\"\u003e\u003cspan class=\"mathinline\"\u003e\\(\\:{[W}_{i}-{W}_{d}]/{W}_{i}\\:\\times\\:\\:\\)\u003c/span\u003e\u003c/span\u003e\u003cem\u003e100\u003c/em\u003e (2)\u003c/p\u003e\n \u003cp\u003eW\u003csub\u003eA\u003c/sub\u003e is weight of absorbed water, W\u003csub\u003ew\u003c/sub\u003e is wet weight, Subsequently, the samples were rinsed with distilled water and dried in vacuum condition at 37\u0026deg;C for 24 hours to determine dry weight (W\u003csub\u003ed\u003c/sub\u003e). W\u003csub\u003eL\u003c/sub\u003e is weight loss and W\u003csub\u003ei\u003c/sub\u003e is initial weight. To maintain a constant pH level, the PBS solution was changed and refreshed weekly. To monitor pH changes, three samples tested over the three-day period were placed back into the same solution until the end of the experiment, ensuring that the solution was not replaced during the period.\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec8\" class=\"Section2\"\u003e\n \u003ch2\u003e2.6. Cytotoxicity Tests\u003c/h2\u003e\n \u003cp\u003eThe MTT assay is a widely used method to assess cell viability by measuring the toxicity of substances. It distinguishes between live and dead cells by examining the impact of compounds on cellular organelles. Mouse embryonic fibroblast cells (NIH3T3) were obtained from the Roshd Azma Company, Karaj. The cells were maintained at 37\u0026deg;C in a humidified environment with 5% CO2 using a mixture of DMEM/F12 culture medium supplemented with 5% fetal bovine serum, penicillin G, and streptomycin (100 mg/L). Cytotoxicity was assessed using the MTT assay, in accordance with the ISO 10993 standard. PCL/F-BG samples at concentrations of 27% and 32%, along with the neat samples, were fabricated into circular shapes with a cross-sectional area of 0.32 cm\u0026sup2;. Each sample was replicated three times. Following UV sterilization, the samples were placed into the wells of a 96-well plate. NIH3T3 cell line cells were cultured at a density of 1 \u0026times; 104 cells/well and the microplate was incubated at 37\u0026deg;C in an atmosphere of 5% CO2. After 24, 48, and 72 h of incubation, 10% MTT dye solution was prepared in the culture medium, and 100 \u0026micro;l was pipetted into each well, followed by two additional hours of incubation. The medium was then removed and the formazan crystals in the living cells were dissolved in dimethyl sulfoxide (DMSO). The absorbance at 570 nm was measured using an ELISA reader (BioRad, US), and the percentage of cell viability was calculated using GraphPad prism software.\u003c/p\u003e\n\u003c/div\u003e"},{"header":"3. Results and Discussion","content":"\u003cdiv id=\"Sec10\" class=\"Section2\"\u003e\n \u003ch2\u003e3.1. BG Size Distribution\u003c/h2\u003e\n \u003cp\u003eField Emission Scanning Electron Microscopy (FESEM) images of the milled F-BG and the resulted particle size distribution chart is shown in Fig. 5. The particle distribution chart reveals that the predominant particle size is approximately 55 nm, indicating the success of achieving a small particle size with a high population density centered around 55 nm. The spherical shape, surface modification, and small size of BG particles facilitate dispersion within the polymer matrix, resulting in the enhancement of composite mechanical properties.\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec11\" class=\"Section2\"\u003e\n \u003ch2\u003e3.2. Mechanical Properties\u003c/h2\u003e\n \u003cp\u003eThe results of the flexural tests on neat PCL and PCL/F-BG nanocomposites are shown in Fig.\u0026nbsp;6. As expected, an increase in the concentration of F-BG particles led to a significant improvement in both strength and elastic modulus of the composite. As previously mentioned, six points and states were used for sampling and evaluating the composite to identify and extract the general trend and behavioral path of the materials. In the first stage, sampling was conducted at four points: 0%, 15%, 30%, and 45%, and the mechanical properties were tested. Based on the mechanical properties obtained at each state, two additional points with finer grids, 27% and 32%, were selected on either side of the maximum point of the first stage (30%). These were chosen for the second stage to complete and enhance the quality of the results and analyses, enabling us to find the composite with the best mechanical properties.\u003c/p\u003e\n \u003cp\u003eThe mechanical properties derivatives elastic modulus and strength were extracted and gathered in Figs. 6 (a) \u0026amp; (b) respectively.