Expression of Matrix Metalloproteinase-1 and its tissue inhibitor in endometriotic tissue
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Endometriotic tissue exhibits higher MMP-1 and lower TIMP-1 expression compared to normal and eutopic endometrium, a pattern that enhances invasiveness and contributes to endometriosis pathogenesis.
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Abstract
The expression level of MMP-1 in the endometriotic tissue was higher, while that of TIMP-1 in the endometriotic tissue was lower, than in the normal and the eutopic endometrium of the patients with endometriosis (H=0.86-13.62, P0.05). The high expression of matrix metalloproteinase-1 and the low expression of TIMP-1 in endometriotic tissue make ectopic endometrial tissue more invasive, and may play an important role in the pathogenesis of endometriosis.
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- europepmc
- last seen: 2026-07-27T06:15:28.040536+00:00