Endometriosis and Gynecological Cancer

Mihai Emil Căpîlna, B Szabó, Lucian Pușcașiu, Aron Toma, Cosmin Rugină
In: Current Women's Health Reviews · 2012 · vol. 8(2) , pp. 150–157 · doi:10.2174/157340412800194867 · W2316171128
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This systematic review examines the links between endometriosis and gynecological cancer, finding evidence that ovarian tumors can arise from endometriosis and discussing risk factors, genetics, and pathways involved.

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This systematic review examines the parallels between endometriosis and gynecological cancers, specifically focusing on risk factors, histological data, and genetic alterations. The authors analyzed literature to determine if ovarian tumors can originate from endometriotic lesions and identified aberrant activation of oncogenic pathways as a key mechanism. Evidence indicates that endometriosis serves as one of several potential sources for the development of ovarian cancer. Understanding these pathophysiological mechanisms is considered essential for preventing endometriosis-associated ovarian cancer and developing effective therapies. This paper is centrally about endometriosis — specifically its role as a precursor or source for ovarian cancer.

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Abstract

Objective: Endometriosis has been suspected of playing a role in the etiology of ovarian cancer. Design: This systematic review addresses the parallels and specific relationship of endometriosis and gynecological cancer regarding risk factors, histological data, genetic alterations, aberrant activation of oncogenic and antiapoptotic pathways, and options in clinical diagnosis. Data sources and eligibility criteria: We have performed a Pubmed search looking for all articles in English, using as key words "endometriosis", "ovarian cancer", "gynecologic cancer", "pathogenesis". Results: The evidence of the published studies suggests that ovarian tumors can arise from more than one potential source, endometriosis being one of these sources. Conclusion: Understanding the mechanism of the development of endometriosis and elucidating its pathogenesis and pathophysiology are intrinsic to the prevention of endometriosis associated ovarian cancer and the search for effective therapies. Keywords: Endometriosis, epidemiology, molecular pathogenesis, ovarian cancer
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Abstract

Design: This systematic review addresses the parallels and specific relationship of endometriosis and gynecological cancer regarding risk factors, histological data, genetic alterations, aberrant activation of oncogenic and antiapoptotic pathways, and options in clinical diagnosis. Data sources and eligibility criteria: We have performed a Pubmed search looking for all articles in English, using as key words “endometriosis”, “ovarian cancer”, “gynecologic cancer”, “pathogenesis”.

Results

The evidence of the published studies suggests that ovarian tumors can arise from more than one potential source, endometriosis being one of these sources.

Conclusion

Understanding the mechanism of the development of endometriosis and elucidating its pathogenesis and pathophysiology are intrinsic to the prevention of endometriosis associated ovarian cancer and the search for effective therapies.

Keywords

Endometriosis, epidemiology, molecular pathogenesis, ovarian cancer

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endometriosis

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