\u003c/p\u003e\n \u003cp\u003eGenerally, the uneven distribution of nanoparticles within the composite results in variability in mechanical properties (the issue which can be seen in standard deviation of the composite containing 45% F-BG). However, the methodology applied for the composite fabrication in the current study could postpone the occurrence of this weakening effect of agglomeration at higher concentrations of reinforcement particles, allowing them to play strengthening role within the composite. This phenomenon is more likely to occur with the BG nanoparticles used in this study due to very small size and consequently high specific surface area and surface energy. This issue has been effectively addressed by surface modification of the particles and various processes to prevent agglomeration both before and after composite fabrication. Thus, the benefits of reducing the particle size can be maximized for enhancing the mechanical properties of the composite. The composites\u0026rsquo; strength trend shows that increasing the amount of F-BG nanoparticles up to 32% enhances the flexural strength, but beyond this threshold, the flexural strength starts to decline significantly. This behavior can be attributed to the distribution challenges and agglomeration of BG nanoparticles within the polymer matrix composite (in B45 sample) which inhibits maximizing F-BG reinforcing effects. The formation of larger agglomerates of clustered particles leads to stress concentration sites, initiating cracks and subsequent fractures under load. This phenomenon reduces the flexural strength of the composites. However, the elastic modulus, being measured at low strain levels, is less affected by this phenomenon. The increase in the amount of the added ceramic component with a higher elastic modulus, results in a higher overall elastic modulus of the composite. Therefore, the more ceramic reinforcing particles are added to the composite, the higher the flexural elastic modulus of the samples, as observed in the Fig.\u0026nbsp;6(a). Despite the challenges of agglomeration, both the overall strength and elastic modulus of PCL/F-BG nanocomposites were significantly higher than those of neat PCL. This is illustrated in the Fig.\u0026nbsp;6, which shows a substantial and significant rise in mechanical properties from the neat polymer to the B32 sample. This demonstrates the effectiveness of F-BG nanoparticles as reinforcing agents and the composite fabrication procedure in improving the strength and elastic modulus of PCL, thereby enhancing the mechanical properties and obtaining superior characteristics. The PCL/32% F-BG sample exhibited the highest flexural strength (25.8 MPa), whereas the PCL/45% F-BG sample showed the highest elastic modulus (1793 MPa), surpassing the second-grade composite PCL/32% F-BG sample. Therefore, the PCL/32% F-BG sample can clearly be selected as having the best mechanical properties characteristics.\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec12\" class=\"Section2\"\u003e\n \u003ch2\u003e3.3. Microstructural Investigations\u003c/h2\u003e\n \u003cp\u003eFor optimal performance of the PCL/F-BG nanocomposite, the polymer matrix must meet several criteria. These include shape and dimensional stability, proper distribution of reinforcements, mechanical and thermal stability, effective load transfer to the reinforcements, and chemical and physical stability, especially in biological environments. Microstructural images of neat PCL and PCL/F-BG nanocomposites, shown in Fig. 7 (a-f), were obtained from the fracture surfaces after the flexural test to evaluate both the fractography of the samples and to simultaneously examine the dispersion and morphology of the additive particles.\u003c/p\u003e\n \u003cp\u003eThe images of neat PCL and even to some extent PCL/15% F-BG shows some stretch fibrils on the fracture surfaces indicating a ductile fracture mode (shown in yellow circles), whereas, the serrated and sharp fracture lines formed on the fracture surfaces of high loadings of ceramic additives like 30%-45% demonstrate the brittle fractures (shown in green circles). As the proportion of additive particles increases, sharper fracture angles and voids become evident, indicating a shift toward brittle fracture behavior.