Title Ex Vivo Assessment of Keratinocytic Carcinomas Using a Fast Mid-Infrared Probe

Title Ex Vivo Assessment of Keratinocytic Carcinomas Using a Fast Mid-Infrared Probe | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 31 October 2025 V1 Latest version Share on Title Ex Vivo Assessment of Keratinocytic Carcinomas Using a Fast Mid-Infrared Probe Authors : Maria G. .Vazquez de Vasquez , Rebecca C. Bradley , Charles L. Hitchcock , Angela S. Casey , Austin Cusick , James Coe 0000-0001-5009-5472 [email protected] , and Ronald Siegle Authors Info & Affiliations https://doi.org/10.22541/au.176193740.06878932/v1 225 views 114 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract A fast mid-infrared spectral probe was used to record infrared (IR) spectra of fresh skin tissue removed from patients with biopsy-proven Keratinocytic cancer (KC) during Mohs surgery. A 150-patient library of IR spectral data was obtained to see if KC can be differentiated from adjacent nonmalignant tissue and normal skin. A linear Support Vector Machine model was found to minimize overtraining and predict the contributions to decisions at each step in the spectrum. Training demonstrated a KC Sensitivity of 93±5% and Specificity 84±6% (3-fold Testing esd) on the full library using equal cost for KC and nontumor cases. Success in this test problem warrants future studies to see if differentiation of melanoma from benign melanocytic as well as other skin lesions is possible. This study was approved by the Advarra Institutional Review Board, #PRO00053468. Supplementary Material File (jb_irm102_8_full.docx) Download 2.79 MB Information & Authors Information Version history V1 Version 1 31 October 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords devices fiber-loop probe keratinocytic carcinoma linear support vector machine mid-infrared spectroscopy skin carcer Authors Affiliations Maria G. .Vazquez de Vasquez IR Medtek LLC View all articles by this author Rebecca C. Bradley IR Medtek LLC View all articles by this author Charles L. Hitchcock IR Medtek LLC View all articles by this author Angela S. Casey Center for Surgical Dermatology View all articles by this author Austin Cusick OhioHealth Riverside Community Medicine View all articles by this author James Coe 0000-0001-5009-5472 [email protected] IR Medtek LLC View all articles by this author Ronald Siegle IR Medtek LLC View all articles by this author Metrics & Citations Metrics Article Usage 225 views 114 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Maria G. .Vazquez de Vasquez, Rebecca C. Bradley, Charles L. Hitchcock, et al. Title Ex Vivo Assessment of Keratinocytic Carcinomas Using a Fast Mid-Infrared Probe. Authorea . 31 October 2025. DOI: https://doi.org/10.22541/au.176193740.06878932/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. 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