\u003c/p\u003e\n \u003cp\u003eMicroscopic observations reveal that BG nanoparticles are nearly uniformly dispersed within the polymer matrix; however, this uniformity diminishes as the concentration of nanoparticles rises, leading to more agglomeration, particularly at higher F-BG percentages from 15\u0026ndash;45% in the PCL/F-BG nanocomposites. Particle accumulation can serve as initiation points for fractures. The agglomerated particles, highlighted in pink circles in the images taken from the fractured surfaces of the specimens, do not appear to be very large in size. Surface modification of BGs enhances the interactions between particles and the polymer chains of the matrix, leading to improved mechanical properties of the PCL matrix. As indicated by the blue circles, some of the F-BGs extended beyond the fracture surface, demonstrating the bridging mechanism and the formation of a connection between the upper and lower surfaces of the crack by the particles during failure. This mechanism, resulting from the strong bonding between particles and polymer chains, contributed to an increase in flexural strength. The bridging particles were eventually pulled out from the upper or lower crack surfaces following interfacial debonding due to the applied stress. Upon the removal of BGs, an empty cavity remained in the fracture surface. The pores, highlighted by red arrows in Fig.\u0026nbsp;7, indicating the spaces left by the particles due to debonding and pull-out.\u003c/p\u003e\n \u003cp\u003eActually, there is a significant difference in surface energy between bio-ceramics and polymers. The high surface energy of the nanoparticles, resulting from large specific surface area, increases propensity for agglomeration. As a result, the reinforcing nanoparticles in polymer matrix composites tend to cluster together, forming interconnected networks. The Van der Waals forces among the nanoparticles further contribute to this agglomeration, hindering effective dispersion and limiting functionality within the composite [\u003cspan class=\"CitationRef\"\u003e40\u003c/span\u003e, \u003cspan class=\"CitationRef\"\u003e41\u003c/span\u003e]. The tendency for agglomeration also increases the viscosity of the polymer/nanoparticle mixture, which can impede the uniform distribution of nanoparticles within the polymer matrix and trap air bubbles formed during mixing. While BG nanoparticles can enhance the mechanical properties of the PCL polymer, achieving a consistent distribution remains a challenge. Optimal dispersion is observed mostly in the PCL/32% F-BG samples.\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec13\" class=\"Section2\"\u003e\n \u003ch2\u003e3.4. Hydrophobicity behavior\u003c/h2\u003e\n \u003cp\u003eHydrophilicity test results for neat PCL and PCL/ F-BG nanocomposites are shown in Table \u003cspan class=\"InternalRef\"\u003e1\u003c/span\u003e.\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e\u003cimg 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\" height=\"433\" width=\"473\"\u003e\u003c/p\u003e\n \u003cp\u003eNeat PCL exhibits a higher contact angle, indicating lower hydrophilicity compared to the PCL/ F-BG nanocomposites. This result highlights the influence of BG nanoparticles with hydrophilic properties. The PCL/15% F-BG nanocomposite has the highest wetting angle among the composites. As expected, with the increasing loadings of nanoparticles, the contact angle decreases, making the nanocomposites more hydrophilic [\u003cspan class=\"CitationRef\"\u003e42\u003c/span\u003e]. The wetting angle continues to decline with the addition of BG nanoparticles, reaching its lowest value and highest hydrophilicity in the optimally selected PCL/32% F-BG sample with the best mechanical properties. In the PCL/45% F-BG nanocomposite, a slight increase in the contact angle is observed compared to PCL/32% F-BG. Although the PCL/45% F-BG composite contains more F-BG ceramic particles compared to the PCL/32% F-BG composite, the higher amount of particle agglomeration within the composite results in a higher contact angle. This agglomeration, which has previously been observed to diminish its composite\u0026rsquo;s mechanical properties, contributes to this phenomenon.\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec14\" class=\"Section2\"\u003e\n \u003ch2\u003e3.5. Biodegradability\u003c/h2\u003e\n \u003cp\u003eThe degradation test results consist of pH changes of PBS solution, water absorption and weight changes of samples in PBS solution at 37 ℃ and in a period of 28 days are shown in Fig. 8. As mentioned, PCL and its composites require a significant amount of time to degrade. The adoption of bulk, non-porous samples with low specific surface area instead of porous scaffold samples with high specific surface area, alongside the interpretative advantages about the neat material under examination, has resulted in a much slower degradation rate. Furthermore, as stated, films prepared from the materials have been shaped in to bulk form under pressure and heat, which has led to the formation of microcracks or potential undetectable flash present on the surfaces of the bulk samples. Figure 8(a) illustrates the pH changes of the samples within the solution. As can be observed, due to the aforementioned reasons, there has been minimal degradation of the bulk samples within this time frame. The slight reduction in the pH of composite samples could be attributed to the detachment of agglomerated BG particles present on the bulk surfaces. This detachment may expose larger specific surface areas of the matrix polymer (created by the void spaces left from the detached clusters). Figure 8(b) shows the water absorption amount of the samples. As expected, the water absorption rate of composite samples has increased over time due to the presence of the hydrophilic component of BG, while the water absorption rate of neat polymer remains nearly zero and almost constant. Additionally, composites containing higher loadings of BG exhibit a higher water absorption rate compared to those with lower concentrations. The nearly zero weight loss of the bulk material samples from days 7 to 28, as shown in Fig. 8(c), indicates a very slow degradation process for the bulk specimens during this period. The greater positive and negative numerical values of weight loss observed on day 3 may be due to the presence of microcracks formed during the hot-pressing process and water penetration into them over the three-day period. Due to the bulk and compact nature of the samples, the vacuum process for drying the samples after removal from the pbs does not effectively remove the infiltrated liquid within the cracks. This results in weight gain in some samples with a low concentration of additives, or greater weight loss due to the detachment of flash or pieces of agglomerated BG from the surface in samples with higher loadings of additives.\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec15\" class=\"Section2\"\u003e\n \u003ch2\u003e3.6. Cytotoxicity Tests\u003c/h2\u003e\n \u003cp\u003eThe MTT test samples and results are shown in Fig. 9.\u003c/p\u003e\n \u003cp\u003eThe MTT test samples and results are shown in Fig.\u0026nbsp;10. There was a notable difference between neat PCL and PCL/F-BG nanocomposites in terms of cell viability. After 24 h, the cell viability of neat PCL was approximately 84.040\u0026thinsp;\u0026plusmn;\u0026thinsp;2.419%, whereas the PCL/27% F-BG and PCL/32% F-BG nanocomposites showed an increase to 89.074\u0026thinsp;\u0026plusmn;\u0026thinsp;0.939 and 92.490\u0026thinsp;\u0026plusmn;\u0026thinsp;1.310, respectively. This indicates that the addition of the current paper\u0026rsquo;s F-BG nanoparticles decreases toxicity compared to that of neat PCL. Over time, the cytotoxicity of PCL increased and the addition of the nanocomposite counteracted this increase. The lowest lethality was observed in the 24-hour period for PCL/32% F-BG nanocomposites. The results of this study showed that the addition of 32% F-BG significantly reduced the cytotoxicity of neat PCL such that the survival rate was above 87%. With extended exposure, there is a possibility that the cells may adapt to environment, improve adhesion to the composite surface, and begin to proliferate. This adaptation period is a crucial consideration when assessing the biocompatibility of PCL/BG nanocomposites in future studies [\u003cspan class=\"CitationRef\"\u003e43\u003c/span\u003e].\u003c/p\u003e\n\u003c/div\u003e"},{"header":"4. Conclusion","content":"\u003cp\u003eEnhancing the mechanical properties of biodegradable polymer composites implanted within bone tissue to match the mechanical properties of the host bone is crucial for maximizing the biocompatibility of the implanted scaffolds for the patient. In this study, efforts were made to optimize production process parameters and material selection. 45S5 BG was surface-modified using APTES, meticulously reduced to approximately 55 nanometers, and incorporated into the composite production while preventing agglomeration. A novel solution casting process was designed, and composite samples with 15%, 30%, 45% wt% and two other derived points of 27% and 32% wt% according to the later point\u0026rsquo;s results were fabricated. To produce flawless, homogeneous, and uniform samples, hot pressing was utilized in designed molds to prepare flexural test samples, which allowed the mechanical properties of various particle loadings to be evaluated. The 32% composite sample, with an excellent elastic modulus of 1193 MPa and a flexural strength of 25.8 MPa, was selected as the optimal BG loading. Comprehensive assessments beyond mechanical properties were also conducted:\u003c/p\u003e \u003cp\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003eMicroscopic evaluation of the fracture surface indicated good quality of particle-to-matrix bonding, composite formation, and uniform distribution of non-agglomerated particles, as well as brittle and ductile fracture assessments of the samples.\u003c/p\u003e \u003c/li\u003e \u003cli\u003e \u003cp\u003eTo evaluate the degradation model of the composite in all scenarios, samples were exposed to PBS in an orbital shaker for 3, 7, 14, 21, and 28 days, assessing water absorption weight, weight loss, and pH changes.\u003c/p\u003e \u003c/li\u003e \u003cli\u003e \u003cp\u003eTo assess the hydrophilicity of the composites, indicative of suitable cell adhesion in the body, the samples were examined, with the optimal 32% sample exhibiting the best hydrophilicity at 69 degrees.\u003c/p\u003e \u003c/li\u003e \u003cli\u003e \u003cp\u003eCytotoxicity tests conducted on the samples over 1, 2, and 3 days indicated not only good cell viability of the 32% F-BG composite at 92.490\u0026thinsp;\u0026plusmn;\u0026thinsp;1.310%, but also an improvement in cell viability compared to neat polymer.\u003c/p\u003e \u003c/li\u003e \u003c/ul\u003e \u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003eThe authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.\u003c/p\u003e\n\u003cp\u003eOn behalf of all authors, the corresponding author states that there is no conflict of interest.\u003c/p\u003e\n\u003ch2\u003eFunding Declaration\u003c/h2\u003e\n\u003cp\u003eThis research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.\u003c/p\u003e\n\u003ch2\u003eAuthor Contribution\u003c/h2\u003e\n\u003cp\u003eAll authors contributed to the study\u0026rsquo;s conception and design.All authors read and approved the final manuscript.Sanaz Toorani: Writing \u0026ndash; original draft, Validation, Investigation, Data curation.Majid Sohrabian: Writing \u0026ndash; review \u0026amp; editing, Consulting, Methodology, Investigation.Mahmood Sameezadeh: Writing \u0026ndash; review \u0026amp; editing, Supervision, Methodology, Conceptualization.Mohadeseh Khalafi: Writing \u0026ndash; editing, Software, Data curation.\u003c/p\u003e\n\u003ch2\u003eData availability statement\u003c/h2\u003e\n\u003cp\u003eThe raw/processed data required to reproduce these findings cannot be shared at this time as the data also forms part of an ongoing study and can be shared if only part of the research data required to reproduce these findings.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e\u003cspan\u003eNikkhah Varkani M et al (2023) Design, preparation and characterization of a high-performance epoxy adhesive with Poly (butylacrylate-block-styrene) Block Copolymer and Zirconia nano particles in aluminum-aluminum bonded joints. 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Biochem Eng J 166:107846\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003ede Melo F et al (2020) \u003cem\u003eMinimally invasive aesthetic treatment of the face and neck using combinations of a PCL-based collagen stimulator, PLLA/PLGA suspension sutures, and cross-linked hyaluronic acid.\u003c/em\u003e Clinical, cosmetic and investigational dermatology, : pp. 333\u0026ndash;344\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eGoncalves EM et al (2016) Three-dimensional printed PCL‐hydroxyapatite scaffolds filled with CNT s for bone cell growth stimulation. J Biomedical Mater Res Part B: Appl Biomaterials 104(6):1210\u0026ndash;1219\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eLebedev SM (2020) PCL-CNT nanocomposites prepared by melt compounding and evaluation of their basic properties. 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The predominant particle size of 55 nm ensured well-distributed, non-agglomerated particles within the composites. Fine flexural specimens were prepared via melt molding with a hot press for mechanical property evaluations. Flexural testing revealed that the PCL/32% F-BG samples exhibited the highest flexural strength (25.8 MPa), whereas the PCL/45% F-BG samples showed the greatest flexural elastic modulus (1793 MPa). Consequently, PCL/32% F-BG was identified as the sample with optimal mechanical properties. Microstructural analysis of the samples and the fractography analysis were performed using FESEM and SEM, confirming the well-dispersed BG nanoparticles within the polymer matrix. To ensure comprehensive evaluations beyond mechanical properties, hydrophilicity tests, weight loss measurements, absorbed water, and pH changes were conducted over 3, 7, 14, and 28 days within the framework of degradation tests. 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